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  • 1
    Electronic Resource
    Electronic Resource
    Serum antibody reactivity against recombinant PrtC of Porphyromonas gingivalis following periodontal therapy (2003)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 38 (2003), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objectives:  In 34 patients with chronic periodontitis, the presence of IgA, IgG, and IgG subclass serum antibodies against recombinant PrtC (rPrtC) of Porphyromonas gingivalis was assessed by immunoblot analysis 24 months after therapy.Methods:  rPrtC was produced from P. gingivalis ATTC 33277 using the plasmid pGEX-2T. In addition, intraoral colonization with P. gingivalis was detected by PCR in subgingival plaque and swab samples from buccal mucosae, tonsils and tongue at baseline, 10 d, and 3, 6, 9, 12, 18, and 24 months.Results:  All patients were found to harbor P. gingivalis in the oral cavity at least once during the observation period. The identified antibody responses against the rPrtC of P. gingivalis were IgA (97%, i.e. 33/34 patients) and IgG (100%, i.e. 34/34), with an IgG subclass distribution of IgG2 (65%, i.e. 22/34 patients) 〉 IgG3 (47%, i.e. 16/34) 〉 IgG1 (38%, i.e. 13/34) 〉 IgG4 (29%, i.e. 10/34). Anti-rPrtC IgA and IgG antibody reactivity was found in all but one patients (anti-rPrtC IgA negative), who tested negative for P. gingivalis at all of the assessed intraoral sites for at least 6 months before sera collection. There was no association between IgG subclass reactivity against the rPrtC of P. gingivalis and progression of periodontal attachment loss.Conclusion:  The results indicated that anti-rPrtC IgA and IgG antibodies may serve as an indicator for past or present intraoral colonization with P. gingivalis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0765.2003.01405.x
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  • 2
    Electronic Resource
    Electronic Resource
    Congenital adrenal hyperplasia and acne in male patients (2003)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 148 (2003), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Seborrhoea is one pathogenic factor for acne. Androgens induce sebum production, and excess androgen may provoke or aggravate acne. In women an androgen disorder is frequently suspected when acne is accompanied by hirsutism or menstrual irregularities. In men acne may be the only symptom of androgen excess. We report three male acne patients in whom hormonal screening revealed irregularities of androgen metabolism suggestive of late-onset congenital adrenal hyperplasia and who benefitted from low-dose glucocorticoids. Disorders of androgen metabolism may influence acne not only in women, but also in men, and these patients may benefit from low-dose glucocorticoid therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2003.05369.x
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  • 3
    Electronic Resource
    Electronic Resource
    Electronic and magnetic properties of the high-T c superconductor EuBa2Cu3O x (1987)
    Springer
    The European physical journal 68 (1987), S. 433-436 
    Details
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Electrical resistivity and magnetic susceptibility show that single phase EuBa2Cu3O x becomes superconducting at 94 K. Magnetization and magnetoresistivity yield a lower critical field of Hc1≃500 G and a variation ofT c with magnetic field of dT c /dH≃1 K/T. The high temperature resistivity shows that at about 700 K due to oxygen loss the sample is driven into a semiconducting state, in which the superconductivity is destroyed. The normal state magnetic susceptibility measured in the superconducting and in the oxygen degased, semiconducting sample indicates that the sample is paramagnetic in the normal state. This paramagnetism is larger than the one expected for trivalent Eu and therefore has to be attributed in part to a magnetic moment on Cu. Eu is found to be stable trivalent between 300 and 4.2 K through Mößbauer-spectroscopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01471073
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  • 4
    Electronic Resource
    Electronic Resource
    Tunneling and point-contact spectroscopy of high-T c superconductors M−Ba2Cu3O7 (M=Y, La, Eu) (1987)
    Springer
    The European physical journal 69 (1987), S. 173-178 
    Details
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Tunneling and point-contact measurements have been performed on different high-T c superconductors M−Ba2Cu3O7 with M=Y, La, Eu. The average energy gaps deduced from the tunneling spectra are about 2Δ=33 meV for the Y- and La-type samples and about 2Δ=38 meV for the Eu-type samples, which give ratios 2Δ/k B T c in the range from 4 to 6. The point-contact characteristics show a distinct minimum in the differential resistance about zero bias and additional sharp spikes up to 40 mV. From these pointcontacts we can give an estimate of the critical current, yielding values in the range from 0.2 to 3 mA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01307273
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  • 5
    Electronic Resource
    Electronic Resource
    Improved upper and lower energy bounds for antiferromagnetic Heisenberg spin systems (2003)
    Springer
    The European physical journal 33 (2003), S. 285-292 
    Details
    ISSN: 1434-6036
    Keywords: PACS. 75.10.Jm Quantized spin models – 75.50.Xx Molecular magnets – 75.50.Ee Antiferromagnetics – 75.40.Mg Numerical simulation studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: Large spin systems as given by magnetic macromolecules or two-dimensional spin arrays rule out an exact diagonalization of the Hamiltonian. Nevertheless, it is possible to derive upper and lower bounds of the minimal energies, i.e. the smallest energies for a given total spin S. The energy bounds are derived under additional assumptions on the topology of the coupling between the spins. The upper bound follows from “n-cyclicity", which roughly means that the graph of interactions can be wrapped round a ring with n vertices. The lower bound improves earlier results and follows from “n-homogeneity", i.e. from the assumption that the set of spins can be decomposed into n subsets where the interactions inside and between spins of different subsets fulfill certain homogeneity conditions. Many Heisenberg spin systems comply with both concepts such that both bounds are available. By investigating small systems which can be numerically diagonalized we find that the upper bounds are considerably closer to the true minimal energies than the lower ones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1140/epjb/e2003-00168-5
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  • 6
    Electronic Resource
    Electronic Resource
    Two-photon excited parametric emission from sodium atoms (1987)
    Springer
    Applied physics 44 (1987), S. 41-44 
    Details
    ISSN: 1432-0649
    Keywords: 42.65 Cq
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Tunable coherent radiation around 840, 830, and 795 nm has been generated upon two-photon excitation of sodium 4d and 5s levels, respectively. The generation is due to special parametric processes. A molecular nature of the emissions, as recently proposed, can be ruled out by the performed investigations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00693982
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  • 7
    Electronic Resource
    Electronic Resource
    Identification of a lys2 mutant of Candida maltosa by means of transformation (1987)
    Springer
    Current genetics 11 (1987), S. 385-391 
    Details
    ISSN: 1432-0983
    Keywords: Candida maltosa ; Transformation ; LYS2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We have isolated five mutants of Candida maltos, which lack the 2-aminoadipate reductase activity, an enzyme involved in the lysine biosynthesis. By means of complementation analysis using protoplast fusion, the isolated mutants were divided into two complementation groups. Thereof the C. maltosa strain G457 could be transformed by the plasmids pDP12 and pDP13, which contain the L YS2-coding gene of Saccharomyces cerevisiae. On the basis of our presented results obtained by studies on hybridization, stability, and recovery of plasmids from C. maltosa transformants, we suggest that transformation does proceed integratively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00378181
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  • 8
    Electronic Resource
    Electronic Resource
    Successful bone marrow transplantation from an unrelated donor in a child with AML in second remission (1987)
    Springer
    Annals of hematology 55 (1987), S. 199-204 
    Details
    ISSN: 1432-0584
    Keywords: Bone Marrow transplantation ; unrelated mismatched donor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In February 1986 we transplanted a 10-year-old girl with AML in second remission with the bone marrow of an unrelated donor. HLA-types were different for one A- and one B-antigen between patient and donor. Conditioning regimen consisted of 14 Gy total body irradiation with lung shielding, 8×3 g/m2 cytosin arabinoside and 90 mg/kg cyclophosphamide. GVHD-prophylaxis was performed with cyclosporin A, methotrexate and prednisolone. Only mild GVHD I of the skin could be observed after rapid engraftment. 100 days after transplantation the patient was in good clinical condition and GVHD-prophylaxis was discontinued without any reactivation of acute or chronic GVHD. Engraftment was documented by sex chromosome and blood group typing. 120 days after transplantation leukemic blasts were detected in the peripheral blood and the child died 130 days after BMT from relapse of the leukemia. Despite the negative outcome, this was the first successful bone marrow transplantation from a unrelated donor in Germany.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320090
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  • 9
    Electronic Resource
    Electronic Resource
    D600 prolongs inactivation of the contractile system in frog twitch fibres (1987)
    Springer
    Pflügers Archiv 410 (1987), S. 75-82 
    Details
    ISSN: 1432-2013
    Keywords: Twitch fibre ; K-contracture ; Inactivation ; D600
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract (1) Single twitch fibres were dissected from tibialis muscles ofRana temporaria and used to study the effect of D600 (gallopamil) on potassium-induced contractures. (2) 95 mM K-Ringer's was applied for 8–15 s at intervals of generally 2.5–5 min; at temperatures of 6–8°C and in the absence of D600 the amplitude of the contractures remained fairly constant. After pretreatment with D600 (30 μM) a single (conditioning) K-contracture was sufficient to ‘paralyze’ the fibres (cf. Eisenberg et al. 1983). (3) Complete paralysis could also be achieved at 18–20°C. In three fibres a single conditioning K-application was sufficient; in two more fibres two or three conditioning K-applications were required. (4) D600-paralysis could not only be achieved with high K-concentrations but also by conditioning with subor suprathreshold K-concentrations (20–40 mM); the duration of the conditioning periods required to induce complete paralysis was approximately the same before and after D600-treatment. (5) Contractures were partially abolished by application of 20–40 mM K-Ringer's for short conditioning periods; after D600-treatment the degree of contracture loss was similar. (6) At low temperature the state of partial or complete paralysis induced by subthreshold K-concentrations and D600 was maintained for long periods of time. (7) The presence of 10 mM Ca2+ did not protect the fibres from being paralyzed by treatment with D600 and high K-Ringer's at low temperature; however, more than one conditioning K-application was required. (8) Resting and action potentials of paralyzed fibres were not significantly different from control values. However, endplate potentials were reduced in size, and failure of neuromuscular transmission was observed in some of these fibres. (9) It is concluded that D600 prolongs the state of inactivation of the contractile mechanism, while the development of inactivation does not seem to be markedly affected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00581899
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  • 10
    Electronic Resource
    Electronic Resource
    Radiological findings in patients with mucopolysaccharidosis I H/S (Hurler-Scheie syndrome) (1987)
    Springer
    Pediatric radiology 17 (1987), S. 409-414 
    Details
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The development of radiological changes in two patients with mucopolysaccharidosis (MPS) Type I H/S is described. Radiological findings reveal enlargement of the sella in one patient, impression of the basilar skull in the other patient. Sclerosis and thickening of the base of skull was observed in both patients. The mandibular necks were short with striking flattening of the superior surfaces of the condyles, when the patients reached adult age. At the age of 12, hypertelorism and spaced teeth were already present in both patients. In addition, they showed early costal, clavicular and scapular changes, irregularities of the acromial joints and acetabulae, hypoplasia of the inferior portion of the iliac bones and flared iliac wings. The flat femurs had short metaphyses and were held in valgus position. Development of dentigerous cysts as well as mandibular changes seem to be rather specific for this variant ofα-L-iduronidase deficiency. In contrast to the classical form of MPS I, skeletal changes of the spine and hands are minimal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02396619
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