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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 1 (1998), S. 305-311 
    ISSN: 1434-6036
    Keywords: PACS. 47.55.Mh Flows through porous media - 82.45.+z Electrochemistry and electrophoresis - 46.30.Pa Friction, wear, adherence, hardness, mechanical contacts, and tribology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: Edison discovered that the coefficient of friction between a metallic plate and a porous material moistened with a dilute electrolyte could be modulated by an electric field. In experiments on the same kind of contacts (clays or chalks on carbon or metals) but without continuous tangential relative motion we measure two electro-mechanical effects at frequencies of the order of 10 kHz. An alternating field induces an alternating normal force between the porous material and the conducting base. The force is lagging by versus the field. A forced normal relative motion induces through the contact a current nearly in phase with the motion. For an explanation we start from Helmholtz theory of stationary electrophoretic phenomena. We present a model in which liquid motions obey the Helmholtz laws. It explains decently the phase relations between causes and effects, and approximately the values of the effects. In optical experiments on contacts between a wet clay and the transparent conducting coating of a glass plate we measure in the frequency range 1-100 kHz a modulation of reflecting power induced by an alternating potential. The decrease of reflecting power is lagging by an angle close to behind the field. We think the modulation observed is induced by a modulation of the amount of liquid in the film present between glass and clay. In friction experiments this alternating liquid lubrication acting exclusively at the very places where friction occurs may have significant effect.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: LASER Excimer irradiation can modify surface properties for biocompatibility improvement of a medical device. The PETs from 3 different origins were used in this study. The samples have been irradiated by excimer LASER with 10 different energies. The surface profile, the surface energy and the materials crystallinity have been assessed. Biological characterizations were made with human embryonic epithelial cells L132: proliferation, vitality, viability, adhesion with the p-NPP, and morphology. - The profile measurements allowed to establish the ablation threshold, which was 36 mJ/cm². The surface hydrophilic state increased reciprocally with the irradiation intensity. The gain is 13 %. The irradiated and non-irradiated product has identical cristallinity. PET was shown not to be toxic for L132 cells. Cell proliferation and cell vitality showed dose-dependant increases reciprocal to the irradiation energy (from 88 to 138% with respect to control). The correlation was highly significant (R² = 0,8). SEM micrographs show that the cells are better spread on the surface of irradiated PET than on untreated PET
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 288-289 (June 2005), p. 47-50 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In order to improve the tissue integration and subsequently the long-term maintenance, the implant surface can be modified by mechanical, physical, chemical or biological functionalization. In this way, the surface becomes biologically active by further grafting of biomolecules. Two principal concepts are considered for materials functionalization. (i) The Drug Delivery Systems (DDS) where the bioactive molecules goes to the target. (ii) The grafting of the bioactive compounds onsmall strongly bound spacer molecules. In this system, the target goes to the bioactive molecules. These techniques provide promising outlooks for any polymeric or ceramic scaffold used in tissue engineering for the construction of whole artificial and functional organs
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Schlafwandeln ; Komplexes Verhalten im Schlaf ; Arousals ; Schlafentzug ; Schlafstadienwechsel ; Stimuli ; Key words Sleepwalking ; Complex behaviour in sleep ; Arousals ; Sleep deprivation ; Stage shifts ; Stimuli
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary
    Notes: Zusammenfassung
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0584
    Keywords: Keywords Multiple myeloma ; Renal failure ; Peripheral blood stem cell transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Multiple myeloma with IgG-lambda monoclonal gammopathy and severe renal impairment with light-chain deposit disease was diagnosed in a 51-year-old man. Following conventional therapy with VAD (vincristine, adriamycin, dexamethasone) a partial remission was achieved. Peripheral blood stem cells (PBSC) were then collected following mobilization with cyclophosphamide and recombinant human granulocyte colony-stimulating factor and enriched for CD34-positive cells by immunoaffinity column. Fourteen months after diagnosis high-dose melphalan was given, followed by infusion of CD34-positive PBSC. Aside from mild oral mucositis and trigonitis, high-dose therapy was tolerated well. After he underwent PBSC transplantation his renal function improved, and the patient has been in in continuous complete remission for 1 year. Thus, high-dose chemotherapy can be safely administered to patients with multiple myeloma and severe renal impairment. Our findings confirm previous reports summarized in the current presentation.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0428
    Keywords: Keywords Diabetic nephropathy ; risk factors ; ACE polymorphism ; glycaemic control ; hypertension.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Diabetic nephropathy represents a major complication in patients with insulin-dependent diabetes mellitus (IDDM). Intervention trials using angiotensin-converting enzyme (ACE) inhibitors have pointed towards the important pathogenetic role of the renin-angiotensin system. Recently an insertion/deletion (I/D) polymorphism for the gene encoding the ACE has been described, the deletion type being associated with higher plasma ACE levels. As the intrarenal renin-angiotensin system might also be activated in this setting, we determined the ACE genotype together with other risk factors for the development of diabetic nephropathy in 122 patients with IDDM from a single centre with (n = 63) and without (n = 59) nephropathy. Long-term glycaemic control was evaluated using mean HbA1c values from the last 10 years. The two patient group were comparable with regard to duration of diabetes and glycaemic control as assessed by current HbA1c values. However, mean long-term HbA1c values were significantly higher in patients with diabetic nephropathy as was systemic blood pressure. The DD genotype was more prevalent in patients with renal disease. In the subgroup of patients who had had diabetes for more than 20 years (n = 90), the DD genotype was even more frequent in patients with nephropathy, and blood pressure and long-term HbA1c values were also higher in patients with renal disease. Logistic regression analysis revealed long-term glycaemic control, blood pressure and the ACE genotype to be independent risk factors for the prevalence of diabetic nephropathy. [Diabetologia (1997) 40: 327–331]
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 288-289 (June 2005), p. 633-636 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: PE is manufactured by Transysteme with the method of thermocompression of PE powder. This company irradiates PE by YAG LASER. We compared the physical behavior of both samples. The DSC reveals a high and similar crystallinity of PE, before and after YAG LASER treatment. Weattability between PE and Li-PE are similar at about 37 mJ/cm². The difference appears with respect to the surface profile and composition: the roughness is 0.20 µm for PE and 0.29µm for Li- PE. XPS reveals many traces of stripping agents on PE. YAG Laser produces a surface cleaning effect. Biological tests reveal a non-toxicity of the polyethylene powder, an improved proliferation and vitality of L132 cells on Li-PE with respect to untreated PE. We have a 4-fold improvement of proliferation and a 2-fold improvement of vitality on Li-PE with respect to PE. As to morphology and cell adhesion behavior, we have no differences between both samples. Thus the irradiation process of PE by YAG LASER improved the biological behaviors of this polymer due to changes in roughness and to surface cleaning
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1858
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Technology
    Notes: Abstract  Microsystems recently have been introduced as tools for screening in modern chemistry, biochemistry and biology. It has been shown that new microsystems can be implemented in the biomedical laboratory by using the microsystemic approach for the sample carrier – the miniaturized microtiter plate (“the nanotiter plate”) – or the production of nanodroplets with ink jetters and to integrate those systems in macrodevices like xyz tables and detection devices like CCD-cameras. We show in this paper that decisive problems of the approach – the evaporation problem and the problem of chemical/biochemical/biological compatibility of the assays and the used materials can be solved successfully. It is possible to realize chemical synthesis in miniaturized flow systems and to perform isothermal amplification of RNA in silicon wafers. Furthermore real high throughput screening with in vivo systems can be performed and all relevant parameters as evaporation, pipetting and detection can be controlled on reasonable time scales.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1573-4994
    Keywords: Phenol photolysis ; ionic forms ; fluorescence spectrum ; XeCl laser
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Absorption and fluorescence techniques were used to study special features of the XeCl laser-induced phototransformation of phenols in water and to compare the results obtained with those of photolysis of phenol solutions exposed to the UV radiation from mercury lamps. XeCl laser-induced phenol photolysis provided photoproducts not found on exposure to UV radiation. This is related to the two-photon population of highly excited phenol states under high-power laser pumping, which gives rise to a new phototransformation reaction pathway.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1573-4994
    Keywords: Bichromophore ; intramolecular electronic energy transfer ; photophysical processes ; internal conversion process ; process of singlet–triplet conversion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Results of experimental and theoretical research for three bichromophore molecules, trans-stilbene-CH2-coumarin 120 (I), 4-methylumbelliferone-CH2-UC 17, and 4-(3-fluoro)-methylumbelliferone-CH2-UC 17 (II, III), are presented. Schemes of photophysical processes in the bichromophore molecules based on quantum chemical calculations by the INDO method and theory of radiationless transitions in polyatomic organic molecules are suggested. After optical excitation to the strong donor absorption band, the fast internal conversion processes develop there. As a result, the molecule is found in the S 1 * -state localized on the acceptor moiety. It is shown that a mechanism of intramolecular transfer energy in bichromophores different from that proposed by Förster may be realized. Excitation energy, initially located on D, will be transferred from the donor moiety to the acceptor chromophore in convenience of the internal conversion process. The intramolecular electronic energy transfer from energy donor to energy acceptor may be interpreted as the internal conversion process. The rate constants of internal conversion are calculated.
    Type of Medium: Electronic Resource
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