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  • 11
    Electronic Resource
    Electronic Resource
    Abdominal wall plasty for a premature infant with congenital diaphragmatic hernia (1997)
    Springer
    Pediatric surgery international 13 (1997), S. 48-51 
    Details
    ISSN: 1437-9813
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This paper reports a premature infant with a congenital diaphragmatic hernia (CDH) who underwent an abdominal wall plasty to enlarge the abdominal cavity, one of twin infants born at 32 weeks weighing 1,255 g. After stabilization, the herniated viscera were reduced from the pleural cavity and the abdominal wall muscle and skin layers were replaced by a Gore-tex patch without closure of the diaphragmatic defect. Respiratory and circulatory conditions were stable during the perioperative period. Postoperatively, a roentogenogram showed expansion of the lung. However, his condition deteriorated 24 h after surgery, triggered by intratracheal suction, and he died on the 4th day of life despite the use of high-frequency oscillation, catecholamines, and vasodilators. Postmortem examination showed severely hypoplastic lungs. Abdominal wall plasty may be a less invasive initial procedure, however, further studies, such as comparison with the standard method or conservative management, are needed using a large clinical group or animal models to justify the usefulness of this procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003830050242
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  • 12
    Electronic Resource
    Electronic Resource
    Ultrastructural observation on the thalamic neuronal inclusions in young mice (1983)
    Springer
    Acta neuropathologica 59 (1983), S. 316-318 
    Details
    ISSN: 1432-0533
    Keywords: Intracytoplasmic inclusions ; Thalamus ; Young mice ; Neurofilament
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neuronal intracytoplasmic inclusions were found in the ventrolateral and posterior nuclei of the thalamus of 3-month-old thiamine-deficient mice and quaking mice. An electron-microscopic study revealed that these inclusions were composed of condensation of parallel rectilinear 10-nm filaments with interconnecting cross-bridges as a hallmark of neurofilaments. They were morphologically indistinguishable from those described in aged mice. This observation indicates that neuronal inclusions in the thalamus, which have been constantly reported in aging mice, can be seen even in young mice in the presence of cellular metabolic disturbances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691499
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  • 13
    Electronic Resource
    Electronic Resource
    Cathepsin B in gingival crevicular fluid of adult periodontitis patients: Identification by immunological and enzymological methods (1996)
    Springer
    Inflammation research 45 (1996), S. 277-282 
    Details
    ISSN: 1420-908X
    Keywords: Cathepsin B ; Cysteine proteinase ; Gingival Crevicular fluid ; Periodontitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cathepsin B (EC 3.4.22.1), a typical lysosomal cysteine proteinase was identified immunologically with anti-human cathepsin B antibody in inflammatory exudate, gingival crevicular fluid (GCF) of adult periodontitis patients. The sensitive enzyme immunoassay (EIA) system initially developed, was rarely influenced by the presence of endogenous, cysteine proteinase inhibitors, cystatin(s), indicating that it is possible to quantify the gross amount of cathepsin B including free enzyme forms and enzyme-inhibitor complex forms using this EIA system. The cathepsin B levels in, GCF as determined by EIA and the activity measured with Z-Arg-Arg-MCA showed positive and significant correlation with various clinical parameters. Immunoblotting analysis revealed that the molecular form was a 29 kDa mature enzyme. More than 95% of Z-Arg-Arg-MCA hydrolytic activity in each GCF sample was inhibited by CA-074, specific inhibitor of cathepsin B. These results strongly suggested that the gross amount of cathepsin B in GCF as well as its activity level is closely associated with the severity of the disease and that cathepsins B play an important role in the pathogenesis of periodontitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02280991
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  • 14
    Electronic Resource
    Electronic Resource
    Formation of (111) Recrystallization Texture in Al-Mg Alloys (1996)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 204-206 (Mar. 1996), p. 371-378 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/01/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.204-206.371.pdf
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  • 15
    Electronic Resource
    Electronic Resource
    Differential expression of IFN-γ, IL-4, IL-10, and IL-1β mRNAs in decalcified tissue sections of mouse lipopolysaccharide-induced periodontitis mandibles assessed by in situ hybridization (1998)
    Springer
    Histochemistry and cell biology 109 (1998), S. 339-347 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  To examine the role of T cell subgroups, Th1 and Th2, in the development of periodontitis, the expression of various cytokines was investigated in a mouse model of alveolar bone resorption using in situ hybridization (ISH) with digoxigenin-labeled oligonucleotides. When mice received repetitive injections with Escherichia coli lipopolysaccharide into the gingiva every 48 h, alveolar bone resorption was detectable after the fourth injection, reaching a maximum after the 13th injection. For the best performance of ISH, we first had to choose a decalcification protocol. Among various decalcification protocols, 10% EDTA (4°C, 5–6 days) was the best for 28S rRNA staining. Positive cells for transcripts of interferon-γ (Th1 product) were detected after the fourth injection, reaching a maximum after the tenth injection. A similar pattern was obtained for interleukin (IL)-10 mRNA (Th2 product) and IL-1β, while the positive cell number reached a maximum after the 13th and 10th injections, respectively. The number of IL-4 mRNA (Th2 product)-positive cells remained low till the tenth injection, but increased thereafter. Consequently, we found that the population change from Th1 to Th2 in the inflammation site correlated with the transition from gingivitis to periodontitis, indicating differential roles of T cell subgroups in the development of periodontitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004180050234
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    Paper (German National Licenses)
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  • 16
    Electronic Resource
    Electronic Resource
    Proton magnetic resonance spectroscopy (1H-MRS) for the evaluation of treatment of brain tumours (1995)
    Springer
    Neuroradiology 37 (1995), S. 99-103 
    Details
    ISSN: 1432-1920
    Keywords: Magnetic resonance spectroscopy ; Brain tumours ; N-acetyl-aspartate ; Lactate ; Embolisation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated metabolic changes in brain tumours following treatment, using proton magnetic resonance spectroscopy. In meningiomas, effective therapeutic embolisation led to an acute increase in lactate. In radiosensitive tumours such as malignant lymphoma, a decrease in lactate and in increase inN-acetyl-aspartate occurred after radiotherapy, which preceded changes observed on magnetic resonance imaging. On the other hand, no significant changes in spectral patterns were observed in malignant gliomas resistant to therapy. Tissue characterisation of brain tumours by spectral patterns on proton magnetic resonance spectroscopy remains controversial. However, we have shown it to be sensitive to metabolic changes following treatment, which may reflect the efficacy of the therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00588621
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  • 17
    Electronic Resource
    Electronic Resource
    Metabolic and neurological patterns in chronic cerebral infarction: a single-voxel 1H-MR spectroscopy study (1997)
    Springer
    Neuroradiology 39 (1997), S. 560-565 
    Details
    ISSN: 1432-1920
    Keywords: Key words Brain metabolism ; Cerebral infarcts ; chronic ; Magnetic resonance spectroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The details of brain metabolism in chronic cerebral infarcts have not been clarified. Using proton MR spectroscopy (1H-MRS) at 1.5 T, we measured biochemical changes in 16 patients with large infarcts involving the motor cortex in the chronic phase (median 293.9 days) and related the findings to clinical data. Localised spectra were obtained using point-resolved spectroscopy, with an echo time of 270 ms. Regions of interest were placed on the frontal lobe, including the precentral gyrus and central sulcus. Motor function was assessed by the manual muscle power test at the time of the 1H-MRS study. Only three patients with severe paresis had no signal in the lesions and a lactate signal was obtained in 13 cases. N -acetyl aspartate (NAA) was observed in 4 cases with recanalisation of an occluded vessel. Motor function correlated strongly with the NAA/choline-containing compounds (Cho) ratio (P 〈 0.01) and lactate/Cho ratio (P 〈 0.01). We found various metabolic patterns, reflecting residual neurological function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050467
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  • 18
    Electronic Resource
    Electronic Resource
    Proton magnetic resonance spectroscopy (1H-MRS) for the evaluation of treatment of brain tumours (1995)
    Springer
    Neuroradiology 37 (1995), S. 99-103 
    Details
    ISSN: 1432-1920
    Keywords: Key words Magnetic resonance spectroscopy ; Brain tumours ; N -acetyl-aspartate ; Lactate ; Embolisation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated metabolic changes in brain tumours following treatment, using proton magnetic resonance spectroscopy. In meningiomas, effective therapeutic embolisation led to an acute increase in lactate. In radiosensitive tumours such as malignant lymphoma, a decrease in lactate and in increase in N-acetyl-aspartate occurred after radiotherapy, which preceded changes observed on magnetic resonance imaging. On the other hand, no significant changes in spectral patterns were observed in malignant gliomas resistant to therapy. Tissue characterisation of brain tumours by spectral patterns on proton magnetic resonance spectroscopy remains controversial. However, we have shown it to be sensitive to metabolic changes following treatment, which may reflect the efficacy of the therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00588621
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 19
    Electronic Resource
    Electronic Resource
    High resolution computed tomography in the diagnosis of cervical disc disease (1983)
    Springer
    Neuroradiology 24 (1983), S. 253-257 
    Details
    ISSN: 1432-1920
    Keywords: X-ray computed tomography ; Spinal cord compression ; Spinal osteophytosis ; Spinal nerve root
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In this study, the authors evaluate the importance of computed tomography (CT) in 15 patients who underwent surgical treatment for cervical disc disease. In nine operated on by an anterior approach, all CT examinations were interpreted as positive for disc herniation and correlated precisely with surgical observations. CT demonstrated protrusion of the disc, centrally in four and posterolaterally in five in all of whom disc material was found posterior to the vertebral body. Of six who underwent laminectomy, either thickening or calcification of the ligamentum flavum was demonstrated by CT and confirmed at surgery in five. Vacuum phenomenon in the intervertebral space and hypertrophy of the intervertebral joint were not infrequently associated. CT can exactly delineate cervical disc lesions and associated pathological changes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00333176
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  • 20
    Electronic Resource
    Electronic Resource
    Supravalvular Aortic Stenosis, Pulmonary Artery Stenosis, and Coronary Artery Stenosis in Twins (1996)
    Springer
    Pediatric cardiology 17 (1996), S. 125-128 
    Details
    ISSN: 1432-1971
    Keywords: Key words: Supravalvular aortic stenosis — Pulmonary arterial stenosis — Coronary ostial stenosis — Twins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Supravalvular aortic stenosis (SVAS) is rare in twins. We report monozygotic twins, both of whom had SVAS, coronary ostial stenosis, and peripheral pulmonary arterial stenosis, but no other phenotypic features of Williams syndrome. One of the twins died suddenly, but the SVAS and the right and left coronary ostial stenoses were enlarged successfully at operation in the other twin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002469900028
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