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  • 2000-2004  (13)
  • 1985-1989  (18)
  • 1975-1979  (15)
  • 1970-1974  (10)
  • 1900-1904  (2)
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  • 11
    Digitale Medien
    Digitale Medien
    Esomeprazole 20 mg on-demand is more acceptable to patients than continuous lansoprazole 15 mg in the long-term maintenance of endoscopy-negative gastro-oesophageal reflux patients: the COMMAND Study (2004)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 20 (2004), S. 0 
    Details
    ISSN: 1365-2036
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background : Symptom relief, through adherence to appropriate maintenance therapy, is the sole objective of treatment for patients with endoscopy-negative gastro-oesophageal reflux disease.Aim : To compare the efficacy of ‘on-demand’ treatment with esomeprazole 20 mg vs. continuous treatment with lansoprazole 15 mg daily in patients with endoscopy-negative gastro-oesophageal reflux disease.Methods : Endoscopy-negative gastro-oesophageal reflux disease patients who achieved complete resolution of heartburn after short-term (2–4 weeks) treatment with esomeprazole 20 mg (n = 774) were randomized to receive either esomeprazole 20 mg on-demand (n =311) or lansoprazole 15 mg continuous daily treatment (n = 311) for 6 months.Results : Significantly more patients were willing to continue taking esomeprazole on-demand than lansoprazole continuous therapy after 6 months (93% vs. 88%; P = 0.02). This superior outcome was achieved despite patients on esomeprazole requiring medication only 38% as often as those on lansoprazole, leading to direct cost savings of more than one-third (36%). Furthermore, patients receiving esomeprazole 20 mg on-demand were more satisfied with their treatment after 1 month compared with patients taking lansoprazole 15 mg continuously.Conclusions : In patients with endoscopy-negative gastro-oesophageal reflux disease, esomeprazole 20 mg on-demand is more acceptable to patients and is an economically more effective treatment than lansoprazole 15 mg continuously.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2036.2004.02155.x
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  • 12
    Digitale Medien
    Digitale Medien
    Alverine citrate fails to relieve the symptoms of irritable bowel syndrome: results of a double-blind, randomized, placebo-controlled trial (2002)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 16 (2002), S. 0 
    Details
    ISSN: 1365-2036
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background : Alverine citrate has been used in the treatment of irritable bowel syndrome for many years.Aims : To compare the efficacy and safety of a new formulation of alverine citrate, a 120-mg capsule, with placebo given three times daily for 12 weeks.Methods : One hundred and seven patients with irritable bowel syndrome were entered into this three-centre, double-blind, randomized, placebo-controlled, parallel group trial. The primary end-point was relief of abdominal pain indicated by improvement in the scores for severity and frequency. Secondary efficacy variables included scores for other clinical symptoms and for overall well-being.Results : The severity and frequency of abdominal pain improved in 66% and 68% of patients treated with alverine citrate vs. 58% and 69% of the placebo group, but these differences were not significant. The mean percentage reduction in the scores for abdominal pain from baseline to the final assessment, although greater in the alverine citrate group (43.7%) compared with the placebo group (33.3%), was not statistically significant.Conclusions : Alverine citrate is no better than placebo at relieving the symptoms of irritable bowel syndrome. Future trials should be designed to take into account the high and persistent placebo response seen in this condition.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2036.2002.01277.x
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  • 13
    Digitale Medien
    Digitale Medien
    Randomized comparison of photodynamic therapy with topical 5-fluorouracil in Bowen's disease (2003)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 148 (2003), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary Background Bowen's disease (BD; intraepithelial squamous cell carcinoma) is therapeutically challenging because lesions, which may be multiple, are frequently located at sites that heal poorly. There is a small risk of progression to invasive carcinoma. Photodynamic therapy (PDT) is an effective treatment for certain non melanoma skin cancers, but comparison studies with other, better-established therapies are limited. Objectives To compare the efficacy and tolerability of PDT and topical 5-fluorouracil (5-FU) in BD. Methods Forty patients from two centres were randomized to either topical PDT or 5-FU. The PDT group was treated with 20% 5-aminolaevulinic acid (ALA) applied 4 h before illumination with 100 J cm−2 narrowband red light (630 ± 15 nm). 5-FU was applied to lesions for 4 weeks. A repeat treatment cycle was performed after 6 weeks if required. Results Twenty-nine of 33 (88%) lesions treated with PDT initially responded completely, compared with 22 of 33 (67%) after 5-FU. After 12 months, two recurrences in the PDT group and six in the 5-FU group reduced complete clinical clearance rates to 82% and 48%, respectively. PDT was significantly more effective (P = 0·006, odds ratio 4·78, 95% confidence interval 1·56–14·62). In the 5-FU group, severe eczematous reactions developed around seven lesions, ulceration in three and erosions in two. No such reactions occurred following PDT. There was no difference in overall pain experienced during each therapy. Conclusions Topical ALA-PDT is more effective than topical 5-FU in the treatment of BD, with fewer adverse events. ALA-PDT should be considered one of the first-line therapeutic options for BD.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2133.2003.05033.x
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  • 14
    Digitale Medien
    Digitale Medien
    Occurrence of trans -ribosylzeatin in Agrobacterium tumefaciens tRNA (1976)
    [s.l.] : Nature Publishing Group
    Nature 262 (1976), S. 153-154 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Four strains of A. tumefaciens were examined. Two strains, IIBV7 and C-58, are virulent and have been shown to harbour a large plasmid which is associated in some way with virulence8. The other two strains IIBNV6 and NT1, are avirulent and do not contain the plasmid. Strains C-58 and NT1 are very ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/262153a0
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  • 15
    Digitale Medien
    Digitale Medien
    Negatively correlated cross-resistance to a synthetic pyrethroid in organo-phosphorus-resistant Tetranychus urticae (1979)
    [s.l.] : Nature Publishing Group
    Nature 281 (1979), S. 298-299 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] A strain of two-spotted spider mite, Tetranychus urticae Koch, resistant to an organophosphorus (OP) insecticide, was observed to be more susceptible to a synthetic pyrethroid (SP) insecticide than was a strain which had no history of exposure to insecticides. To confirm this observation ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/281298a0
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  • 16
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    Unbekannt
    A possible basis for individual differences in magnitude-estimation behaviour (1974)
    London, etc. : Periodicals Archive Online (PAO)
    British journal of psychology. 65 (1974) 85 
    Details
    ISSN: 0007-1269
    Thema: Psychologie
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:0047-1974-065-00-000010
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  • 17
    Digitale Medien
    Digitale Medien
    Meal size in nymphs of Locusta migratoria (1972)
    Springer
    Entomologia experimentalis et applicata 15 (1972), S. 399-410 
    Details
    ISSN: 1570-7458
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Die Nahrungsmenge, die von einer Larve der Wanderheuschrecke, Locusta migratoria L., im fünften Entwicklungsstadium bei einer einzigen Mahlzeit verzehrt wird, wurde ermittelt, indem ihr Darm und Darminhalt sofort nach dem Fressen gewogen wurden. In der Mitte des Entwicklungsstadiums wurden größere Mengen verzehrt, Weibchen fraßen mehr als Männchen, jedoch sind die weiblichen Larven ja auch größer. Die Menge der aufgenommenen Nahrung vergrößerte sich mit der Dauer künstlichen Futterentzuges. Sie erreichte ihren Höhepunkt nach sechs Stunden, nach welcher Zeit der Vorderdarm absolut leer war. Die verzehrten Mengen waren je nach der Art der Nahrung unterschiedlich. Auch stellten die Insekten sich so ein, daß sie von einer bestimmten Nahrung mehr zu sich nahmen, wenn sie daran aufgezogen worden waren. Nach längeren Zeitspannen der Isolierung hatten sie die Tendenz, weniger zu fressen. Temperatur und Feuchtigkeit hatten keinen Einfluß auf die Mengen, die verzehrt wurden, außer bei 40°, bei welcher Temperatur sich das gesamte Verhalten zum Fressen ändert.
    Notizen: Abstract Meal size in fifth-instar nymphs of Locusta migratoria L. has been investigated by weighing the gut and its contents immediately after feeding. Larger meals are taken in mid-instar, while females eat more in one meal than males under the same conditions. Bigger meals are also eaten after longer periods of food deprivation, but after deprivation for two hours or less, corresponding with the normal interfeed length, meals are smaller than would be expected from the potential maximum foregut volume. The maximum volume attained varies with the type of food available to the insects and is influenced by previous conditioning. Temperature and humidity do not affect meal size except at 40°, at which temperature the usual pattern of feeding is completely altered.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00293604
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  • 18
    Digitale Medien
    Digitale Medien
    The yrast spectroscopy of neutron-rich nuclei produced in deep-inelastic processes (2003)
    Springer
    The European physical journal 20 (2003), S. 111-112 
    Details
    ISSN: 1434-601X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract. The highly sensitive GASP array at the INFN Legnaro Laboratory was used to study the $\gamma$ -ray de-excitation of neutron-rich nuclei produced in the deep-inelastic processes which occur when 230 MeV 36S ions interact with a target of 176Yb. Yrast decay schemes were identified in over forty target-like fragments and in over twenty projectile-like fragments. Analysis of the data has resulted in extensions to the yrast decay sequences of the target-like species, 176Hf, 166Er, 172Yb, and 152Sm. New transitions have also been observed in a number of projectile-like species including 34P and 41Cl. Experimental results are compared with the results of shell model calculations.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1140/epja/i2002-10334-y
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  • 19
    Digitale Medien
    Digitale Medien
    Use of the64Ni(36S,34Si)66Zn reaction to measure the mass of34Si (1985)
    Springer
    The European physical journal 321 (1985), S. 119-123 
    Details
    ISSN: 1434-601X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract The reaction64Ni(36S,34Si)66Zn atE=198 MeV has been used to measure the mass excess of34Si; a value of −19.971 −0.044 +0.037 MeV was obtained. This result which is in agreement with the previous value (−19.85±0.30 MeV) is in excellent agreement with recent shell-model mass predictions. The result is discussed within the context of the proposed region of deformation aroundZ=11,N=20.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01411955
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  • 20
    Digitale Medien
    Digitale Medien
    Insect behavior at the leaf surface and learning as aspects of host plant selection (1989)
    Springer
    Cellular and molecular life sciences 45 (1989), S. 215-222 
    Details
    ISSN: 1420-9071
    Schlagwort(e): Behavior ; learning ; leaf surface ; wax ; insects ; food selection ; secondary compounds
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Direct observations on the feeding behavior of insect herbivores are uncommon, but important. The important aspects of host-plant selection by phytophagous insects that have been revealed by such observations are the role of chemicals in the leaf surface, and learning. There are few detailed reports of behavior at the leaf surface, but these indicate that many, if not all, insects exhibit behavior pattenrs that can be interpreted as an examination of the quality of the surface and acceptance or rejection may follow without further testing. A number of experiments show that chemicals from the leaf surface commonly contribute to the acceptability or otherwise of a plant and in most cases so far the active chemicals are of widespread occurrence, not having a specific association with the host plant. Some experiments show that the association between surface chemicals and plant palatability is learned, but in other cases there is evidence of an innate response. Habituation to deterrent chemicals has been demonstrated in the laboratory, but not in the field. Food aversion learning also occurs and may be important in dietary switching by polyphagous insects.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01951806
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