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  • 2000-2004  (3)
  • 1980-1984  (11)
  • 1965-1969  (37)
  • 1930-1934  (1)
  • 11
    Electronic Resource
    Electronic Resource
    Mutation of p53 with loss of heterozygosity in the osteosarcomatous component of a dedifferentiated chondrosarcoma (2000)
    Springer
    Virchows Archiv 436 (2000), S. 494-497 
    Details
    ISSN: 1432-2307
    Keywords: Key words Dedifferentiated chondrosarcoma ; p53 mutation ; p53 LOH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We investigated a dedifferentiated chondrosarcoma of a 61-year-old woman with an osteosarcomatous high-grade component for p53 alteration. The low-grade cartilaginous and the high-grade osteosarcomatous components of the tumor were macrodissected and evaluated separately by immunohistochemistry and molecular biology. We used PCR-SSCP analysis and direct sequencing to screen exons 4–8 for p53 mutations. The p53 intron 1-polymorphism was investigated for loss of heterozygosity. A functionally relevant p53 missense mutation in codon 193 of exon 6 (A-to-T transversion) with loss of wild-type allele was detected only in the dedifferentiated component. Using the monoclonal antibody DO-1, immunohistochemistry failed to show p53 overexpression. This evidence of p53 mutation may be regarded as at least a co-factor that ”switched” the preexisting low-grade conventional chondrosarcoma to a highly malignant dedifferentiated tumor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050478
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  • 12
    Electronic Resource
    Electronic Resource
    Tolerance of Phenylalanine after Intravenous Administration in Phenylketonurics, Heterozygous Carriers, and Normal Adults (1966)
    [s.l.] : Nature Publishing Group
    Nature 209 (1966), S. 1148-1149 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The purpose of the investigation described in this communication was to estimate the rate of elimination of phenylalanine from the blood. We tested seventeen healthy adults, nine heterozygotes, and six phenylketonurics. First we obtained a fasting specimen of capillary blood by means of a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2091148a0
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  • 13
    Electronic Resource
    Electronic Resource
    Bindung per os aufgenommener Gifte durch antidote und Antidotgemische (1966)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 253 (1966), S. 76-77 
    Details
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00259284
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  • 14
    Electronic Resource
    Electronic Resource
    Pyridoxin-abhängige Veränderungen im chemischen Aufbau der Hyphen vonNeurospora sitophila (1968)
    Springer
    Archives of microbiology 61 (1968), S. 30-39 
    Details
    ISSN: 1432-072X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung Neurospora sitophila 299 (pyridoxinbedürftig) zeigt mit steigendem Angebot an Pyridoxol · HCl im Medium statistisch gesicherte Zunahmen an Protein, Zellwandsubstanzen (einschließlich Chitin) und Asche sowie Abnahmen an RNA und DNA. Der Lipidgehalt ist vom Pyridoxolangebot unabhängig. Der Durchmesser der Hyphen ist im Pyridoxinmangel statistisch signifikant größer als bei ausreichenden Gaben. Bei elektronenmikroskopischer Betrachtung gibt es keinen Anhalt für Pyridoxin-induzierte Veränderungen der Zellwandstärke.
    Notes: Summary With rising concentrations of pyridoxine in culture mediumNeurospora sitophila 299 (pyridoxineless) shows a significant increase of the relative amounts of protein, cell wall substances (incl. chitin), and ash, and a decrease of RNA and DNA. The lipid contents remain unchanged. The diameters of pyridoxine deficient hyphae are significantly greater than those of normal hyphae. Electron microscopic examination shows that B6-deficient cells do not contain a thinner or thicker than normal cell wall layer external to the membrane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00704289
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  • 15
    Electronic Resource
    Electronic Resource
    Phenylalanin-Toleranz bei Frühgeborenen, reifen Neugeborenen, Säuglingen und Erwachsenen (1966)
    Springer
    Journal of molecular medicine 44 (1966), S. 1076-1081 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary 1. The phenylalanine tolerance was estimated after intravenous injection of L-phenylalanine in premature newborns, mature newborns, infants and normal adults. The elimination of phenylalanine from the blood followed the pattern of a monomolecular reaction. The rate of elimination was, therefore, chosen for the comparison of the degree of tolerance. 2. The tolerance of phenylalanine was markedly reduced in most of the prematures; the same was found in some of the mature newborn infants. Compared with the tolerance in adults there was no decrease of phenylalanine tolerance in most of the mature newborns and in all infants. 3. The relation of phenylalanine tolerance to the activity of phenylalanine hydroxylase and to the development of the phenylalanine hydroxylase system was discussed.
    Notes: Zusammenfassung 1. Die Phenylalanin-Toleranz wurde vergleichend bei Frühgeborenen, reifen Neugeborenen, Säuglingen und Erwachsenen bestimmt. Die Untersuchung erfolgte nach intravenöser Injektion von L-Phenylalanin. Die Elimination von Phenylalanin aus dem Blut erfolgte entsprechend einer Exponentialfunktion. Zur Beurteilung des Toleranzgrades wurde die Eliminationshalbwertszeit gewählt. 2. Die Phenylalanin-Toleranz war bei den meisten Frühgeborenen herabgesetzt. Bei reifen Neugeborenen kamen Toleranzverminderungen vor; sie waren jedoch wesentlich seltener. Die meisten Neugeborenen und alle Säuglinge zeigten eine Phenylalanin-Toleranz, die der beim normalen Erwachsenen entspricht. 3. Es werden die Beziehungen diskutiert, die zwischen der Phenylalanin-Toleranz und der Aktivität der Phenylalaninhydroxylase bestehen, und es wird auf die bei neonatalen Tieren beobachteten Aktivitätsverminderung des Phenylalaninhydroxylase-Systems hingewiesen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716309
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  • 16
    Electronic Resource
    Electronic Resource
    Heat flow model of rapid solidification with nonhomogeneous thermal contact (1984)
    Springer
    Journal of materials science 19 (1984), S. 2145-2152 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A heat flow model is presented of the solidification process of a thin melt layer on a heat conducting substrate. The model is based on the two-dimensional heat conduction equation, which was solved numerically. The effect of coexisting regions of good and bad thermal contact between foil and substrate is considered. The numerical results for thermal parameters of the Al-Cu eutectic alloy show considerable deviations from one-dimensional solidification models. Except for drastic differences in the magnitude of the solidification rate near the foil-substrate interface, the solidification direction deviates from being perpendicular to the substrate and large lateral temperature gradients occur. Interruption of the thermal contact may lead to back-melting effects. A new quantity, the effective diffusion length, is introduced which allows some conclusions to be drawn concerning the behaviour of the frozen microstructure during subsequent cooling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01058090
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  • 17
    Electronic Resource
    Electronic Resource
    Measurement of the spectral flux density of negative muons at very low energies (1982)
    Springer
    The European physical journal 304 (1982), S. 333-334 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The spectral flux density of negative muons has been measured down to 5 eV.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01421514
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  • 18
    Electronic Resource
    Electronic Resource
    Trennung von einkernigen kationischen Rutheniumnitrosylnitrato-Komplexen mittels trägerfreier Duchflußisotachophorese (1983)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 315 (1983), S. 448-453 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Mit der kontinuierlichen trägerfreien Durchflußisotachophorese gelingt die präparative Gewinnung von sechs einkernigen kationischen Rutheniumnitrosylnitrato-Komplexen. Die Reinheitskontrolle geschieht durch Capillarisotachophorese.
    Notes: Summary Continuous carrier-free free-flow isotachophoresis permits the preparative isolation of six mononuclear cationic ruthenium nitrosyl nitrato complexes. The purity of the complexes is controlled by capillary isotachophoresis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00487058
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  • 19
    Electronic Resource
    Electronic Resource
    Extraktionsverhalten von Rutheniumnitrosyl-Komplexen in salpetersauren Lösungen (1984)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 319 (1984), S. 38-46 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Lösungen von Rutheniumnitrosylnitro-, Rutheniumnitrosylnitronitrato- und Rutheniumnitrosylnitrato-Komplexen lassen sich mit Hilfe von Papierelektrophorese, Extraktions-Chromatographie und Extraktionen eindeutig voneinander unterscheiden. Kontaktzeit, HNO3-Konzentration, NO 3 − -Konzentration, HDBP-Gehalt der organischen Phase und Zusatz von F−, SO 4 2− , H2PO 4 − und C2O 4 2− beeinflussen stark die Extraktion der Rutheniumnitrosylnitrato-Komplexe mit TBP in Dodecan.
    Notes: Summary Solutions of ruthenium-nitrosyl-nitro, ruthenium-nitrosyl-nitro-nitrato and ruthenium-nitrosyl-nitrato complexes can be distinguished clearly from each other by means of paper electrophoresis, extraction chromatography and extractions. The contact time, HNO3-concentration, NO 3 − -concentration, HDBP-content of the organic phase and the addition of F−, SO 4 2− , H2PO 4 − and C2O 4 2− exert a strong influence on the extraction of the ruthenium-nitrosyl-nitrato complexes with TBP in dodecane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00476227
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  • 20
    Electronic Resource
    Electronic Resource
    Zum induzierten Zerfall von unsymmetrischen Acylperoxiden (1967)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 79 (1967), S. 1006-1006 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19670792277
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