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  • 2000-2004  (29)
  • 1980-1984  (66)
  • 1950-1954  (126)
  • 1925-1929  (9)
  • 1915-1919  (2)
  • 11
    Electronic Resource
    Electronic Resource
    Mutations in the NOD2/CARD15 gene in Crohn's disease are associated with ileocecal resection and are a risk factor for reoperation (2004)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 19 (2004), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Mutations within the NOD2/CARD15 gene have recently been shown to be associated with Crohn's disease.Aims : To investigate the clinical impact of the three common NOD2/CARD15 mutations in patients with Crohn's disease.Methods : We investigated the prevalence of the three common NOD2/CARD15 mutations (Arg702Trp, Gly908Arg, 3020insC) in 180 patients with Crohn's disease, 70 patients with ulcerative colitis and 97 controls. In patients with Crohn's disease, prevalence of NOD2/CARD15 mutations were correlated to clinical and demographical parameters.Results : In Crohn's disease patients, 35.6% carried at least one mutant allele of NOD2/CARD15 mutations compared with 14.3% of patients with ulcerative colitis (P = 0.006) and to 15.5% of controls (P = 0.0001). Genotype phenotype analyses revealed that NOD2/CARD15 mutations determined younger age at disease diagnosis (P = 0.03), ileal disease location (P = 0.01) and ileocecal resections (P = 0.0002). Interestingly, reoperation with resection of the anastomosis was significantly more frequent in patients with NOD2/CARD15 mutations (P = 0.01).Conclusions : Our investigations support the current hypothesis that NOD2/CARD15 mutations are associated with a phenotype of Crohn's disease with younger age at diagnosis, ileal involvement, ileocecal resections and a high risk of postoperative relapse and reoperation. NOD2/CARD15 mutations might therefore be used to identify high risk patients for relapse prevention strategies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2004.01967.x
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  • 12
    Electronic Resource
    Electronic Resource
    Congenital adrenal hyperplasia and acne in male patients (2003)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 148 (2003), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Seborrhoea is one pathogenic factor for acne. Androgens induce sebum production, and excess androgen may provoke or aggravate acne. In women an androgen disorder is frequently suspected when acne is accompanied by hirsutism or menstrual irregularities. In men acne may be the only symptom of androgen excess. We report three male acne patients in whom hormonal screening revealed irregularities of androgen metabolism suggestive of late-onset congenital adrenal hyperplasia and who benefitted from low-dose glucocorticoids. Disorders of androgen metabolism may influence acne not only in women, but also in men, and these patients may benefit from low-dose glucocorticoid therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2003.05369.x
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  • 13
    Electronic Resource
    Electronic Resource
    Kinematical two-dimensional multiple-diffraction intensity profiles. Application to ω–ψ scans of silicon and diamond obtained with synchrotron radiation (2001)
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 34 (2001), S. 157-165 
    Details
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: In a previous paper by Rossmanith [J. Appl. Cryst. (2000), 33, 1405–1414], expressions for the calculation of multiple-diffraction patterns observed in ω–ψ scans of Bragg reflections were derived within the framework of the kinematical theory, taking into account the divergence and wavelength spread of the incident beam, as well as the mosaic structure of the crystal sample. Agreement with Cu Kα experiments was demonstrated. In this paper, it is shown that the theoretical expressions are also suitable for synchrotron radiation experiments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0021889801001352
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  • 14
    Electronic Resource
    Electronic Resource
    Theoretical investigations of the dynamical neutron diffraction by magnetic single crystals (1983)
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 39 (1983), S. 679-682 
    Details
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The fundamental equations for dynamical magnetic neutron diffraction including an external magnetic field are given. The reflecting power is calculated for some special cases for asymmetrical Laue geometry. Some Pendellösung effects are discussed. Analytical and numerical results for the integrated reflecting power are presented
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108767383001373
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  • 15
    Electronic Resource
    Electronic Resource
    Experiments on dynamical magnetic neutron diffraction by DyFeO3 (1983)
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 39 (1983), S. 682-685 
    Details
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The integrated reflecting powers of two nuclear and one magnetic reflexions of a DyFeO3 crystal have been measured. The results indicate that dynamical magnetic diffraction occurs. In addition, the integrated reflecting power of the magnetic reflexion was measured as a function of the magnetic field applied to the crystal, The results are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108767383001385
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  • 16
    Electronic Resource
    Electronic Resource
    2,3,4-Tri-O-acetyl-α-D-xylopyranosylfluorid bei 115 K und 295 K (1982)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 38 (1982), S. 2732-2735 
    Details
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0567740882009790
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  • 17
    Electronic Resource
    Electronic Resource
    Structure of 2,4-diazido-2,4-dideoxy-1,6-anhydro-β-D-glucopyranose (1980)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 36 (1980), S. 2646-2650 
    Details
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0567740880009600
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  • 18
    Electronic Resource
    Electronic Resource
    Einfluß des natürlichen Isotopengehaltes von Nährstoffen auf den Untergrund bei13C-Atemtests (1983)
    Springer
    European journal of nutrition 22 (1983), S. 107-115 
    Details
    ISSN: 1436-6215
    Keywords: 13C-Atemtest ; natürlicher Isotopengehalt von Nahrungsmitteln ; 13CO2-Gehalt der Atemluft ; parenterale Ernährung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary The long-term variation of the mean δ13C-value of breath-CO2 of Europeans (base value −26‰) was ±1‰ over a period of several months. However, the ingestion of products from corn, a C4-plant, caused remarkably higher shifts. In a fasted state and during rest a stability of the base value of ±0.3‰ could be attained for several hours. Longer fasting periods imply a shift of the CO2-δ-value due to the metabolism of body products. — By a change of the main energy source to corn products the δ13C-base line could be shifted to −18‰ within one day. After this shift even the metabolism of products from C3-plants could be investigated. The degradation curve and the integral degradation of fats were largely dependent on the method of application, and the base value largely interfered with the results. The period of maximum disintegration for a naturally and uniformly labelled fat was different from that of an artificially labelled trilinoleate. The results shall be used for the adjustment and the correction of the base line in13C-breath tests, especially with patients under parenteral nutrition.
    Notes: Zusammenfassung Der mittlere δ13C-Wert im CO2 der Atemluft von Europäern (Basiswert −26‰) zeigt eine Langzeitschwankung über mehrere Monate von ±1,0‰; der Verzehr von Produkten aus C4-Pflanzen (z. B. Mais) hat allerdings erheblich höhere Änderungen zur Folge. Im Nüchternzustand und in Ruhe wird während 6 h eine Stabilität des Basiswertes von ±0,3‰ erreicht; nach längeren Nüchternphasen kann aber der Abbau körpereigener Substanzen zu Verschiebungen führen. Durch Umstellung der Energieversorgung auf Maisprodukte ist es möglich, den Basiswert innerhalb eines Tages auf −18‰ zu heben; dann läßt sich auch der Abbau von Substanzen aus C3-Pflanzen verfolgen. Der Verlauf und die Rate des Abbaues von markierten Fetten sind stark von der Art der Applikation abhängig, und die Messung des Gesamtumsatzes wird durch den Untergrund stark beeinträchtigt. Der Zeitpunkt des maximalen Abbaues von uniform markiertem Fett (Sojaöl) unterschied sich von dem eines in der Carboxylgruppe markierten Trilinoleats. Die Resultate sind Grundlage zur Einstellung bzw. Korrektur von Basiswerten bei13C-Atemtests, besonders bei Patienten mit parenteraler Ernährung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02026207
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  • 19
    Electronic Resource
    Electronic Resource
    Die Cnidogenese der Octocorallia (Anthozoa, Cnidaria): I. Sekretionund Differenzierung von Kapsel und Schlauch (1981)
    Springer
    Helgoland marine research 34 (1981), S. 463-484 
    Details
    ISSN: 1438-3888
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The ultrastructural differentiation of capsule and its relation to tube development is described in several Octocorallia species(Alcyonaria: Alcyonium digitatum, Parerythropodium coralloides, Cornularia cornucopiae, Paralcyonium elegans; Pennatularia: Pteroeides spinosum, Veretillum cynomorium; Gorgonaria: Pseudopterogorgia aerosa), all of which have only one type nematocyst. In the Octocorallia, capsule and tube are secreted successively by the Golgi apparatus associated with a primary centriolar complex. During the secretion of the external tube, the outer capsular wall (sclera) is structurally differentiated; inside the capsule the material of the inner capsular wall is separated from the later capsular content (matrix). The primary wall differentiation enables the capsules to “grow” after capsular secretion has been completed. Following tube secretion, the external tube is completely transferred into the capsule, without the tube wall being transformed into capsular wall, as previously suggested (Westfall, 1966; Ivester, 1977). During early invagination of the tube wall, the coarse, granulated matrix of the external tube is transferred into the internal tube. From this material the spines are developed, which are observed before the tube is completely transferred into the capsule. By a secondary wall differentiation the previously structureless inner capsular wall changes to a complex structure, extending again the capsule, thus mixing the capsular content and enabling the tube to shift to a position, which corresponds with that of mature capsules. These observations demonstrate for the first time the differentiation of the capsule and its close relationship to the differentiation of the tube in nematocysts of Octocorallia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01995918
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  • 20
    Electronic Resource
    Electronic Resource
    Die Cnidogenese der Octocorallia (Anthozoa, Cnidaria): II. Reifung, Wanderung und Zerfall von Cnidoblast und Nesselkapsel (1982)
    Springer
    Helgoland marine research 35 (1982), S. 97-118 
    Details
    ISSN: 1438-3888
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Migration of cnidoblasts has never been observed in Anthozoa. In contrast to hydrozoans, anthozoans are repeatedly reported to develop nematocysts locally without migration in the entoderm as well as in the ectoderm. The majority of the nematocysts studied in different Octocorallia species (Alcyonaria:Alcyonarium digitatum, Parerythropodium coralloides; Gorgonaria:Pseudopterogorgia aerosa; Pennatularia:Veretillum cynomorium) originate from the ectoderm of the scapus, where, however, no mature nematocysts occur. Cnidoblasts containing immature nematocysts accumulate in the distal scapus, from where they migrate singly like amoebae into the pinnulae of the tentacles. The nematocysts mature during migration, during which the capsular matrix becomes completely electron-translucent. Only in the oral disc, where few nematocysts occur, do they mature locally without migration. In the Octocorallia, nematocyst development and maturation takes places only in the ectoderm. Development of nematocysts has never been observed in the entoderm, nor in the pharynx; this demonstrates its entodermal origin. The entoderm contains only degenerated or phagocytized nematocysts. Contrary to hydrozoans, the mature anthozoan cnidocyte is rounded and has no processes to the mesogloea. Instead of a cnidocil it has a ciliary cone consisting of a normal flagellum, stereocilia and macrovilli. The cnidocyte is characterised by abundant electron-translucent cytoplasm and nematocyst-anchoring structures made up of cross-striated, collagen-like fibrillae and a fibrous basal ring. The position of the cross-striated fibrillae is distally similar to that of the supportive rods in hydrozoan cnidoblasts. The present study clearly demonstrates that structure and, possibly, function of an octocorallian cnidocyte is much simpler than that of a hydrozoan cnidocyte. On the other hand, cnidoblast migration, occurring in Hydrozoa as well in Octocorallia, turned out to be a much older phylogenetic character than was formerly believed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02289837
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