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  • 1
    Electronic Resource
    Electronic Resource
    Critical Issues in the Conduct and Interpretation of Clinical Trials (1983)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Public Health 4 (1983), S. 25-46 
    Details
    ISSN: 0163-7525
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pu.04.050183.000325
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  • 2
    Electronic Resource
    Electronic Resource
    Does previous infection protect against atopic eczema and recurrent wheeze ininfancy? (2004)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 34 (2004), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Frequent infection in infancy and early childhood has been hypothesized to explain the low prevalence of asthma and other atopic disease among children in developing countries (the so-called ‘hygiene hypothesis’), but the low prevalence in Eastern Europe remains unexplained.Objective To test the hygiene hypothesis in the Republic of Belarus by examining the relationship between gastrointestinal (GI) and respiratory infection and two potentially atopic outcomes in the first 12 months of life: atopic eczema and recurrent wheeze.Methods We carried out two case–control studies nested within a large (n=17 046) randomized trial in Belarus, with cases defined as (1) first occurrence of atopic eczema (n=819) and (2) second episode of wheezing (n=112). Incidence density sampling was used to select four matched controls born within 1 month at the same hospital as the case. Exposure was defined as one or more episodes of GI or respiratory infection (examined separately) with onset 〉7 days before onset of the case's atopic outcome. Analyses controlled for family atopic history, duration of exclusive breastfeeding, sex, birth weight, maternal education, and (for recurrent wheeze) maternal smoking.Results For atopic eczema, prior GI infection occurred in 7.4% of cases vs. 6.0% of controls [adjusted OR=1.27 (0.94–1.72)] and prior respiratory infection in 35.2% vs. 32.6% [adjusted OR=1.14 (95% CI=0.94–1.37)]. For recurrent wheeze, prior GI infection occurred in 9.8% of cases vs. 7.4% of controls [adjusted OR=1.30 (0.60–2.82)].Conclusion Our results do not support the hypothesis that infection protects against atopic eczema or recurrent wheezing in the first 12 months of life.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.2004.1940.x
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  • 3
    Electronic Resource
    Electronic Resource
    Soymilk reduces hair growth and hair follicle dimensions (2001)
    Copenhagen : Munksgaard International Publishers
    Experimental dermatology 10 (2001), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: We have recently shown that soybean-derived serine protease inhibitors and soybean extracts alter skin pigmentation, suggesting that soymilk could be used as a natural alternative to skin lightening. The present studies were initiated to examine the possible effect of STI, BBI and soymilk on hair pigmentation. Interestingly, these agents were found to affect not only hair pigmentation, but also the rate of hair growth, the dimensions of the hair follicle and hair shaft, and the appearance of the hair. The studies presented here provide first evidence, at the morphological and histological level, that soymilk and the soybean-derived serine protease inhibitors could be used as effective agents for hair care and management. These agents could reduce the rate of hair growth, decrease hair shaft dimensions and alter the pattern of melanogenic gene expression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0625.2001.100603.x
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  • 4
    Electronic Resource
    Electronic Resource
    Alterations of Amino Acid Transmitter Systems in Spinal Cords of Chronic Paraplegic Dogs (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 42 (1984), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The high-affinity uptake of [3H]serotonin, [3H]glutamate, and [3H]-γ-aminobutyric acid (3H]GABA) and the Na+-independent binding of [3H]glutamate and [3H]GABA were studied using spinal cord preparations obtained from normal mongrel dogs and from dogs made paraplegic by midthoracic spinal cord crush. Lumbosa-cral regions of the spinal cord were removed either before (1 week) or after (3 to 8 weeks) onset of spasticity. A myelin-free synaptosomal fraction was obtained by cen-trifugation and used for studying high-affinity uptake and for preparing synaptic plasma membranes for Na+-inde-pendent binding experiments. For the paraplegic groups, the uptake of 30 nM [3H]serotonin was 66 and 18% of control values after 1 and 3 weeks, respectively. Eadie-Hofstee analysis of [3H]serotonin uptake showed a 90% reduction in Vmax for the paraplegic group relative to control values, thereby indicating the expected loss of descending serotonergic pathways. The high-affinity uptakes of 1 μM [3H]glutamate and [3H]GABA were the same in both the control and nonspastic paraplegic groups after 1 week. However, after 3 weeks, the uptakes of [3H]glutamate and [3H]GABA were 60-70% higher for the spastic group than for the control animals. For both amino acids, Eadie-Hofstee plots revealed no difference in Km and higher Vmax for the spastic group relative to control values. After 1 and 3 weeks, the Na+ -independent binding of 5 nM [3H]glutamate was 40-85% higher and the binding of 10 nM [3H]GABA was 40-60% lower for the paraplegic groups relative to the values for the control animals. Scatchard analysis revealed significant changes in Bmax values for both amino acids. Overall, the data indicate an increase in segmental amino acid excitatory influence which occurred when signs of spasticity were evident.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1984.tb12752.x
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  • 5
    Electronic Resource
    Electronic Resource
    Expression of the α and β subunits of Ca2+/calmodulin kinase II in the cerebellum of jaundiced Gunn rats during development: a quantitative light microscopic analysis (2000)
    Springer
    Acta neuropathologica 99 (2000), S. 393-401 
    Details
    ISSN: 1432-0533
    Keywords: Key words Hyperbilirubinemia ; Bilirubin ¶encephalopathy ; Kernicterus ; Cerebellum ; Purkinje cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The homozygous (jj) jaundiced Gunn rat model for hyperbilirubinemia displays pronounced cerebellar hypoplasia. To examine the cellular mechanisms involved in bilirubin toxicity, this study focused on the effect of hyperbilirubinemia on calcium/calmodulin-dependent kinase II (CaM kinase II). CaM kinase II is a neuronally enriched enzyme which performs several important functions. Immunohistochemical analysis of alternating serial sections were performed using monoclonal antibodies for the α and β subunits of CaM kinase II. Measurements were made of the total numbers of stained cells in each of the deep cerebellar nuclei and of Purkinje and granule cell densities in cerebellar lobules II, VI, and IX. The β subunit was present in Purkinje cells and deep cerebellar nuclei of both groups at all ages, but only granule cells which had migrated through the Purkinje cell layer showed staining for β subunit; external granule cells were completely negative. Many Purkinje cells had degenerated in the older animals, and the percent of granule cells stained for β subunit was significantly reduced. The α subunit was found exclusively in Purkinje cells, although its appearance was delayed in the jaundiced animals. Sulfadimethoxine was administered to some jj rats 24 h or ¶15 days prior to sacrifice to increase brain bilirubin concentration. Results showed that bilirubin exposure modulated both α and β CaM kinase II subunit expression in selective neuronal populations, but sulfadimethoxine had no acute effect on enzyme immunoreactivity. Thus, developmental expression of the α and β subunits of CaM kinase II was affected by chronic bilirubin exposure during early postnatal development of jaundiced Gunn rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010051141
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  • 6
    Electronic Resource
    Electronic Resource
    The design of a study of the drug etiology of agranulocytosis and aplastic anemia (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 833-836 
    Details
    ISSN: 1432-1041
    Keywords: agranulocytosis ; aplastic anaemia ; international case control study ; incidence ; di-pyrone ; pyrazolone derivatives
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607096
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  • 7
    Electronic Resource
    Electronic Resource
    Risk of breast cancer in relation to the use of rauwolfia alkaloids (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 143-146 
    Details
    ISSN: 1432-1041
    Keywords: alkaloids ; breast cancer ; rauwolfia ; antihypertensive drugs ; case control study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a case-control study of 1881 women with breast cancer and 1523 controls with benign conditions, 65 cases (3.5%) and 64 controls (4.2%) reported having used a drug that contained rauwolfia, giving a rate ratio estimate of 0.8 (95% confidence interval, 0.5–1.1). Use that ended more than a year previously was negatively associated with breast cancer (rate ratio, 0.5; 95% confidence interval, 0.2–0.9). The risk of breast cancer did not vary significantly according to duration of use. Nor did it vary within strata of varying base-line risk, such as age at first pregnancy. The data suggest that rauwolfia alkaloids do not increase the risk of breast cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00630277
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  • 8
    Electronic Resource
    Electronic Resource
    Clinical heterogeneity in the tricho-dento-osseous syndrome (1983)
    Springer
    Human genetics 〈Berlin〉 64 (1983), S. 116-121 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The tricho-dento-osseous syndrome (TDO syndrome) involves morphologic abnormalities of hair, teeth, and skeleton. Clinical findings of the TDO syndrome are excessively curly (fuzzy) hair, enamel hypoplasia, and skeletal findings of a generalized pattern of osseous sclerosis. We report an autosomal dominant syndrome with similar hair and teeth morphology, but with a skeletal dysplasia consisting of sclerosis and thickening of the calvarium with long bones that show subtle undertubulation but no sclerosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327105
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  • 9
    Electronic Resource
    Electronic Resource
    Laser-biophysics (1982)
    Springer
    Applied physics 28 (1982), S. 240-245 
    Details
    ISSN: 1432-0649
    Keywords: 87 ; 82.65
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00697851
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  • 10
    Electronic Resource
    Electronic Resource
    Kaolin refractories after service in a blast-furnace hearth (1984)
    Springer
    Refractories and industrial ceramics 25 (1984), S. 718-723 
    Details
    ISSN: 1573-9139
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Conclusions During service differentiated changes in properties and structure of the refractories across the thickness of the lining occur in the lining of the blast-furnace hearth. The most intense processes under the action of the slag and the gaseous medium occur in the working zone of the lining, which leads to a reduction in open porosity of the refractory to 6–10%, an increase in apparent density to 2.40–2.45 g/cm3 and in the compressive strength to 80–132 MPa, a decrease in the mullite content, and the formation of up to 12% glass, melilite, calcium ferrites, anorthite, and other minerals. The mechanism of lining failure in the blast-furnace hearth is a step-by-step multistage process of impregnation of the lining with solid, liquid, and gaseous substances, interaction of them with the refractory, and chemical, mechanical, and thermal failures of the newly formed constituents under the influence of various factors. Refractory blocks and type ShPD-42 brick based on kaolin raw material are recommended for lining the iron-notch apertures and the upper portion of the blast-furnace hearth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01389949
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