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  • 1
    Electronic Resource
    Electronic Resource
    Uric Acid in Nonhuman Primates with Special Reference to Its Renal Transport (1974)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 14 (1974), S. 355-364 
    Details
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pa.14.040174.002035
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  • 2
    Electronic Resource
    Electronic Resource
    The role of circulating food antigen-specific lymphocytes in food allergic children with atopic dermatitis (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 135 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In this study we evaluated antigen-specific in vitro responses of peripheral blood lymphocytes to lipopoiysaccharide (LPS)-depleted food allergens in children who reacted to food challenge (cow's milk or hen's egg) with a deterioration of their atopic dermatitis (AD). Some ofthe children showed immediate symptoms (urticaria, bronchial asthma or gastrointestinal symptoms) as well. The proliferation of casein-stimulated lymphocytes from children reacting to cow's milk (age (0.7–5.9 years) was significantly higher (P〈0.01) than the proliferation of lymphocytes from 15 children with AD without milk allergy (age: 2.1–9.1 years). Twenty-eight T-cell clones (TCC) were established from the blood of three children sensitized to cow's milk and hen's egg who reacted to double-blind, placebo-controlled oral food challenge both with a deterioration of AD and wilh immediate symptoms. Surprisingly, 16 of 28 casein- or ovalhumin-specific TCC were CD8+. All TCC produced high amounts of IFN-γ upon stimulation with concanavalin A. In addition. 75%. of the CD4+ TCC and 44% of the CD8+ TCC secreted IL-4. Our results indicate that: (i) food-specific proliferation of blood lymphocytes can be detected in patients with clinically relevant food allergy with LPS-depleted allergens in vitro and (ii) circulating food-specific lymphocytes are CD4+ and CD8+ T cells with the capacity of producing both type 1 and type 2 cytokines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1996.d01-1098.x
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  • 3
    Electronic Resource
    Electronic Resource
    Circulating soluble L-selectin [Circulatin] in atopic dermatitis (1999)
    Copenhagen : Munksgaard International Publishers
    Allergy 54 (1999), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.1999.00225.x
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  • 4
    Electronic Resource
    Electronic Resource
    Mixed micelle formation between gramicidin-S and a nonionic detergent: a nuclear magnetic resonance model study of peptide/detergent aggregation (1999)
    Springer
    European biophysics journal 28 (1999), S. 166-173 
    Details
    ISSN: 1432-1017
    Keywords: Key words Cyclopeptide ; Surfactant ; Interaction ; Micelle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract The interaction of the cyclic decapeptide antibiotic gramicidin-S (GrS) with the nonionic detergent octaethylene glycol mono-n-dodecyl ether was studied by NMR spectroscopy. Detergent binding led to a slightly altered average conformation in the d-Phe side chains of the peptide. The changing diamagnetic shielding of nearby protons resulted in chemical shift variations, the largest effect being observed for the d-Phe C α proton. The continuous upfield shift of this proton resonance, indicating rapid exchange of the peptide between detergent-associated and unassociated states, was employed for an evaluation of the detergent/peptide aggregation equilibria. The nonlinear binding plot thus obtained was attributed to essentially different aggregational states, depending on the detergent/peptide ratio. The almost linear dependence of the spin-lattice relaxation rate and of the hydrogen-deuterium exchange rate on the fraction of detergent-associated GrS could be reconciled with a simple model, comprising binding of detergent monomers and cooperative binding of micelles at low and high detergent/peptide molar ratios, respectively. Thus, GrS provides a useful model for a study of backbone dynamics and water penetration in detergent- and membrane-bound peptides and proteins. The results will also be discussed with reference to the interaction of GrS with biological membranes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002490050196
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  • 5
    Electronic Resource
    Electronic Resource
    Die quantitative bestimmung des diquat in biologischem material (1973)
    Springer
    Archives of toxicology 30 (1973), S. 111-114 
    Details
    ISSN: 1432-0738
    Keywords: Diquat ; Reglone® ; Herbicide-Analytics ; Diquat ; Reglone® ; Herbicid-Analytik
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Diquat wird durch den stark sauren Kationenaustauscher Permutit R S 40 aus dem Untersuchungsmaterial isoliert und anschlißend mit gesättigter Ammoniumchloridlösung eluiert. Die spektrophotometrische Gehaltsbestimmung erfolgt nach Reduktion der Verbindung zum grün gefärbten Radikal bei 379 nm.
    Notes: Abstract Permutit R S 40, an acid ion exchange resin, can be used to determine the herbicide Diquat. This compound is eluated by the ion exchange column with a cold saturated NH4 Cl solution. The spectrophotometric determination is carried through after reduction to a green colored radical.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02425928
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  • 6
    Electronic Resource
    Electronic Resource
    Klinik, Toxikologie und Therapie einer schweren Carbromalvergiftung mit letalem Ausgang (1970)
    Springer
    Archives of toxicology 26 (1970), S. 149-160 
    Details
    ISSN: 1432-0738
    Keywords: Carbromal Poisoning ; Elimination ; Forced Diuresis ; Peritoneal Dialysis ; Carbromal-Vergiftung ; Elimination ; forcierte Diurese ; Peritonealdialyse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Eine schwere Carbromalvergiftung mit letalem Ausgang wurde in ihrem kimischen Verlauf beschrieben. Aufgrund fortlaufend durchgeführter chemisch-toxikologischer Untersuchungen konnten die Carbromalkonzentration im Serum und die eliminierten Carbromalmengen angegeben werden. Die Effektivität der einzelnen Eliminationsverfahren, insbesondere der forcierten Diurese und Peritonealdialyse, lie\ sich anhand der Aufzeichnungen näher untersuchen. Die Todesursache wurde von pathologisch-anatomischer und von chemischtoxikologischer Sicht besprochen.
    Notes: Summary The course of a lethal carbromal (bromdiethylacetylurea) poisoning is described. Continuous quantitation of carbromal levels in the serum and the amount excreted was performed. The effectiveness of several methods of elimination of the poison, in particular forced diuresis and peritoneal dialysis, could be compared. The cause of death is discussed from a pathological-anatomical and chemical-toxicological point of view.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00577801
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  • 7
    Electronic Resource
    Electronic Resource
    Klinik, Toxikologie und Therapie einer schweren Carbamazepin-Vergiftung (1971)
    Springer
    Archives of toxicology 27 (1971), S. 193-203 
    Details
    ISSN: 1432-0738
    Keywords: Carbamazepin Poisoning ; Elimination ; Forced Diuresis ; Peritoneal Dialysis ; EEG in Carbamazepin Poisoning ; Carbamazepin-Vergiftung ; Elimination ; forcierte Diurese ; Peritonealdialyse ; EEG bei Carbamazepin-Vergiftung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Eine schwere Carbamazepin-Vergiftung wurde in ihrem klinischen Verlauf beschrieben. Aufgrund fortlaufend durchgeführter chemischtoxikologischer Bestimmungen von Carbamazepin in Blut, Harn, Peritonealdialysat und Magenspülflüssigkeit konnte die Effektivität der einzelnen Eliminationsverfahren näher untersucht werden.
    Notes: Abstract The course of a severe Carbamazepin poisoning is described. By performing continuous quantitation of Carbamazepin in the blood urine, peritoneal dialysate and gastric washings, the effectiveness of the various modes of elimination of the poison could be compared.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315042
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  • 8
    Electronic Resource
    Electronic Resource
    Klinik und Toxikologie einer mit extrakorporaler Hämodialyse behandelten Carbromal-Vergiftung mit letalem Ausgang (1971)
    Springer
    Archives of toxicology 28 (1971), S. 149-158 
    Details
    ISSN: 1432-0738
    Keywords: Carbromal Poisoning ; Anuria ; Elimination of Brominated Mono-Ureides ; Hemodialysis ; Carbromal Vergiftung ; Anurie ; Elimination bromierter Monoureide ; Hämodialyse bei Carbromal Vergiftung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Eine schwere Carbromal-Intoxikation mit letalem Ausgang wurde in ihrem klinischen Verlauf beschrieben. Auf Grund fortlaufend durchgeführter chemisch-toxikologischer Bestimmungen von Bromid im Serum, Magenspülflüssigkeit, Harn und Hämodialyse-Waschlösung konnte die Elimination bromierter Harnstoffderivate näher untersucht werden.
    Notes: Abstract The clinical course of a case of severe Carbromal poisoning with lethal outcome is described. Bromide was serially determined in serum, urine, gastric washings and in the bath-fluid from hemodialysis to further characterize the elimination of brominated mono-ureides.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00330244
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  • 9
    Electronic Resource
    Electronic Resource
    Zur Klinik der schweren Carbromal-Intoxikation (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 39-49 
    Details
    ISSN: 1432-1440
    Keywords: Severe carbromal poisoning ; clinical course ; DIC-heparinization ; haemodialysis ; Schwere Carbromal-Intoxikation ; Klink ; DIC-Heparinisierung ; Hämodialyse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 27 Fällen schwerer Carbromal-Intoxikation werden die klinischen Befunde, die wichtigsten Komplikationen und Verlaufsvarianten analysiert. Daraus ergeben sich differentialtherapeutische Richtlinien: Allgemeine Intensivtherapie, Detoxikation unter besonderer Berücksichtigung der Hämodialyse, Heparinisierung im Falle einer DIC.
    Notes: Summary This report deals with 27 cases of severe carbromal poisoning. The analysis of the clinical course, its prevalent varieties and complications forms the basis of detailed therapeutic guide-lines: general supportive care, measures of detoxication including haemodialysis, and heparinization in case of DIC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468521
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  • 10
    Electronic Resource
    Electronic Resource
    Mercury contaminated sites — Behaviour of mercury and its species in lysimeter experiments (1995)
    Springer
    Water, air & soil pollution 80 (1995), S. 1089-1098 
    Details
    ISSN: 1573-2932
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract In a polluted site in Germany not only metallic, ionic and MeHg could be detected, but also organomercurials such as methyl- ethyl- and phenyl-mercury. In addition sometimes other organomercurials could be separated but up to now not identified. Extraction of the organomercurials from soil and percolating water was performed by dithizone, differentiation and detection by High-Performance-Liquid-Chromatography and atomic fluorescence detection, respectively. Differentiation between gaseous organic and gaseous elemental mercury was done by adsorption on Carbotrap® and gold filters, thermal desorption and detection by atomic fluorescence The behaviour of 8 organomercurials in soil is described. For this a lysimeter of a new design was filled with polluted soil. The top layer of the soil was spiked with 8 organomercurials. The percolating water and the air above the soil, were analyzed. Different layers of the soil were also investigated after the experiment. By synthetic rain the movement of Hg species is low: the compounds stay in the first centimeters. Ethoxyethylmercury+, tolylmercury+, and nitromersol were not detected in the percocolate. Concentrations of phenylmercury+ and hydroxymercurybenzoicacid decreased. Methoxymethylmercury+ increased. In the head of the lysimeter, volatile Hg(0) concentration increased during 150 hours by a factor of 5, while volatile organic mercury decreased during this time by a factor of 10. The organomercurial-content in soil decreased.A transformation of organic to inorganic Hg is therefore presumed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01189769
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