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  • 1995-1999  (3)
  • Arthroscopic lateral release  (1)
  • Cavitation  (1)
  • Children  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 157 (1998), S. 382-385 
    ISSN: 1432-1076
    Keywords: Key words Chronic hepatitis B ; Children ; Alpha-interferon ; Non-responder ; Retreatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract More than 50% of children with chronic hepatitis B do not respond to treatment with alpha-interferon. Since these patients continue to display high viral replication and progressive liver disease, retreatment should be considered. To date it has not been well evaluated whether a second course of treatment could increase the response rate. In two alpha-interferon retreatment trials in adult patients the response rate, defined by seroconversion from HBeAg to anti-HBe, ranged between 11% and 44%. One beta-interferon retreatment study in children reported a seroconversion rate of 32%. Regrettably, none of the studies included a control group observing the `spontaneous' seroconversion rate after a first interferon cycle. Thus, a nonrandomized alpha-interferon retreatment study in children including control patients was performed. Alpha-interferon for retreatment was administered 3 times a week for 16–24 weeks in 15 children (5–16 years) at least 6 months after ceasing the first cycle. Four children received 5 MU/m2 of a natural alpha-interferon and 11 children 9 MU/m2 recombinant alpha-interferon 2b. Follow up was 18–47 months after initial treatment. In parallel, a control group of 19 un-retreated children with comparable clinical and demographic data was followed for 12–39 months. HBeAg seroconversion was observed in 5 (33%) of the retreated children and in 5 (26%) of the control patients during follow up. The difference is not significant. In the initially nonresponding children, those with high ALT levels before the first treatment showed late HBeAg seroconversion more frequently than those with low ALT levels (P = 0.017) irrespective of retreatment. The ALT level before retreatment was not a predictor for response. Conclusions A second cycle of alpha-interferon during the 3 years following the first treatment in nonresponding children with chronic hepatitis B can be safely performed but did not increase HBeAg/anti-HBe seroconversion compared with the spontaneous seroconversion rate of patients without retreatment.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of orthopaedic surgery & traumatology 7 (1997), S. 271-275 
    ISSN: 1432-1068
    Keywords: Arthroscopic lateral release ; Patellar compression syndrome ; Section arthroscopique de l'aileron rotulien ; Syndrome fémoro-patellaire
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Dans cet article nous présentons la technique, les résultats ainsi que les complications et les indications de la section de l'aileron rotulien externe et la capsulorhaphie interne, à partir des résultats obtenus par l'examen de 7o malades souffrant les uns d'une légère latéralisation rotulienne externe et d'une hyperpression fémoro-patellaire externe (42 malades), les autres d'une luxation recidivante de la rotule (28 malades). La moyenne d'âge était de 26.2 ans (entre 9 et 54 ans). Au moment de l'examen de contrôle (m=64 mois) les malades ont été soumis à un examen clinique et radiologique. Les résultats ont été évalués conformément au score de Crosby et de Insall. 77 % des patients traités par relâchement latéral externe étaient satisfaits du résultat de l'opération (score analogue visuel) et 68 % des patients traités par capsulorhaphie. Par contre seulement 45 % des malades souffrant d'une ar-throse fémoro-patellaire traités par relâchement latéral externe parlaient d'une nette amélioration. Le score dit de Crosby et Insall donnait des résultats très significatifs mais ne montrait aucune différence parmi les résultats obtenus dans ces trois groupes. 13 % des malades souffraient d'un glissement de la rotule anormal en mobilisation active. Le test de glissement passif de la rotule montrait une hyper-mobilité de la rotule vers le côté latéral dans 37 % des cas et vers le côté médial dans 8o % des cas. Les radiographies des deux genoux montraient un angle de sulcus accru de 143 %. Cependant, aucune progression de l'arthrose n'a pu être relevée dans les articulations fémoro-patellaires opérées. Une hémarthrose post-opératoire précoce, nécessitant une révision, a été constatée dans un grand nombre de cas. Intérêt clinique: Vu les résultats sur les malades ayant souffert d'un syndrome d'hyperpression rotulienne sans arthrose patello-fémorale et les malades souffrant d'une luxation ou subluxation récidivante de la rotule, ces patients sont de bons candidats pour une section endoscopique de l'aileron rotulien externe et éventuellement pour capsulorhaphie interne. Dans une population relativement jeune la section endoscopique de l'aileron externe est une technique chirur-gicale relativement simple qui peut néanmoins être suivie par une technique “ouverte” en cas de défaillance de la première procédure.
    Notes: Summary Based on the results of 70 patients with mild lateral tracking and lateral compression of the patella, intact (22 patients) or defective (20 patients) cartilage of the patellofemoral joint, and recurrent patellofemoral dislocation (28 patients) we present the technique, results, complications and indications for the lateral retinacular release and medial imbrication of the vastus medialis obliquus. The average age of the patients was 26.2 years (range 9–54). At time of follow-up (m = 64 months) the patients were examined clinically as well as radiologically. The results were evaluated according to a Crosby and Insall score. 77% of the patients with mild lateral tracking and lateral compression (lateral release) were satisfied with the operative result (visual analog scale), as well as 68% of the patients with recurrent patellofemoral dislocation (lateral release and medial imbrication). Only 45% of the patients with patellofemoral arthritis (lateral release) reported an improvement in their condition after this procedure. The Crosby and Insall score showed significant improvement but did not show any difference between the 3 groups. 13% of the patients showed an abnormal lateral tracking of the patella in active motion. The passive patellar glide test showed patellar hypermobility to the lateral side in 37% of the cases and to the medial side in 80%. X-rays of both knees showed a sulcus angle of 143°. No progression in osteoarthritis in the operated patellofemoral joint was found. Hemarthrosis complicated a high number of cases in the early postoperative period, and in 3 cases an open revision was necessary. Clinical relevance: According to our results patients with patellar compression syndrome without patellofemoral arthrosis and patients with recurrent dislocation or subluxation of the patella are good candidates for endoscopic lateral release and medial imbrication of the medial vastus obliquus. In a young population endoscopic lateral release is a relatively simple surgical procedure making an open technique in failed cases possible later on.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1434-4726
    Keywords: Key words Hypopharyngeal malignancy ; Cancer ; therapy ; High-energy pulsed ultrasound ; Cell ; destruction ; Cavitation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The cytotoxic and anti-proliferative effects of high-energy pulsed ultrasound (HEPUS) on human squamous cell carcinoma cells cloned from the hypopharynx (FaDu) and benign connective tissue cells (fibroblasts) were investigated in vitro. Sonication was carried out using an experimental piezoelectric, self-focusing burst-signal transducer. To increase the induction of cavitation, the transducer used was specifically designed to produce multiple oscillations with a high negative pressure amplitude. In both cell lines tested, the application of 100, 800 and 2000 pulses resulted in a high reduction of vital cells. After 2000 pulses, 4.0 ± 1.1% of the fibroblasts but only 2.0 ± 0.4% of the FaDu cells survived HEPUS exposure. A postexposure inhibiting effect of HEPUS for 10 days on the proliferation of surviving cells was noted for the FaDu cells exposed to 2000 pulses, but not as much for the fibroblasts. These findings support the hypothesis that human squamous cell carcinoma cells of the hypopharynx might be more sensitive to HEPUS than fibroblasts and that total tumor cell ablation might be possible in vitro given a sufficient number of HEPUS pulses.
    Type of Medium: Electronic Resource
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