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  • 1
    Electronic Resource
    Electronic Resource
    Generalized amyloidosis from β2-microglobulin, with caecal perforation after long-term haemodialysis (1991)
    Springer
    Virchows Archiv 419 (1991), S. 349-353 
    Details
    ISSN: 1432-2307
    Keywords: Long-term haemodialysis ; β 2-Microglobulin ; Derived amyloidosis ; Caecal perforation ; Pathological hip fracture ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 73-year-old man with chronic renal failure of undetermined aetiology had received haemodialysis for 12 years when he died of acute purulent peritonitis due to caecal perforation. Amyloid deposits detected in a cystic bone lesion in the left hip had caused a pathological fracture 17 days before death. At autopsy, extensive amyloid deposits were found in the osteoarticular system, in the cartilaginous surface and the capsular tissue of joints, ligaments, vertebral discs and bone. In addition, vascular amyloid deposits were diagnosed in the heart, kidneys, testes, lungs, skin and in the gastrointestinal tract. A special feature of this case were interstitial amyloid deposits forming a fine-meshed structure in the myocardium and plate-like deposits in the gastrointestinal tract. Immunohistochemically, all these deposits reacted strongly with antibody to humanβ 2-microglobulin but showed no reaction with antibodies to AA, Alambda, A-kappa and AF. The present case demonstrates that extra-osteoarticular manifestations of AB-amyloidosis can cause serious complications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606526
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  • 2
    Electronic Resource
    Electronic Resource
    Fatal bleeding from duodenal varices as a late complication of neonatal thrombosis of the inferior vena cava (1992)
    Springer
    Virchows Archiv 420 (1992), S. 367-370 
    Details
    ISSN: 1432-2307
    Keywords: Thrombosis of inferior vena cava ; Collateral circulation ; Duodenal varices ; Neonatal renal vein thrombosis ; Autopsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 21-year-old man was hospitalized with repeated bleeding from the gastrointestinal tract, the cause of which could not be detected by gastroscopy, colonoscopy or arteriography. After the third surgical intervention he died of uncontrollable bleeding. At autopsy, marked and partly ulcerated duodenal varices were found to be the cause of the bleeding. They were part of a collateral circulation that had developed from chronic obstruction of the inferior vena cava, where thrombosis had arisen in association with neonatal renal vein thrombosis. There was consecutive renal infarction which had required a left nephrectomy on the 2nd day after birth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01600217
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A simple method for incubation of tissue sections in immunohistochemistry (1981)
    Springer
    Histochemistry and cell biology 72 (1981), S. 315-319 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The construction of a simple “incubatin chamber” is presented by which a homogeneous incubation of tissue sections with calculable amounts of immunoreagents is guaranteed. The incubation of large area sections, and parallel incubations of 10 slides are possible. As an example of application a case of alpha-1-antitrypsin deficiency in the liver is demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00517144
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  • 4
    Electronic Resource
    Electronic Resource
    Regression zerebraler Posttransplantationslymphome unter Cyclosporin-A-Reduktion (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 1189-1194 
    Details
    ISSN: 1432-1440
    Keywords: Kidney transplantation ; Immunosuppressive cytostatic therapy ; Cyclosporine A ; Malignant Non-Hodgkin-lymphoma ; Cerebral lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 4.5 months after successfull kidney transplantation a Non-Hodgkin-lymphoma with polymorph centroblastic appearance of the tonsillar gland developed in a 21 years old male patient during immunosuppressive therapy with cyclosporine A and prednisone parallel to infection with Epstein Barr virus. Focal epileptic seizures occurred and were due to cerebral posttransplantation lymphomas as proven by brain biopsy. Reduction of immunosuppressive therapy led to complete remission as shown by CCT and MRI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01815278
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  • 5
    Electronic Resource
    Electronic Resource
    Ascites als Komplikation hepatischer Speicherung von Hydroxyethylstärke (HES) bei Langzeitdialyse (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 862-866 
    Details
    ISSN: 1432-1440
    Keywords: Hemodialysis ; Hydroxyethyl starch ; Liver ; Storage ; Ascites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three adult dialysis patients developed ascites after having received repeatedly the plasma substitue hydroxyethyl starch (HES 40/0.5). In two cases (total dose 180, and 330 g HES, respectively) the ascites was reversible after discontinuation of the HES administration. In the third case (total dose 915 g HES) the ascites could be controlled only by implantation of a Denver shunt. In this latter case it was shown by histological, electron microscopical, and biochemical findings that the ascites was caused by hepatic sinusoidal obstruction due to an extreme storage of HES in the sinusoidal lining cells. Additional storage was detected in hepatocytes, bile duct epithelia, endothelial cells, and fibroblasts in the portal tracts. Biochemically HES was found in liver tissue at a concentration of 4% (w/w). Although in renal impairment plasma clearance of HES is not significantly different from normal individuals, long-term administration of HES must be regarded inadvisable because of tissue storage which apparently is especially significant in this condition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01712005
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  • 6
    Electronic Resource
    Electronic Resource
    225. Experimentelle Untersuchungen über respiratorische Komplikationen bei der akuten Pankreatitis (1984)
    Springer
    Langenbeck's archives of surgery 364 (1984), S. 543-543 
    Details
    ISSN: 1435-2451
    Keywords: Pancreatitis ; Pulmonary function ; Surfactant ; Pankreatitis ; Lungenfunktion ; Surfactant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Am Modell der taurocholatinduzierten akuten hämorrhagischen Pankreatitis der Ratte wurden die Auswirkungen dieser Erkrankung auf das respiratorische System untersucht. Vier bzw. 24 h nach Induktion kam es zu einem Abfall des pH, des Basenexcess und des pO2, wärend der pCO2 geringgradig erhöht war. Die Compliance-Parameter erfuhren eine pankreatitisbedingte Verschlechterung; das extravasale Lungenwasser als Maß für ein evtl. auftretendes Lungenödem blieb dagegen weitgehend unbeeinflußt. Ein Schock als Ursache für die respiratorischen Störungen kann aufgrund der unveränderten Kreislaufparameter und des normalen Serumlactats ausgeschlossen werden. Die Veränderung der Compliance-Parameter spricht für eine Surfactant-Schädigung im Rahmen der akuten Pankreatitis.
    Notes: Summary The model of taurocholate-induced acute hemorrhagic pancreatitis in the rat was used to investigate the effects of this disease on the respiratory system. After induction (4 and 24 h) there was a decrease in pH, base excess, and pO2 while pCO2 was slightly increased. The parameters of lung compliance deteriorated due to pancreatitis; however, the extravascular lung water, as indicator for a lung edema, remained unchanged. This respiratory disorder cannot be caused by shock because the circulatory parameters and serum lactete were stable. Deterioration of the compliance parameters may be caused by lung surfactant damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01823399
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    Paper (German National Licenses)
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