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  • 1
    Electronic Resource
    Electronic Resource
    Human colonic (Na++K+)-ATPase and specific ouabain binding are not influenced by lipoxygenase products or superoxide radicals (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 599-600 
    Details
    ISSN: 1432-1440
    Keywords: Colonic (Na++K+)-ATPase ; Specific ouabain binding ; Lipoxygenase pathway products ; Superoxide radicals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of lipoxygenase products (5-, 12-, 15-HETE, LTB4) and superoxide radicals on human colonic (Na++K+)-ATPase and specific ouabain binding were measured. No significant inhibition in concentrations up to 3 × 10−5 M was observed. The results are discussed with regard to a possible role of lipoxygenase products and radicals in the pathogenesis of water and electrolyte disturbances in various diarrheal states including inflammatory bowel disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01720836
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Increased dose-response relationship of liver plasma membrane adenylate cyclase to glucagon stimulation in diabetic rats. A possible role of the guanyl nucleotide-binding regulatory protein (1982)
    Springer
    Diabetologia 22 (1982), S. 464-467 
    Details
    ISSN: 1432-0428
    Keywords: Streptozotocin diabetes ; glucagon stimulation ; adenylate cyclase dose response relationship ; stimulatory effect of guanosine triphosphate ; guanyl nucleotide-depending regulatory protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In view of controversial findings regarding the mechanism for the increased intracellular hepatic cyclic 3′:5′ adenosine monophosphate levels in diabetic rats, we studied the dose-response relationship of the adenylate cyclase to glucagon stimulation in severely diabetic and in diabetic, insulin-treated rats. An enhanced response to glucagon and an additional augmenting effect of guanosine triphosphate on hormonal stimulation of the adenylate cyclase activity were found in diabetes which were reversible with insulin treatment. The results suggest a role of the regulatory guanyl nucleotide-binding protein in diabetes leading to an increased dose response relationship of the hepatic adenylate cyclase system to glucagon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00282591
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Studies on the in vitro binding of D-penicillamine to cholestyramine (1982)
    Springer
    Cellular and molecular life sciences 38 (1982), S. 482-484 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Adsorption of D-penicillamine to cholestyramine depends on the amount of the resin, the pH and the presence of other compounds such as bile salts. In the usual drug to resin ratio (150 mg D-penicillamine and 4–8 g cholestyramine per single dose) the percentage of D-penicillamine adsorbed to cholestyramine was about 10% of the applied dose; Bile salts (10 mmoles/1) inhibited this small adsorption by 87%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01952651
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Comparative pharmacokinetics of sulphasalazine and sulphapyridine after rectal and oral administration to patients with ulcerative colitis (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 275-277 
    Details
    ISSN: 1432-1041
    Keywords: sulphapyridine ; sulphasalazine ; pharmacokinetics ; rectal administration ; oral administration ; plasma levels ; ulcerative colitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Rectal administration of sulphasalazine to patients with ulcerative colitis has recently been shown to have similar therapeutic activity but fewer side effects than oral treatment. The present study is a comparison of the pharmacokinetics of sulphasalazine (SASP) and its metabolite sulphapyridine (SP) after rectal and oral administration of SASP to 6 patients with ulcerative colitis. The areas under the concentration-time curves (AUC) and the maximum concentrations (Cmax) of SASP and SP were significantly lower after rectal than oral administration of SASP (p〈0.05). These findings support the view that the lower frequency of side effects after rectal administration of SASP may result from the lower plasma levels of SASP and SP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00630300
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  • 5
    Electronic Resource
    Electronic Resource
    Soybean lipoxygenase inhibition: Studies with the sulphasalazine metabolites N-acetylaminosalicylic acid, 5-aminosalicylic acid and sulphapyridine (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 449-451 
    Details
    ISSN: 1432-1041
    Keywords: lipoxygenase inhibition ; antiinflammatory drugs ; N-acetyl-aminosalicylic acid ; 5-aminosalicylic acid ; sulphapyridine ; soybean ; therapeutic actions ; ulcerative colitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Soybean lipoxygenase inhibition has been proposed as an in vitro biochemical model for the antiinflammatory action of certain drugs used in the treatment of ulcerative colitis. In an extension of a recent study which showed that therapeutically active compounds, such as sulphasalazine and its colonic metabolite 5-aminosalicylic acid were soybean lipoxygenase inhibitors, it has now been shown that N-acetylaminosalicylic acid, the principal metabolite of 5-aminosalicylic acid, also inhibits soybean lipoxygenase in a dose dependent and noncompetitive manner (Ki 3.0×10−8M, IC50 250 µM). Sulphapyridine, the other major metabolite of sulphasalazine, which has been demonstrated to be inactive in the treatment of ulcerative colitis, did not inhibit the lipoxygenase activity. The findings further support the hypothesis that only the therapeutically active compounds are soybean lipoxygenase inhibitors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542139
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Lack of effect of haemodialysis on mebendazole kinetics: Studies in a patient with echinococcosis and renal failure (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 243-245 
    Details
    ISSN: 1432-1041
    Keywords: mebendazole ; haemodialysis ; echinococcosis ; pharmacokinetics ; protein binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of haemodialysis on mebendazole kinetics has been studied in a patient receiving both mebendazole therapy and haemodialysis. The procedure of haemodialysis did not influence the plasma concentration — time profiles or the mean daily plasma levels. The arterio-venous difference in the dialyser was negligible and no mebendazole could be detected in the dialysate. Protein binding of mebendazole was 90% before dialysis and 88% during dialysis and not significantly different from the binding in patients without renal disease (91.4±1.9%, n=22).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544053
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  • 7
    Electronic Resource
    Electronic Resource
    Inverse relationship between colonic (Na+ + K+)-ATPase activity and degree of mucosal inflammation in inflammatory bowel disease (1988)
    Springer
    Digestive diseases and sciences 33 (1988), S. 417-422 
    Details
    ISSN: 1573-2568
    Keywords: inflammatory bowel disease ; (Na+ + K+)-ATPase ; 5′-nucleotidase ; mucosal inflammation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In inflammatory bowel disease (IBD), mucosal damage and loss of colonic function are regarded as major consequences of inflammation. Decreased colonic (Na+ + K+)-ATPase activities with diminished reabsorption of sodium and water have been found in active stages of ulcerative colitis. In this study, we report an inverse relationship between colonic (Na+ + K+)-ATPase activity and the degree of mucosal inflammation in 19 patients with IBD of mild to moderate disease activity. Various macroscopic and histologic types of mucosal lesions were differently associated with the (Na+ + K+)-ATPase activities. 5′-nucleotidase activity was not associated with the degree of mucosal inflammation or the kind of macroscopic or histologic lesions. Our findings support the view that, in contrast to 5′-nucleotidase, (Na+ + K+)-ATPase activity may better reflect the severity of mucosal damage and the degree of inflammation in IBD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01536025
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    Paper (German National Licenses)
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