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  • 1985-1989  (2)
  • 1960-1964
  • Acquired immune deficiency syndrome (AIDS)  (1)
  • Cytokeratins  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Chronic HIV encephalitis — I. cerebrospinal fluid diagnosis (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 21-25 
    Details
    ISSN: 1432-1440
    Keywords: Acquired immune deficiency syndrome (AIDS) ; Cerebrospinal fluid ; HIV encephalitis ; HIV-specific antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To establish a reliable procedure for the early detection of central nervous system involvement in HIV infection, paired cerebrospinal fluid and serum samples of 59 patients were analysed. Fifteen were HIV antibody positive without clinical symptoms (stage I), 12 had lymphadenopathy syndrome or AIDS-related complex (stage II), and 32 had AIDS (stage III). Intrathecal synthesis of HIV antibodies was determined by a modified ELISA. Antibodies in CSF and serum were evaluated at identical immunoglobulin G levels to correct for the actual blood-CSF-barrier permeability. A CSF/serum quotient above 1.5 is indicative of intrathecal antibody synthesis, which was found in 47% of the patients in stage I, 67% in stage II, and 84% in stage III. These findings indicate an early and frequent invasion of the CNS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01735208
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cloning and characterization of keratin D, a murine endodermal cytoskeletal protein induced during in vitro differentiation of F9 teratocarcinoma cells (1987)
    Springer
    Development genes and evolution 196 (1987), S. 16-21 
    Details
    ISSN: 1432-041X
    Keywords: F9 cells ; Differentiation ; Retinoic acid ; mRNA ; Cytokeratins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We have identified a cDNA coding for the murine keratin D from a collection of clones representing F9 teratocarcinoma stem cell mRNA sequences. These sequences are synthesized specifically after the addition of retinoic acid and cAMP to the culture medium. The clone is 1,382 nucleotides long and contains the entire information for the active polypeptide, the complete 3′ end and most, if not all, of the 5′ non-coding region. The mRNA is found in hepatocytes, in PYS-2 cells (an endodermal cell line) and in differentiated (retinoic-acid-treated) F9 cells, but not in untreated F9 cells. The length of the mRNA is 1.4 kb, as estimated by Northern blot hybridization. Southern hybridization performed under very stringent conditions detects a single fragment hybridizing strongly with the cloned cDNA, suggesting that the mouse genome contains only one or very few copies of this gene. We present the first complete sequence of a keratin expressed in simple epithelia, i.e. keratin D, and discuss its structural features.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00376018
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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