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  • 1985-1989  (4)
  • HIV encephalitis  (2)
  • Dolichos biflorus agglutinin  (1)
  • Enzyme-linked immunosorbent assay  (1)
Source
Material
Years
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Chronic HIV encephalitis — I. cerebrospinal fluid diagnosis (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 21-25 
    Details
    ISSN: 1432-1440
    Keywords: Acquired immune deficiency syndrome (AIDS) ; Cerebrospinal fluid ; HIV encephalitis ; HIV-specific antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To establish a reliable procedure for the early detection of central nervous system involvement in HIV infection, paired cerebrospinal fluid and serum samples of 59 patients were analysed. Fifteen were HIV antibody positive without clinical symptoms (stage I), 12 had lymphadenopathy syndrome or AIDS-related complex (stage II), and 32 had AIDS (stage III). Intrathecal synthesis of HIV antibodies was determined by a modified ELISA. Antibodies in CSF and serum were evaluated at identical immunoglobulin G levels to correct for the actual blood-CSF-barrier permeability. A CSF/serum quotient above 1.5 is indicative of intrathecal antibody synthesis, which was found in 47% of the patients in stage I, 67% in stage II, and 84% in stage III. These findings indicate an early and frequent invasion of the CNS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01735208
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Chronic HIV encephalitis — II. clinical aspects (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 26-31 
    Details
    ISSN: 1432-1440
    Keywords: AIDS ; Dementia ; HIV encephalitis ; Neuropsychiatric symptomatology ; Psychological testing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Combined medical, neurological, and serological investigations were carried out in 59 patients infected with human immunodeficiency virus (HIV). In stage I clinical and neuropsychiatric testing did not reveal evidence for HIV encephalitis as diagnosed by local antibody production in CSF. Neuropsychiatric abnormalities, brain atrophy, memory and cognitive impairment reliably indicated HIV encephalitis in later stages. The commonest symptoms were cerebellar and brainstem signs, followed by dementia. Epileptic fits and hemipareses always were associated with cerebral toxoplasmosis. A polyneuropathy was frequently found but other causes have to be considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01735209
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Affinity cytochemistry of vascular endothelia in brain tumors by biotinylated Ulex europaeus type I lectin (UEA I) (1985)
    Springer
    Acta neuropathologica 67 (1985), S. 128-135 
    Details
    ISSN: 1432-0533
    Keywords: Ulex europaeus type I lectin ; Dolichos biflorus agglutinin ; Factor VIII-related antigen ; Cytochemistry ; Vascular endothelia ; Brain tumors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The vascularization of 50 tumors of the central nervous system (CNS) including 17 meningeomas, 25 neuroectodermal tumors, i.e., astrocytomas, oligodendrogliomas, mixed gliomas, glioblastomas, medulloblastomas, seven metastatic carcinomas, and one malignant hemangioendothelioma were investigated using biotinylated Ulex europaeus type I lectin (UEA I) in an indirect avidinbiotin-peroxidase procedure. The cytochemical staining pattern of UEA I on paraffin sections was compared with that of biotinylated Dolichos biflorus lectin (DBA), and with the immunocytochemical staining of factor VIII related antigen (F VIII/RAG) by polyclonal antisera using the PAP technique. UEA I visualized the endothelia of blood vessels with equal intensity, sensitivity, and reliability in normal brain and in tumor tissue with neovascularization. While large, medium, and small vessels were equally well demonstrated by UEA I and antibodies against FVIII/RAG, capillaries and endothelial sprouts were stained more consistently and intensely by UEA I. No reliable cytochemical staining could be obtained by DBA regardless of tissue or cell type investigated. It is concluded that UEA I is a highly useful cytochemical marker for the identification of vascular endothelia in paraffin sections of human brain tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688133
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Cerebrospinal fluid immunoglobulins and virus-specific antibodies in disorders affecting the facial nerve (1987)
    Springer
    Journal of neurology 234 (1987), S. 308-314 
    Details
    ISSN: 1432-1459
    Keywords: Facial nerve palsy ; CSF ; Immunoglobulins ; Enzyme-linked immunosorbent assay ; Virus-specific antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sixty-two patients with acute idiopathic peripheral facial nerve palsy (AIPFP) and 31 patients with lymphocytic meningoradiculitis (Garin-Bujadoux or Bannwarth's syndrome) are described. Results of cerebrospinal fluid (CSF) analysis, including the measurement of immunoglobulins (Ig) G, A, and M, indicate that pleocytosis and/or disturbance of the blood-CSF barrier (BCB) and/or local immunoglobulin synthesis within the central nervous system (CNS) do occur in about 25% of patients with AIPFP. The commonest finding is a slight to moderate breakdown of BCB function without evidence of intrathecal immunoglobulin synthesis. In only about 10% of patients, further support for an inflammatory process within the CNS is found by intrathecal synthesis of oligoclonal IgG and/or localized synthesis of IgG and/or IgA. The majority of cases (75%) do not show any signs of an inflammatory process within the CNS. In contrast, lymphocytic meningopolyradiculitis (LMR) has a characteristic CSF profile with early impairment of BCB permeability as well as with rapid and predominant intrathecal IgM synthesis, which helps to distinguish monosymptomatic LMR from AIPFP. By applying a sensitive enzyme-linked immunosorbent assay to identical concentrations of IgG in serum and CSF, evidence of intrathecal synthesis of virus-specific antibodies was found only in 2 of 13 patients with AIPFP. In contrast, all 4 patients with herpes zoster oticus and peripheral facial palsy (Ramsay Hunt syndrome) showed an intrathecal IgG synthesis to varicella zoster virus lasting for up to 4 months after onset of disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314286
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    Paper (German National Licenses)
    Fulltext
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