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  • 1
    Electronic Resource
    Electronic Resource
    Simultaneous occurrence of perimembranous glomerulonephritis and glomerular amyloidosis (1978)
    Springer
    Virchows Archiv 378 (1978), S. 315-320 
    Details
    ISSN: 1432-2307
    Keywords: Perimembranous glomerulonephritis ; Glomerular amyloidosis ; Therapy with D-penicillamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The results of electron microscopic examination of renal biopsies from 3 patients with rheumatoid arthritis treated with penicillamine are presented. All 3 patients developed a nephrotic syndrome upon discontinuation of penicillamine therapy. When viewed with the electron microscope, segmental forms of perimembranous glomerulonephritis (Stages I–II of Ehrenreich and Churg) and glomerular renal amyloidosis Grade I–III were observed. In all three cases the nephrotic syndrome was considered to be due to the simultaneous occurrence of the two disease processes. In 2 cases perimembranous glomerulonephritis with immuno-complex-deposits was assumed to be the dominant factor in the causation of the disease, in the other case amyloidosis was the principle abnormality.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00465597
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Indomethacin induced hypotension in sodium and volume depleted rats (1979)
    Springer
    Journal of molecular medicine 57 (1979), S. 143-145 
    Details
    ISSN: 1432-1440
    Keywords: Indometacin ; Plasma-Reninaktivität ; Hypotonie ; Indomethacin ; Plasma Renin Activity ; Arterial Hypotension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary After a single oral dose of 4 mg/kg indomethacin (IDM) to sodium and volume depleted rats plasma renin activity (PRA) and systolic blood pressure fell significantly within four hours. In sodium repleted animals indomethacin did not change systolic blood pressure (BP) although plasma renin activity was decreased. Thus, indomethacin by inhibition of prostaglandin synthesis may diminish the blood pressure maintaining effect of the stimulated renin-angiotensin system in sodium and volume depletion.
    Notes: Zusammenfassung Nach einer einmaligen oralen Gabe von 4 mg/kg Indometacin kam es innerhalb von 4 h bei Natrium- und Volumenverarmten Ratten zu einem signifikanten Abfall der Plasma-Reninaktivität und des systolischen Blutdrucks. Bei normalen Ratten führte die Indometacingabe lediglich zur Erniedrigung der Plasma-Reninaktivität ohne Beeinflussung des arteriellen Blutdruckes. Es wird deshalb angenommen, daß Indometacin über eine Hemmung der Prostaglandinsynthese den Blutdruck stabilisierenden Effekt des Renin-Angiotensin-Systems bei Natrium- und Volumenverarmung, vermindern kann.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01476055
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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