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  • 1
    Electronic Resource
    Electronic Resource
    D600 prolongs inactivation of the contractile system in frog twitch fibres (1987)
    Springer
    Pflügers Archiv 410 (1987), S. 75-82 
    Details
    ISSN: 1432-2013
    Keywords: Twitch fibre ; K-contracture ; Inactivation ; D600
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract (1) Single twitch fibres were dissected from tibialis muscles ofRana temporaria and used to study the effect of D600 (gallopamil) on potassium-induced contractures. (2) 95 mM K-Ringer's was applied for 8–15 s at intervals of generally 2.5–5 min; at temperatures of 6–8°C and in the absence of D600 the amplitude of the contractures remained fairly constant. After pretreatment with D600 (30 μM) a single (conditioning) K-contracture was sufficient to ‘paralyze’ the fibres (cf. Eisenberg et al. 1983). (3) Complete paralysis could also be achieved at 18–20°C. In three fibres a single conditioning K-application was sufficient; in two more fibres two or three conditioning K-applications were required. (4) D600-paralysis could not only be achieved with high K-concentrations but also by conditioning with subor suprathreshold K-concentrations (20–40 mM); the duration of the conditioning periods required to induce complete paralysis was approximately the same before and after D600-treatment. (5) Contractures were partially abolished by application of 20–40 mM K-Ringer's for short conditioning periods; after D600-treatment the degree of contracture loss was similar. (6) At low temperature the state of partial or complete paralysis induced by subthreshold K-concentrations and D600 was maintained for long periods of time. (7) The presence of 10 mM Ca2+ did not protect the fibres from being paralyzed by treatment with D600 and high K-Ringer's at low temperature; however, more than one conditioning K-application was required. (8) Resting and action potentials of paralyzed fibres were not significantly different from control values. However, endplate potentials were reduced in size, and failure of neuromuscular transmission was observed in some of these fibres. (9) It is concluded that D600 prolongs the state of inactivation of the contractile mechanism, while the development of inactivation does not seem to be markedly affected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00581899
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of D600 on potassium contractures of slow muscle fibres ofRana temporaria (1988)
    Springer
    Pflügers Archiv 412 (1988), S. 390-396 
    Details
    ISSN: 1432-2013
    Keywords: Slow fibre ; K-Contracture ; D600 ; Inactivation ; Repriming
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract (1) The effect of 30 μM D600 on the amplitude and time course of isometric contractures was studied in single slow fibres ofRana temporaria. (2) D600 only slightly reduced the amplitude of contractures evoked with 30 or 95 mM K-Ringer's. Maintenance of tension was strongly impaired by D600 only during exposure to 95 mM K. The caffeine contracture was not affected. (3) Addition of 10 mM Ca2+ or other divalent cations to the medium strongly counteracted the effect of D600 on maintained tension. The order of efficiency was Ca2+=Ni2+〉Co2+〉Mn2+〉Mg2+. (4) During 2 min exposure to 95 mM K-Ringer's the slow fibres inactivated to a variable degree; recovery from inactivation in normal Ringer's proceeded with a half time of the order of 1 min, while in the presence of D600 recovery was prolonged 3.3 to 27 times. (5) It is concluded that the effect of D600 on the contractile behaviour of slow fibres fromRana temporaria is predominantly due to a prolongation of the inactivated state. It is suggested that D600 binds to a site at the outer membrane surface which also binds divalent cations and determines the degree of contractile inactivation during exposure to potassium. Blocking of Ca2+ channels is unlikely to be the mechanism of this D600-effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01907557
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  • 3
    Electronic Resource
    Electronic Resource
    Competitive action of divalent cations and D600 in frog slow muscle fibers (1989)
    Springer
    The journal of membrane biology 112 (1989), S. 185-192 
    Details
    ISSN: 1432-1424
    Keywords: slow fiber ; K contracture ; D600 ; divalent cations ; competitive binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Single, slow muscle fibers fromRana temporaria were equilibrated in normal Ringer's. 95 mmol/liter K1-solution containing various concentrations of Ca2+, Ni2+, Mn2 or Mg2+ was applied, and the ensuing contractures were recorded isometrically. While peak tension (F max) was little affected, maintained tension (measured 1 min after onset of contracture) strongly depended on the concentration and species of divalent cations. Tension was maintained at its peak value in the presence of all species of divalent cations provided their concentrations were adequately increased. Dose-response curves were hyperbolic: Lineweaver-Burk plots revealed straight lines with different slopes intersecting near 1/F max, and indicating the following order of efficiency: Ni2+〉Ca2+〉Mn2+〉〉Mg2+. Hill plots for these cations resulted in straight lines with slopes near 1. Qualitatively similar relationships were obtained with contracture solutions containing D6000 (3–12 μmol/liter). However, under these conditions higher concentrations of Ca2+ or Ni2+ were required in order to fully maintain tension. After a step concentration change in the medium during contracture, the effects of Ca2+ or D600 were detectable only after a delay of 9 and 18 sec, respectively. It is concluded that divalent cations and D600 compete for the same binding site according to a 1:1 reaction. This site is presumably located inside the transverse tubular system and controls inactivation of the contractile force.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01871279
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  • 4
    Electronic Resource
    Electronic Resource
    New Prophosphatranes: Novel intermediates to five-coordinate phosphatranesDedicated to Professor Kurt Issleib on his 70th Birthday (1989)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 578 (1989), S. 75-80 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Neue Prophosphatrane: Neuartige Zwischenstufen auf dem Wege zu pentakoordinierten PhosphatranenDie Reaktion von N(CH2CH2NHMe)3 mit P(NMe2)3 oder P(NMe2)2Cl ergibt die Phosphatranvorstufe N(CH2CH2NMe)3P. Dessen Umsetzung mit Oxydationsmitteln ode Elektrophilen führt zu nicht-transannular-stabilisierten, tetrakoordinierten Derivaten N(CH2CH2NMe)3P—X, (X: O, S, Se, N3Ph, NPh, CS2, 1/2 PtCl2). Die Strukturen der beschriebenen Verbindungen werden anhand ihrer 1H-, 13C- und 31P-NMR-Daten diskutiert.
    Notes: The reaction of N(CH2CH2NHMe)3 with P(NMe2)3 or P(NMe2)2Cl yields the phosphatrane precursor N(CH2CH2NMe)2P,4. With oxydizing agents or electrophiles 4 is converted to the untransannulated four-coordinated derivatives N(CH2CH2NMe)3P—X, (X: O, S, Se, N3Ph, NPh, I CS2, 1/2 PtCl2). The structures of the compounds described are discussed by 1H, 13C, and 31P n.m.r. data.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19895780109
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  • 5
    Electronic Resource
    Electronic Resource
    Darstellung und Charakterisierung von Selenverbindungen mit dem 2,4,6-Tris(trifluormethyl)phenyl-SubstituentenProfessor Dietrich Babel zum 60. Geburtstage am 28. Juli 1990 gewidmet (1990)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 586 (1990), S. 7-18 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Preparation and Characterization of Selenium Compounds with the 2,4,6-tris(trifluoromethyl)phenyl SubstituentReaction of 2,4,6-tris(trifluoromethyl)phenyl lithium and red selenium results in a product which by acidic hydrolysis yields bis[2,4,6-tris(trifluoromethyl)phenyl] diselenide 1. With diazomethane this compound reacts to form bis[2,4,6-tris(trifluoromethyl)phenylselenenyl] methane 2, with bis(triphenylphosphine)ethene platinum(0) the corresponding bis(triphenylphosphine)bis-[2,4,6-tris(trifluoromethyl)phenylselenenyl] platinum(II) 3 is formed. Chlorine and bromine cleave the selenium-selenium bond in 1 and 2,4,6-tris(trifluoromethyl)phenylselenenyl chloride 4 and -bromide 5 are formed. The selenenyl halides are starting materials for the preparation of N,N′-bis-[2,4,6-tris(trifluoromethyl)phenylselenenyl] sulfur(IV) diimide 6 and sulfinylimino-2,4,6-tris(trifluoromethyl)phenyl selenide 7. The X-ray structures of 1 and 7 are discussed.
    Notes: Durch Reaktion von 2,4,6-Tris(trifluormethyl)phenyllithium mit rotem Selen und anschließender saurer Hydrolyse des Reaktionsprodukts bildet sich Bis[2,4,6-tris(trifluormethyl)phenyl]diselenid 1. Mit Diazomethan reagiert diese Verbindung zu Bis[2,4,6-tris(trifluormethyl)phenylselenenyl]methan 2, mit Ethen-bis(triphenylphosphan)-platin(0) entsteht Bis[2,4,6-tris(trifluormethyl)phenylselenenyl]bis(triphenylphosphan) platin(II) 3. Chlor und Brom spalten die Selen-Selen Bindung in 1 unter Bildung von 2,4,6-Tris(trifluormethyl)phenylselenenylchlorid 4 und -bromid 5. Die Selenenylhalogenide sind Ausgangsstoffe für N,N′-Bis[2,4,6-tris(trifluormethyl)phenyl-selenenyl]schwefel(IV)-diimid 6 und Sulfinylimino-2,4,6-tris(trifluormethyl)phenyl-selenid 7. Die Einkristall-Röntgenstrukturen von 1 und 7 werden diskutiert.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19905860102
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  • 6
    Electronic Resource
    Electronic Resource
    C-metallierte Aminophosphine 1. α-lithiierte DimethylaminophosphineProfessor Marianne Baudler zum 65. Geburtstage am 27. April 1986 gewidmet (1986)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 535 (1986), S. 47-55 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: C-metalated Aminophosphines. 1. α-lithiated DimethylaminophosphinesThe preparation of dimethylaminophosphines of the general formula Z—CH2—Pdma2 and (Z—CH2)2Pdma, respectively (Z = (CH3)3Si, C6H5), their monometalation and the reactions of these metalated species with chlorosilanes, bis-(dimethylamino)-chlorophosphine and trimethylsilylmethyl-dichlorophosphine are described. The n.m.r. spectra of the prepared compounds are discussed.
    Notes: Es wird die Darstellung von Dimethylaminophosphinen der allgemeinen Formulierung Z—CH2—Pdma2 bzw. (Z—CH2)2Pdma, deren Monolithiierung zu Z—CH(Li)—Pdma2 bzw. Z—CH(Li)—P(dma)—CH2—Z (Z = (CH3)3Si, C6H5) und die Reaktionen dieser lithiierten Spezies mit Chlorsilanen sowie Bis-(dimethylamino)-chlorphosphin und Trimethylsilylmethyldichlorphosphin beschrieben. Die NMR-Daten der dargestellten Verbindungen werden diskutiert.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19865350407
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  • 7
    Electronic Resource
    Electronic Resource
    ESR-Untersuchungen an bestrahlten PhosphatgläsernProfessor Günther Rienäcker zum 70. Geburtstage am 13. Mai 1974 gewidmet. (1974)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 405 (1974), S. 286-298 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: ESR Studies of Radiation Processes in Phosphate GlassesRadiation processes in phosphate glasses are investigated by ESR and optical measurements. ESR shows a hole-centre in the systems K2O/P2O5 and K2O/MGO/P2O5 which depends on manner and concentration of the cations. Its nature is explained in somewhat a different way than given by BEEKENKAMP or by MIURA and HASEGAWA. Another hole-centre which is independent of cations is discussed in agreement with optical investigations. The electrons set free by radiation react with O2 solved in the glass or with cations. The particels Ag0, Ag2+, Ag+2 have been found and Agn+4 may be present too in the system K2O/MgO/Ag2O/P2O5. The system K2O/MgO/Tl2O/P2O5 shows analogous reactions, but full explanation of the lines could not yet be given.
    Notes: Durch ESR-Untersuchungen und Vergleiche mit optischen Messungen werden Aussagen über die durch Bestrahlung in Phosphatgläsern ablaufenden Vorgänge gemacht. In den Systemen K2O/P2O5 und K2O/MgO/P2O5 wird durch ESR-Messungen ein kationenabhängiges Lochzentrum gefunden, dessen Natur in Abweichung von den Modellen nach BEEKENKAMP und nach MIURA u. HASEGAWA erklärt wird. Ein weiteres kationenunabhängiges Lochzentrum wird in Übereinstimmung mit optischen Untersuchungen gedeutet. Die durch Bestrahlung freigesetzten Elektronen lagern sich an im Glas gelösten Sauerstoff (O2) an oder reagieren mit den Kationen. Im System K2O/MgO/Ag2O/P2O5 werden die Teilchen Ag0, Ag2+, Ag+2 gefunden und Agn+4 wahrscheinlich gemacht. Für das System K2O/MgO/Tl2O/P2O5 gelten analoge Verhältnisse. Eine ausführliche Zuordnung konnte aber dabei noch nicht vorgenommen werden.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19744050309
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  • 8
    Electronic Resource
    Electronic Resource
    Ylidenmalonitrilphosphine (NC)2C=C(X)PRR′Professor Gerhard Fritz zum 60. Geburtstage gewidmet (1979)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 459 (1979), S. 131-139 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Ylidenmalonitrilphosphines (NC)2C=C(X)PRR′Ylidenmalonitrilphosphines of the general formula (NC)2C=C(X)PRR′ (X = Alkyl, Cl, NH2, PRR′; R = Ph, R′ = Ph, H) are prepared under different conditions from (NC)2C=C(X)Cl (X = Alkyl, Cl, NH2) and prim. or sek. phosphines and their monosubstituted alkali or trimethylsilyl derivatives respectively. The synthesis as well as the behaviour of (NC)2C=C(X)PRR′ are compared with the corresponding oxygen analogues of the type O=C(X)PRR′. The structure of the title compounds are elucidated by investigation of their mass, i.r., and n.m.r. spectra.
    Notes: Ylidenmalonitrilphosphine der allgemeinen Formel (NC)2C=C(X)PRR′ (X = Alkyl, Cl, NH2, PRR′; R = Ph, R′ = H, Ph) lassen sich unter verschiedenen Reaktionsbedingungen aus (NC)2C=CXCl (X = Alkyl, Cl, NH2) und prim. oder sek. Phosphinen bzw. deren monosubstituierten Alkali- sowie Trimethylsilylderivate herstellen. Sowohl Synthese als auch Eigenschaften der Ylidenmalonitrilphosphine werden mit den Sauerstoffanaloga des Typs O=C(X)PRR′ verglichen und IR-, NMR- sowie massenspektroskopisch charakterisiert.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19794590114
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  • 9
    Electronic Resource
    Electronic Resource
    Carbosilylierte Phospha-alkeneProfessor Rolf Appel zum 60. Geburtstage am 25. Februar 1981 gewidmet (1981)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 473 (1981), S. 85-90 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Carbosilylated phospha-alkenesLithium-tris-trimethylsilylmethanide, (Me3Si)3C-Li, reacts with various organodichlorophosphines to give tris-(trimethylsilyl)-methyl-organochlorophosphines, the termal treatment of which under elimination of trimethylchlorosilane results in formation of the title compounds of the general formula B.NMR-data as well as the synthesis of compounds A and B will be discussed.
    Notes: Lithium-tris-trimethylsilylmethanid, (Me3Si)3C-Li, reagiert mit verschieden substituierten Organyldichlorphosphinen zur Tris-Trimethylsilylmethyl-organylchlorphosphinen A, deren thermische Beanspruchung unter Abspaltung von Trimethylchlorsilan zu den Titelverbindungen der allgemeinen Formel B führt.Die NMR-spektroskopischen Daten der Verbindungen des Typs A und B sowie deren Synthese wer-den diskntiert.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19814730209
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  • 10
    Electronic Resource
    Electronic Resource
    2,4,6-Tris(tert.butyl)phenyl-substituierte Phosphine (1982)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 488 (1982), S. 75-79 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: 2,4,6-Tris(tert.butyl)phenyl Substituted PhosphinesTris(tert.butyl)phenyl-lithium reacts with PCl3 to give 2,4,6-tris(tert.butyl)phenyldihalogenophosphine which is reduced by LiAlH4 yielding 2,4,6-tris(tert.butyl)phenylphosphine. The same reaction by using (CH3)3Si—CH2—PCl2 leads to 2,4,6-tris(tert.butyl)phenyl-trimethylsilylmethylhalogenophosphine. Thermal treatment of this compound results under elimination of HCl and (CH3)3SiCl in the formation of . The nmr data of the compounds synthesized are discussed.
    Notes: Tris(tert.butyl)phenyl-lithium reagiert mit PCl3 oder (CH3)3Si—CH2—PCl2 zum 2,4,6-Tris(tert.butyl)phenyl-dihalogenphosphin bzw. entsprechenden -trimethylsilylmethylhalogenphosphin. Während sich ersteres mit LiAlH4 in das 2,4,6-Tris(tert.butyl)phenylphosphin überführen läßt, liefert letzteres durch thermische Beanspruchung nach Abspalten von HCl bzw. (CH3)3SiCl die Phosphine mit zweifach koordiniertem Phosphor. Die 1H- sowie 31P-NMR-Daten der dargestellten Verbindungen werden diskutiert.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19824880109
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