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  • 74.20Mn  (1)
  • Acquired immunodeficiency virus  (1)
  • Alpha-interferon  (1)
  • 1
    ISSN: 1432-1440
    Keywords: Bacillary angiomatosis ; Rochalimaea ; Acquired immunodeficiency virus ; Human immunodeficiency virus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 52-year old male homosexual patient with acquired immunodeficiency syndrome (AIDS) presented in our clinic with multiple nodular papules (more than 100) spread over the whole body which had developed within 3 months. Bacillary angiomatosis was suspected, which is a bacterial infectious disease recognized recently mainly in patients with AIDS. Histological and immunohistochemical examinations of extirpated skin lesions were in agreement with the diagnosis, and the detection of rod-shaped bacteria in the lesions by Warthin-Starry silver stain confirmed it. The patient was treated with 2 × 100 mg doxycycline per day. The fever disappeared, and the cutaneous lesions showed a slight tendency to improve. However, after 5 days of therapy the patient showed increasing weakness, with muscle and bone pain. The patient died 10 days after the doxycyline therapy had been started. The cutaneous lesions in bacillary angiomatosis may resemble Kaposi's sarcoma and may therefore be misdiagnosed. The disease may be fatal, but timely antibiotic treatment is usually effective; therefore the diagnosis of bacillary angiomatosis is important. Although many cases have been reported from the United States, only one case is known from Europe. Our finding of bacillary angiomatosis in a German AIDS patient supports the concept of a worldwide distribution of this bacterial agent.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 157 (1998), S. 382-385 
    ISSN: 1432-1076
    Keywords: Key words Chronic hepatitis B ; Children ; Alpha-interferon ; Non-responder ; Retreatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract More than 50% of children with chronic hepatitis B do not respond to treatment with alpha-interferon. Since these patients continue to display high viral replication and progressive liver disease, retreatment should be considered. To date it has not been well evaluated whether a second course of treatment could increase the response rate. In two alpha-interferon retreatment trials in adult patients the response rate, defined by seroconversion from HBeAg to anti-HBe, ranged between 11% and 44%. One beta-interferon retreatment study in children reported a seroconversion rate of 32%. Regrettably, none of the studies included a control group observing the `spontaneous' seroconversion rate after a first interferon cycle. Thus, a nonrandomized alpha-interferon retreatment study in children including control patients was performed. Alpha-interferon for retreatment was administered 3 times a week for 16–24 weeks in 15 children (5–16 years) at least 6 months after ceasing the first cycle. Four children received 5 MU/m2 of a natural alpha-interferon and 11 children 9 MU/m2 recombinant alpha-interferon 2b. Follow up was 18–47 months after initial treatment. In parallel, a control group of 19 un-retreated children with comparable clinical and demographic data was followed for 12–39 months. HBeAg seroconversion was observed in 5 (33%) of the retreated children and in 5 (26%) of the control patients during follow up. The difference is not significant. In the initially nonresponding children, those with high ALT levels before the first treatment showed late HBeAg seroconversion more frequently than those with low ALT levels (P = 0.017) irrespective of retreatment. The ALT level before retreatment was not a predictor for response. Conclusions A second cycle of alpha-interferon during the 3 years following the first treatment in nonresponding children with chronic hepatitis B can be safely performed but did not increase HBeAg/anti-HBe seroconversion compared with the spontaneous seroconversion rate of patients without retreatment.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-7357
    Keywords: 74.20Mn ; 74.25.−q ; 74.72.−h
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Based on the fact that high-Tc superconductors exhibit strong fluctuations, we have allowed the presence of pair fluctuations in the framework of the T-matrix formalism using the 2-D negative Hubbard model for temperatures above and below Tc. Our equations are fully self-consistent. For T ≥ Tc the electronic properties change drastically with respect to BCS treatment, namely, there is a pseudogap around the chemical potential in the density of states, and the spectral function, A(k,ω), vs. ω exhibits a double peak structure which is related to the appearance of this pseudogap. For T ≤ Tc, we have generalized the formalism in order to include the order parameter.
    Type of Medium: Electronic Resource
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