ZIB

1

Electronic Resource

Specific and rapid assay of urinary oxalic acid using high-performance liquid chromatography

Imaoka, S. ; Funae, Y. ; Sugimoto, T. ; [et al.]

Amsterdam : Elsevier

Analytical Biochemistry 128 (1983), S. 459-464

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ISSN: 0003-2697

Keywords: 9-anthryldiazomethane ; fluorescent derivative ; high-performance liquid chromatography ; oxalic acid ; urine

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1016/0003-2697(83)90401-3

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2

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Kinetic properties of tyrosine hydroxylase with natural tetrahydrobiopterin as cofactor

Oka, K. ; Kato, T. ; Sugimoto, T. ; [et al.]

Amsterdam : Elsevier

BBA - Enzymology 661 (1981), S. 45-53

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ISSN: 0005-2744

Keywords: Cofactor kinetics ; Tetrahydrobiopterin ; Tyrosine hydroxylase

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology

Type of Medium: Electronic Resource

URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2744(81)90082-6

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3

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Effects of structures of tetrahydropterin cofactors on tyrosine hydroxylase

Kato, T. ; Oka, K. ; Nagatsu, T. ; [et al.]

Amsterdam : Elsevier

BBA - Enzymology 612 (1980), S. 226-232

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ISSN: 0005-2744

Keywords: Stereoisomer ; Tetrahydropterin structure ; Tyrosine hydroxylase

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology

Type of Medium: Electronic Resource

URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2744(80)90296-X

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4

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Kinetic properties of tyrosine hydroxylase purified from bovine adrenal medulla and bovine caudate nucleus

Oka, K. ; Ashiba, G. ; Sugimoto, T. ; [et al.]

Amsterdam : Elsevier

Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular 706 (1982), S. 188-196

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ISSN: 0167-4838

Keywords: (Adrenal medulla, Caudate nucleus) ; Cofactor kinetics ; Tyrosine hydroxylase

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Medicine

Type of Medium: Electronic Resource

URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4838(82)90486-1

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5

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Stimulation of prostaglandin E"2 release from cultured rabbit gastric cells by sodium deoxycholate

Okano, K. ; Ivey, K.J. ; Sugimoto, T. ; [et al.]

Amsterdam : Elsevier

Prostaglandins 47 (1994), S. 423-436

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ISSN: 0090-6980

Keywords: Prostaglandin E"2 ; calcium ; calmodulin ; cultured rabbit gastric cells ; phospholipase A"2 ; protein kinase C ; sodium deoxycholate

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Medicine

Type of Medium: Electronic Resource

URL: http://linkinghub.elsevier.com/retrieve/pii/0090-6980(94)90043-4

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6

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Translocation of protein kinase C α and ζ in rat glomerular mesangial cells cultured under high glucose conditions (1994)

Kikkawa, R. ; Haneda, M. ; Uzu, T. ; [et al.]

Springer

Diabetologia 37 (1994), S. 838-841

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ISSN: 1432-0428

Keywords: Diabetic nephropathy ; glomerular mesangial cells ; protein kinase C ; isoenzymes ; high glucose

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary The activities and expression of protein kinase C isoenzymes were examined in glomerular mesangial cells cultured under high glucose conditions. Exposure of cells to high glucose concentrations (27.8 mmol/l) for more than 3 days resulted in a significant elevation of protein kinase C activities in the membrane fraction. Of the protein kinase C isoenzymes, the levels of protein kinase C α significantly increased in the membrane fraction after 3 days of exposure to glucose, and protein kinase C ζ increased after 5 days of exposure. Levels of protein kinase C δ and ε remained unchanged and protein kinase C Β and γ were not detected. These results indicate that protein kinase C α and ζ are translocated under high glucose conditions possibly through different mechanisms.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00404342

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7

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Plasma adenosine concentrations are elevated in Dahl salt-sensitive rats (1995)

Yamada, K. ; Goto, A. ; Ishii, M. ; [et al.]

Springer

Cellular and molecular life sciences 51 (1995), S. 227-229

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ISSN: 1420-9071

Keywords: Adenosine ; Dahl salt-sensitive rats ; high-performance liquid chromatography ; hypertension

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract We measured plasma levels of adenosine in Dahl salt-sensitive rats (DS) and Dahl salt-resistant rats (DR) to examine the potential role of adenosine in cardiovascular regulation in this type of hypertension. Plasma adenosine concentrations were significantly higher in DS than in DR. The NaCl content in the diet did not affect plasma adenosine concentration in either DS or DR. Significant positive correlation was found between adenosine concentrations and systolic blood pressure when the data for DS and DR were analyzed together. These results suggest that adenosine may play an important role in the pathophysiology of hypertension in DS.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01931102

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8

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Renal and hormonal effects of alpha1-adrenoceptor blockade by bunazosin in essential hypertension (1989)

Hirata, Y. ; Fukui, K. ; Dan, Y. ; [et al.]

Springer

European journal of clinical pharmacology 36 (1989), S. 575-578

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ISSN: 1432-1041

Keywords: bunazosin ; hypertension ; alpha1-adrenoceptor blocker ; blood pressure ; renal blood flow ; renal function ; renin ; aldosterone ; atrial natriuretic peptide

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The renal and hormonal effects of the α1-adrenoceptor blocker bunazosin were examined in 6 patients with essential hypertension. Oral bunazosin for 4 to 12 weeks significantly decreased mean blood pressure by 10%, increased effective renal blood flow and creatinine clearance by 34% and 37%, respectively, the plasma norepinephrine concentration was elevated by 60%, and the plasma atrial natriuretic peptide level was lowered by 22%. The plasma renin activity and aldosterone concentration were unchanged. Thus, a moderate reduction in blood pressure was produced by bunazosin treatment while maintaining renal perfusion.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00637738

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9

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Roles of Ca2+ and protein kinase C in regulation of prostaglandin E2 release by cultured rabbit gastric epithelial cells (1993)

Ota, S. ; Hata, Y. ; Terano, A. ; [et al.]

Springer

Digestive diseases and sciences 38 (1993), S. 1426-1434

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ISSN: 1573-2568

Keywords: cultured rabbit gastric cells ; prostaglandin E2 release ; protein kinase C ; Ca2+ ; cAMP

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Prostaglandin (PG) has been reported to be one of the important protective factors in the gastric mucosa. However the mechanism of the regulation of endogenous PG production has not been well studied. We investigated the possible roles of Ca2+, cAMP, and protein kinase C (PKC) in the regulation of PGE2 release from cultured rabbit gastric mucosal cells. PGE2 was measured by radioimmunoassay. A23187 (Ca2+ ionophore) at 2×10−6 M significantly increased PGE2 release. Deprivation of Ca2+ from the medium blocked the A23187-induced increase of PGE2. TMB-8 (a putative inhibitor of Ca2+ release from intracellular stores) did not have any significant effects on the increase of PGE2-induced by A23187. Thus, A23187 increased PGE2 through the influx of extracellular Ca2+. W7 or compound 48/80 (calmodulin inhibitors) did not alter the response of PGE2 caused by A23187. Exogenous administration of cAMP, forskolin (an activator of adenylate cyclase), or 2-chloroadenosine (a possible activator of adenylate cyclase through adenosine A2 receptor) had neither significant effects on PGE2 release nor an effect on A23187-induced increase of PGE2 release. 12-O-tetradecanoylphorbol 13-acetate (TPA, an activator of PKC) significantly stimulated PGE2 release in a dose-dependent fashion, whereas another phorbol ester with no biological activity did not. A23187 at 0.8×10−6 M, but not cAMP, potentiated the TPA-induced increase of PGE2. Mepacrine (a phospholipase A2 inhibitor) reduced the A23187-and TPA-induced increase of PGE2. These results suggest that Ca2+ and protein kinase C may play important roles in the regulation of PGE2 release by cultured rabbit gastric cells.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01308599

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10

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Protective effect of tauroursodeoxycholate against chenodeoxycholate-induced damage to cultured rabbit gastric cells (1991)

Ota, S. ; Tsukahara, H. ; Terano, A. ; [et al.]

Springer

Digestive diseases and sciences 36 (1991), S. 409-416

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ISSN: 1573-2568

Keywords: cultured rabbit gastric cells ; cytoprotection ; tauroursodeoxycholate ; ursodeoxycholate ; chenodeoxycholate

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Ursodeoxycholate (UDC) and tauroursodeoxycholate (TUDC) have been reported to be protective against liver injury induced by other bile salts. UDC also has been shown to be effective against refluxed bile-induced gastritis after gastric surgery. However the mechanism of the therapeutic effect of UDC on gastric mucosa has not been known. In the present study, cytoprotective actions of UDC and TUDC against chenodeoxycholate (CDC)-induced gastric injury were investigated using rabbit gastric cell cultures without systemic factors. Rabbit gastric mucosal cells were cultured after the isolation of rabbit gastric cells with collagenase and ethylenediaminetetraacetic acid. Cytotoxicity was quantified by measuring51Cr release from prelabeled cells and MTT assay. Prostaglandin (PG) E2 was assayed by radioimmunoassay. Concentrations of CDC〉0.5mM or UDC〉5mM caused cellular damage and increased51Cr release in a dose-dependent and time-dependent fashion, while TUDC up to 10 mM did not. TUDC, but not UDC, showed a significant decrease of CDC (1.5 mM)-induced51Cr release dose dependently. The protective effect of TUDC against CDC-induced damage was confirmed by MTT assay. On phase-contrast microscopy, disruption of monolayers induced by CDC (1.5 mM) was clearly protected by TUDC (10 mM). Free radical scavengers (500 units/ml of superoxide dismutase, 300 units/ml of catalase, and 100 mM of dimethyl sulfoxide) or a calcium blocker (10−7–10−5 M verapamil) did not show significant protection against CDC-induced damage. Deprivation of Ca2+ in the media did not affect CDC-induced damage. Thus free radicals of Ca2+ might not be involved in the cell toxicity of CDC. Although TUDC (10 mM) significantly increased PGE2 production by cultured cells, indomethacin (10−4 M) did not reduce protective effects of TUDC, as assessed by51Cr release and MTT assay. In conclusion TUDC is cytoprotective against CDC-induced damage to cultured rabbit gastric cells. Neither free radicals, Ca2+, nor endogenous PGs may play leading roles in the mechanism of this action.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01298867

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