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  • Insulin receptor  (5)
  • Acetaldehyde  (3)
  • FMRFamide  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Co-expression of mutant and normal human insulin receptors in COS 7 cells
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Gene Structure and Expression 1216 (1993), S. 425-430 
    Details
    ISSN: 0167-4781
    Keywords: (Human) ; COS 7 cell ; Co-transfection ; Insulin receptor ; Insulin resistance ; Tyrosine kinase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4781(93)90010-B
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The ligand binding characteristics of a kinase-defective A/K1018 human insulin receptor expressed in Rat 1 fibroblasts
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Molecular Cell Research 1053 (1990), S. 185-188 
    Details
    ISSN: 0167-4889
    Keywords: Alpha-beta subunit interaction ; Insulin receptor ; Kinase defective insulin receptor ; Ligand binding affinity ; Tyrosine kinase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4889(90)90012-3
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  • 3
    Electronic Resource
    Electronic Resource
    Chemiluminescence in the crude extracts of soybean seedlings. Postulated mechanism on the formation of hydroperoxide intermediates
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/General Subjects 1117 (1992), S. 107-113 
    Details
    ISSN: 0304-4165
    Keywords: Acetaldehyde ; Chemiluminescence ; Emission spectrum ; Hydrogen peroxide ; Hydroperoxy intermediate ; Soybean seedling
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0304-4165(92)90066-4
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  • 4
    Electronic Resource
    Electronic Resource
    Impaired acetaldehyde metabolism in partially hepatectomized rats (1985)
    Springer
    Research in experimental medicine 185 (1985), S. 13-20 
    Details
    ISSN: 1433-8580
    Keywords: Acetaldehyde ; Ethanol ; Partial hepatectomy ; Liver injury ; Carbon tetrachloride
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two-thirds hepatectomy in rats resulted in elevated blood ethanol and acetaldehyde levels as compared to those of sham operated and CCl4-induced toxic injured rats. The acetaldehyde/ethanol ratio increased also. Although the liver mass regenerated within 3 days, ethanol metabolism remained disturbed. Mitochondrial aldehyde dehydrogenase activity was significantly diminished only following partial hepatectomy. The results suggest that abnormal ethanol and especially acetaldehyde metabolism in partially hepatectomized rats is not due simply to reduced liver tissue but to a diminished aldehyde dehydrogenase activity in the remaining tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851523
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of high hepatic acetaldehyde level following simultaneous administration of ethanol and cyanamide on liver function in rats (1985)
    Springer
    Research in experimental medicine 185 (1985), S. 221-225 
    Details
    ISSN: 1433-8580
    Keywords: Ethanol ; Acetaldehyde ; Liver injury ; Cyanamide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Extremely high concentrations of hepatic acetaldehyde were induced in rats by the intragastric administration of ethanol and cyanamide, an aldehyde dehydrogenase inhibitor; and these high levels were maintained for 4 weeks. Liver function tests, including mitochondrial ornithine carbamoyltransferase (OCT) and GOT activities, were within normal limits, and no increase in either hepatic triglyceride or collagen contents was observed. These results suggest that hepatotoxic effects of ethanol are not derived from the high acetaldehyde levels in the liver.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852036
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  • 6
    Electronic Resource
    Electronic Resource
    Binding specificity and intramolecular signal transmission of uncleaved insulin proreceptor in transformed lymphocytes from a patient with extreme insulin resistance (1989)
    Springer
    Diabetologia 32 (1989), S. 371-377 
    Details
    ISSN: 1432-0428
    Keywords: Insulin receptor ; insulin proreceptor ; insulin resistance ; transformed lymphocytes ; point mutation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An alteration of an amino acid sequence in the processing site of the insulin proreceptor by a point mutation of the insulin receptor gene produced extreme insulin resistance. We characterized functional properties of the unprocessed insulin receptor in transformed lymphocytes from a patient. Insulin binding to intact cells and to a partially purified insulin receptor preparation was radically decreased to 20% and 18% of the control values, respectively. In competitive insulin binding to intact cells, [LeuA3]-, [LeuB24]-, [SerB24-insulin, and mini-proinsulin ([B(1–29)-Ala-Ala-Lys-A(1–21)]-insulin) had the same relative binding activity in both the patient's and the control cells, but proinsulin and IGF-I were markedly less able to displace 125I-insulin in the patient's cells. In contrast to the study in intact cells, proinsulin and IGF-I as well as other insulin analogues had the same relative binding activity to bind to the partially lectin-purified insulin receptor preparations from both the patient's and the control cells. As regards the signal transduction after receptor binding, insulin-stimulated autophosphorylation of the unprocessed insulin proreceptor occurred proportionally to the amount of decreased insulin binding. With 0.025% trypsin treatment, the abnormal binding characteristics and autophosphorylation were normalized through conversion to functionally normal receptors. In spite of the abnormal processing, self-association of receptors into oligomeric structures was observed in the proreceptor. These results suggest that the unprocessed insulin proreceptor in the plasma membranes has an altered conformation which affects its binding characteristics but not its intramolecular signal transmission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00277261
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  • 7
    Electronic Resource
    Electronic Resource
    A mutation (Trp1193→Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance (1993)
    Springer
    Diabetologia 36 (1993), S. 414-422 
    Details
    ISSN: 1432-0428
    Keywords: Insulin receptor ; mutation ; tyrosine kinase activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We evaluated a 35-year-old diabetic male patient with type A insulin resistance, showing acanthosis nigricans. Insulin binding to the patient's Epstein-Barr-virus transformed lymphocytes was mildly reduced. The maximal insulin-stimulated autophosphorylation of the insulin receptor from the patient's transformed lymphocytes was decreased to 45% of that from the control subjects. On examination, the biological activities of insulin and insulin-like growth factor I in the patient's cultured fibroblasts, insulin sensitivity of amino isobutyric acid uptake and thymidine incorporation was decreased, but insulin-like growth factor I action was normal. The sequence analysis of amplified genomic DNA revealed that the patient was heterozygous for a mutation substituting Leu for Trp at codon 1193 in exon 20 of the insulin receptor gene. The patient's mother and sister were also heterozygous for a mutation in the insulin receptor gene that substituted Leu for Trp1193 in the Β subunit of the receptor. Therefore, the mutation causes insulin resistance in a dominant fashion. They were less hyperglycaemic and more hyperinsulinaemic than the proband after glucose loading. The mother had diabetes mellitus but did not show acanthosis nigricans, while the sister did not have diabetes and showed acanthosis nigricans. These results suggest that this mutation causes defective tyrosine kinase activity of the insulin receptor, which results in insulin resistance. Insulin action and phenotypic appearance may be mediated by different factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402277
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  • 8
    Electronic Resource
    Electronic Resource
    Insulin, S-sulphonate A and S-sulphonate B-chain receptor binding to human cultured lymphocytes (1977)
    Springer
    Diabetologia 13 (1977), S. 251-255 
    Details
    ISSN: 1432-0428
    Keywords: Insulin receptor ; cultured lymphocytes ; insulin structure function relationship ; insulin chains
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ability of insulin and the S-sulphonate A and B-chain derivatives to bind to a receptor on cultured human lymphocytes was evaluated. A receptor site for the S-sulphonate A-chain was identified and was strongly influenced by the intact insulin molecule. S-sulphonate A-chain weakly interfered with insulin binding. S-sulphonate B-chain showed no evidence of significant binding and did not interfere with insulin or S-sulphonate A chain binding.14CO2 production from14C-1-glucose was stimulated by insulin in cultured lymphocytes and this effect was blunted by S-sulphonate A-chain. The sulphhydryl blocking agent used in the production of insulin A-chain appears to be of critical importance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01219708
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  • 9
    Electronic Resource
    Electronic Resource
    Innervation and control of the heart of a gastropod,Rapana (1987)
    Springer
    Cellular and molecular life sciences 43 (1987), S. 981-986 
    Details
    ISSN: 1420-9071
    Keywords: Molluscan heart ; neurotransmitter ; serotonin ; FMRFamide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The innervation and control of the heart of a prosobranch mollusc,Rapana thomasiana, were studied. Acetylcholine was found to be an inhibitory neurotransmitter. Both serotonin and FMRFamide (Phe-Met-Arg-Phe-NH2) showed excitatory effects on the heart; FMRFamide had greater inotropic and more regulatory chronotropic effects than serotonin. The effects of serotonin were blocked by methysergide, while the effects of FMRFamide and of stimulating the excitatory cardiac nerves were not blocked. Stimulation of circumesophageal ganglia elicited a slow enhancement of heart beat together with body movement. This enhancement was blocked by methysergide. Serotonin was considered to act at the heart as a local neurohormone. Although the mechanism of action of FMRFamide is still not yet clarified, it is possible that FMRFamide plays a physiological role as a cardioregulatory substance, as indicated by the physiological and histological findings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01952213
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  • 10
    Electronic Resource
    Electronic Resource
    Action and immunoreactivity of neuropeptides in the buccal neuromuscular system of a prosobranch mollusc, Rapana thomasiana (1991)
    Springer
    Cell & tissue research 264 (1991), S. 57-62 
    Details
    ISSN: 1432-0878
    Keywords: FMRFamide ; Catch-relaxing peptide (CARP) ; Radula muscle ; Immunohistochemistry ; Rapana thomasiana (Mollusca)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In a prosobranch mollusc, Rapana thomasiana, the catch-relaxing peptide H-Ala-Met-Pro-Met-Leu-Arg-Leu-NH2 (CARP) was found to depress the contraction of the radula protractor and retractor elicited by electrical stimulations. The action of CARP was in contrast to that of other neuropeptides, H-Phe-Met-Arg-Phe-NH2 (FMRFamide) and H-Phe-Leu-Arg-Phe-NH2 (FLRFamide), which enhanced the contraction of the radula protractor and retractor, respectively. By immunohistochemical examinations, FMRFamide-like immunoreactive neurons were found on the rostral side of the right buccal ganglion and the caudal side of the left ganglion, where some CARP-like immunoreactive neurons were also distributed, indicating a possible coexistence of FMRFamide and CARP. FMRFamide- and CARP-like immunoreactivities were also detected in the neuropile of buccal ganglia, radula nerves arising from the ganglia, and nerve fibers in the radula muscles. The present results suggest that FMRFamide- and CARP-like peptides are involved in the regulation of the contraction of the radula muscles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00305722
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