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  • Age  (1)
  • Key words Bladder cancer • Lymph node staging • Positron emission tomography • FDG  (1)
  • 1
    ISSN: 1432-1440
    Keywords: Medullary thyroid carcinoma ; Prognostic factors ; Sporadic and familial form ; Age ; Sex ; Tumor stage at diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A retrospective study of 741 patients with medullary thyroid carcinoma diagnosed between 1967 and 1991 was carried out by members of the German Medullary Thyroid Carcinoma Study Group to evaluate prognostic factors. A total of 559 patients (75%) were considered to have sporadic disease, and 182 (25%) had the familial type. The sex ratio (male to female) was 1:1.4 in sporadic disease patients, and the mean age at diagnosis was 45.9 years (range 5-81 years). For familial disease patients the sex ratio was 1:1.1, and the mean age at diagnosis was 33.4 (range 5–77 years). The follow-up time for 630 patients ranged from 1 month to 20.8 years (mean 13.0 years). The overall adjusted survival rate was 86.7% at 5 years and 64.2% at 10 years. In a univariate analysis the stage of disease at diagnosis, age, sex, and type of disease (sporadic, familial) were relevant prognostic factors, with a better prognosis for young female patients with familial disease and diagnosed at an early stage. In a multivariate proportional hazards analysis, the difference in the survival rate of patients with familial disease versus those with the sporadic form disappeared, while prognostic information provided by age and sex was still significant. The poorer prognosis of patients with sporadic medullary thyroid carcinoma may be related to the patients' older age at detection and more advanced tumor stage at diagnosis. There seems to be no difference in biological behavior between tumors of the sporadic and those of the familial type.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1433-0563
    Keywords: Key words Bladder cancer • Lymph node staging • Positron emission tomography • FDG ; Schlüsselwörter Harnblasenkarzinom • Lymphknotenstaging • Positronenemissionstomographie • FDG
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Positronenemissionstomographie (PET) stellt ein neues bildgebendes Verfahren dar, mit der Stoffwechselvorgänge und nicht morphologische Veränderungen untersucht werden können. Da Tumoren eine erhöhte Glykolyse aufweisen, können diese mittels radioaktiv markierter Glukose und PET nachgewiesen werden. Dieser Ansatz hat sich bereits bei unterschiedlichen Tumorentitäten bewährt. In dieser Studie wurde die PET beim Lymphknotenstaging des Harnblasenkarzinoms untersucht. Bei 64 Patienten wurde präoperativ eine PET des Beckens nach i. v.-Injektion von Fluor-Deoxy-Glukose (FDG) durchgeführt, so daß der PET-Befund mit dem histologischen Befund des Operationspräparates nach klassischem operativen Lymphknotenstaging verglichen werden konnte. Beim Lymphknotenstaging wurden bei 14 Patienten positive Lymphknoten richtig erkannt; ein falsch-negatives Ergebnis trat bei 7 Patienten auf. Bei 37 Patienten wurden die Lymphknoten als richtig-negativ bewertet, 6mal war ein falsch-positives Ergebnis erzielt worden. Aus diesen Daten errechnet sich eine Sensitivität von 67 %, eine Spezifität von 86 % und eine Treffsicherheit von 80 %. Somit sind die PET-Ergebnisse ermutigend und scheinen besser zu sein als die klassischen Stagingverfahren, wie CT und MRT.
    Notes: Summary PET is a new method in nuclear medicine which examines the metabolism and not the morphology. Tumors show a higher rate of glycolysis than benign tissue and hence can be detected by radioactive glucose. This method has proved good for various tumors. In this study the lymph node staging of bladder cancer by PET was investigated. In 64 patients a PET of the pelvis after injection of fluorodeoxyglucose (FDG) was carried out preoperatively; the PET-results were compared with the histology of the OR specimen after classical pelvic lymphadenectomy. For lymph node staging positive nodes were found in 14 patients which was correct; a false-negative result was obtained in 7 patients. In 37 patients the PET-result was true-negative and in 6 patients false-positive resulting in a sensitivity of 67 %, a specificity of 86 % and an accuracy of 80 %. Therefore, our PET results are encouraging and seem to be better than those obtained by classical staging procedures such as CT or MRI.
    Type of Medium: Electronic Resource
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