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  • Cardiac sympathetic nerve system  (1)
  • Elevated thyroglobulin  (1)
  • Parametric imaging  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Parametric imaging in cerebral radionuclide angiography (RNA) by planar imaging improving presentation and objectivation of cerebral blood flow (1989)
    Springer
    European journal of nuclear medicine 15 (1989), S. 96-99 
    Details
    ISSN: 1619-7089
    Keywords: Radionuclide angiography ; Parametric imaging ; Cerebral blood flow ; Appearance time ; Transit time
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Methods of parametric imaging of radionuclide angiography using parameters like appearance time, peak time, transit time, height of peak, arterial slope and area of inflow were developed and evaluated regarding their diagnostic meaning in 111 patients suffering from TIA or PRIND and in 30 normal persons. The meaning of these single parameters could shown depended on the specificity of the diagnostic question. Local cerebral blood flow can be estimated most favourably by parametric images of area of inflow whereas transit time is most promising as a diagnostic tool for evaluation of total cerebral blood flow classified with reference to severity of the perfusion disturbance. Appearance time is suited very well to estimation of collateral perfusion. Blood flow in great cerebral arteries could be seen well by non parametric imaging of radioactivity inflow in the brain supplying arterial vessels in the cranial floor. Applying a combination of the parametric images, the sensitivity for detection of disturbances of cerebral blood flow amounts to 0.91. A specificity of 0.88 and accuracy of 0.90 were found. The described combination of evaluation of RNA using various parameters is considered a well suited method for detection of disturbances in local and total cerebral blood flow by means of planar imaging.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00702627
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Sympathetic innervation of the left ventricle is impaired in arrhythmogenic right ventricular disease (1993)
    Springer
    European journal of nuclear medicine 20 (1993), S. 207-212 
    Details
    ISSN: 1619-7089
    Keywords: Iodine-123 metaiodobenzylguanidine single photon emission tomography ; Arrhythmogenic right ventricular disease ; Cardiac sympathetic nerve system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Arrhythmogenic right ventricular disease (ARVD) is a disease of unknown origin that primarily affects the right ventricle and is characterized by ventricular tachyarrhythmias which may lead to syncope and even, though rarely, sudden cardiac death. In 25 patients with ARVD, sympathetic innervation of the left ventricle was assessed by iodine-123 metaiodobenzylguanidine single photon emission tomography (1231-MIBG SPET). In addition, thallium-201 SPET was performed. The diagnosis of ARVD was made by an electrophysiological study and right and left heart catheterization including right ventricular endomyocardial biopsy. Ischaemic heart disease was excluded by coronary angiography. A group of seven patients without any evidence of heart disease served as a control group. Twenty-two of the 25 patients showed reduced uptake of 123I-MIBG. The abnormal areas were located predominantly in posterior and posteroseptal segments of the heart. No focus of increased 123I-MIBG activity could be demonstrated. No patient had signs of left ventricular involvement on left ventricular angiography. In contrast to the results of the 123I-MIBG SPET, those of 201TI SPET were normal in 16 patients. The remaining nine patients showed areas of slight hypoperfusion not correlated with the reduced 123I-MIBG uptake. 123I-MIBG scintigraphy allows detection of left ventricular adrenergic dysinnervation in ARVD patients without morphological or functional abnormalities of the left ventricle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00170000
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Positron emission tomography with F-18-deoxyglucose in patients with differentiated thyroid carcinoma, elevated thyroglobulin levels, and negative iodine scans (1998)
    Springer
    Langenbeck's archives of surgery 383 (1998), S. 160-163 
    Details
    ISSN: 1435-2451
    Keywords: Key words FDG-PET ; Thyroid carcinoma ; Elevated thyroglobulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Introduction: In patients with differentiated thyroid carcinoma, elevated serum levels of thyroglobulin (hTg) may occur in spite of otherwise negative diagnostic procedures and in particular in spite of a negative iodine-131 scan. Positron emission tomography with F-18-deoxyglucose (FDG-PET) is a potentially useful method for the detection of metastatic lesions or the recurrence of thyroid cancer. We aimed to investigate whether FDG-PET is capable of detecting metastastic lesions or recurrence in patients with differentiated thyroid carcinoma, elevated serum levels of thyroglobulin, and otherwise negative diagnostic procedures, including the iodine-131 scan. Methods: From a group of 500 patients with differentiated thyroid carcinoma, a subgroup of 32 patients had elevated serum hTg-levels, negative iodine-131 scans, negative cervical and abdominal ultrasound, and negative X-ray of the chest. In 12 of these patients (hTg 77.8±94.3 ng/ml, range 1.5 – 277 ng/ml, median 20 ng/ml), FDG-PET was performed. All but one FDG-PET study was performed in a state of hypothyroidism (TSH 75.8±32.2 µIU/ml, range 31 – 116 µIU/ml, median 74.6 µIU/ml). Results: In 6 of the 12 patients investigated, the FDG-PET was positive. In three of the patients, the diagnosis was confirmed by computed tomography or magnetic resonance imaging. In patients with a positive FDG-PET finding, the hTg level was 146.7±90.1 ng/ml (23 – 277 ng/ml, median 144.5 ng/ml). In contrast, in patients with a negative finding the hTg level was only 9.0±7.6 ng/ml (range 1.5 – 17 ng/ml, median 8.1 ng/ml), P = 0.01. Conclusion: These preliminary results show that in patients with differentiated thyroid carcinoma, elevated hTg levels, and otherwise negative “conventional” diagnostic procedures, FDG-PET is helpful in detecting metastatic lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004230050109
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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