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  • 1
    Electronic Resource
    Electronic Resource
    Antenatal diagnosis of vein of Galen aneurysmal malformation: MR study of fetal brain and postnatal follow-up (1996)
    Springer
    Neuroradiology 38 (1996), S. 87-90 
    Details
    ISSN: 1432-1920
    Keywords: Vein of Galen aneurysmal malformation ; Prenatal diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract About 20 cases of prenatal diagnosis of vein of Galen aneurysmal Malformation (VGAM) have been described. We present a case diagnosed prenatally by Doppler ultrasonography. Prenatal MRI and postnatal radiological studies including post-treatment MRI and MRA, were carried out.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00593231
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  • 2
    Electronic Resource
    Electronic Resource
    Antenatal diagnosis of vein of Galen aneurysmal malformation: MR study of fetal brain and postnatal follow-up (1995)
    Springer
    Neuroradiology 38 (1995), S. 87-90 
    Details
    ISSN: 1432-1920
    Keywords: Key words Vein of Galen aneurysmal malformation ; Prenatal diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract About 20 cases of prenatal diagnosis of vein of Galen aneurysmal Malformation (VGAM) have been described. We present a case diagnosed prenatally by Doppler ultrasonography. Prenatal MRI and postnatal radiological studies including post-treatment MRI and MRA, were carried out.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00593231
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Magnetisation transfer ratios of contrast-enhancing and nonenhancing lesions in multiple sclerosis (1996)
    Springer
    Neuroradiology 38 (1996), S. 115-119 
    Details
    ISSN: 1432-1920
    Keywords: Magnetic resonance imaging ; Magnetisation transfer ; Magnetisation transfer ratio ; Multiple sclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Magnetisation transfer (MT) is a recently introduced technique for assessing the water content of tissues in vivo and its relationship to macromolecules or membranes. It has been suggested that MT could provide indirect evidence of the characteristics of multiple sclerosis (MS) lesions (oedema, demyelination, or gliosis). Our aims were to characterise brain MS lesions and to compare the magnetisation transfer ratio (MTR) values of lesions with different patterns of contrast enhancement. In patients with MS we measured the MTR of 65 gadolinium-enhancing and 292 nonenhancing lesions. Using the equation published by Dousset et al. we studied 29 patients with clinically definite MS and 10 healthy controls. Lesions had significantly lower MT than the normal-appearing white matter of the patients or the normal white matter of healthy controls. There was no difference in the MTR of enhancing and nonenhancing lesions. Enhancement was homogeneous in 45 and ring-like in 20 lesions; MTR values were lower in the latter. These findings are presumably related to the differences in pathological features of enhancing (different amounts of proteins and inflammatory cells, oedema and demyelination) and nonenhancing (gliosis, demyelination and axonal loss) lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00604792
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Magnetisation transfer ratios of contrast-enhancing and nonenhancing lesions in multiple sclerosis (1996)
    Springer
    Neuroradiology 38 (1996), S. 115-119 
    Details
    ISSN: 1432-1920
    Keywords: Key words Magnetic resonance imaging ; Magnetisation transfer ; Magnetisation transfer ratio ; Multiple sclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Magnetisation transfer (MT) is a recently introduced technique for assessing the water content of tissues in vivo and its relationship to macromolecules or membranes. It has been suggested that MT could provide indirect evidence of the characteristics of multiple sclerosis (MS) lesions (oedema, demyelination, or gliosis). Our aims were to characterise brain MS lesions and to compare the magnetisation transfer ratio (MTR) values of lesions with different patterns of contrast enhancement. In patients with MS we measured the MTR of 65 gadolinium-enhancing and 292 nonenhancing lesions. Using the equation published by Dousset et al. we studied 29 patients with clinically definite MS and 10 healthy controls. Lesions had significantly lower MT than the normal-appearing white matter of the patients or the normal white matter of healthy controls. There was no difference in the MTR of enhancing and nonenhancing lesions. Enhancement was homogeneous in 45 and ring-like in 20 lesions; MTR values were lower in the latter. These findings are presumably related to the differences in pathological features of enhancing (different amounts of proteins and inflammatory cells, oedema and demyelination) and nonenhancing (gliosis, demyelination and axonal loss) lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00604792
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Combined genetic analysis of partial blast resistance in an upland rice population and recurrent selection for line and hybrid values (1996)
    Springer
    Theoretical and applied genetics 92 (1996), S. 644-653 
    Details
    ISSN: 1432-2242
    Keywords: Key words Quantitative genetics ; Recurrent selection ; Partial resistance ; Magnaporthe grisea ; Oryza sativa L.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  The CNA-IRAT 5 upland rice population has been improved for 4 years by recurrent selection for blast resistance in Brazil. In order to predict the efficiency of recurrent selection in different test systems and to compare the relative advantage of hybrids versus pure line breeding, a combined genetic analysis of partial blast resistance in the CNA-IRAT 5 population was undertaken. A three-level hierarchical design in inbreeding and a factorial design were derived from the base population. Partial blast resistance of lines and hybrids was evaluated in the greenhouse and in the field by inoculation with one virulent blast isolate. The means and genetic variances of the hybrids and lines were estimated. Genetic advance by recurrent selection was predicted from estimates of variance components. The inheritance of partial blast resistance was mainly additive but non-additive effects were detected at both levels of means and variances. Mean heterosis ranged from 4%–8% for lesion size and lesion density to 10–12% for leaf and panicle resistance. High dominance or homozygous dominance variances relative to additive variance and negative covariance between additive and homozygous dominance effects were estimated. A low frequency of favourable alleles for partial resistance would explain the observed organisation of genetic variability in the base population. Recurrent selection will efficiently improve partial blast resistance of the CNA-IRAT 5 population. Genetic advance for line or hybrid values was expected to be higher testing doubled haploid lines than S1 lines, or than general combining ability. Two components of partial resistance assessed in the greenhouse, lesion size and lesion density, could be used as indirect selection criteria to improve field resistance. On the whole, hybrid breeding for partial blast resistance appeared to be slightly more advantageous than pure line breeding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220050174
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  • 6
    Electronic Resource
    Electronic Resource
    Correlation between multimodal evoked potentials and magnetic resonance imaging in multiple sclerosis (1989)
    Springer
    Journal of neurology 236 (1989), S. 4-8 
    Details
    ISSN: 1432-1459
    Keywords: Multiple sclerosis ; Diagnosis ; Electrophysiological tests ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sixty multiple sclerosis (MS) patients (33 definite, 13 probale and 14 suspected were investigated by computed tomography (CT), magnetic resonance imaging (MRI), multimodality evoked potentials (EPs) and cerebrospinal fluid (CSF) electrophoresis. MRI abnormalities were found in 50 cases, while at least one abnormal evoked potential was detected in each of 52 cases. Brain-stem auditory evoked potentials were more sensitive than MRI for the detection of brainstem involvement. All the patients with oligoclonal bands had abnormal MRI and none of the patients with normal MRI had oligoclonal bands in the CSF. The number and the extent of MRI lesions were significantly correlated with the duration of disease and with the degree of disability. Our observations stress the importance of the combined use of MRI and EPs in detecting silent CNS lesions in MS patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314209
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  • 7
    Electronic Resource
    Electronic Resource
    Benign and secondary progressive multiple sclerosis: a preliminary quantitative MRI study (1994)
    Springer
    Journal of neurology 241 (1994), S. 246-251 
    Details
    ISSN: 1432-1459
    Keywords: Quantitative MRI ; Disability ; Multiple sclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a preliminary study, we compared by means of quantitative magnetic resonance imaging (MRI) methods (1) the T2 values and the decay characteristics of chronic brain lesions, (2) the T2 values of normal-appearing frontal white matter (NAWM) and (3) brain lesion volumes in patients with benign and secondary progressive multiple sclerosis (MS) in order to evaluate the mechanisms underlying the development of disability. Eleven clinically definite MS patients with either benign MS (n = 5) or secondary progressive MS (n = 6) were studied. Fifty-two chronic lesions (identified by comparison with MRI scans obtained at least 12 months previously) were identified. The mean T2 of large lesions (cross-sectional area greater than 41 mm2) and of the NAWM was similar in both clinical groups. However, small lesions had higher mean T2 values (P 〈 0.01) in the benign group, probably at least in part because of partial volume effects. Analysis of large lesions revealed biexponential T2 relaxation in 6 of 8 “secondary progressive” and in 2 of 16 “benign” lesions, perhaps indicating a greater degree of axonal loss in large lesions of patients with secondary progressive MS. Patients with secondary progressive MS had higher (although not significant) total and infratentorial lesion loads than those of the benign group. These preliminary findings suggest, but do not establish, that variations in the extent, site and pathological nature of lesions may all contribute to different patterns of disease evolution in MS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00863776
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  • 8
    Electronic Resource
    Electronic Resource
    Acute myelopathy of unknown aetiology: a clinical, neurophysiological and MRI study of short-and long-term prognostic factors (1995)
    Springer
    Journal of neurology 242 (1995), S. 497-503 
    Details
    ISSN: 1432-1459
    Keywords: Acute myelopathy ; Magnetic resonance imaging ; Evoked potentials ; Multiple sclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Brain and spinal cord magnetic resonance imaging (MRI), multimodal evoked potentials (EPs) and cerebrospinal fluid (CSF) analysis were performed in 27 patients with acute myelopathy of unknown aetiology (AMUA), to detect the diagnostic and prognostic values of paraclinical tests at presentation. Spinal cord MRI was abnormal in 56% and brain MRI in 33% of the patients. Visual EPs were abnormal in 7%, median somatosensory EPs in 17%, tibial somatosensory EPs in 56% and motor EPs in 35% of the cases examined. Brain-stem acoustic EPs were normal in all the patients. CSF oligoclonal bands (OBs) were detected in 30% of cases. The patients were divided into subgroups according to the short-term clinical outcome (complete, partial or absent recovery). There were no significant differences among the three groups as regards MRI findings. Patients with complete recovery showed a significantly lower frequency of tibial somatosensory EP and motor EP abnormalities. According to the paraclinical findings at onset and on the basis of a long-term clinical follow-up (mean duration 24 months), 6 patients were diagnosed as having clinically definite multiple sclerosis, while 21 did not develop further neurological disturbances. Only the presence of CSF OBs was significantly more frequent in patients with definite multiple sclerosis. Our study indicates that EPs exploring spinal cord function are more powerful than spinal MRI for predicting the short-term outcome of AMUA, while the combined use of brain MRI and CSF OBs has the highest negative predictive value for the subsequent development of clinically definite multiple sclerosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00867419
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  • 9
    Electronic Resource
    Electronic Resource
    Acute- and insidious-onset myelopathy of undetermined aetiology: contribution of paraclinical tests to the diagnosis of multiple sclerosis (1990)
    Springer
    Journal of neurology 237 (1990), S. 171-176 
    Details
    ISSN: 1432-1459
    Keywords: Multiple sclerosis ; Myelopathy ; Magnetic resonance imaging ; Evoked potentials
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Brain magnetic resonance imaging (MRI), multimodality evoked potentials (EPs) and cerebrospinal fluid examination were performed in 42 patients with myelopathy of undetermined aetiology in order to detect abnormalities usually related to multiple sclerosis (MS). Patients were divided into three groups: insidious-onset myelopathy with only motor signs (group A; 11 patients), with both motor and sensory signs (group B; 18 patients) and acute-onset myelopathy (group C; 13 patients). Multiple brain MRI lesions were found in 18 patients (2 of group A, 13 of group B and 3 of group C). Another 7 patients had a single white-matter lesion. Visual EPs were abnormal in 21 and brain-stem auditory EPs in 12 patients. Paraclinical tests supported the diagnosis of MS in 25 patients (60%) by showing subclinical brain abnormalities. Oligoclonal bands were found in 16 of these 25 patients. The findings strongly suggest a diagnosis of MS in the patients of group B.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314590
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  • 10
    Electronic Resource
    Electronic Resource
    Contribution of magnetic resonance imaging techniques in understanding cognitive impairment in multiple sclerosis (1998)
    Springer
    Neurological sciences 19 (1998), S. S399 
    Details
    ISSN: 1590-3478
    Keywords: Multiple sclerosis ; Magnetic resonance imaging ; Cognitive functions ; Magnetization transfer imaging Frontal lobe
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario In questa revisione della letteratura, vengono presentati e discussi i risultati di recenti studi di risonanza magnetica (RM) quantitativa nei quali il grado di deficit cognitivo in pazienti affetti da sclerosi multipla e stato correlato con l'estensione e la gravity delle alterazioni encefaliche evidenziate con tecniche differenti di RM, al fine di raggiungere una migliore comprensione dei meccanismi patogenetici sottesi allo sviluppo di tall deficit.
    Notes: Abstract In this review, the results of recent quantitative magnetic resonance imaging (MRI) studies correlating the degree of cognitive impairment in multiple sclerosis patients with the extent and severity of brain abnormalities seen using MRI techniques are presented and discussed with the ultimate goal of a better understanding of the pathophysiological mechanisms underlying the development of such deficits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00539595
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