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  • 11
    Digitale Medien
    Digitale Medien
    Interferon in chronic myeloid leukemia (1993)
    Springer
    Annals of hematology 67 (1993), S. 101-106 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Chronic myeloid leukemia ; Interferon ; Hydroxyurea ; Busulfan ; Bone marrow transplantation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The therapeutic efficacy of interferon-alpha (IFN-α) in the treatment of chronic myeloid leukemia is currently being tested in a number of institutional, interinstitutional, and international trials. There is no doubt that responses are achieved in many patients, and in a small subset complete eradication of clonogenic cells may be possible. However, it has not yet been shown that overall survival of patients treated with IFN-α is better than that of those treated with conventional cytoreductive drugs. There are still controversial opinions on problems such as dosages and duration of treatment, combination with cytostatic agents, definition of responses, and relevance of cytogenic and molecular data. An international workshop discussed the data on interferon therapy and attempted to define the role of interferon today in the management of chronic myeloid leukemia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01788134
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  • 12
    Digitale Medien
    Digitale Medien
    Antibody incubation of human marrow graft for prevention graft versus host disease (1980)
    Springer
    Annals of hematology 40 (1980), S. 387-397 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Knochenmarktransplantation ; Vermeidung von GvH ; T-Zell-Globulin ; Bone marrow transplantation ; Prevention of GvH ; Preincubation of donor bone marrow ; Specific anti-T-cell globulin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary An in vitro incubation of incompatible donor bone marrow by xenogenic anti-T-cell globulin (ATG) suppressed an otherwise lethal GvH reaction in animal models. An application of this principle to clinical bone marrow transplantation was successfully tried in three patients with acute lymphoblastic leukemia. Preparation of the specific anti-human T-cell globulin (ATCG-H) was carried out by absorption of anti-human thymocyte globulin with liver-kidney homogenate, chronic lymphocytic leukemia cells of B-cell type, and erythrocytes. Subsequent testing revealed that the serum still reacted with human T-cells but no longer reduced the number of colony-forming units in culture (CFU-C). All three bone marrow recipients were treated by chemotherapeutic conditioning and total body irradiation followed by grafting of in vitro treated bone marrow from HLA-identical siblings. The transplantation of the bone marrow was well tolerated and no major side effects were encountered. No patient so far (24, 7, 6 months) has shown any signs of GvHD. The in vitro pretransplantation treatment of bone marrow with anti T-globulin may be a new approach to the prevention for GvHD in man.
    Notizen: Zusammenfassung Tierexperimentelle Befunde ergaben den Hinweis, daß bei Knochenmarktransplantation mit inkompatiblem Spendermark eine Vorinkubation des Spendermarkes mit xenogenem Anti-T-Zell-Globulin eine sonst toxisch verlaufende Graft versus Host-(GvH)Erkrankung vermeidet. Bei drei Patienten mit akuter lymphatischer Leukämie wurde dieses Prinzip bei der Knochenmarktransplantation erfolgreich klinisch angewandt. Zur Anwendung gelangte ein spezifisches antihumanes Anti-T-Zell-Globulin (ATCG-H), das durch mehrere Absorptionsschritte aus rohem antihumanem Globulin (ATG) gewonnen wurde. Eine Vortestung des Serums ergab eine unveränderte Reaktion gegen menschliche T-Zell-Lymphozyten ohne toxische Nebenwirkungen auf in vitro nachweisbare Vorläuferzellen der Hämopoese (CFU-C). Die Knochenmarktransplantation wurde bei allen drei Patienten nach üblicher Chemotherapie („Konditionierung“) und Ganzkörperbestrahlung mittels vorinkubiertem Spendermark von HLA-identischen Geschwisterndurchgeführt. Toxische Nebenwirkungen durch die Vorinkubation traten nicht auf. Anzeichen einer GvH wurden bisher (24, 7, 6 Monate) bei den Empfängern nicht beobachtet. Die in vitro -Vorinkubation von Spenderknochenmark kann somit als ungefährlicher neuer Versuch zur Vermeidung einer GvH beim Menschen empfohlen werden.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01029680
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  • 13
    Digitale Medien
    Digitale Medien
    Transplant activities in Germany in 1998 – a survey facilitated by the National Registry for Hemopoietic Stem Cell Transplantation (2000)
    Springer
    Annals of hematology 79 (2000), S. 437-443 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Key words Blood stem cell transplantation ; Data management quality control
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  To improve the infrastructure of hemopoietic stem-cell transplantations in our country, the German Registry for Hemopoietic Stem-Cell Transplantations (DRST) was established in 1998. The present paper summarizes the current status of the DRST and gives a survey of transplant activities in Germany in 1998 in terms of transplant units, transplant types, transplant frequencies and underlying diseases.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002770000194
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  • 14
    Digitale Medien
    Digitale Medien
    Knochenmarktransplantation bei akuter Leukämie: Prophylaktische Antiserumbehandlung des Knochenmarks zur Unterdrückung einer Transplantat-gegen-Wirt-Reaktion (1981)
    Springer
    Annals of hematology 43 (1981), S. 113-118 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Acute leukemia ; Bone marrow transplantation ; Anti-T-cell-globulin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Anti-human-thymocyte globulin (AHTZG) was applied to prevent GvHD in clinical bone marrow transplantation. AHTZG produced by absorption with several cell preparations reacted specifically with T-lymphocyte populations and was no longer inhibitory to human CFUc and bone marrow growth in diffusion chambers. Marrow grafts of 14 patients with ALL were incubated in vitro with AHTZG and transferred to the recipients conditioned with antileukemic chemotherapy and total body irradiation of 1000 rad. Ten patients were transplanted after relaps, four patients during remission. The patients tolerated the marrow without side effects and a hemopoietic engraftment was seen in 12 cases. Three patients showed signs of GvHD on the skin, two of them showed later on also manifestations in the liver. In the other cases no GvHD could be detected. Five out of 14 patients are still alive between 144 and 964 days post transplantation in remission.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00320471
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  • 15
    Digitale Medien
    Digitale Medien
    Book reviews (1981)
    Springer
    Annals of hematology 42 (1981), S. 263-265 
    Details
    ISSN: 1432-0584
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00996757
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  • 16
    Digitale Medien
    Digitale Medien
    Adriamycin und autologe Knochenmarktransplantation (1982)
    Springer
    Annals of hematology 44 (1982), S. 115-120 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Adriamycin ; Toxocity ; Autologous bone marrow transplantation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We investigated the toxicity of adriamycin (ADM) in dogs with regard to autologous bone marrow transplantation (BMT). Gastrointestinal toxicity limited the dose of ADM in single administration (3.0 mg/kg) and chronic cardiotoxicity in repeated administration (9×1.5 mg/kg every two weeks). The recovery of hemopoiesis was complete within 25 days after single and repeated doses of ADM as indicated by the restoration of blood counts and concentration of hemopoietic precursors (CFUc) as well as proliferate activity of bone marrow. At this time bone marrow was obtained and reinfused after total body irradiation (TBI) with 10 Gy. Single and repeated doses of 1.5 mg/kg ADM did not delay recovery of blood counts after autologous BMT as compared to transplantation of untreated marrow — in contrast a single dose of 3.0 mg/kg ADM did. Our results indicate that toxicity of ADM is not influenced by autologous BMT. Previous shorter therapy with conventional doses of ADM does not preclude autologous BMT.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00320100
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  • 17
    Digitale Medien
    Digitale Medien
    Biopterin level in blood cells as a marker for hemopoietic cell proliferation during autologous bone marrow transplantation in beagle dogs (1982)
    Springer
    Annals of hematology 44 (1982), S. 261-270 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Biopterin ; Bone marrow transplantation ; Hemopoiesis ; Reticulocytes
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Bone marrow aplasia was induced by fractionated whole body irradiation with 3000 R and restitution was started by autologous bone marrow transplantation. During the period of aplasia the amount of buffy coat biopterin clearly followed the decline of leukocytes and, vice versa, during reconstitution it largely paralleled their increase in number. The amount of red cell biopterin closely correlated with the number of reticulocytes rather than with the fairly constant values for hematocrit or of erythrocytic protein. Thereby it clearly followed the various periods of red cell recovery. The amount of cellular biopterin, its concentration with respect to cell number or to unit of protein and the percentage distribution of biopterin among the cell fractions are presented as characteristics of the activity of hemopoietic cell proliferation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00320700
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  • 18
    Digitale Medien
    Digitale Medien
    Randomized study on the treatment of chronic myeloid leukemia (CML) in chronic phase with busulfan versus hydroxyurea versus interferon-alpha (1988)
    Springer
    Annals of hematology 56 (1988), S. 87-91 
    Details
    ISSN: 1432-0584
    Schlagwort(e): CML ; Busulfan ; Hydroxyurea ; Interferon-alpha ; Duration of chronic phase ; Prospective study
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary For palliative therapy during the chronic phase of CML busulfan has proved to be the drug of choice. During the past years hydroxyurea and also interferon-alpha have gained increasing significance since they might prolong the duration of the chronic phase. In a multicenter study it is being determined, whether the use of hydroxyurea or of interferon-alpha instead of busulfan prolongs the duration of the chronic phase of Philadelphia positive CML. Additional goals are the examination of whether the types of disease evolution and the terminal phases differ between the treatment groups, and the prospective recognition of prognostic criteria for the duration of the chronic phase of CML. By December 31, 1987, 326 CML-patients had been randomized, 150 for busulfan, 150 for hydroxyurea and 26 for interferon-alpha. The average age is 50 years. 59 patients reached the end of the chronic phase, 55 died. The mean observation time of all patients is 1.34 years. At present no significant difference in survival is recognizable between the busulfan and hydroxyurea groups. Fewer adverse effects have been observed in the hydroxyurea group. Philadelphia chromosome negative patients show a higher average age and tend to have lower white blood cell and platelet counts. The number of patients having received interferon-alpha is still too small to allow evaluation. This report intends to document organization and progress of this study which to our knowledge is, at present, the largest ongoing prospective multicenter study on the therapy of CML.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00633471
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  • 19
    Digitale Medien
    Digitale Medien
    Idarubicin monotherapy in multiply pretreated leukemia patients: response in relation to P-glycoprotein expression (1997)
    Springer
    Annals of hematology 74 (1997), S. 57-64 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Key words P-Glycoprotein ; AML ; ALL ; CML ; Idarubicin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  The aim of the study was to test whether fractionated (weekly) idarubicin administration to multiply pretreated leukemia patients is effective and tolerable for outpatient treatment, and whether idarubicin alone can overcome P-glycoprotein (P-gp)-related resistance. P-gp was assessed with an immunocytological technique using the monoclonal antibody 4E3.16. P-gp expression was characterized as a percentage of P-gp-positive blasts. Additionally, the function of P-gp was determined with the rhodamine-123 (R-123) accumulation test in combination with or without verapamil and expressed as the R123 accumulation ratio. Fractionated idarubicin (12 mg/m2/week) was given to 36 acute myelogenous leukemia (AML) patients, 12 acute lymphoblastic leukemia (ALL) patients, and eight chronic myelogenous leukemia (CML) patients in blast crisis. Furthermore, 11 AML and four ALL patients were treated with fractionated daunorubicin at a dose of 50 mg/m2/week. All patients had been pretreated with drugs inducing P-gp-related resistance including daunorubicin and/or doxorubicin or vindesine (CML patients). Of 71 pretreated patients, 51 (72%) had a P-gp value between 25 and 98%. Six of these patients with increased P-gp expression had a nonpumping P-gp; four of them were CD34 positive. Of 51 patients with increased P-gp expression, 30 (59%) were CD34 positive. With regard to idarubicin monotherapy, overall response was 33/56 (59%) patients, and 23/33 (70%) responding patients showed a P-gp expression between 25 and 95%. All idarubicin-responding patients with high P-gp expression before treatment showed a clear reduction of P-gp-positive blasts. No patients with P-gp expression between 34 and 85% treated with fractionated daunorubicin showed response or reduction of P-gp-positive blasts in bone marrow. This study demonstrates that P-gp-related resistance can be overcome in multiply pretreated leukemia patients with idarubicin alone, and that the protocol used here is tolerable for outpatient treatment.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002770050258
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  • 20
    Digitale Medien
    Digitale Medien
    Insulin degrading enzyme activity and insulin binding of erythrocytes in normal subjects and Type 2 (non-insulin-dependent) diabetic patients (1984)
    Springer
    Diabetologia 27 (1984), S. 17-22 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Insulin degrading enzyme activity ; insulin binding ; insulin resistance ; Type 2 diabetes ; erythrocytes
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Specific insulin degrading enzyme activity of erythrocytes was determined in relation to erythrocyte insulin binding in 16 healthy subjects, 14 Type 1 (insulin-dependent) and various groups of Type 2 (non-insulin-dependent) diabetic patients (n = 39). Degrading activity was increased in Type 2 diabetic patients on sulphonylureas, as well as in a subgroup with good metabolic control (p〈0.001) and in patients with secondary failure to oral therapy (p〈0.02); degrading activity returned to normal in the latter patients after 1 week of insulin treatment. Highest degrading activity was found in insulintreated, yet insulin-insensitive patients (daily insulin dose 〉80 U). Degrading activity was significantly correlated in healthy subjects both with circulating insulin concentrations and maximal specific insulin binding. In contrast, in Type 2 diabetic subjects, degrading activity was inversely correlated with serum insulin with no apparent association with maximal specific insulin binding except in those patients given 1 week of insulin treatment. High erythrocyte insulin degrading enzyme activity might be a common feature in the insulin-insensitive Type 2 diabetic patient and might occur subsequent to some aspect of insulin deficiency at the tissue level.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00253495
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