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  • 11
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and pharmacodynamics of alprenolol in the treatment of hypertension (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 89-95 
    Details
    ISSN: 1432-1041
    Keywords: Adrenergic beta receptor blockade ; drug plasma concentrations ; plasma renin activity ; essential hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The kinetics of alprenolol, in relation to its effect on blood pressure and plasma renin activity, have been studied in sixteen patients. A within-patient comparison was made between therapy for six weeks with placebo or alprenolol 200 mg thrice daily. Thirteen patients responded to alprenolol by a significant fall in blood pressure. In three other patients treatment did not lower blood pressure. In the group as a whole there was no significant correlation between the fall in systolic, diastolic or mean blood pressure, and the steady-state plasma alprenolol concentration, renin status, or degree of beta blockade. However, the thirteen responsive patients showed a significant relationship (p〈0.05 – 0.001) between the log mean steady-state plasma alprenolol concentration and the hypotensive response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609465
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  • 12
    Electronic Resource
    Electronic Resource
    Clinical pharmacology in europe (1991)
    Springer
    European journal of clinical pharmacology 41 (1991), S. 185-186 
    Details
    ISSN: 1432-1041
    Keywords: Clinical pharmacology ; Europe ; European task force
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315427
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  • 13
    Electronic Resource
    Electronic Resource
    Report for the European Journal of Clinical Pharmacology (1996)
    Springer
    European journal of clinical pharmacology 49 (1996), S. 425-426 
    Details
    ISSN: 1432-1041
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00203791
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  • 14
    Electronic Resource
    Electronic Resource
    European association of clinical pharmacology and therapeutics (1993)
    Springer
    European journal of clinical pharmacology 45 (1993), S. 295-296 
    Details
    ISSN: 1432-1041
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265943
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  • 15
    Electronic Resource
    Electronic Resource
    Chloroquine in malaria (1993)
    Springer
    European journal of clinical pharmacology 44 (1993), S. 271-274 
    Details
    ISSN: 1432-1041
    Keywords: Chloroquine ; Malaria ; prophylaxis schedules ; side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Two antimalarial prophylactic regimens were compared in healthy subjects belonging to the flying personnel of Scandinavian Airlines System. Regimen I: 310 mg chloroquine (CQ) base was given once weekly, starting the week prior to departure to the endemic area, then weekly during presence there and for four weeks after return. Regimen II: a loading dose of 620 mg chloroquine base was given at the latest 48 h prior to departure to the endemic area, followed by 310 mg base weekly throughout the visit. Blood samples were analysed by HPLC for CQ and its major metabolite desethylchloroquine (CQM). Regimen I gave suboptimal whole blood concentrations of CQ and CQM at the end of the first week of treatment. Regimen II gave prophylactic concentrations from the beginning of visit up to 6 weeks after departure from the endemic area. Both regimens were well tolerated, but Regimen II appeared better accepted by the volunteers due to its shorter duration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00271370
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  • 16
    Electronic Resource
    Electronic Resource
    The effects of long term administration of dopamine on renal function in hypertensive patients (1973)
    Springer
    European journal of clinical pharmacology 6 (1973), S. 150-155 
    Details
    ISSN: 1432-1041
    Keywords: Dopamine ; renal blood flow ; hypertension ; renal failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of an intravenous infusion of dopamine (0.5 to 1.25 µg/kg/min) for periods of between 36 and 105h has been studied in eight patients with hypertension and varying degrees of renal impairment. There was a significant rise in the glomerular filtration rate (GFR) from 31.2±20.2 to 42.8±26.8 ml/min (p〈.05) after four hours of the infusion but after 48 h of infusion the mean GFR was no different from the control value. The paraaminohippuric acid (PAH) clearance also rose from 129.8±115.4 ml/min to 173.1±164.3 ml/min (p〈0.05) after four hours of infusion, but like the GFR it was no different from control after 48 h of the infusion. The daily urine volumes increased significantly during the dopamine infusion from 2176.0±49.2 ml/day to 3809.0±118.8 ml/day (p〈0.002) but had returned to control values after 48 h of continuing dopamine infusion. Following the end of the infusion there was a significant reduction in the urine volume to 1213.0±195.0 ml/day (p〈0.001). There was a rise in sodium excretion during the dopamine infusion from 94.8±50.7 meq/day to 264.7±172.8 meq/day (p〈0.01) with a fall after the end of the infusion to 33.2±27.5 meq/day (p〈0.05). There was no change in the blood urea during the dopamine infusion but after stopping the infusion the blood urea rose from 83.5±39.4 mg% to 95.1±39.0 mg% (p〈0.02). We conclude that intravenous infusion of dopamine to patients with hypertension and renal impairment may produce initial clinical improvement but is of little therapeutic benefit when given for prolonged periods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558278
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  • 17
    Electronic Resource
    Electronic Resource
    Effect of dose size on amodiaquine pharmacokinetics after oral administration (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 331-333 
    Details
    ISSN: 1432-1041
    Keywords: amodiaquine ; desethylamodiaquine ; first-order pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Plasma and urine concentrations of amodiaquine (AQ) and desethylamodiaquine (AQm) have been measured after oral administration of AQ 200, 400 and 600 mg in randomised order to 6 healthy subjects. The relationships between AQ dose size and the areas under the plasma concentration vs time curves for AQ and AQm were linear. Likewise there were linear relationships between AQ dose size and the mass of both AQ and AQm excreted in the urine. These data indicate that after oral administration within this dose range AQ displays first-order pharmacokinetics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637573
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  • 18
    Electronic Resource
    Electronic Resource
    The relative systemic availability of ivermectin after administration as capsule, tablet, and oral solution (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 681-684 
    Details
    ISSN: 1432-1041
    Keywords: ivermectin ; bioavailability ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Administration of 12-mg doses of ivermectin (H2B1a) to 12 healthy volunteers in the form of tablets, capsules, and alcoholic oral solution showed the solution to have approximately twice the systemic availability as either of the solid forms, as evidence both by the maximum concentrations of drug attained in plasma and by the corresponding areas under the plasma concentration vs time curves. However, the two solid formulations showed similar systemic availability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637608
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  • 19
    Electronic Resource
    Electronic Resource
    The effect of dopamine on renal blood flow in man (1971)
    Springer
    European journal of clinical pharmacology 3 (1971), S. 131-136 
    Details
    ISSN: 1432-1041
    Keywords: Dopamine ; renal blood flow ; indicator dilution technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary 1. The effect of dopamine on renal blood flow as measured directly by an indicator dilution technique has been studied in eleven hypertensive patients. — 2. Dopamine (1 and 2 µg/kg body wt/min) caused a mean increase of 77.1% and 121.6% respectively in renal blood flow. This was four to five times greater than the corresponding change produced in cardiac output (+16.8% and +37% respectively over control values). — Neither propranolol (2 studies) nor phentolamine (1 study) blocked these changes in renal blood flow. — 4. Dopamine 2 µg/kg body wt/min caused a mean increase in sodium excretion from 0.269±0.246 mequiv/min to 0.942±0.429 mequiv/min in 4 hypertensive subjects. There was also an increase in glomerular filtration rate, measured by inulin clearance, from 95.2±13.8 ml/min to 124.7±13.4 ml/min and in effective renal blood flow measured by PAH clearance from 490.2±170.8ml/min to 673.0±256.2 ml/min.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00572452
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  • 20
    Electronic Resource
    Electronic Resource
    Experiments on the dynamics of droplet collisions in a vacuum (2000)
    Springer
    Experiments in fluids 29 (2000), S. 347-358 
    Details
    ISSN: 1432-1114
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Highly controlled experiments of binary droplet collisions in a vacuum environment are performed in order to study the collision dynamics devoid of aerodynamic effects that could otherwise obstruct the experimental observations by causing distortion or even disintegration of the coalesced mass. Pre-collision droplets are generated from capillary stream break-up at wavelengths much larger than those generated with the typical Rayleigh droplet formation in order to reduce the interactions among the collision products. Experimental results show that the range of droplet Weber number necessary to describe the boundaries between permanent coalescence and coalescence followed by separation is several orders of magnitude higher than has been reported in experiments conducted at standard atmospheric pressures with lower viscosity liquids (i.e. hydrocarbon fuels and water). Additionally, the time periods of both the oblate and prolate portions of the coalesced droplet oscillation have been measured and it is reported for the first time that the time period for the prolate portion of the oscillation grows exponentially with the Weber number. Finally, new pictorial results are presented for droplet collisions between non-spherical droplets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003489900092
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