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  • 1
    Electronic Resource
    Electronic Resource
    Complete reversion and prevention of rectal adenomas in colectomized patients with familial adenomatous polyposis by rectal low-dose sulindac maintenance treatment (1995)
    Springer
    Diseases of the colon & rectum 38 (1995), S. 813-830 
    Details
    ISSN: 1530-0358
    Keywords: Adenoma reversion ; Colectomy ; Dysplasia reversion ; FAP ; Familial adenomatous polyposis ; Low-dose maintenance therapy ; NSAID ; Prostaglandins ; Sulindac
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: This nonrandomized, controlled Phase II pilot study aims at the lowest effective dose of rectally applied sulindac to achieve and maintain adenoma reversion in colectomized patients with familial adenomatous polyposis (FAP). METHODS: The study group (n = 15) underwent proctoscopic and laboratory follow-up for polyp reversion every 6 to 12 weeks. Polyp reversion was followed by dose reduction in predefined steps. Proliferating cell nuclear antigen/cyclin (PCNA) and KI-67 proliferation indices (PI) were performed by point counting. Prostaglandin (PG)E2 and PGF2α were quantified by time-resolved competitive fluorescence immunoassay. RESULTS: All patients responded to therapy within 6 to 24 weeks. Sixty and 87 percent of patients achieved complete adenoma reversion after 48 weeks at 53 and 67 mg of sulindac per day per patient on average, respectively. Reversion was evident compared with the control group. Dose reduction by one-sixth to one-eighth of the usual oral dose was significant (Mann's trend test,P 〈 0.05). PCNA and KI-67 Pls of adenomatous and flat mucosa were significantly reduced (Wilcoxon's test,P 〈0.05). Correlation of PCNA and KI-67 Pls indicate similar reaction of different tissue structures (Spearman's rank correlation test,P 〈0.01). Nonsteroidal anti-inflammatory drug-induced redifferentiation from high-grade to low-grade dysplasia occurred in all but two patients. Tissue-PGE2 levels were greatly reduced. Unwanted, curable side effects were rare (gastritis,n =2), and laboratory controls are within detection limits. CONCLUSIONS: Low-dose rectal sulindac maintenance therapy is highly effective in achieving complete adenoma reversion without relapse in 87 percent of patients after 33 months. Rectal FAP phenotype should be crucial for the surgical decision. Colectomy with ileorectal anastomosis and regular chemoprevention might proceed to be a promising alternative to pouch procedures. Chemoprevention with lower incidence of FAP-related tumors via dysplasia reversion may be possible in the future.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02049838
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  • 2
    Electronic Resource
    Electronic Resource
    Eiweißhaushalt und Leberfunktion nach chirurgischen Operationen (1969)
    Springer
    Langenbeck's archives of surgery 323 (1969), S. 345-361 
    Details
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei chirurgischen Patienten wurde das Verhalten der Stickstoffbilanz, der Kreatinin-Harnsäure- und Harnstoffkonzentration im Serum, Bilirubinkonzentration und—Ausscheidung, 2-Farbstofftest, Serumcholesterinaktivität, und DPN-abhängige Fermente vor-und zu verschiedenen Zeiten nach der Operation bestimmt. Es fanden sich einige charakteristische Veränderungen im Proteinhaushalt. Ein nennenswerter Leberschaden ließ sich ausschließen.
    Notes: Summary In surgical Patients nitrogen balance, creatinine-, uric acid-, urea-and bilirubinconcentration in serum und urine was determined. In various intervals after the operation liver function tests were done. We found characteristic changes in protein metabolism. No serious liver deterioration were found in patients whose liver function was normal before operation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01440064
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  • 3
    Electronic Resource
    Electronic Resource
    Über eine Methode zur kontinuierlichen Motilitäts- und Druckregistrierung im Verdauungskanal mit Hilfe von Dehnungsmessstreifen (1957)
    Springer
    Journal of molecular medicine 35 (1957), S. 586-588 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Es wird eine neue Meßanordnung beschrieben. Ihre wesentlichsten Bestandteile stellen ein Dehnungsmeßstreifen und ein Übertrager (Druckkammer) dar. Mit Hilfe dieser Apparatur ist es möglich, in muskulären Hohlorganen, vor allen Dingen denen des Magen-Darmkanals, sowohl die Motilität fortlaufend zu registrieren als auch kontinuierliche Messungen des absoluten Innendrucks verzerrungsfrei vorzunehmen. Da sich die Beobachtung von Bewegungsvorgängen und Druckänderungen in Hohlorganen zweckmäßig ergänzen, erscheint es vorteilhaft, beide Vorgänge auf elektrischem Wege unter Vermeidung eines kostspieligen apparativen Aufwandes mit dem gleichen, hier angegebenen Gerät zu erfassen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01480811
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  • 4
    Electronic Resource
    Electronic Resource
    Clinical efficacy of low molecular weight heparin in postoperative thrombosis prophylaxis (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 349-353 
    Details
    ISSN: 1432-1440
    Keywords: Deep venous thrombosis ; Heparin prophylaxis ; Fractionated heparin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a randomized controlled clinical trial, the efficacy and safety of two low molecular weight heparin (LMWH) fractions in the prophylaxis of deep vein thrombosis (DVT) were assessed. One hundred twenty-six patients undergoing major abdominal surgery received alternatively 2,500 APTT units b.i.d. of two LMWH fractions or 5,000 APTT units b.i.d. of an unfractionated sodium mucosal heparin (UFH). LMWH 2 differed from LMWH 1 by presenting a lower mean molecular weight and a higher anti-Xa/APTT ratio in vitro. Patients were randomly allocated to the three groups, and the development of DVT was studied with the125I-fibrinogen uptake test (RFUT). The study was interrupted and the code broken prematurely because of otherwise unexplainable bleeding events. While no thrombosis and no severe bleeding were detected in the UFH group, three (7%) RFUT-positive DVT and two (5%) hemorrhagic complications occurred in the LMWH 1 group. No thrombosis and nine (22%) cases of severe bleeding were observed in the LMWH 2 group. Thus, the latter group differed significantly from the control group with regard to subjective and objective criteria for postoperative bleeding. Although these results do not allow general conclusions as to the value of LMWH fractions in the prevention of DVT, they indicate that these preparations just as ordinary heparin have a limited therapeutic range.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716253
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  • 5
    Electronic Resource
    Electronic Resource
    Die Bestimmung des Gesamteiweissgehaltes aus dem Papierelektropherogramm (1955)
    Springer
    Journal of molecular medicine 33 (1955), S. 187-188 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01467304
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  • 6
    Electronic Resource
    Electronic Resource
    The NSAID sulindac reverses rectal adenomas in colectomized patients with familial adenomatous polyposis: clinical results of a dose-finding study on rectal sulindac administration (1993)
    Springer
    International journal of colorectal disease 8 (1993), S. 13-17 
    Details
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Après colectomie et anastomose iléo-rectale (AIR) pour le traitement de la polypose adénomateuse familiale (PAF) il demeure un risque de malignisation de la muqueuse rectale. Une application locale (rectale) de Sulindac a été effectuée avec des doses initiales élevées et une poursuite du traitement avec des doses plus faibles afin de diminuer les effets nocifs. L'étude dose-relation avec des suppositoires de Sulindac a commencé avec une dose de 300 mg de Sulindac quotidiens par malade pendant 6 semaines. Selon l'évaluation de la régression des polypes en proctoscopie, les doses de Sulindac étaient réduites de façon prédéfinie. 10 des 15 malades ont développé une rémission complète après 42 semaines de traitement tandis que les autres avaient une rémission partielle. La réponse a été réévaluée 6 à 24 semaines après le début du traitement par Sulindac. Après 36 semaines, 13 des 15 patients avaient reçu 25 à 50 mg quotidiens. L'augmentation du nombre des rémissions partielles après 42 semaines de traitement à la dose de 100 mg de Sulindac quotidiens peut indiquer une première approximation pour des doses réduites entre 100 et 25 mg de Sulindac quotidiens mais peut aussi souligner l'importance du traitement à long terme plutot que de l'intensité des doses thérapeutiques.
    Notes: Abstract After colectomy with ileorectal anastomosis (IRA) for treatment of familial adenomatous polyposis (FAP), the rectal mucosa remains, with the risk of malignant change. Locoregional (rectal) sulindac has been applied, with initial higher-dose therapy and subsequent low-dose maintenance therapy to minimise side-effects. The dose-finding study with sulindac suppositories started with a dose of 300 mg sulindac daily per patient over 6 weeks. Depending on proctoscopical evaluation of regression of polyposis, sulindac doses were reduced in predefined steps. Ten of 15 patients developed a complete remission following 42 weeks of treatment, while the rest had partial remission. Responses were recorded 6–24 weeks after beginning sulindac treatment. After 36 weeks, 13/15 patients received 25–50 mg sulindac daily. An increase in the number of partial remissions after 42 weeks of treatment at doses of 100 mg sulindac daily may indicate the first approach to a reduced dose between 100 mg to 25 mg sulindac daily, but may also point to the importance of long-term treatment rather than dose-intense therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00341270
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  • 7
    Electronic Resource
    Electronic Resource
    Comparative studies of cardia carcinoma and infracardial gastric carcinoma (1993)
    Springer
    Journal of cancer research and clinical oncology 120 (1993), S. 91-94 
    Details
    ISSN: 1432-1335
    Keywords: Cardia carcinoma ; Infracardial gastric carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a part retrospective, part prospective study, 354 carcinomas of the cardia were compared with 1259 infracardial gastric carcinomas with regard to the age and sex of the patients, macroscopic classification, microscopic classifications, depth of invasion, and survival rates. Mortality rates are generally higher in cardia carcinoma than in stomach carcinoma. The difference is due to the significantly poorer survival of cardia carcinoma patients in stage I, while mortality rates in stages II, III, and IV of both types are approximately similar. Highly significant differences were also found with regard to sex ratio, incidence of macro- and microscopic subtypes, and invasive growth. The typical cardia carcinoma occurs preferentially in men, is mostly well-delineated, and is manifested as an ulcerated or polypoid, well-differentiated tumor of expansive growth, corresponding to Laurén's intestinal type. These results confirm the concepts of McPeak and Warren, MacDonald, and Siewert et al., that the carcinoma located in the cardia must be seen as a separate entity of gastric carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01200730
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  • 8
    Electronic Resource
    Electronic Resource
    Adenocarcinomas of esophagus and cardia in comparison with gastric carcinoma (1993)
    Springer
    Journal of cancer research and clinical oncology 120 (1993), S. 95-99 
    Details
    ISSN: 1432-1335
    Keywords: Adenocarcinoma ; Gastric carcinoma ; Esophagus ; Cardia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Since the carcinomas of the cardia and the adenocarcinomas of the esophagus show many similarities in their histological and morphological descriptions, a detailed comparative study was attempted on the basis of 66 esophageal carcinomas in adenoid differentiation, 359 carcinomas of the cardia, 1288 gastric carcinomas in infracardial localisation, and 492 squamous carcinomas of the esophagus. The evaluation yielded no significant differences between the adenocarcinomas of the esophagus and the cardia neither in age and sex distribution nor with regard to the classifications of Borrmann, WHO, Ming, and Laurén, but a significant discrimination was possible between esophageal and cardial adenocarcinoma together, on the one hand, and infracardial gastric carcinoma on the other. Furthermore, esophageal adenocarcinomas were localized preferentially in the lower third, unlike squamous carcinomas of the same organ. These results suggest that esophageal adenocarcinoma and carcinoma of the cardia must be considered as one separate entity, probably originating from a common stem cell. They further suggest that the cardia belongs to the esophagus rather than to the stomach.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01200731
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  • 9
    Electronic Resource
    Electronic Resource
    Endodermal germ cell carcinoma (endodermal sinus tumor) of the vagina in infant girls (1979)
    Springer
    Journal of cancer research and clinical oncology 94 (1979), S. 295-306 
    Details
    ISSN: 1432-1335
    Keywords: Endodermal sinus tumor ; Pathology ; Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An endodermal sinus tumor (endodermal germ cell carcinoma) was diagnosed in a 1-year-old girl in the vagina after vaginal hemorrhage; the tumor was completely removed by radical abdominal surgery. Postoperative polychemotherapy was performed for two years with Actinomycin D, Adriamycin, Vincristin, and Cyclophosphamide. The infant is now tumor-free for 26 months, showing almost normal somatic and psychic development. The characteristic histological patterns and clinical course of this strongly malignant tumor are demonstrated, based on 25 published casereports of endodermal sinus tumors in the vagina of little girls (aged 5–26 months). This neoplasm in early infancy has to be separated from the clear-cell adenocarcinoma of the vagina which occurs after puberty in adolescent girls and young women, and is induced by stilbestrol therapy to the mother during early pregnancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00419289
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  • 10
    Electronic Resource
    Electronic Resource
    Untersuchungen über enterale Antibiose bei der Ratte (1956)
    Springer
    Clinical and experimental medicine 127 (1956), S. 160-167 
    Details
    ISSN: 1591-9528
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung 1. Die für die klinische Anwendung der Antibiotica wichtige Frage der Beeinflussung der Blutgerinnungsfaktoren nach langdauernder Behandlung mit hohen oralen Dosen von Tetracyclinderivaten wurde an Ratten untersucht. 2. Es ergab sich eine nach 4 Wochen einsetzende Verlängerung der Spontangerinnungszeit nachSchulten, die nach weiteren 8 Behandlungswochen konstant blieb. Nach Absetzen des Terramycin waren 3 Wochen zu einer Teilrückbildung, 4 Wochen zur Normalisierung der Gerinnungszeit erforderlich. 3. Die Werte der Gerinnungsfaktoren V und VII, des getrennt bestimmten Prothrombin sowie derQuick-Zeit gingen nach 4 wöchiger Gabe von 100 mg/kg Oxytetracyclin auf etwa die Hälfte des Normalwertes zurück. Nach 16 Wochen weiterer Behandlung blieben die Werte unverändert. 4. Ghlortetracyclin blieb nach 4 wöchiger Behandlung ohne Einfluß auf die untersuchten Faktoren. 5. Die mit hohen Marcumardosen induzierte starke Verringerung der Blutgerinnungsfaktoren (Prothrombin und Faktor VII) schloß auch den Faktor V ein. Bei den mit 100 mg/kg Oxytetracyclin p. o. 4 Wochen lang behandelten Tieren zeigte sich keine Erniedrigung der Dicumaroltoleranz, die Restitution der Faktoren auf 50 mg/kg Vitamin K1 erfolgte bei ihnen ebenso rasch wie bei den Kontrollen, allerdings nur auf die schon vor dem Versuch erniedrigten Werte. 6. Aus der letztgenannten Beobachtung wie aus weiteren vergeblichen Versuchen, die Erniedrigung der Gerinnungsfaktoren durch Terramycin mit Vitamin K1 zu beheben, wird geschlossen, daß nicht ein durch die veränderte Darmflora hervorgerufener Vitamin K-Mangel, sondern eine Störung der spezifischen Proteinsynthese Ursache der Veränderungen ist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02047935
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