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  • 1
    Electronic Resource
    Electronic Resource
    Preface and Conference Summary (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 6 (1977), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1977.tb02091.x
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  • 2
    Electronic Resource
    Electronic Resource
    Effective treatment after failure of omeprazole plus amoxycillin to eradicate Helicobacter pylori infection in peptic ulcer disease (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 8 (1994), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Methods: Fifty patients with relapsing or complicated Helicobacter pylori positive duodenal (n= 41) or gastric ulcer disease (n= 9) and failure of a combined treatment with omeprazole plus amoxycillin to eradicate H. pylori infection were re-treated with either oral triple therapy (bismuth subsalicylate, metronidazole, tetracycline) plus ranitidine [group I: n= 22] or high-dose omeprazole (40 mg b.d. to t.d.s.) plus amoxycillin (1 g t.d.s.) [group II: n= 28]. Results: Patients of group I and II had similar demographic and clinical characteristics. The overall proportion of eradication of H. pylori infection was 81.8% in group I and 78.6% in group II (P= N.S.) as judged from negative bacterial findings by means of an urease test, specific culture and histology after modified Giemsa stain. Ulcer healing was observed in all patients after a maximum duration of 10 weeks. Ten patients on triple therapy and only one patient on omeprazole plus amoxycillin (45.5%vs. 3.6%; P 〈 0.001) complained of side effects without necessity of discontinuation of the study medication in either group. Twenty patients (group I: n= 10: group II: n= 10) with relapsing duodenal ulcer disease and successful cure were prospectively followed for one year without any evidence of ulcer relapse or H. pylori re-infection. Conclusion: Oral triple therapy plus ranitidine or highdose omeprazole plus amoxycillin remain highly effective in eradicating H. pylori infection in patients with peptic ulcer disease and treatment failure of omeprazole/amoxycillin, but the omeprazole enhanced antibiotic monotherapy seems to be superior with regard to side effects. Thus, high-dose omeprazole/amoxycillin is recommended as the treatment of first choice in these selected patients. Triple therapy should be reserved for patients intolerant of amoxycillin
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1994.tb00295.x
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  • 3
    Electronic Resource
    Electronic Resource
    IgG AND IgA HEAVY CHAIN ALLOTYPES IN TYPE 1 DIABETES (1983)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 10 (1983), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: IgG and IgA heavy chain allotypes were determined in the sera of 483 Caucasian Type 1 diabetes patients and 503 Caucasian healthy controls. There was no significant difference between patients and controls neither on the level of Gm phenotype frequencies nor on the level of Gm three-locus and two-locus haplotype frequencies. A selective IgA deficiency was found in 14 patients (2.9%) but in none of the control individuals (P〈10-4).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1983.tb00807.x
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  • 4
    Electronic Resource
    Electronic Resource
    NO INTERACTION BETWEEN HLA AND IMMUNOGLOBULIN IgG HEAVY CHAIN ALLOTYPES IN EARLY ONSET TYPE 1 DIABETES (1985)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 12 (1985), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Immunoglobulin heavy and light chain genes are often discussed as susceptibility genes for insulin dependent (type 1) diabetes mellitus (IDDM) in addition to HLA-DR3 and DR4. Accordingly we analysed 175 unrelated patients for an interaction between immunoglobulin allotype antigens (Gm) and HLA. While DR3 and DR4 antigens and DR3/DR4 heterozygotes occur significantly more often among diabetics than among normal controls, their Gm allotype frequencies are very similar. An interaction between special Gm allotypes and phenotypes, on the one side, and DR3, DR4 or DR3, 4 on the other side could not be demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1985.tb00834.x
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  • 5
    Electronic Resource
    Electronic Resource
    HL-A antigens in carcinoma of the breast, ovarium, cervix and endometrium: Possible association of haplotype HL-A10-W18 with carcinoma of the breast (1975)
    Springer
    Journal of cancer research and clinical oncology 83 (1975), S. 219-222 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei insgesamt 163 kaukasischen Patientinnen mit Carcinomen verschiedener Organe (60 Mamma-, 64 Cervix-, 19 Endometrium- und 20 Ovarial-Carcinome) wurden 24 HL-A-Antigene bestimmt und deren Frequenz mit den analogen Werten von 1000 klinisch gesunden Kontrollpersonen verglichen. Während dieser Vergleich für Cervix-, Endometrium und Ovarial-Carcinom keine eindeutig signifikanten Frequenzabweichungen ergab, konnte durch eine kombinierte Auswertung der eigenen HL-A-Daten mit den HL-A-Antigenfrequenzen aus vier anderen HL-A-Studien bei Mamma-Carcinom-Patienten (insgesamt 641 Patientinnen) eine mögliche Assoziation mit den Antigenen HL-A10 und W18 bzw. dem Haplotyp HL-A10-W18 aufgezeigt werden.
    Notes: Summary 24 HL-A antigens were determined in a total of 163 Caucasien cancer patients (60 breast cancers, 64 cancers of the cervix uteri, 19 cancers of the endometrium and 20 cancers of the ovary). The comparison of the antigen frequencies with the analogous values from 1000 healthy controls yielded no outstandingly significant deviations for cancer of the cervix, endometrium and ovary. In breast cancer patients, however, there might be an association with the antigens HL-A10 and W18 or the haplotype HL-A10-W18, as indicated by the results of a combined evaluation of our data together with the results of four different HL-A studies in breast cancer patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304091
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  • 6
    Electronic Resource
    Electronic Resource
    Zur Genetik des Morbus Crohn: Untersuchung der HLA-Assoziation bei 169 Patienten (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 747-751 
    Details
    ISSN: 1432-1440
    Keywords: HLA-association ; Crohn's disease ; Immunological aspects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Histocompatibility (HLA) antigen phenotypes have been studied in 169 patients with Crohn's disease. The following results could bei shown: 1. HLA-Aw33, -B45 and -Cw3 showed a positive association and HLA-A26, -DR3 and -DRw8 a negative association with Crohn's disease compared to healthy controls. However, when the p-values were corrected by multiplying them by the number of determined antigens per gen-locus, the differences were not significant. 2. Patients with a late onset of the disease (〉25 years) showed a statistical significant negative association with HLA-DR3. 3. Numerous studies revealed no significant association between Crohn's disease and HLA-antigens except Smolen et al. (HLA-B12). 4. The significant association of Crohn's disease and HLA-B12 reported by Smolen et al. could be caused by an increased frequency of HLA-B45 as we found in our patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01733826
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  • 7
    Electronic Resource
    Electronic Resource
    Prevalence of cytoplasmatic islet cell antibodies and insulin autoantibodies is increased in subjects with genetically defined high risk for insulin-dependent diabetes mellitus (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 66-73 
    Details
    ISSN: 1432-1440
    Keywords: Immunology ; Diabetes mellitus ; Prediabetes ; Islet cell antibodies ; Insulin autoantibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The presence of cytoplasmatic islet cell antibodies (ICA) and IgG insulin autoantibodies (IgG-IAA) has been observed in the prediabetic state of type 1 (insulin-dependent) diabetes (IDDM). We therefore analyzed the prevalence of these markers in sera from 1117 healthy HLA-typed first-degree relatives (1° Rel) of IDDM patients. ICA was determined by indirect immunofluorescence on cryostat sections of human pancreas. For IgG-IAA measurement a competitive solid-phase ELISA was used. ICA were present in 3.5% of 1° Rel vs 0.4% of controls (P〈0.025). The highest frequencies of ICA were found in individuals of IDDM multiplex families (7.7%) and HLA-DR1,3 (5.4%), -DR1,4 (5.8%), and -DR3,4 (6.7%) positive subjects. We therefore conclude that the prevalence of ICA is increased in 1° Rel with high genetic risk for diabetes. IgG-IAA occurred in 9.9% of 1° Rel vs 1.4% of controls (P〈0.01). Like ICA, IgG-IAA were significantly increased in a group of subjects being positive for either HLA-DR1,3-DR1,4, or -DR3,4 (16.5%,P〈0.01). In multiplex families, however, prevalence of IgG-IAA was not increased. In contrast to ICA there was an additional influence of age and sex: IgG-IAA were found more often in siblings (mean age, 16.6 years; prevalence, 15.0%) than in parents (mean age, 44.1 years; prevalence, 8.3%) of IDDM patients (P〈0.01). In brothers the prevalence of IgG-IAA is higher than in other 1° Rel. Only a weak association between ICA and IgG-IAA was observed in subjects (n=810) tested for both antibodies. IgG-IAA occurred in 6/35 (17%) ICA positive 1°Rel, while ICA were found in 6/79 (8%) IgG-IAA positive relatives.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01735654
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  • 8
    Electronic Resource
    Electronic Resource
    Autoantikörper gegen Lymphocyten (CoCoCy) bei Patienten mit verschiedenen Formen der Hepatitis und Cirrhose (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 227-233 
    Details
    ISSN: 1432-1440
    Keywords: Lymphocytes ; Autoantibodies ; Hepatitis ; Cirrhosis ; Immunology ; Lymphocyten ; Autoantikörper ; Hepatitis ; Cirrhose ; Immunologie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Seren von insgesamt 282 Patienten mit verschiedenen Formen der Hepatitis und Cirrhose wurden auf das Vorhandensein lymphocytärer Antikörper untersucht. Bei diesen Antikörpern handelt es sich um 19S-IgM-Immunglobuline, die in vitro optimal bei einer Temperatur von 15°C unter Komplementverbrauch reagieren und keine HLA-Spezifität aufweisen. Sie waren in Prozentsätzen zwischen 14% und 48% bei Patienten mit Hepatopathien nachweisbar, wobei die höchste Frequenz bei chronisch-aggressiver Hepatitis (CAH) und die niedrigste bei Patienten mit chronisch-persistierender Hepatitis (CPH) beobachtet wurden. Bei Patienten mit akuter Hepatitis (blander und rezidivierender Verlauf) lag die Häufigkeit des Nachweises der Kältelymphocytotoxine (Cold reactingComplement dependant lympho-Cytotoxins=CoCoCy) zwischen denjenigen der CAH- und CPH-Patienten. Eine Korrelation zum Hepatitis-B-Antigen bestand nicht. Diese Antikörper waren nicht nur bei Leberpatienten, sondern auch in der Kontrollgruppe der HB-Ag-positiven und HBAg-negativen Blutspender in 20% bzw. 6% nachweisbar. Die Serumkonzentration der CoCoCy ist gering. Der Nachweis dieser Antikörper ist weniger von diagnostischem als von pathogenetischem Interesse. Möglicherweise sind die CoCoCy ein „Brutto-Parameter“ für die Immunreaktivität. Sie besitzen wahrscheinlich T-Zell-Spezifität und sind unabhängig von dem spezifischen Antigenstimulus der Immunreaktion.
    Notes: Summary Sera of altogether 282 patients with different forms of hepatitis and cirrhosis were screened forcold reactingcomplement dependent auto-lympho-cytotoxins (CoCoCy). These antibodies are 19S-IgM-immunoglobins and have no HLA-antigen-specificity. CoCoCy occurred in 48% of the patients with chronic aggressive hepatitis (CAH), in 14% of the patients with chronic persistent hepatitis (CPH) and in intermediate rates in the sera of patients with acute hepatitis. No correlation was found between CoCoCy and hepatitis B-antigen (HB-Ag). CoCoCy could be demonstrated also in 20% of the sera of a HB-Agpositive and in 6% of a HB-Ag-negative control group. The serum concentration of CoCoCy is low. CoCoCy seem to be of T-cell-specificity and to reflect the overall-immunoreactivity without relation to the specificity of the antigenic stimulus. Thus demonstration of CoCoCy may be of pathogeneic and pathodynamic rather than of diagnostic interest.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01469130
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  • 9
    Electronic Resource
    Electronic Resource
    Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity (1994)
    Springer
    Diabetologia 37 (1994), S. 471-475 
    Details
    ISSN: 1432-0428
    Keywords: Key words IDDM, chronic pancreatitis, islet cell antibodies, autoimmunity.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The hypothesis was tested that islet autoimmunity is induced by ongoing islet cell destruction in subjects with susceptibility genes HLA-DR 3 and/or DR 4. Sixty-one patients with confirmed chronic pancreatitis were analysed, 30 of whom expressed HLA-DR 3 and/or DR 4. Electron microscopy studies in 10 patients showed that the inflammatory process also affected islets, as recognisable from islet cell lysis, intrainsular fibrosis and immune cell infiltrates. None of the sera tested contained any of three markers of islet autoimmunity, ICA, IAA or GAD antibodies. A correlation was seen between the loss of exocrine function, as determined by the ALTAB-test, and of beta-cell function, as determined by the C-peptide response to i. v. glucagon. However, there was no preferential loss of beta-cell function in patients with HLA-DR 3 and/or DR 4. We conclude that islet cell destruction occurs during chronic pancreatitis, but does not trigger islet autoimmunity, even in the presence of HLA-DR 3 and/or DR 4. [Diabetologia (1994) 37: 471–475]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050134
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  • 10
    Electronic Resource
    Electronic Resource
    Islet cell antibodies and the development of diabetes mellitus in relation to mumps infection and mumps vaccination (1986)
    Springer
    Diabetologia 29 (1986), S. 30-33 
    Details
    ISSN: 1432-0428
    Keywords: Islet cell antibodies ; Type 1 diabetes mellitus ; mumps infection ; virus infections ; autoimmunity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Islet cell antibodies were investigated in 127 non-diabetic children after mumps infection and in four out of seven children who developed diabetes mellitus shortly after active mumps vaccination. Twenty-one of the children who had mumps and all four vaccinated children who were tested had islet cell cytoplasmic antibodies. In contrast, islet cell surface antibodies were detected in 43 out of 68 patients with mumps infection and in 32 out of 44 patients with other viral diseases. All but one mumps-infected child and all the other viral infected patients investigated did not develop diabetes mellitus. The mumps-infected ICA positive children did not show those HLA-frequencies associated with Type 1 diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02427277
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