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  • 1
    Electronic Resource
    Electronic Resource
    Chronic cutaneous sclerodermoid graft-versus-host disease: evaluation by 20-MHz sonography (2003)
    Oxford, UK : Blackwell Science Ltd
    Journal of the European Academy of Dermatology and Venereology 17 (2003), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Chronic graft-versus-host disease (GVHD) is an immunological disorder frequently occurring as a late consequence of allogeneic bone marrow transplantation. Two variants, cutaneous lichenoid and sclerodermoid, have been described, based on clinical and histopathological examinations. It is, however, difficult to determine non-invasively the degree of cutaneous GVHD in vivo. Ultrasonographic methods have recently provided us with the means for objective and non-invasive monitoring of the dynamics of many chronic skin diseases.Aim, patients and methods In five patients with chronic cutaneous sclerodermoid GVHD skin thickness was measured with a 20-MHz B-mode ultrasound scanner (DUB 20S, taberna pro medicum, Lüneburg, Germany) in a clinically well-defined target skin lesion. Additionally cutaneous GVHD was assessed histologically before and after treatment.Results In all patients before treatment the corium of sclerotic skin was thicker than the corresponding areas of healthy skin. The skin thickness was increased from 45% to 83%. In the subcutaneous tissue proper echo-rich reflexes were prominent, representing the correlate of subcutaneous fibrotic trabeculae. In all patients ultrasonographic evidence of regression was shown (decrease of skin thickness by 18–83%). Moreover, it was demonstrated that quantitative assessment of skin thickness is feasible.Conclusions In this paper we describe the detailed sonographic features of cutaneous sclerodermoid GVHD for the first time. As the method is simple and non-invasive, repeated examinations are possible. This provides the basis for monitoring treatment effects and efficient follow-up in these chronically progressive clinical conditions after bone marrow transplantation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-3083.2003.00516.x
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  • 2
    Electronic Resource
    Electronic Resource
    Cytomegalovirus (CMV) infections in patients receiving CMV-IgG-hyperimmunoglobulin prophylaxis after bone-marrow transplantation (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 967-974 
    Details
    ISSN: 1432-1440
    Keywords: Bone-marrow transplantation ; Cytomegalovirus infection ; Interstitial pneumonia ; Hyperimmunoglobulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Conditioning therapy with aggressive chemotherapy and irradiation induces a state of transient combined immunodeficiency in bonemarrow transplant recipients. This promotes the occurrence of severe cytomegalovirus (CMV) infections, the most frequent lethal complication after bone-marrow transplantation (BMT) at present. Forty-four BMT recipients received CMV-IgG-hyperimmunoglobulin for CMV prophylaxis intravenously. The efficacy of this prophylaxis and possible risk factors for the occurrence of CMV-induced interstitial pneumonia (IP) were analyzed. Risk factors for the promotion of a CMV-IP were: additional immunosuppressive therapy after BMT, CMV-positive serostatus of the recipient, CMV-seropositive granulocyte transfusion, CMV infection immediately prior to BMT, and HLA-haploidentical BMT. In this study the incidence of graftversus-host disease was low and was not associated with the incidence of CMV infections. The use of T-cell-depleted grafts did not result in increased CMV infections or IP and may possibly have improved the immunological reconstitution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01717831
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  • 3
    Electronic Resource
    Electronic Resource
    Neurological outcome after a severe herpes simplex encephalitis treated with acyclovir and β-interferon time course of intracranial pressure (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 286-289 
    Details
    ISSN: 1432-1440
    Keywords: Herpes-Simplex encephalitis ; Intracranial pressure monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A severe herpes simplex encephalitis with documented intra-cerebral lesions and brain edema was treated successfully with acyclovir andβ-interferon. The increase in intracranial pressure during the second week was well controlled by ICP monitoring. Life-threatening pressure peaks were avoided through the use of thiopental, osmodiuretics, TRIS, and lidocaine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02116059
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  • 4
    Electronic Resource
    Electronic Resource
    Book review (1988)
    Springer
    Annals of hematology 57 (1988), S. 292-292 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320355
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  • 5
    Electronic Resource
    Electronic Resource
    Low incidence of invasive fungal infections after bone marrow transplantation in patients receiving amphotericin B inhalations during neutropenia (1994)
    Springer
    Annals of hematology 68 (1994), S. 21-26 
    Details
    ISSN: 1432-0584
    Keywords: Fungal infection ; Bone marrow transplantation ; Amphotericin B inhalations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The incidence of invasive fungal infections after bone marrow transplantation (BMT) was analyzed in 303 consecutive marrow graft recipients (allogeneicn=271, autologousn=27, syngeneicn=5). All patients received inhalations with amphotericin B (10 mg twice daily) during neutropenia. The overall incidence of invasive fungal infections within the first 120 days after transplant was 3.6% (11/303; aspergillosis: 6; yeast infection: 5). Four of the 11 cases occurred early, and seven cases were observed after neutrophil recovery and discontinuation of amphotericin B inhalation treatment. Late infection was significantly associated with the development of acute graft-versus-host disease. Four of the 11 infections (early 2/4; late: 2/7) were observed in patients with a history of previous fungal infection. Other patient and treatment characteristics were not helpful in defining potential risk factors. In particular, the incidence of invasive fungal infections did not differ between patients with more or less strict reverse isolation measures. Occasional side effects such as initial mild cough and bad taste were rare, usually disappeared during continued administration, and were in no case the reason for discontinuation of treatment. These data suggest that aerosolized amphotericin B may be a useful, convenient, and efficient prophylactic antifungal regimen in BMT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01695915
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  • 6
    Electronic Resource
    Electronic Resource
    Treatment results of nine patients with burkitt's lymphoma (1986)
    Springer
    Annals of hematology 53 (1986), S. 279-286 
    Details
    ISSN: 1432-0584
    Keywords: Non-Hodgkins Lymphoma ; Burkitt's Lymphoma ; Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary From 6/79 until 2/86, 9 patients (median age 39) with Burkitt's lymphoma were treated. Stage D disease was seen in 7 cases, stage C in two and stage A in one. The main symptom was abdominal pain or a rapidly progressing abdominal tumor. Three patients had bone marrow involvement and two had a Burkitt's leukemia. Three had typical chromosomal aberrations. Therapy consisted of a variety of chemotherapy regimens plus additional radiotherapy and/or bulk surgery. Two patients achieved complete remissions (of 6 and 20+ months duration), and 4 partial remissions were obtained. The remaining patients had either progressive, drug resistant disease or died early. One patient is currently alive and in complete remission at 20+ months. A second patient is alive at 20+ months in partial remission with traces of IgM-paraprotein still detectable. The main causes of death were tumor-lysis syndrom (4 patients) and therapy related sepsis with progressive tumor (3 patients). This poor outcome is probably due to a high proportion of high-risk patients and suboptimal therapy for this rapidly proliferating tumor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320885
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  • 7
    Electronic Resource
    Electronic Resource
    Book reviews (1985)
    Springer
    Annals of hematology 50 (1985), S. 121-127 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00321177
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  • 8
    Electronic Resource
    Electronic Resource
    Outcome of peripheral blood stem cell mobilization in advanced phases of CML is dependent on the type of chemotherapy applied (1998)
    Springer
    Annals of hematology 77 (1998), S. 21-26 
    Details
    ISSN: 1432-0584
    Keywords: Key words CML ; Chemotherapy ; PBSC mobilization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  High-dose chemotherapy with autologous transplantation of in vivo purged PBSC is a novel investigational approach to treating chronic myelogenous leukemia (CML) patients not responsive to conventional therapy with interferon-α (IFN-α) and not eligible for allogeneic transplantation. PBSC mobilization using either '5+2/7+3'-type chemotherapy or 'mini-ICE/ICE' chemotherapy was investigated in 43 patients with advanced phases of Philadelphia (Ph)-positive CML. Thirty patients were in late chronic phase (〉12 months post diagnosis) and 13 patients in accelerated phase (AP) or blast crisis (BC). Contamination with Ph-positive cells was evaluated in harvests from 37/43 patients. The outcome of PBSC mobilization was dependent on the type of chemotherapy administered: a complete or major cytogenetic response (〈35% Ph-positive metaphases) in leukapheresis collections was obtained in ten of 15 patients treated with 'mini-ICE/ICE' but in only three of 28 patients treated with '5+2/7+3' chemotherapy. One patient (1/43) in blast crisis died during mobilization therapy (2%). Twenty-five patients underwent PBSC transplantation and all of them engrafted successfully. Transplantation-related mortality was 0%. The data show that in advanced phases of CML the chance of harvesting Ph-negative peripheral blood stem cells depends on the type of chemotherapy used for mobilization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050406
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  • 9
    Electronic Resource
    Electronic Resource
    Infectious complications after allogeneic bone marrow transplantation with and without T-cell depletion of donor marrow (1989)
    Springer
    Infection 17 (1989), S. 124-130 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 67 erwachsenen Patienten wurden die Infektkomplikationen nach allogener Knochenmarktransplantation (KMT) während verschiedener Zeitintervalle (Tag 0 bis Tag 30, 31 bis 100, 101 bis 365, 366 bis 730) untersucht. Siebenundzwanzig Patienten erhielten ein Transplantat ohne T-Zell-Depletion (TCD) unter Verwendung von Methotrexat oder Cyclosporin A als Prophylaxe einer Graftversus-Host-Reaktion (GvHD) und 40 Patienten ein Transplantat mit TCD durch Einsatz des monoklonalen Lymphozyten-Antikörpers Campath-1 und humanem Komplement. Die TCD verminderte Häufigkeit und Schweregrad der GvHD signifikant (p〈0.01), war aber mit einer erhöhten Transplantatabstoßung verknüpft. Während der verschiedenen Zeitintervalle hatten Patienten mit TCD eine ähnliche, niedrigere oder statistisch signifikant niedrigere Anzahl von bakteriellen, mykotischen oder viralen Infektionen und außerdem eine statistisch signifikant niedrigere Anzahl von tödlichen Infektionen (p=0.05) im Vergleich zu Patienten ohne TCD.
    Notes: Summary The infectious complications during different time intervals after allogeneic bone marrow transplantation (BMT) (day 0 to day 30, 31 to 100, 101 to 365, 366 to 730) were reviewed in 67 adult patients, 27 of whom received transplants without T-cell depletion (TCD) using methotrexate or cyclosporin A for prophylaxis of graft-versus-host disease (GvHD) and 40 of whom received donor marrow with TCD using the monoclonal anti-lymphocyte antibody campath-1 and human complement. The use of TCD reduced the incidence and severity of GvHD significantly (p〈0.01), but was associated with an increased rate of graft rejections. During all time intervals patients with TCD had a similar, lower or statistically significantly lower number of bacterial, fungal or viral infections and a statistically significantly lower number of lethal infections (p=0.05) as compared with patients without TCD. This finding might be explained by the fact that with TCD immunological reconstitution can take place unimpaired by GvHD or its prophylaxis or treatment, resulting in a decreased incidence of infections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01644010
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