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  • 1
    Electronic Resource
    Electronic Resource
    Influence of Aminonucleoside on the Pyridine Nucleotide Concentration of the Rat Kidney (1965)
    [s.l.] : Nature Publishing Group
    Nature 206 (1965), S. 947-948 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Several groups of research workers believe that the structural similarity of AMN and adenosine is indicative of a possible antagonistic action of AMN on adenosine -containing compounds which are essential for metabolism, such as ATP and pyridinenucleotides. Previous investigations have shown that ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/206947a0
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  • 2
    Electronic Resource
    Electronic Resource
    Isolation of Glomerula from Rat Kidney (1960)
    [s.l.] : Nature Publishing Group
    Nature 188 (1960), S. 498-499 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Table 1. DISTRIBUTION OF ALKALINE PHOSPHATASE IN FRACTIONS H, M, T AND G Fraction A protein X s H 8 0-651 0- 0-220 (homogenate ) 7 030 0-662 0-015 M (medulla) T I 0-180 0-293 (tubular material ) G 0-030 (glomerula) This was achieved by pushing out the glomerula of the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/188498a0
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  • 3
    Electronic Resource
    Electronic Resource
    An improved method for the determination of free and esterified carnitine
    Amsterdam : Elsevier
    Clinica Chimica Acta 149 (1985), S. 263-268 
    Details
    ISSN: 0009-8981
    Keywords: Acylcarnitines ; Carnitine ; Normal plasma values ; Radiochemical- enzymatic assay
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(85)90340-7
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  • 4
    Electronic Resource
    Electronic Resource
    Über die Feinstruktur der Pigmentflecken in der menschlichen Iris (1972)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 184 (1972), S. 74-87 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Feinstruktur des Naevus iridis beim Menschen wurde mittels des Raster- und Transmissions-Elektronenmikroskops untersucht. Zur Vorderkammer hin finden sich in der Hauptsache abgerundete Zellen mit feinhöckeriger Oberfläche. Flache Deckzellen und spindelförmige Zelltypen sind selten. Das Cytoplasma der Naevuszellen findet sich dicht mit Pigmentgranula besetzt. Es weist außerdem einen ausgedehnten Golgi-Komplex mit Centrosomen, Mitochondrien, freie Ribosomen und Filamente auf. An der Zellmembran werden Pinocytosevesikel und charakteristische Membranspezialisierungen beobachtet. Die Bindegewebszellen im Naevusgewebe besitzen große Granula-Komplexe. Außerdem kommen normale Irismelanocyten vor. Die Naevuszelle ist ein hoch differenzierter Zelltyp, der strukturell dem Irismelanocyt nahesteht.
    Notes: Summary The fine structure of naevus iridis of the human iris was studied by scanning and transmission electron microscopy. Mainly rounded cells with a raspberrylike surface were found towards the anterior chamber. Flat covering cells and spindlelike cell types occur rarely. The cytoplasm of the naevus cells is densely filled with pigment granules. There is an extensive Golgi complex with centrosomes, mitochondria, free ribosomes and filaments. Pinocytotic vesicles and characteristic membrane specializations were observed at the cell membrane. The connective tissue cells of the naevus possess extensive accumulations of pigment granules. There are also melanocytes of normal appearance. The naevus cell is a further differentiated cell type which structurally resembles the iris melanocyte.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410497
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  • 5
    Electronic Resource
    Electronic Resource
    Erfolgreiche Behandlung der Kappa-Leichtketten-Nephropathie durch Membranplasmaseparation (MPS) (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 931-935 
    Details
    ISSN: 1432-1440
    Keywords: Kappa light chain nephropathy ; Plasma exchange therapy ; Membrane plasma separation ; Calcium-free dialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Often the diagnosis “light chain nephropathy” is not made before renal failure has developed. In the past these patients had a poor prognosis. Special features of this disease and improvement of renal function by plasma exchange therapy are shown in a case report. A 51-year-old man admitted to hospital with renal failure, proteinuria and hypercalcaemia was treated by Ca-free dialysis and membrane plasma separation (MPS). Renal biopsy studied by light and electron microscopy showed mainly tubular protein casts. It is assumed that this nephropathy is caused by a direct toxic effect of the kappa light chains on function and structure of tubuli. Proteinuria was markedly lowered and renal failure was made partly reversible by prompt and effective MPS. Thus, MPS may improve the prognosis of this stage of disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727447
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  • 6
    Electronic Resource
    Electronic Resource
    Book reviews (1981)
    Springer
    Annals of hematology 43 (1981), S. 393-394 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320319
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  • 7
    Electronic Resource
    Electronic Resource
    Cellano-sensibilisierung mit hämolytisch-hämorrhagischem Transfusionszwischenfall (1969)
    Springer
    Annals of hematology 18 (1969), S. 267-275 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A detailed report is given of a transfusion reaction of the hemorrhagichemolytic type due to the rare antibody anti-Cellano. The search for compatible blood for the patient-she had the blood group formula A1 ccD Ee KK-was further complicated by the development of a secondary antibody of the specificity anti-C (C major). This secondary antibody for a short time had the same titre (1: 512) as the anti-Cellano but showed both a different mode of reaction and a different stability. The necessity to use the optimal techniques for the serologic compatibility tests and to work only with fresh drawn blood samples when investigating sensitized patients is stressed. Among the therapeutical and organizational consequences the availability of samples of rare blood groups for the identification of irregular antibodies and of donors of this rare blood type is thought to be of special importance.
    Notes: Zusammenfassung Es wird ausführlich über einen hämolytischen, hämorrhagischen Transfusionszwischenfall berichtet, als dessen Ursache der seltene Antikörper Anti-Cellano diagnostiziert wurde. Die Suche nach kompatiblen Blutkonserven für die Patientin mit der Blutgruppenformel A1 ccD. Ee KK wurde noch kompliziert durch das nachträgliche Auftreten eines sekundären Antikörpers der Spezifität Anti-C (C-major) mit kurzfristig gleicher Titerhöhe (1: 512), aber unterschiedlicher Reaktionsweise und unterschiedlichem Stabilitätsverhalten. In der Reihe der therapeutischen und organisatorischen Konsequenzen wird neben der Forderung nach optimaler Technik der serologischen Verträglichkeitsprobe und für diese nach stets frischen Blutproben bei sensibilisierten Patienten die Notwendigkeit betont, seltene Blutmuster zur Identifizierung irregulärer Antikörper und entsprechende Blutspender dieser seltenen Formel verfügbar zu haben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01632627
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  • 8
    Electronic Resource
    Electronic Resource
    Book review (1982)
    Springer
    Annals of hematology 45 (1982), S. 295-298 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320200
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  • 9
    Electronic Resource
    Electronic Resource
    Isosorbide dinitrate in plasma and dialysate during haemodialysis (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 187-190 
    Details
    ISSN: 1432-1041
    Keywords: isosorbide dinitrate ; haemodialysis ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In 10 patients with end stage renal disease on regular haemodialysis the plasma concentrations and dialyzer clearance of isosorbide dinitrate (ISDN) were determined after an oral dose of a retarded release formulation of 60 mg ISDN. The maximal plasma concentration of ISDN 2–7 h after oral administration was higher (14 ng/ml) than has been reported in healthy volunteers. The haemodialyzer clearance of ISDN was 92.4 ml/min at a blood flow of 200 ml/min and dialysate flow of 500 ml/min. During a 5-h haemodialysis an average of 0.3 mg ISDN was removed from the patient's circulation, representing about 0.5% of the administered dose and about 3% of the available drug in the circulation. No influence of haemodialysis on the plasma level of ISDN was found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614300
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  • 10
    Electronic Resource
    Electronic Resource
    HLA-DR-MT matching improves graft survival rate in cadaver kidney transplantation (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 17-23 
    Details
    ISSN: 1432-1440
    Keywords: MHC ; Cadaver kidney transplantation ; Graft survival rate ; Blood transfusions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of prospective HLA-DR matching on the graft survival rate was investigated in a multicenter analysis of 85 transplants. Simultaneously in a retrospective analysis of graft outcome the importance of matching for MT-antigens MT1, MT2 and MT3 as a newly defined B-cell alloantigen system was evaluated. HLA-DR antigens and MT-specificities were determined on B-cells enriched by nylon-wool filtration using locally well characterised HLA-DR antisera and the antiserum set of the 8th International Histocompatibility Workshop (“discase set”) which allowed the definition of the HLA-DR specificities HLA-DR 1–9 and of the MT-antigens MT 1–3. HLA-DR matching showed a significantly improved graft outcome only in HLA-DR identical donor-recipient combinations. In 11 of 60 patients with one HLA-DR compatibility additional matching for two MT-antigens, however, improved the two year graft survival rate from 60% to 91%. Altogether 17 patients were matched for two MT-specificities with their kidney donor and showed a superior prognosis of 94% at two years compared to 53% or 17% of recipients with one or zero MT compatibility. Graft outcome in this patient group was also superior to that of HLA-DR identical or HLA-AB identical grafts. These data suggested that the MT-system rather than the HLA-DR antigens may be of critical importance in cadaver kidney transplantation. In addition a favorable influence of pretransplant blood transfusions on less HLA-DR matched grafts was confirmed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01484435
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