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  • 1
    ISSN: 1433-0385
    Keywords: Key words: Colorectal liver metastases ; Elderly patient ; Liver resection. ; Schlüsselwörter: Colorectale Lebermetastasierung ; hohes Lebensalter ; Leberresektion.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Zwischen 1987 und 1996 wurden 302 Patienten mit colorectalen Lebermetastasen stationär behandelt. Aus diesem Kollektiv wurden 252 vollständig dokumentierte Fälle ausgewertet. 45 Patienten (18 %) hatten das 70. Lebensjahr vollendet. In dieser Gruppe wurden 17 große, anatomische Leberresektionen und 8 atypische Leberteilresektionen durchgeführt. Bei 9 Patienten wurde eine irresektable Metastasierung bei der Therapie des Primarius diagnostiziert. In 3 Fällen mußte eine Laparotomie als Exploration beendet werden. Acht Patienten wurden konservativ behandelt. Die Letalität nach Leberteilresektion betrug 4 %, die Morbidität 28 %. Die 5-Jahres-Überlebensrate (Kaplan-Meier) der R0-resezierten Patienten (n = 21) beträgt 44 %. Der Vergleich der geriatrischen Patientengruppe mit der Gruppe der jüngeren Patienten zeigt keine signifikanten Unterschiede bezüglich Art und Radikalität der Therapie oder des Stadiums der Erkrankung. Langzeitüberleben, Letalität und Morbidität nach Leberteilresektion zeigen ebenfalls keine signifikanten Unterschiede. Diese Ergebnisse zeigen, daß auch geriatrische Patienten mit colorectaler Lebermetastasierung durch eine Leberteilresektion effektiv und mit kurativer Intention behandelt werden können.
    Notes: Summary. Between 1987 and 1996 302 patients were treated for colorectal liver metastases. Out of this pool 252 completely documented cases were analysed. Forty-five patients (18 %) of this population were 70 years or older at time of admission. In this population 17 major resections and 8 minor liver resections were performed. In 9 patients irresectable metastases were diagnosed during treatment of the primary tumor. In 3 cases laparotomy had to be finished as exploration. Eight patients were treated without surgery. Mortality after liver resection was 4 %, morbidity 28 %. The 5-year-survival-rate (Kaplan-Meier) of the R0 resected patients (n = 21) was 44 %. Comparison between the elderly patients and the younger population shows no significant differences in type and extent of treatment or in stage of disease. Survival, morbidity and mortality after liver resection also show no significant differences. These results show that even in elderly patients liver resection for colorectal metastases can be performed efficently and with a curative intention.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1433-0385
    Keywords: Key words: Laparoscopic surgery ; Partial gastrectomy ; Duodenal ulcer. ; Schlüsselwörter: Laparoskopische Chirurgie ; Magenresektion ; Ulcus duodeni.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Bei einem Patienten mit rezidivierendem Ulcusleiden und Blutungskomplikationen unter medikamentöser Therapie wurde eine laparoskopische 2/3-Resektion des Magens mit intracorporaler Anastomose nach Roux-Y durchgeführt. Die Operation ließ sich ohne größere Schwierigkeiten in 3 Std bei einem Blutverlust von 〈 10 ml fertigstellen. Der 6tägige postoperative Krankenhausaufenthalt verlief unkompliziert, der weitere Verlauf von bisher 2 Monaten ebenfalls. Diese Operation wie auch eine Durchsicht der in der Literatur publizierten Ergebnisse haben uns gezeigt, daß eine Magenresektion in geeigneten Fällen durchaus laparoskopisch durchgeführt werden kann.
    Notes: Summary. In a patient with recurrent ulcer disease under medication, which was complicated by episodes of bleeding, a laparoscopic partial gastric resection with intracorporal Roux-en-Y anastomosis was performed. The operation was completed within 3 h with blood loss 〈 10 ml. The postoperative hospital stay of 6 days was uncomplicated as was the further follow-up (2 months so far). This operation and the study of results published in the literature showed us that a gastric resection can certainly be performed laparoscopically in the appropriate patient.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1433-0385
    Keywords: Keywords: Parathyroid carcinoma – Hyperparathyroidism – Hypercalcemia – Symptomatic transitory psychotic syndrome. ; Schlüsselwörter: Nebenschilddrüsencarcinom – Hyperparathyreoidismus – Hypercalciämie – Durchgangssyndrom.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Bei einem 78 jährigen Patienten bestand nach Laparotomie ein schweres Durchgangssyndrom. Bei anhaltender Somnolenz stellten sich cardiopulmonale Dekompensationszeichen und eine Darmatonie ein. Eine fortbestehende Hypercalciämie führte zur Diagnose eines primären Hyperparathyreoidismus. Nach Resektion eines großen Nebenschilddrüsencarcinoms kam es zu einer kontinuierlichen Besserung der gesamten Symptomatik.
    Notes: Abstract. We present a 78-year-old patient who suffered from symptomatic transitory psychotic syndrome after laparotomy. Persisting somnolence appeared with cardiopulmonary decompensation and gastrointestinal atony. Due to prolonged hypercalcemia primary hyperparathyreoidism was diagnosed. Resection of a large carcinoma of the parathyroids led to continuous clinical improvement.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Archives of orthopaedic and trauma surgery 116 (1997), S. 246-248 
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Secondary chondrosarcoma of the bone of the hand arising from a solitary enchondroma is a rare entity, with only 16 published cases in the literature. We report the clinicopathologic findings of a new case arising from a preexisting solitary enchondroma. A review of the literature is discussed.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Archives of orthopaedic and trauma surgery 116 (1997), S. 246-248 
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Secondary chondrosarcoma of the bone of the hand arising from a solitary enchondroma is a rare entity, with only 16 published cases in the literature. We report the clinicopathologic findings of a new case arising from a preexisting solitary enchondroma. A review of the literature is discussed.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Der Pathologe 15 (1994), S. 49-53 
    ISSN: 1432-1963
    Keywords: Schlüsselwörter: Plexiformer fibrohistiozytischer Tumor – Histiozytäre Tumoren – Fibromatose – Immunhistologie – Ultrastruktur ; Key words: Plexiform fibrohistiocytic tumour – Histiocytic tumours – Fibromatosis – Immunohistology – Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract. An example of a plexiform fibrohistiocytic tumour (PFT) is presented for the first time in the German-language literature. The diagnostic criteria for this rare soft-tissue neoplasm of childhood and young adulthood, which is mostly subcutaneous in location and has a tendency to recur, include the plexiform structure which gives it its name, extensive siderin deposits and numerous osteoclast-like giant cells. The development of the tumour described here, which occurred in the field of radiation of a malignant haemangiopericytoma excised 7 years previously, indicates the possibility of induction of PFT by radiation.
    Notes: Zusammenfassung. Vorgestellt wird der Fall eines bislang in der deutschsprachigen Literatur nicht dokumentierten plexiformen fibrohistiozytischen Tumors (PFT). Diagnostische Kriterien dieser seltenen, vornehmlich subkutan lokalisierten und zu Rezidiven neigenden, insgesamt aber prognostisch günstig zu bewertenden Weichgewebsgeschwulst des Kindes- und jungen Erwachsenenalters sind ihre namensgebende plexiforme Struktur sowie der Nachweis ausgedehnter Siderinablagerungen und zahlreicher Riesenzellen vom Osteoklastentyp. Die Entwicklung der hier beschriebenen Neoplasie im Bestrahlungsfeld eines 7 Jahre zuvor resezierten malignen Hämangioperizytoms weist auf die Möglichkeit einer Strahleninduktion des PFT hin.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 124 (1998), S. 199-206 
    ISSN: 1432-1335
    Keywords: Key words Soft-tissue sarcoma ; Survival ; Prognostic data
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Since 1988, treatment strategies for our sarcoma patients have been determined by the same team and operations performed by one surgeon. The aim of this study was to analyse prognostic data on local recurrence and survival of 101 consecutive patients who presented in our institution with the primary tumour manifestation. After a median follow-up of 35 months, the local recurrence rate was 13.5%, the mean survival time was 68 months and the 5-year survival rate was 83%. Besides positive lymph nodes (only 3 patients) the quality of resection significantly influenced local recurrences (P〈0.05). Univariate predictors of mortality were tumour grade (P〈0.01), tumour size (P〈0.05), distant metastases (P〈0.01), and resection quality (P〈0.01). Multivariate predictors of mortality consisted of grade (P〈0.0001), positive lymph nodes (P〈0.001) and resection quality (P〈0.01). In this homogeneous group of patients, excellent recurrence and survival rates could be achieved. An optimized surgical treatment not only reduces the rate of local recurrences but also augments survival time.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-2218
    Keywords: Key words: Gastric perforation — Peritonitis — Laparoscopic versus open repair — Pneumoperitoneum — Abdominal sepsis — Septic shock
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Laparoscopy is increasingly used in conditions complicated by peritonitis, e.g., peptic ulcer perforation. Of some theoretical concern is the capnoperitoneum, which may aggravate peritonitis and induce septic shock due to increased intraabdominal pressure and distension of the peritoneum. This animal study was devised to analyze the effectiveness of laparoscopic versus traditional open repair of gastric perforation and abdominal lavage for associated peritonitis. Methods: To simulate gastric perforation, female Duroc pigs were subjects to standardized gastrotomy. Either 6 or 12 h after gastric perforation, the animals underwent either traditional open or laparoscopic repair of the gastric defect and peritoneal lavage. The subjects were divided into the following four groups: peritonitis for 6 h and open surgery (group I) or laparoscopic surgery (group II); peritonitis for 12 h and open surgery (group III) or laparoscopic surgery (group IV). After an observation period of 6 days, the surviving animals were killed. The main outcome criteria were survival, perioperative changes of hemodynamics suggestive for septic shock, bacteremia, and endotoxemia. Results: There were no significant differences between group I and II. Mortality was 22% in group III, as compared to 78% in group IV (p= 0.045). In group IV, the incidence of perioperative bacteremia and plasma endotoxin concentrations were significantly higher than in group III. Concomitantly, decreased mean arterial pressure and systemic vascular resistance, and increased cardiac output suggested a higher incidence of septic shock in group IV. Conclusion: Critical appraisal of laparoscopic surgery is warranted in conditions associated with severe, longstanding peritonitis.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-2218
    Keywords: Perforated gastroduodenal ulcer ; Laparoscopic surgical repair ; Pneumoperitoneum ; Peritonitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Laparoscopic surgical repair of perforated gastroduodenal ulcer is technically feasible. To study the effect of a pneumoperitoneum on the extent and severity of peritonitis this animal study was devised. In rats gastric ulceration was induced by instillation of ethanol (50%, 2 ml) and followed by gastrotomy to simulate perforation. Animals were randomly allocated to pneumoperitoneum (PP) and control groups. In PP groups CO2 was insufflated intraperitoneally 6, 9, 12, and 24 h after gastrotomy. In controls the abdomen was only punctured. Animals were sacrificed 5 h after the end of PP or abdominal puncture. Blood cultures and intraabdominal swabs were assessed. A peritonitis severity score (PSS) based on histologies from peritoneum, liver, left kidney, spleen, and first jejunal loop was estimated. Six and 9 h after gastrotomy no significant differences between the PP and control groups were observed; 12 h after gastrotomy cultures of blood samples and abdominal swabs were positive in 67% and 75% in the PP group compared to 42% (P〈0.05), and 42% (P〈0.05) in controls. The mean PSS was 20.8 (standard deviation [SD] 2.2) in the PP group compared to 11.3 (1.5) (P〈0.01) in controls; 24 h after gastrotomy cultures of blood samples and abdominal swabs were positive in 83% and 100% in the PP group compared to 42% (P〈0.05) and 50% (P〈0.01) in controls. The mean PSS was 22.1 (1.5) in the PP group compared to 11.8 (2.4) (P〈0.01) in the controls. In rats a pneumoperitoneum aggravates the extent and severity of peritonitis, when the interval between gastric ulcer perforation and pneumoperitoneum lasts 12 h or longer.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-2218
    Keywords: Key words: Laparoscopic colorectal surgery — Multicenter study — Sigmoid diverticulitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: In the large bowel, resection of the sigmoid colon is the most commonly performed laparoscopic intervention because large bowel lesions often are located in this part of the bowel and the procedure technically is the most favorable one. A number of publications involving case series or the results of highly experienced individual surgeons already have confirmed the feasibility of laparoscopic resection in cases of diverticulitis. The aim of the present prospective multicentric investigation was to check the results obtained by a large number of surgeons performing laparoscopic resection of the sigmoid colon for diverticulitis in various stages of severity. Results: Between January 8, 1995 and January 1, 1998, the Laparoscopic Colorectal Surgery Study Group recruited 1,118 patients to the prospective multicenter study. Diverticulitis of the sigmoid colon, which accounted for 304 cases, was the most common indication for laparoscopic intervention. In most of these patients undergoing laparoscopic surgery (81.9%), the diverticulitis manifested as acute phlegmonous peridiverticulitis, recurrent attacks of inflammation, or stenosis. Complicated forms of diverticulitis in Hinchey stages I to IV and late complications of chronic diverticular disease with fistula formation and bleeding accounted for only 18.1% of the cases. For the overall group, the conversion rate was 7.2%. Patients with less severe diverticulitis (i.e., those presenting with peridiverticulitis, stenosis, or recurrent attacks of inflammation) had a conversion rate of 4.8% and the rate for complicated cases was 18.2%. Regarding laparoscopically completed interventions, 3 of 282 patients died (1.1%). In the group of patients with peridiverticulitis, stenosis, or recurrent attacks of inflammation the overall complication rate was 14.8%. The group with perforated diverticulitis in Hinchey stages I to IV or those with fistula and bleeding, the corresponding rate was 28.9%, and after conversion it was 31.8%. Conclusions: Laparoscopic colorectal interventions in sigmoid diverticulitis are, for the most part, carried out as elective procedures for peridiverticulitis, stenosis, or recurrent attacks of inflammation. The conversion, complication, and mortality rates associated with these interventions are acceptable. Laparoscopic procedures in Hinchey stages I to IV sigmoid diverticulitis and in the presence of fistula and bleeding are more likely to be associated with complications, and should be carried out only by highly experienced laparoscopic surgeons.
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