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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 26 (1954), S. 1914-1916 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 24 (1952), S. 1576-1579 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1831
    Keywords: Key words Chlamydia ; Persistent infection ; Monocytes ; Transcription
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The principal host cell for persistently infecting synovial Chlamydia trachomatis is the macrophage. During infection of human monocytes/macrophages in culture this bacterium displays aberrant morphology and produces no new elementary bodies, reflecting the situation in synovium. Here we investigate the metabolic status of C. trachomatis (serovar K) during an extended infection of human peripheral monocytes in vitro. Using reverse transcription-polymerase chain reaction assays, we have shown that primary transcripts from the chlamydial rRNA operons are present throughout a 10-day course of infection. Other assays targeting mRNAs from chlamydial genes encoding r-proteins S5 and L5, the glycyl-tRNA synthetase, the 60-kDa cysteine-rich outer membrane protein, and the KDO transferase indicate that these messengers are also present throughout the entire 10-day period. The gene encoding the 57-kDa heat-shock protein (hsp60) is expressed by the bacterium throughout the 10-day infection of cultured monocytes, but transcript levels from the gene encoding the major outer membrane protein (omp1) appear to be attenuated. Western analyses targeting these latter proteins confirm the presence of the hsp60 gene product, and the virtual absence of major outer membrane protein, in chlamydia-infected cultured human monocytes. Thus, during extended infection of human monocytes in vitro, chlamydia are non-productive but transcriptionally active; the pattern of transcriptional activity reflects that known for persistent C. trachomatis infection in vivo in synovial tissue.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Nekrolytisches migratorisches Erythem ; Paraneoplasie ; Plattenepithelkarzinom ; Glukagonom ; Key words Necrolytic migratory erythema ; Paraneoplasia ; Squamous cell carcinoma ; Glucagonoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A 59-year-old Caucasian man suffered from persistent disseminated necrolytic skin lesions for 8 months. They failed to respond to a variety of therapeutic regimens but then cleared spontaneously within a few days. After one week an invasive squamous cell carcinoma of the hypopharynx became clinically apparent. At autopsy, the expected glucagonoma often associated with necrolytic migratory erythema was not found.
    Notes: Zusammenfassung Nach achtmonatiger therapierefraktärer Persistenz disseminierter nekrolytischer Hautveränderungen kam es bei einem 59jährigen Patienten zu einer spontanen Abheilung der Läsionen innerhalb weniger Tage. Eine Woche später manifestierte sich klinisch ein invasiv wachsendes Plattenepithelkarzinom des Hypopharynx. Ein im Rahmen der kutanen Paraneoplasie zu erwartendes Glukagonom konnte autoptisch nicht nachgewiesen werden.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Der Hautarzt 48 (1997), S. 492-495 
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Embolia cutis medicamentosa ; Hautnekrose ; Intramuskuläre Injektion ; Key words Embolia cutis medicamentosa ; Skin necrosis ; Intramuscular injection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A 35 year-old male suffered from an extremely painful embolia cutis medicamentosa. The atypical segmental localization first led to the diagnosis of herpes zoster and an antiviral therapy. Regarding the unusual course of the complication following an intramuscular injection in this case, the question for the real pathomechanisms still remains.
    Notes: Zusammenfassung Wir berichten über den Fall eines 35jährigen Bürokaufmannes, der an einer ausgesprochen schmerzhaften Embolia cutis medicamentosa litt. Als Besonderheit ist die untypische segmentale Lokalisation im Versorgungsgebiet L1 zu werten, die zunächst zu der klinischen Diagnose eines nekrotisierenden Zosters und einer konservativen antiviralen Therapie führte sowie der ungewöhnliche Verlauf der subjektiven Beschwerden und das Intervall bis zum Auftreten der charakteristischen Hauterscheinungen, wodurch sich erneut die Frage nach den zugrundeliegenden pathogenetischen Vorgängen stellt.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism 1042 (1990), S. 395-403 
    ISSN: 0005-2760
    Keywords: (Human U937 cell line) ; Arachidonic acid metabolism ; Cell differentiation ; Cyclooxygenase ; Icosanoid ; Phospholipase A"2
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: NCAM plays an essential role in neural development and regeneration. We have recently demonstrated a direct interaction between the fibronectin type III modules (F3) of NCAM and the extracellular part of the FGF receptor and also identified a binding site localized in the second F3 module. The corresponding peptide motif (FGL) activated the FGF receptor, promoted neuritogenesis and protected DA neurons in vitro. In a rat model of A-beta (amyloid-beta peptide) induced neurite toxicity, FGL rescued the deficit in learning and improved neuropathology. Thus, small artificial mimetics of NCAM with agonist-like effects are attractive lead-candidates for drug development for the treatment of neurodegenerative diseases.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Child 31 (2005), S. 0 
    ISSN: 1365-2214
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Background  Bullying has been shown to be a serious problem amongst school children, but few studies have been population-based and included pre-school children.Methods  The study is part of a cross-sectional comparative study in 1984 and 1996, focusing on children's and their families’ health and welfare in the Nordic countries. At each point of time parents of 3000 randomly selected children aged 2–17 years in each of five Nordic countries received a postal questionnaire. Altogether approximately 20 000 questionnaires were completed. The prevalence of bullying, risk factors for bullying and possible effect factors were analysed.Results  Parents reported bullying of their child in 15.1% of the cases. Bullying varied from 7.2% in Sweden to about 20% in Denmark and Finland. There was a small increase in bullying from 13.7% in 1984 to 16.4% in 1996. Bullying was most frequent in boys (OR: 1.4) and in children 2–6 and 7–12 years old (OR: 2.0 and 2.2 compared with older children). Children of single parents and of parents with low education had increased risks (OR: 1.4 and 1.4). Children with chronic conditions had higher risks for being bullied (OR: 2.3). In 1996 children with psychiatric/nervous problems and hyperactivity had high risks for being bullied (OR: 8.8 and 10.5) and for bullying others (3.9 and 3.5). Being bullied was associated with poor thriving and psychosomatic and psychological problems. No countries had national interventions before 1984, but Sweden had early focused on the problem and implemented a strong national policy before 1996. After 1996 national anti-bullying policies were strengthened in the Nordic countries, most in Sweden and Norway.Conclusion  Bullying is common among Nordic children, including pre-school children. Bullying is a threat to children's health, and augments problems in children with chronic conditions. The low prevalence of bullying in Sweden may be a result from sustained, strong anti-bullying policies. There is still a need for continuing interventions.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Child 29 (2003), S. 0 
    ISSN: 1365-2214
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: ESSOP – the European Society for Social Paediatrics – was initiated in Lund, Sweden in 1977, and at the annual congress in Spetses, Greece, its 25th anniversary was celebrated. At the congress, Professor Lennart Köhler, who started the organization and for 10 years was its first Secretary General, presented his recollections from the life of ESSOP, its people, activities, strategies and ideologies, and the main lines of development over the years. This paper presents an edited version of his speech for the benefit of the readers of Child: Care, Health and Development.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd.
    Child 29 (2003), S. 0 
    ISSN: 1365-2214
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Background  In a recent project, commissioned by the European Union, a set of Child Health Indicators were identified and recommended for use in all Member States. In that work, by a group of European experts, children's development was one of the key areas that were reviewed to clarify its role in this set of indicators. This paper deals with neurological (in a broad sense), social and moral aspects of development; other aspects, such as nutrition and physical growth, mental health, quality of life were dealt with in other areas.Methods  A number of methods are used to monitor children's neurodevelopment, to identify early deviations that could be treated or alleviated. Few tests fulfil basic criteria of screening and quality of evidence. For Child Health Programmes, developmental surveillance is instead recommended. As a proxy to social development, as part of children's process of adaptation into society, education indicators are recommended, such as suggested by OECD and UNICEF. Moral development is discarded as an indicator, because norms and values vary too much between countries.Conclusion  For now the Child Health Indicators of Life and Development Project found no ground to recommend any particular method or combination of methods for a general monitoring of children's neurological, intellectual, language and moral development, and for including the results as national indicators of children's health and well-being in EU. For social development, indicators in the educational area seem most promising, as they have been proposed and used by OECD and UNESCO. In an ambitious monitoring programme, these indicators could be included as determinants of children's health and development.
    Type of Medium: Electronic Resource
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