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  • 1
    Electronic Resource
    Electronic Resource
    Bioluminescence and chemiluminescence: new perspectives - Wiley, Chichester, 1987 (ISBN 0-471-91470-3). xv + 600 pp. Price £55.00.
    Amsterdam : Elsevier
    Analytica Chimica Acta 199 (1987), S. 273-274 
    Details
    ISSN: 0003-2670
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0003-2670(00)82832-9
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  • 2
    Electronic Resource
    Electronic Resource
    Ether-lipids and cell immunity. A potential role for antitumor activity
    Amsterdam : Elsevier
    Prostaglandins 34 (1987), S. 161 
    Details
    ISSN: 0090-6980
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0090-6980(87)90204-8
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  • 3
    Electronic Resource
    Electronic Resource
    PAF-related analogues and their interaction with immunocomponent cells
    Amsterdam : Elsevier
    Prostaglandins 34 (1987), S. 160 
    Details
    ISSN: 0090-6980
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0090-6980(87)90203-6
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  • 4
    Electronic Resource
    Electronic Resource
    Interferon (IFN)-γ is a main mediator of keratinocyte (HaCaT) apoptosis and contributes to autocrine IFN-γ and tumour necrosis factor-α production (2005)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 152 (2005), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Apoptosis of keratinocytes or intestinal epithelial cells is an important pathophysiological mechanism of organ damage during acute graft-versus-host disease.Objectives  To analyse in detail the mediators and their mutual interaction leading to keratinocyte apoptosis.Methods  Experiments were performed using a keratinocyte cell line (HaCaT) and human skin explant cultures.Results  Supernatants (SN) of major histocompatibility complex nonmatched mixed lymphocyte cultures (MLCs) induced apoptosis in HaCaT cells and also in keratinocytes from skin biopsies. Although both interferon (IFN)-γ and Fas ligand (FasL) were detected in MLC-SN by enzyme-linked immunosorbent assay, the apoptosis-inducing capacity could be fully abrogated by neutralization of IFN-γ, but not by neutralization of FasL. Recombinant (r) IFN-γ induced HaCaT keratinocyte apoptosis in a dose- and time-dependent manner. Induction of HaCaT apoptosis by rFasL alone was induced only at higher doses than present in MLC-SN, but apoptosis was dramatically enhanced in the presence of rIFN-γ. Further synergistic effects with IFN-γ in the induction of apoptosis were also observed with agonistic antitumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 antibody, soluble TRAIL and TNF-α. However, in contrast to FasL and TRAIL, TNF-α alone did not induce HaCaT apoptosis. Interleukin-1β and lipopolysaccharide did not enhance the apoptosis-inducing effect of IFN-γ. Beside its apoptosis-inducing capacity in HaCaT cells, rIFN-γ also induced autocrine IFN-γ production, and combined treatment with IFN-γ and TNF-α induced autocrine TNF-α production. Neutralization of autocrine IFN-γ protected HaCaT cells from apoptosis.Conclusions  Taken together, our data suggest a central role for IFN-γ in HaCaT keratinocyte apoptosis but also show the importance of co-acting mediators such as TNF-α, TRAIL and FasL, which potentiate the effect of paracrine and autocrine IFN-γ and TNF-α release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2005.06508.x
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  • 5
    Electronic Resource
    Electronic Resource
    Entstehung, Begutachtung und Behandlung der Kahnbeinpseudarthrose der Hand (1965)
    Springer
    Langenbeck's archives of surgery 309 (1965), S. 56-63 
    Details
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01440086
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  • 6
    Electronic Resource
    Electronic Resource
    Häufigkeit und Therapie der Tetanuserkrankung bei Bergbauverletzungen unter Tage (1956)
    Springer
    Langenbeck's archives of surgery 284 (1956), S. 124-125 
    Details
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01483998
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  • 7
    Electronic Resource
    Electronic Resource
    Chemomodulation of drugs involved in multidrug resistance in chronic lymphatic leukemia of the B-cell type (1994)
    Springer
    Cancer chemotherapy and pharmacology 34 (1994), S. 307-316 
    Details
    ISSN: 1432-0843
    Keywords: Chemomodulation ; Multidrug resistance ; Lymphatic leukemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Reduced drug accumulation may be one reason for intrinsic drug resistance in chronic lymphatic leukemia of the B-cell type (B-CLL). Immunophenotyped leukemic human B-cells from 38 cases of B-CLL were characterized for P-glycoprotein (PGP) content. In all, 30 cases of B-CLL were additionally analyzed for further parameters: accumulation of daunorubicin (DNR,n=20) and rhodamine 123 (Rh123,n=30) in both the presence and the absence of verapamil (VRP). Also, 16 cases of B-CLL were analyzed for vincristine (VCR) accumulation with or without VRP. Concerning the relative expression of PGP, these 16 cases of B-CLL were representative for the whole group of 30 cases. Spontaneous accumulation of Rh123 and VCR varied over a wide range: accumulation of Rh123, by a factor of 11.8; accumulation of VCR, by a factor of 9.7; and accumulation of DNR, by a factor of 3.6. VRP modulated the accumulation of RH123 in 16/30 cases (53%), that of VCR in 69% of cases, and that of DNR in 11% of cases. The maximal VRP-mediated increases in accumulation amounted to factors of 1.3 for DNR, 2.3 for Rh123, and 7.8 for VCR. Spontaneous drug accumulation did not correlate with the extent of chemomodulation. The amount of PGP in B-CLL cells (all cases studied were PGP-positive) did not correlate with drug accumulation or with the extent of VRP-mediated chemomodulation. Thus, high expression of PGP is only partially responsible for defective drug accumulation in B-CLL. Only the degree of chemomodulation by VRP is predictive for the extent of the PGP-related functional drug accumulation defect. Thus, in B-CLL, PGP-independent drug accumulation defects seem to be as important as those mediated by PGP. The extent of this drug accumulation defect varies for the different drugs in the following order VCR〉Rh123〉DNR. The relevance of PGP-mediated and-independent drug accumulation defects in vivo may depend to a large extent on the drug being used and on the individual cell type. Both types of defect in drug accumulation are of high importance when regimens include VCR a drug commonly used in second-line chemotherapy of B-CLL. Both defects in drug accumulation may be responsible for intrinsic VCR resistance in B-CLL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686038
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  • 8
    Electronic Resource
    Electronic Resource
    Chemomodulation of drugs involved in multidrug resistance in chronic lymphatic leukemia of the B-cell type (1994)
    Springer
    Cancer chemotherapy and pharmacology 34 (1994), S. 307-316 
    Details
    ISSN: 1432-0843
    Keywords: Key words: Chemomodulation – Multidrug resistance – Lymphatic leukemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Reduced drug accumulation may be one reason for intrinsic drug resistance in chronic lymphatic leukemia of the B-cell type (B-CLL). Immunophenotyped leukemic human B-cells from 38 cases of B-CLL were characterized for P-glycoprotein (PGP) content. In all, 30 cases of B-CLL were additionally analyzed for further parameters: accumulation of daunorubicin (DNR, n = 20) and rhodamine 123 (Rh123, n = 30) in both the presence and the absence of verapamil (VRP). Also, 16 cases of B-CLL were analyzed for vincristine (VCR) accumulation with or without VRP. Concerning the relative expression of PGP, these 16 cases of B-CLL were representative for the whole group of 30 cases. Spontaneous accumulation of Rh123 and VCR varied over a wide range: accumulation of Rh123, by a factor of 11.8; accumulation of VCR, by a factor of 9.7; and accumulation of DNR, by a factor of 3.6. VRP modulated the accumulation of RH123 in 16/30 cases (53%), that of VCR in 69% of cases, and that of DNR in 11% of cases. The maximal VRP-mediated increases in accumulation amounted to factors of 1.3 for DNR, 2.3 for Rh123, and 7.8 for VCR. Spontaneous drug accumulation did not correlate with the extent of chemomodulation. The amount of PGP in B-CLL cells (all cases studied were PGP-positive) did not correlate with drug accumulation or with the extent of VRP-mediated chemomodulation. Thus, high expression of PGP is only partially responsible for defective drug accumulation in B-CLL. Only the degree of chemomodulation by VRP is predictive for the extent of the PGP-related functional drug accumulation defect. Thus, in B-CLL, PGP-independent drug accumulation defects seem to be as important as those mediated by PGP. The extent of this drug accumulation defect varies for the different drugs in the following order VCR〉Rh123〉DNR. The relevance of PGP-mediated and -independent drug accumulation defects in vivo may depend to a large extent on the drug being used and on the individual cell type. Both types of defect in drug accumulation are of high importance when regimens include VCR a drug commonly used in second-line chemotherapy of B-CLL. Both defects in drug accumulation may be responsible for intrinsic VCR resistance in B-CLL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800050147
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  • 9
    Electronic Resource
    Electronic Resource
    Phase I trial of adoptive immunotherapy of cancer patients using monocyte-derived macrophages activated with interferon γ and lipopolysaccharide (1997)
    Springer
    Cancer immunology immunotherapy 45 (1997), S. 250-256 
    Details
    ISSN: 1432-0851
    Keywords: Key words Immunotherapy ; Monocytes/macrophages ; Interferon γ ; Endotoxin ; Lipopolysaccharides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Cells of the monocyte/macrophage lineage have shown antitumor activity in vitro and in murine models after activation with interferon (IFN) γ. In vitro data suggest an additional effect on macrophage antitumor activity when IFNγ is combined with endotoxin (lipopolysaccharides; LPS). In this study we treated nine cancer patients with a total of 62 MAK infusion cycles with autologous macrophages given intravenously (i.v.) after in vitro activation with IFNγ and LPS. Low-grade fever (WHO I/II) was the commonest side-effect. Chills, nausea, and headache were noted when the number of transfused macrophages exceeded 2×108. One WHO IV toxicity occurred, consisting of hypotension after transfer of 3×108 cells, defining this dose as the maximum cell number tolerated. After pretreatment with ibuprofen, however, the maximum cell number could be increased without reaching dose-limiting toxicity. The highest number of cells reinfused was 15×108. Circulating interleukin(IL)-6 increased in a dose-dependent manner as did IL-1 receptor antagonist (IL-1RA) and IL-8. Tumor response consisted of one case of stable disease (12 weeks) in a patient with formerly progressing colorectal cancer and progressive diseases in eight patients. This study indicates that reinfusion of autologous LPS-activated macrophages upon pretreatment with ibuprofen is feasible and tolerated without major side-effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00006671
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  • 10
    Electronic Resource
    Electronic Resource
    Hemmung der Thrombozytenaggregation als therapeutisches Prinzip Übersicht über die Literatur und derzeit zugelassene Thrombozyten- aggregationshemmer (2000)
    Springer
    Der Internist 41 (2000), S. S034 
    Details
    ISSN: 1432-1289
    Keywords: Schlüsselwörter ; Chrombozytenaggregationshemmer ; Zyklooxygenase ; ADP ; GPIIb-IIIa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zum Thema Wir verfügen heute über mehrere wirksame und in großen Multizenter-Studien überprüfte plättcheninhibitorische Substanzen, die aus dem klinischen Alltag nicht mehr wegzudenken sind. Neben der Azetylsalizylsäure, den ADP-Rezeptor-Antagonisten Ticlopidin und Clopidogrel, dem Dipyridamol und dem Trapidil sind die relativ neuen Glykoprotein GPIIb-IIIa-Rezeptor-Antagonisten (Abciximab, Tirofiban und Eptifibatid) für eine Vielzahl von Indikationen im täglichen Gebrauch. Dieser Artikel will eine Übersicht über die wichtigsten Substanzgruppen und deren Vertreter, insgesamt acht derzeit in Deutschland als Thrombozytenaggregationshemmer zugelassene Substanzen, und über entsprechende Literatur besonders zu den großen Studien liefern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001080070005
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