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  • 1
    Electronic Resource
    Electronic Resource
    Vergleichende plethysmographische Untersuchungen arterieller und venöser hämodynamischer Parameter an Unterschenkel und Fuß bei tiefer Beinvenenthrombose (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 233-241 
    Details
    ISSN: 1432-1440
    Keywords: Arterial inflow ; Venous volume ; Maximum venous outflow ; Strain gauge plethysmography Deep venous thrombosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 33 patients with acute deep venous thrombosis of the lower extremity, all verified by phlebography, and in 36 healthy subjects arterial inflow, venous volume and maximum venous outflow were measured by mercury-strain gauge plethysmography. The measurements were performed simultaneously in both legs at the calf and foot level with a cuff pressure of 60 mm Hg for 4 min. In contrast to thrombotic occlusions proximal to the knee and multi-level thromboses, which could be identified by a significantly (p〈0.001) reduced venous volume and maximum venous outflow (measurement at the calf level), isolated calf vein thromboses could not be detected even by sensing from the foot level or only if all three deep veins of the calf were occluded. The best diagnostic criterion for proximal deep venous thrombosis was the correlation of maximum venous outflow and venous volume (83% right positive), if these parameters were determined from the calf. The results indicate that deep calf vein thrombosis can be detected, even if sensed from the foot, only in cases with cross sectional thrombotic occlusions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01496129
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  • 2
    Electronic Resource
    Electronic Resource
    Häufigkeit und Bedeutung von Nierenarterienstenosen bei Patienten mit peripherer arterieller Verschlußkrankheit (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 339-342 
    Details
    ISSN: 1432-1440
    Keywords: Renal artery stenosis ; Hypertension ; Peripheral arterial occlusive disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to evaluate the prevalence of renal artery stenoses and the coincidence with hypertension, in this study 110 patients (24 women, 86 men, mean age 63.2±8.6 years) underwent retrograde aortography for reason of symptomatic arteriosclerosis obliterans of the lower limb arteries. In 18 (16.4%) patients renal artery stenoses by which the lumen was narrowed for more than 30% and in 2 (1.8%) patients occlusions of one renal artery were found, all of which seemed to be of arteriosclerotic origin. 12 (60%) patients with renal artery stenoses or occlusions showed arterial hypertension (RR 171±33/94±16 mmHg) inspite of adequate antihypertensive medication, 8 were normotensive even though renal artery stenoses were found angiographically. On the other hand 30 (33%) of the 90 patients without renal artery stenoses were hypertensive (RR 165±15/93±9 mmHg). These data support the observation that renal artery stenoses must not result in hypertension, but clearly indicate the higher prevalence of hypertension in patients with renal artery stenoses or occlusions. With regard to the low-risk procedure of percutaneous transluminal dilatation of renal arteries, it seems to be valuable for hypertensive patients to include renovasography into the angiographic evaluation of symptomatic lower limb arteriosclerosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01485024
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  • 3
    Electronic Resource
    Electronic Resource
    Körperliche Leistungsfähigkeit und Totalhämoglobin vor und nach operativer Behandlung von Mitralfehlern und Shuntvitien (1966)
    Springer
    Journal of molecular medicine 44 (1966), S. 1289-1294 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A significant increase of the working capacity of patients who had mitral commissurotomy was found about 14 months after the operation. The total amount of hemoglobin showed practically no change. In patients in whom two postoperative controls were done, there was a tendency for the working capacity to increase as more time elapsed after the operation. Patients who were operated for atrial septal defect showed a definite decrease in the amount of total hemoglobin, whereas the working capacity either remained unchanged or increased a little. The hemoglobin concentration of the blood showed postoperatively an increase in cases of mitral stenosis. In atrial septal defect a decrease was found. Additional examples are also given for the effect of other operative procedures on the mitral valve and also of other congenital anomalies with shunts on working capacity, total hemoglobin and hemoglobin concentration.
    Notes: Zusammenfassung Die Mitralkommissurotomie führte durchschnittlich nach 14 Monaten zu einer deutlichen Zunahme der Arbeitskapazität bei praktisch unverändertem Totalhämoglobin. Bei den Patienten mit zwei postoperativen Kontrollen bestand eine Besserung der Arbeitskapazität mit zunehmendem Abstand von der Operation. Nach operativem Verschluß eines Vorhofseptumdefektes fand sich eine eindeutige Abnahme des Totalhämoglobins bei nicht oder nur wenig verbesserter Arbeitskapazität. Die Hämoglobinkonzentration des Blutes zeigte postoperativ bei Mitralstenosen eine Zunahme, während bei Vorhofseptumdefekten eine Abnahme zu verzeichnen war. Zudem werden noch Beispiele über die Wirkung einiger anderer Korrekturen bei Mitral- und Shuntvitien angeführt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716599
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  • 4
    Electronic Resource
    Electronic Resource
    Juvenile arteritis of extracranial arteries with hypereosinophilia (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 526-529 
    Details
    ISSN: 1432-1440
    Keywords: Hypereosinophilia ; Extracranial arteritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The case history of a 23-year-old man presenting with a progressive tender swelling in both temporal regions is described. Eosinophilia varied between 28% and 48% and IgE was markedly increased (1,380 U/l). Arteriography revealed tortuous, enlarged temporal and occipital arteries intersected by stenoses. The pathology diagnosis was chronic necrotizing panarteritis of the temporal artery with pseudoaneurysms, fibrinoid necroses, scar tissue, occasional giant cells, and abundant hypereosinophilia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01713061
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  • 5
    Electronic Resource
    Electronic Resource
    6. Gemeinsame Jahrestagung der Angiologischen Gesellschaften der Bundesrepublik Deutschland, der Schweiz und Österreichs Satellitensymposium über Intravitalmikroskopie Wien 11.–14. Oktober 1987 (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 937-947 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01745508
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  • 6
    Electronic Resource
    Electronic Resource
    Vollblutviscosität bei verschiedenen Schergeschwindigkeiten und ihre Beeinflussung durch niedermolekuläres Dextran (1967)
    Springer
    Journal of molecular medicine 45 (1967), S. 939-943 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The correlation between total blood viscosity at various shear rates and hematocrits ranging from 36 to 52% is described. There is an aproximatively linear relationship between the two parameters, if anemic and polycythemic patients are excluded. The coefficient of correlation for three shear rates (230, 46 and 11.5 sec−1) varies between 0.87 and 0.92. The measurements of viscosity in 60 healthy persons were carried out with a cone plate viscosimeter. Viscosity of whole and defibrinated blood was compared. The differences were in excess of those found between serum and plasma. It was concluded that cell protein interreactions play an important part in whole blood viscosity. Addition of low molecular weight dextran to whole blood in vitro increases viscosity. In vivo, however, hematocrit and whole blood viscosity are lowered consistently, wheras plasma viscosity increases (4 experiments on mongrel dogs). The rheologic consequences of these findings are discussed.
    Notes: Zusammenfassung Kegel-Platte-Viscosimeter erleichtern Viscositätsbestimmungen bei verschiedenen Schergeschwindigkeiten und damit Untersuchungen über die rheologischen Eigenschaften des Blutes. In einem mittleren Bereich zwischen 36% und 52% Hämatokrit besteht eine angenähert lineare Beziehung zwischen Vollblutviscosität und Hämatokrit. Die Korrelationen (r=0,87–0,92) werden für drei verschiedene Schergeschwindigkeiten angegeben (60 gesunde Probanden). Der Einfluß der Plasmaeiweiße auf die Vollblutviscosität wurde durch Bestimmung der Viscositätsdifferenz zwischen Vollblut und defibriniertem Blut untersucht. Da diese Unterschiede die Differenz zwischen Serum- und Plasmaviscosität übersteigen, müssen für Vollblut Interreaktionen zwischen Erythrocyten und Plasmaeiweißen angenommen werden. Wird in vitro Blut mit niedermolekulärem Dextran (Rheomakrodex) gemischt, so kommt es bei Konzentrationen von über 2% zu einer deutlichen Zunahme der Viscosität. Im Gegensatz dazu vermindert die intravenöse Infusion von 500 ml Rheomakrodex beim Hund (vier Experimente) Hämatokrit und Gesamtblutviscosität beträchtlich, während die Plasmaviscosität leicht ansteigt. Die rheologische Bedeutung dieser Befunde wird diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01726936
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  • 7
    Electronic Resource
    Electronic Resource
    Möglichkeiten und Grenzen der qualitativen Venen-Diagnostik mit Doppler-Ultraschall (Ergebnisse einer Blindstudie) (1971)
    Springer
    Journal of molecular medicine 49 (1971), S. 245-251 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In einer Blindstudie wurden die Ergebnisse von 42 anterograden und 35 retrograden Beinphlebographien der Doppler-Ultraschall-Diagnose gegenübergestellt. Für die Beurteilung der Abflußbehinderung in den tiefen Oberschenkel- und Beckenvenen aufgrund von Stenosen oder thrombotischen Verschlüssen ergab sich eine Übereinstimmung von 93%. Im Vergleich mit der Preßphlebographie konnte für die Klappeninsuffizienz eine Übereinstimmung von 94% erreicht werden. Die nicht übereinstimmenden Fälle wurden im einzelnen dargestellt. Es zeigte sich, daß die falsch positiven und falsch negativen Doppler-Entscheidungen sich zum größten Teil daraus ergaben, daß dieses Verfahren nur funktionelle, nicht aber morphologische Aussagen über das untersuchte Gefäß liefern kann. Es wurde deutlich, daß größte Sorgfalt bei der Doppler-Untersuchung erforderlich ist und daß jede Untersuchergruppe die Treffsicherheit ihrer Diagnose durch eine Reihe von Phlebographien überprüfen sollte.
    Notes: Summary The Doppler ultrasound method is applied for the diagnosis of thrombotic occlusions and insufficient valvular function in the deep venous system of the legs. A blind study was carried out in order to demonstrate the validity of this method. — The diagnoses obtained in the course of 42 ascending and 35 pelvic phlebographies with Valsalva manoeuvre were used as reference and compared with those established on the basis of the Doppler ultrasound technique. — The agreement between ultrasonic and venographic findings from the evaluation of chronic thrombosis of the pelvic and deep femoral veins was 93%. The accuracy of the Doppler method in discerning venous valve insufficiency corresponded to 94%. The cases are presented in which the two methods yielded different results. It could be demonstrated that false positive and false negative results of the Doppler ultrasonic method were mostly due to the fact that the latter allows only functional but not morphological conclusions on the vessels investigated. It appeared that the examination with the Doppler technique must be performed carefully and each team should check the validity of the findings obtained with the Doppler method by a series of phlebographies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01485424
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  • 8
    Electronic Resource
    Electronic Resource
    Cryofibrinogenemic purpura (1987)
    Springer
    Archives of dermatological research 279 (1987), S. S24 
    Details
    ISSN: 1432-069X
    Keywords: Cryofibrinogen ; Purpura ; Cryoproteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 50-year-old male patient had three episodes of acrally located purpura within 12 years without any other symptoms. The first two episodes which lasted several months coincided with the intake of beta-blockers; the third episode developed after a respiratory infection. A cryofibrinogenemia was found without any evidence of an underlying primary disease, especially not of a neoplasm. The clinical, histological, immunohistological, and electron microscopical findings, as well as the results obtained by intravital fluorescence videomicroscopy are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00585916
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  • 9
    Electronic Resource
    Electronic Resource
    Microinjection technique for pharmacological evaluation of microvascular permeability in human skin (1996)
    Springer
    European journal of clinical pharmacology 49 (1996), S. 365-369 
    Details
    ISSN: 1432-1041
    Keywords: Key words Fluorescence videomicroscopy ; Histamine ; Cetirizine; sodium fluorescein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract A new technique which combines skin micro injection of minute amounts of drugs (0.5 μl) and measurement of capillary permeability by intravital fluorescence videomicroscopy and densitometry is introduced. Glass micropipettes with a tip diameter of 7–9 μm are inserted by a micromanipulator into the stratum papillare containing the capillary loops and used for microinjection by microsyringe and special dispenser. Transcapillary diffusion of sodium fluorescein applied by intravenous bolus injection is visualised by fluorescence videomicroscopy and stored on videotape. Perivascular fluorescent light intensity (FLI) is measured in arbitrary units (AU) by videodensitometry around the site of microinjection during playback of the videotapes. The method was tested by microinjection of 0.5 μl histamine (1‰ solution) at the distal tibial plateau. Mean FLI values representing microvascular permeability were 2186 AU 10 min after microinjection of histamine, 420 AU after physiologic saline and 1228 AU after histamine combined with oral intake of 20 mg cetirizine. Cetirizine significantly reduced (P 〈 0.01) the increased permeability induced by histamine. However, the mean values after injection of the H1-blocker were still significantly enhanced (P 〈 0.01) when compared to the mean values observed after injection of physiologic saline solution, which provoked only minor microtrauma. The technique offers new scope for pharmacological testing in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050033
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  • 10
    Electronic Resource
    Electronic Resource
    Microinjection technique for pharmacological evaluation of microvascular permeability in human skin (1996)
    Springer
    European journal of clinical pharmacology 49 (1996), S. 365-369 
    Details
    ISSN: 1432-1041
    Keywords: Fluorescence videomicroscopy ; Histamine ; Cetirizine ; sodium fluorescein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract A new technique which combines skin microinjection of minute amounts of drugs (0.5 μl) and measurement of capillary permeability by intravital fluorescence videomicroscopy and densitometry is introduced. Glass micropipettes with a tip diameter of 7–9 μm are inserted by a micromanipulator into the stratum papillare containing the capillary loops and used for microinjection by microsyringe and special dispenser. Transcapillary diffusion of sodium fluorescein applied by intravenous bolus injection is visualised by fluorescence videomicroscopy and stored on videotape. Perivascular fluorescent light intensity (FLI) is measured in arbitrary units (AU) by videodensitometry around the site of microinjection during playback of the videotapes. The method was tested by microinjection of 0.5 μl histamine (1‰ solution) at the distal tibial plateau. Mean FLI values representing microvascular permeability were 2186 AU 10 min after microinjection of histamine, 420 AU after physiologic saline and 1228 AU after histamine combined with oral intake of 20 mg cetirizine. Cetirizine significantly reduced (P〈0.01) the increased permeability induced by histamine. However, the mean values after injection of the H1-blocker were still significantly enhanced (P〈0.01) when compared to the mean values observed after injection of physiologic saline solution, which provoked only minor microtrauma. The technique offers new scope for pharmacological testing in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00203779
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