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  • 1
    Electronic Resource
    Electronic Resource
    Lewis acid-base behavior of dihydrodecacarbonyltriosmium: versatile pathways to mixed-metal clusters (1980)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 102 (1980), S. 6156-6157 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00539a037
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  • 2
    Electronic Resource
    Electronic Resource
    Direct mass spectrometric determination of silicone membrane permeable electrochemical products (1980)
    s.l. : American Chemical Society
    Analytical chemistry 52 (1980), S. 1102-1105 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac50057a024
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  • 3
    Electronic Resource
    Electronic Resource
    Halofantrine : a new substance for treatment of multidrug-resistant malaria (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 69-73 
    Details
    ISSN: 1432-1440
    Keywords: Halofantrine ; Malaria ; Plasmodium falciparum ; Multidrug resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00210972
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  • 4
    Electronic Resource
    Electronic Resource
    Hemodynamic profile of intravenous fenoldopam in patients with hypertensive crisis (1993)
    Springer
    Journal of molecular medicine 72 (1993), S. 60-64 
    Details
    ISSN: 1432-1440
    Keywords: Fenoldopam ; Hypertensive crisis ; Hemodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fenoldopam, a newly developed intravenous dopaminergic DA1 receptor agonist, was used in an open, prospective study for blood pressure control in 12 patients presenting with hypertensive crisis. At a dose of 0.2–0.5 μg kg−1 min−1 fenoldopam decreased systolic blood pressure from 209±13 to 151±17 mmHg and diastolic blood pressure from 114±10 to 78±10 mmHg. Blood pressure was controlled in all 12 patients within 5–50 min. In none of the patients did rebound hypertension occur upon termination of the study medication, nor was any adverse event reported. Major hemodynamic changes induced by fenoldopam were a decrease in total peripheral resistance from 1853±611 to 1193±368 and in pulmonary vascular resistance from 252±170 to 180±74 dyne s−1 cm−5. In patients with high left ventricular filling pressure at study pulmonary capillary wedge pressure decreased while the stroke volume index and mixed venous oxygen saturation increased under fenoldopam. Thus, fenoldopam appears to be a rapid-acting, well-tolerated, and highly effective intravenous substance for the treatment of severe hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00231120
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  • 5
    Electronic Resource
    Electronic Resource
    Patterns of deletions of the dystrophin gene in different European populations (1993)
    Springer
    Human genetics 〈Berlin〉 91 (1993), S. 342-346 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The distribution of deletion breakpoints in the dystrophin gene was studied in a series of subjects belonging to different European populations. The data, obtained from the literature or directly from the present study, refer to population samples from France, Finland, Germany, Italy, Netherland, Switzerland, and U.K. (England, Scotland, Wales). In total, 1516 breakpoints were assigned to different introns, 359 in the region encompassing the first 40 exons and 1157 (76%) in the distal part of the gene. Intron 7 appears to be equally involved as the starting or ending breakpoint, whereas intron 44 is involved mostly as a starting breakpoint. Breakpoint distribution by intron seems to differ in different populations, reaching statistical significance in the case of introns 44, 49, and 53. This finding suggests that some intronic sequences might contain preferential breakpoints that might vary in different populations, possibly as a consequence of genetic drift.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00217354
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  • 6
    Electronic Resource
    Electronic Resource
    No evidence for linkage of autosomal dominant proximal spinal muscular atrophies to chromosome 5q markers (1991)
    Springer
    Human genetics 〈Berlin〉 86 (1991), S. 317-318 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Two recent articles have reported the linkage of a gene for recessive spinal muscular atrophy (SMA) on the chromosome region 5q11.2–13.3. Our data show no linkage of the dominantly inherited forms of SMA to this chromosome region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00202419
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  • 7
    Electronic Resource
    Electronic Resource
    Immunogenicity and reactogenicity of a Haemophilus influenzae type b tetanus conjugate vaccine when administered separately or mixed with concomitant diphtheria-tetanus-toxoid and acellular pertussis vaccine for primary and for booster immunizations (1998)
    Springer
    European journal of pediatrics 157 (1998), S. 208-214 
    Details
    ISSN: 1432-1076
    Keywords: Key wordsHaemophilus influenzae type b ; Acellular pertussis ; Vaccination ; PRP-tetanus ; Diphtheria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract With an increasing number of new vaccines available for routine childhood immunization, combination vaccines are needed in order to maintain or achieve a high compliance with recommended immunization programmes. In a prospective, randomized, comparative, multi-centre study, 822 healthy infants were enrolled to receive three doses of either a candidate or a commercially available Haemophilus influenzae type b (Hib) vaccine concomitantly with diphtheria-, tetanus- acellular pertussis (DTaP) vaccine. Study subjects were randomly allocated to one of the following groups: (1) separate, or (2) mixed injection of DTaP and candidate Hib vaccine, or (3) separate injection of DTaP and commercial Hib vaccine. One year later the first 189 study subjects received either separate or mixed injections of the same Hib and DTaP vaccines as booster doses. Evaluation of reactogenicity was based on diary cards completed by parents. Immunogenicity was documented by measuring IgG antibody concentrations in serum samples taken before and 4 weeks after primary and booster vaccination. No serious adverse events occurred and most local and systemic reactions were mild to moderate. Booster doses were more reactogenic than primary doses with all groups. Antibody concentrations against pertussis antigens were similar to those seen with DTaP alone. All but one subject had protective antibody concentrations against diphtheria and tetanus. Primary immune response to the Hib vaccine was significantly lower in the group receiving the mixed Hib-DTaP vaccine, however, ≥95% of vaccinees had anti-Hib antibody concentrations ≥0.15 μg/ml and there was a marked booster response (〉100-fold) in all groups. Conclusions Mixing DTaP and Hib vaccines for primary immunization caused a decrease in anti-Hib antibody response, although after primary immunization as after booster doses, all subjects showed antibody concentrations considered to be protective for invasive Hib disease. Mixing of the vaccines did not result in increased reactogenicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050797
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  • 8
    Electronic Resource
    Electronic Resource
    Hemodynamic effects of dobutamine in children with cardiovascular failure (1982)
    Springer
    European journal of pediatrics 139 (1982), S. 4-7 
    Details
    ISSN: 1432-1076
    Keywords: Children ; Dobutamine ; Hemodynamics ; Improvement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of dobutamine, a synthetic catecholamine, was studied in 12 patients aged one day to 14 years with low cardiac output syndromes. After initial stabilization of the patients dobutamine was administered by continuous infusion in a dosage of 7.5 or 10 μg/kg/min. Heart rate, cardiac output (using thermodilution technique and/or pulse contour method), mean systemic and mean pulmonary artery pressures were determined before and after the dobutamine infusion. Systemic and pulmonary vascular resistances, cardiac index and stroke volume index were calculated. Cardiac output and cardiac index increased significantly in every patient, whereas the heart rate changed only slightly, suggesting that the increase in cardiac output was mainly due to the alteration of stroke volume. The mean arterial pressure increased significantly, but the mean pulmonary artery pressure was unchanged. No side effects were observed during the dobutamine infusion. Dobutamine is a potent inotropic drug with limited chronotropic and peripheral vascular effects in newborns, infants and chidren.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442069
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  • 9
    Electronic Resource
    Electronic Resource
    Evidence for induction of polysaccharide specific B-cell-memory in the 1st year of life: plain Haemophilus influenzae type b - PRP (Hib) boosters children primed with a tetanus-conjugate Hib-DTPa-HBV combined vaccine (1996)
    Springer
    European journal of pediatrics 156 (1996), S. 18-24 
    Details
    ISSN: 1432-1076
    Keywords: Key words Haemophilus influenzae type b  ;   Combination vaccine  ;  Immunological memory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The lack of an adequate immune response to the major polysaccharide of the Haemophilus influenzae type b (Hib) capsule (polyribosyl ribitol phosphate) (PRP) in very young infants (〈 18 months) can be overcome by conjugating PRP to a T-cell dependent carrier protein. We studied whether administration of a tetanus-PRP conjugate vaccine reconstituted with a diphtheria-tetanus-acellular pertussis-hepatitis B (DTPa-HBV) vaccine as a three dose primary course at 3, 4 and 5 months of age induced PRP-specific immunological memory, by examining the anti-PRP response to a dose of unconjugated PRP given with the DTPa-HBV booster approximately 1 year later. The unconjugated PRP elicited protective anti-PRP antibody levels (≥ 0.15 μg/ml) in all but 3 of the 369 vaccinees, including 13 infants who failed to demonstrate a measurable immune response after the primary course. In a sub-cohort of 54 subjects all had anti-PRP levels ≥ 0.5 μg/ml within 7–14 days of the booster showing a rapid anamnestic type response. Both primary and booster responses were predominantly IgG1 indicating a T-cell dependent response. The DTPa-HBV components elicited protective anti-diphtheria, anti-tetanus and anti-HBs antibody levels in ≥ 98.5% of vaccinees, and immune responses to each of the acellular pertussis vaccine components in 92.3%–97.3% of subjects. Conclusion The tetanus-PRP conjugate vaccine not only elicited a good primary humoral response, but also induced immunological memory so that the infants were able to mount a large and rapid immune response to subsequent exposure to plain PRP, indicating that protection against circulating wild-type Hib had been generated. Successful induction of immunological memory occurred even when there was no measurable humoral anti-PRP response to the primary course. Tetanus-PRP conjugate vaccine can be used in combination with DTPa-HBV vaccine, when administered separately or as a single injection in the same syringe, in primary immunisation schedules at 3, 4 and 5 months of age.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050544
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  • 10
    Electronic Resource
    Electronic Resource
    Effects of Processing on the Bioavailability and Chemistry of Iron Powders in a Liquid Milk-Based Product (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 46 (1981), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Relative Biological Value (RBV) was determined by hemoglobin repletion before and after processing of a canned milk-based product which contained 25% U.S. RDA for iron from either ferric orthophosphate (FOP), electrolytic iron (EI), or carbonyl iron (CI). RBV's for the two elemental iron sources were significantly greater than the RBV for FOP regardless of processing. Processing increased significantly the RBV of EI and CI, whereas, the RBV of FOP remained unchanged. In the processed product containing elemental iron powders, 60% of the iron was in the ferrous state, while 〈0.1% of the iron from FOP was found as Fe++.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1981.tb15384.x
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