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  • 1
    Electronic Resource
    Electronic Resource
    One-Step SSM Process by MSC & HPDC for Metallic Components (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 141-143 (July 2008), p. 103-108 
    Details
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Notes: The preliminary experimental results on microstructure evolution and simulation of analternative semisolid route to manufacture near-net shape components are reported. The rheocastingfor semi-solid alloys was first performed by conventional mechanical stircasting (MSC), followedby direct shaping of the SSM slurry into a high-pressure die-casting machine (HPDC), thusavoiding the storage and reheated to the semisolid state of the ingots prior the shaping process.To assure high quality for the semisolid slurry, the microstructural evolution was characterized bydigital image analyses. The HPDC process of a simple part, simulated using CFD tools (Flow-3D®-Flow Science Inc.) is also reported. By means of such simulation the integrity of shapingcomponents was studied
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/24/transtech_doi~10.4028%252Fwww.scientific.net%252FSSP.141-143.103.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    Groundwater salinization in Pico Island (Azores, Portugal): origin and mechanisms (2000)
    Springer
    Environmental geology 39 (2000), S. 1181-1189 
    Details
    ISSN: 1432-0495
    Keywords: Key words Coastal aquifers ; Groundwater¶quality ; Hydrochemistry ; Salinization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  A hydrogeochemical survey was conducted on Pico Island (Azores archipelago) in order to evaluate the groundwater chemistry patterns and the main mineralization processes. Samples were from cold waters and corresponded mainly to sodium chloride type. Conductivity measurements were ∼82–9790 μS/cm and suggest the existence of highly mineralized waters. In fact, 18% had a conductivity 〉5130 μS/cm and the total dissolved solid (TDS) value for two of the wells was from the brackish water range. The changes in groundwater composition are because of two main processes: (1) silicate mineral dissolution, especially in a few springs located at high altitude and (2) water salinization in the coastal area, as a result of saltwater intrusion and sea-salt spraying. The salinization process corresponds to a binary mixing system, as suggested by the chloride and δ18O data, and explains the sharp concentration increase in major and minor species detected in several wells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002540000109
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  • 3
    Electronic Resource
    Electronic Resource
    Validation of a quality of life questionnaire for critically ill patients (1996)
    Springer
    Intensive care medicine 22 (1996), S. 1034-1042 
    Details
    ISSN: 1432-1238
    Keywords: Key words Health status ; Intensive care ; Quality of life
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: Development and validation of quality of life questionnaire for critical care patients. Design: Prospective study. Setting: Intensive care unit (ICU) of a general hospital and ICUs of 83 Spanish hospitals. Sample: Patients admitted to the ICU 〉18 years of age; close family members. Method: A committee of experts designed a questionnaire with characteristics judged essential for intensive care use: easy, quick administration (5–10 min); capable of completion by patient or close family member, by direct or telephone interview. Fifteen items relevant to critical care patients were grouped in three subscales: basic physiological activities, normal daily activities, and emotional state. Reproducibility of interobserver, intraobserver, patient/family member and telephone/direct interviews was analysed and also internal consistency, responsiveness, and main components. Results: Internal consistency (578 patients): Cronbach‘s alpha coefficient=0.85. Reproducibility: intraobserver reproducibility (n=150): Spearman correlation coefficient=0.92. Interobserver (n=85): correlation=0.92. Patient/family member (n=81): correlation=0.92. Telephone/direct interview (n=54): correlation=0.96. Validity: factorial analysis confirmed that the three subscales were fundamental questionnaire components. There was good concordance between questionnaire/subscale and Glasgow Outcome Scale (GOS) results. Responsiveness: quality of life score changes between preadmission and 6 months‘ postdischarge correlated with GOS findings (weighted kappa index=0.56). Conclusions: Questionnaire meets objectives recommended for critical care use, and fulfills essential requirements of validity and reproducibility when applied to critically ill patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01699224
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  • 4
    Electronic Resource
    Electronic Resource
    Validation of a quality of life questionnaire for critically ill patients (1996)
    Springer
    Intensive care medicine 22 (1996), S. 1034-1042 
    Details
    ISSN: 1432-1238
    Keywords: Health status ; Intensive care ; Quality of life
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective Development and validation of quality of life questionnaire for critical care patients. Design Prospective study. Setting Intensive care unit (ICU) of a general hospital and ICUs of 83 Spanish hospitals. Sample Patients admitted to the ICU〉18 years of age; close family members. Method A committee of experts designed a questionnaire with characteristics judged essential for intensive care use: easy, quick administration (5–10 min); capable of completion by patient or close family member, by direct or telephone interview. Fifteen items relevant to critical care patients were grouped in three subscales: basic physiological activities, normal daily activities, and emotional state. Reproducibility of interobserver, intraobserver, patient/family member and telephone/direct interviews was analysed and also internal consistency, responsiveness, and main components. Results Internal consistency (578 patients): Cronbach's alpha coefficient=0.85. Reproducibility: intraobserver reproducibility (n=150): Spearman correlation coefficient=0.92. Interobserver (n=85); correlation=0.92. Patient/family member (n=81): correlation=0.92. Telephone/direct interview (n=54): correlation=0.96. Validity: factorial analysis confirmed that the three subscales were fundamental questionnaire components. There was good concordance between questionnaire/subscale and Glasgow Outcome Scale (GOS) results. Responsiveness: quality of life score changes between preadmission and 6 months' postdischarge correlated with GOS findings (weighted kappa index=0.56). Conclusions Questionnaire meets objectives recommended for critical care use, and fulfills essential requirements of validity and reproducibility when applied to critically ill patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01699224
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  • 5
    Electronic Resource
    Electronic Resource
    The lung in systemic lupus erythematosus: a survey of 104 patients with special reference to lupus induced pulmonary haemorrhage and its pathogenesis (1992)
    Springer
    European radiology 2 (1992), S. 429-432 
    Details
    ISSN: 1432-1084
    Keywords: Systemic lupus erythematosus ; Pulmonary complications ; Massive lupus induced pulmonary haemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this review is to establish the incidence and the clinical and radiological characteristics of the massive lupus-induced pulmonary haemorrhage in patients with systemic lupus erythematosus (SLE). In 104 cases of SLE, 4 patients were diagnosed with pulmonary haemorrhage and they all fulfilled the following criteria: (1) rapidly progressing bilateral airspace consolidation; (2) a sudden decrease in the haemotocrit with a cough that produced bloody sputum and/or histiocytes with haemosiderin-laden macrophages in sputum or in the material from the bronchoalveorar washing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00176348
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of triflusal and its main metabolite HTB on platelet interaction with subendothelium in healthy volunteers (1995)
    Springer
    European journal of clinical pharmacology 47 (1995), S. 497-502 
    Details
    ISSN: 1432-1041
    Keywords: Triflusal ; Acetylsalicylic acid ; platelet activation ; platelet-vessel wall interaction ; subendothelium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract The ex vivo effect of triflusal and acetylsalicylic acid (ASA) on platelet interaction with the subendothelium using the Baumgartner perfusion system (wall shear rate 350 s−1) was assessed in blood from 10 healthy volunteers who given a 15-day course of triflusal 600 mg per day and ASA 400 mg per day in a crossover trial. The percentage of platelets on the subendothelium showed a decrease of 62% in samples from subjects on ASA and a decrease of 93% in those from subjects on triflusal (P〈0.005). The percentage of the subendothelial surface covered by platelets was reduced by 23.3% after treatment with ASA, mainly due to inhibition of aggregates (75.2%), and by 29.9% after treatment with triflusal, mainly due to inhibition of aggregates (89.6%) and of adhesion (25%). The subendothelial surface covered by activated platelets (adhesions and thrombi) showed 32.5% inhibition after treatment with triflusal and 11.6% after treatment with ASA (P〈0.043 vs. triflusal). In the in vitro experiments, 10 μmol·l−1 triflusal did not modify the percentage of the subendothelium covered by platelets. HTB 1 mmol·l−1 inhibited adhesion (26%) and aggregates (18%). We conclude that HTB participates in the ex vivo effects of triflusal on the platelet-subendothelium interaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00193701
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of dipyridamole with or without aspirin on urine protein excretion in patients with membranous glomerulonephritis (1992)
    Springer
    European journal of clinical pharmacology 43 (1992), S. 307-309 
    Details
    ISSN: 1432-1041
    Keywords: Dipyridamole, Acetylsalicylic acid, Urinary protein excretion ; antiplatelet agents, platelet aggregation, thromboxane synthesis, glomerulonephritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The antiproteinuric effect of the antiplatelet agent dipyridamole has been assessed after inhibiton of thromboxane B2 (TxB2) synthesis in 8 patients with confirmed membranous glomerulonephritis. There were three study periods, each of 30 days, and 45 days apart, namely a washout period, treatment with dipyridamole 300 mg/d, and dipyridamole 225 mg/d plus aspirin 150 mg/d. On Days 1 and 30 of each study period serum and urine creatinine, 24-h excretion of protein, creatinine clearance, platelet aggregometry on whole blood and serum TxB2 were measured. Treatment with dipyridamole alone or with aspirin produced significant inhibition of platelet aggregation and a fall in 24-h protein excretion; the latter amounted to 54% with dipyridamole alone and 56 % with dipyridamole plus aspirin (NS). Dipyridamole plus aspirin caused an 82 % reduction in serum TxB2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02333029
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  • 8
    Electronic Resource
    Electronic Resource
    Risk Factors Predicting Recurrence in Patients Operated on for Intracranial Meningioma. A Multivariate Analysis (1999)
    Springer
    Acta neurochirurgica 141 (1999), S. 921-932 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Meningioma; recurrence; radiotherapy; computed tomography.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  The authors undertook a follow-up study of 286 patients who underwent surgical treatment for intracranial meningioma between 1973 and 1994, in order to analyse clinical, radiological, topographic, histopathological and therapeutic factors significantly influencing tumour recurrence.  All patients were followed by using either computed tomography (CT) or magnetic resonance from 3 months to 17 years since first surgery (mean follow-up: 4.1 years). Forty-four (15.4%) recurrences were detected during this time period. Overall recurrence rates were 14%, 37% and 61% at 5, 10 and 15 years, respectively.  Factors significantly associated with tumour relapse in bivariate analysis were: tumour location at petroclival and parasagittal (middle third) regions, incomplete surgical resection (assessed by Simpson's classification), atypical and malignant histological types (WHO classification), presence of nucleolar prominence, presence of more than 2 mitosis per 10 high-power fields, and heterogeneous tumour contrast enhancement on the CT scan.  The multivariate analysis using the Cox's proportional hazards model identified the following risk factors for recurrence: incomplete surgical resection (Relative risk: 2.2; 95% Confidence interval: 1.33–3.64), non conventional histological type (RR: 2.13; 95%CI: 1–4.53), heterogeneous contrast enhancement on the CT scan (RR: 2.25; 95%CI: 1.1–4.72) and presence of more than 2 mitosis per 10 high-power fields (RR: 2.28; 95%CI: 0.99–5.27). Patients without any of these features showed low recurrence rates (4% and 18% at 5 and 10 years), and thus, they need less clinical and radiological controls through the follow-up than patients with some of these risk factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050398
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  • 9
    Electronic Resource
    Electronic Resource
    Age and Outcome After Severe Head Injury (2000)
    Springer
    Acta neurochirurgica 142 (2000), S. 373-381 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Age; prognosis; severe head injury; logistic regression.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary ¶ The authors analyzed the relationship between patient age and the final outcome in a series of 810 patients aged 14 years or older who were consecutively admitted between 1987 and 1996 after suffering a severe closed head injury.  The most relevant clinico-radiological variables were prospectively collected in a Data Bank. Stratified and logistic regression analyses were performed in order to assess the influence of age on adverse outcome and the interaction between patient age and other prognostic indicators.  Our results reaffirm that the adverse outcome rate increases steadily with age in severe head injured patients and that age effect on outcome is independent of other prognostic variables. The odds of having an adverse outcome increases significantly over 35 years of age being 10 times higher in patients older than 65 years as compared to those aged 15–25 years (reference age group). The adverse influence of an advanced age on the final outcome has not yet been satisfactorily explained but an older brain may have an impaired ability to recover after a pathological insult as compared to a younger one.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050445
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  • 10
    Electronic Resource
    Electronic Resource
    Renal tubular sodium and water metabolism in brain tumour patients submitted to craniotomy (1993)
    Springer
    Acta neurochirurgica 125 (1993), S. 86-91 
    Details
    ISSN: 0942-0940
    Keywords: ADH ; brain tumour ; craniotomy ; hyponatraemia ; salt-wasting ; SIADH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Purpose To evaluate the effect of Brain Tomour (BT) and Neurosurgery (NS) on the renal handling of H2O and Na, and the clinical importance of SIADH in this setting. Methods Fourteen patients with BT pre-op for NS and 6 controls (C) pre-op for general surgery, were assessed in a controlled prospective trial. All patients were normovolaemic, with normal renal function. They received 400 mg of lithium carbonate (Li) 8 hours before each of two test periods (I and II) and a standard water load only before period II. Clearances studies were performed pre-op (period I) and 24 hours post-op (period II). Results Serum Na was normal at all times. Despite normovolaemia, a 1% decrement in serum osmolality and the water load, ADH dramaticaly increased from time I to II mainly in the BT group (36.2±9.4 vs 7.1±0.6 pmol/L, p=0.02). FENa, FELi and FEUricA were significantly more elevated in the BT group pre and post-op (at time II respectively 4.6±1.6 vs 1.1±0.3%; 29.3±4.9 vs 22.6±5.5; 26.0±8.1 vs 11.3±2.2, p=0.03). Proximal and distal H2O re-absorption and distal fractional Na re-absorption were identical in both groups pre and post-operatively. Conclusions 1-BT and NS always induce a SIADH. 2-There was a primary Na loss at the proximal tubule level not explained by ADH increment, that did not significantly changed H2O handling. 3-To prevent hyponatraemia, hypotonic I.V. fluids should be avoided, but more importantly saline must be provided to this potentially salt-wasting condition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401833
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