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  • 1
    Electronic Resource
    Electronic Resource
    Renal effects of a new anabolic steroid (29'038-Ba) in old age (1968)
    Springer
    European journal of clinical pharmacology 1 (1968), S. 43-46 
    Details
    ISSN: 1432-1041
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Description / Table of Contents: Zusammenfassung Die Einwirkung von 29'038-Ba, einem neuen langwirkenden injizierbaren anabolen Steroid auf die Nieren, wurde bei einer Gruppe von fünfzehn älteren Patienten mit normaler and beeinträchtigter Nierenfunktion untersucht. Die Nieren-Clearance von Inulin und endogenem Kreatinin, die geschätzte Nierendurchblutung und die TmPAH erhöhten sick um 16,8 bzw. 17,2 bzw. 17,9 bzw. 35,3% nach Verabreichung von insgesamt 400 mg dieses Präparates. Hingegen wurden nur unbedeuteade Veränderungen der CPAH and der maximalen Konzentrationskapazität festgestellt. Irgendwelche Störungen der Leberfunktion konnten bei keinem Patienten beobachtet werden. Auch wurden keine allgemeinen Nebenwirkungen beobachtet, bis auf eine zeitweilig gesteigerte Libido bei drei Patientinnen gegen Mitte der Behandlungszeit.
    Notes: Summary The renal effects of 29'038-Ba, a new long-acting injectable anabolic steroid, have been studied in a group of fifteen elderly subjects with normal or impaired renal function. Renal clearances of inulin and endogenous creatinine, the estimated renal blood flow, and the TmPAH were increased by 16.8, 17.2, 17.9 and 35.3 percent respectively after administration of a total of 400 mg of this compound, in contrast to non-significant changes of CPAH and maximal concentrating capacity. No disturbances of liver function were observed in any of the subjects studied. No general side-effects were noticed except for transiently increased libido, reported by three female subjects in the middle of the treatment-period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418703
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  • 2
    Electronic Resource
    Electronic Resource
    Inter-cohort differences in coronary heart disease mortality in the 25-year follow-up of the seven countries study (1993)
    Springer
    European journal of epidemiology 9 (1993), S. 527-536 
    Details
    ISSN: 1573-7284
    Keywords: Coronary heart disease ; Risk factors ; Population comparison
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sixteen cohorts of men aged 40–59 years at entry were examined with the measurement of some risk factors and then followed-up for mortality and causes of death for 25 years. These cohorts were located in the USA (1 cohort), Finland (2), the Netherlands (1), Italy (3), the former Yugoslavia (5), Greece (2), and Japan (2), and included a total of 12,763 subjects. Large differences in age-adjusted coronary heart disease (CHD) death rates were found, with extremes of 45 per 1000 in 25 years in Tanushimaru, Japan, to 288 per 1000 in 25 years in East Finland. In general, higher rates were found in the US and Northern European cohorts as compared to the Southern European and Japanese cohorts. However, during the last 10 years of follow-up large increases of CHD death rates were found in some Yugoslavian areas. Out of 5 measured entry characteristics treated as age-adjusted levels (serum cholesterol, systolic blood pressure, cigarette smoking, body mass index and physical activity at work), only serum cholesterol was significant in explaining cohort differences in CHD death rates. Over 50% of the variance in CHD death rates in 25 years was accounted for by the difference in mean serum cholesterol. This association tended to decline with increasing length of follow-up, but this was due to the great changes in mean serum cholesterol in the two Jugoslavian cohorts of Velika Krsna and Zrenjanin. When these two cohorts were excluded the association increased with time. Changes in mean serum cholesterol between year 0 and 10 helped in explaining differences in CHD death rates from year 10 onward. It can be concluded that this study suggests that mean serum cholesterol is the major risk factor in explaining cross-cultural differences in CHD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00209531
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  • 3
    Electronic Resource
    Electronic Resource
    The role of volume expansion, of prostaglandins and catecholamines in the development of acute renal failure (1982)
    Springer
    Cellular and molecular life sciences 38 (1982), S. 476-478 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A single injection either of isotonic or hypertonic saline solutions protected rats against acute renal failure (ARF) induced with glycerol. This protection was accompanied by increased urinary prostaglandin E (PGE) concentration. On the contrary, a single s.c. injection either of hypotonic saline or isotonic glucose solution, which did not increase urinary PGE concentration, or depletion of the endogenous catecholamines, using reserpine, did not protect the animals against acute renal failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01952647
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  • 4
    Electronic Resource
    Electronic Resource
    Carotid pressure plethysmograms (1961)
    Springer
    Basic research in cardiology 36 (1961), S. 49-58 
    Details
    ISSN: 1435-1803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02119853
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  • 5
    Electronic Resource
    Electronic Resource
    Dilemmas of prolonging life of elderly patients in terminal system failure (1991)
    Springer
    Geriatric nephrology and urology 1 (1991), S. 139-142 
    Details
    ISSN: 1573-7306
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00577149
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  • 6
    Electronic Resource
    Electronic Resource
    Controlled ten-day antimicrobial therapy in asymptomatic bacteriuria of old age: relations with localization, mobility and mortality (1994)
    Springer
    Geriatric nephrology and urology 4 (1994), S. 137-143 
    Details
    ISSN: 1573-7306
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effectiveness of a 10-day i.m. antimicrobial therapy in eradicating bacteriuria for six months, preventing decline of physical status and reducing mortality for five years was tested in 73 ambulant, self-caring bacteriuric residents of a retirement home (16 men) compared to 264 non-bacteriuric subjects (79 men), and in 29 bacteriuric controls under no treatment (4 men), all groups having a mean age of 82.5 years. Structural abnormalities by ultrasonography were detected in 29% of 69 treated bacteriuric subjects and 18.4% of 76 non-bacteriuric controls (N.S.). Seventy-five percent of bacteriuric men and 56% of women had positive antibody coated bacteria (ABC+) in the urine. One of three agents was used: netilmicine 150 mg/d (26 subjects), ceforanide 1.0 g/d (23 subjects), and cotrimoxazole 160/800 mg/d (24 subjects). At one week post therapy 61.6% of treated subjects had negative urines vs. 27.6% of untreated controls (p〈0.005); at one and six months negative urines were present in 52.2% and 44.8% of subjects treated vs. 39.3% and 40% of controls (N.S.). Netilmicine and ceforanide were more effective at one week and one month, cotrimoxazole at six months. Elimination of bacteria ACB(+) or (−) was equal but relapses were more numerous in ACB(+) strains. At 18 months “good” mobility was more frequent among subjects originally non-bacteriuric than among the treated bacteriuric subjects (61.1% vs. 38.6%, p〈0.01). There were no deaths among the treated bacteriuric subjects for six months, but thereafter mortality rose fast so that at 18 months their cumulative mortality was significantly higher than in the non-bacteriuric subjects (p〈0.0001). Subsequently, however, mortality accelerated in both groups, so that at 5 years cumulative mortality was equally high among originally bacteriuric and non-bacteriuric subjects. The study shows that: (a) the treatment used was moderately effective in eradicating bacteriuria, urines remaining sterile in almost half of the subjects for up to six months; (b) successful therapy did not alter the evolution of physical disability; (c) therapy delayed the onset of mortality for six months but did not reduce subsequently the high death rate of bacteriuric subjects during 18 months; (d) over the 5-year follow-up the high mortality of subjects with mean age 87.5 years conceals earlier occurring mortality differences between groups which should be assessed in younger subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01523973
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