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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 23 (1994), S. 0 
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Changes in the oral microbial flora, some of which are related to mucosal disease, have been delected in the elderly, but the causes are not fully understood. This study has examined the possible role of micronutrient depletions in the reduced colonisation resistance and oral infection exhibited by some elderly subjects. The oral health, oral microbiology and micronutrient status of 37 geriatric patients aged 65–91 years (mean 81 years) were examined. Ten of the patients had no oral mucosal disease. Mucosal pathology in the remainder included erythema (27%). denture stomatitis (24%). angular cheilitis (16%) and atrophic glossitis (41%). Those with mucosal pathology had significantly lower serum iron concentrations (P= 0.02). Serum or plasma concentrations of zinc, copper, selenium, C-reactive protein, transferring, caeruloplasmin, albumin, vitamin A and vitamin E were not significantly different between those with oral disease and those with healthy mouths. Similarly, activity of the selenium-containing enzyme, red cell glutathione peroxidase, did not differ significantly between the two groups. In both groups, plasma selenium concentrations (82%), red cell glutathione peroxidase activity (47%), plasma zinc concentrations (58%) and albumin concentrations (44%) tended to be below the lower limit of the reference interval. The influence of sub-clinical infection on these values is discussed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Urological research 11 (1983), S. 285-290 
    ISSN: 1434-0879
    Keywords: Trace metals ; Cadmium ; Kidney cortex ; Ischaemic heart disease ; Medulla
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The trace element content of kidneys has been documented in very few international centres. Significant differences can be demonstrated between the cortical and medullary levels of calcium, zinc and cadmium. For the West of Scotland the values for the latter are similar to those found in Scandinavia. There are significantly higher cadmium contents in subjects who smoke and who have evidence of ischaemic heart disease.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Urological research 12 (1984), S. 213-215 
    ISSN: 1434-0879
    Keywords: Methyl-prednisolone ; Male sub-fertility ; Trace metals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of 96 mg methylprednisolone on trace metals and hormone levels was measured in 13 males with sub-fertility associated with an antibody problem. Over a period of 5 days the serum zinc was significantly reduced (p〈0.05) as was the serum testosterone (p〈0.01). By contrast the luteinising hormone levels rose (p〈0.01) within 3 days of administration of the steroid. The lability of serum zinc to the administration of steroids is further demonstrated by its significant fall (p〈0.01) after 3 days of therapy. These results suggest an adreno-cortical control of zinc in serum.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Urological research 7 (1979), S. 285-289 
    ISSN: 1434-0879
    Keywords: Cadmium ; Iron ; Bendrofluazide ; Hypercalciuria Hyperzincuria ; Treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cadmium induces a variety of effects on kidney tubules including hypercalciuria. This is accompanied by hyperzincuria. The present work shows that both of these biochemical abnormalities can be corrected but where a state of cadmium-induced-anaemia exists urine zinc and calcium excretion do not follow the expected parallel course in response to iron therapy as they do with bendrofluazide.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Environmental geochemistry and health 10 (1988), S. 3-9 
    ISSN: 1573-2983
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Medicine
    Notes: Abstract The variability of household dust lead concentration and loadings over the period of about a year has been examined in 10 homes. The overall uncertainty on a single sample is ± 65% for lead concentration and ± 81% for lead loading. Redecoration involving electric sanding and/or blow lamp preparation of painted surfaces is the major cause of variation in lead levels. The effect is short lived, levels returning to normal within 2 months of redecoration ending. There is evidence of a seasonal trend for dust loading and lead loading but not for lead concentration. The implications of these findings for blood lead — dust lead exposure studies are considered.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of inherited metabolic disease 15 (1992), S. 161-170 
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Investigation using DNA markers in a family with Wilson disease revealed that an apparently normal child of 10 years of age with non-diagnostic copper biochemistry had the disease. The procedure used linked restriction fragment length polymorphic markers. Demonstration of increased liver copper concentration from a liver biopsy confirmed the diagnosis and the child was started on chelation therapy. Two other asymptomatic siblings were shown, using the same techniques, not to have the disease. Similar analysis was carried out on another family with just one index case.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of inherited metabolic disease 6 (1983), S. 5-8 
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Trace element levels in tissues show changes in various diseases including inborn errors of metabolism. Such changes may be primary or secondary due to stress or diseases of the liver and gastrointestinal tract. Measurement of trace elements in these cases may be essential both for diagnostic and therapeutic purposes. Trace element measurements can also be useful in other areas of clinical interest including nutrition, toxicity and therapy with inorganic pharmaceutical agents. The available techniques for measuring trace elements in tissues are summarized and the various problems of each are discussed.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 42 (1999), S. 389-401 
    ISSN: 1437-1588
    Keywords: SchlüsselwörterVirusbedingte hämorrhagische Fieber (Ebola Marburg ; Lassa ; Krim-Kongo) ; Pest ; Seuchenhygiene ; Quarantäne ; Internationale Gesundheitsvorschriften ; Reisemedizin ; Tropenkrankheiten ; Emerging diseases ; öffentlicher Gesundheitsdienst ; Zivilmilitärische Zusammenarbeit ; Key words Viral Haemorrhagic Fevers (Ebola-Marburg Viral Diseases ; Lassa Fever ; Crimean-Congo Haemorrhagic Fever) ; Pneumonic Plague ; Control of Epidemics ; Quarantine ; International Health Regulations ; Travelling Medicine ; Tropical Diseases ; Emerging Diseases ; Public Health (Services) ; Civilian-Military Co-operation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary At present, the importation into Germany of life-threatening and highly contagious diseases such as pneumonic plague and Ebola is unlikely, but cannot be ruled out. In spite of the extreme rarity of these diseases, guidelines are necessary to prevent the spread of these agents in case of their importation. In Germany, marked regional differences exist with respect to the development of emergency regulations and the availability of specialized centers for diagnostics and therapy. A federal framework is missing. A concept is presented here in which the capacity to respond is substantially augmented with limited additional cost through inter-regional cooperation using existing infrastructure and federally standardized procedures.
    Notes: Zusammenfassung Ein Einschleppen lebensbedrohender und zugleich hochkontagiöser Infektionskrankheiten wie Lungenpest oder Ebola-Fieber nach Deutschland erscheint zur Zeit nicht sehr wahrscheinlich, ist aber grundsätzlich nicht auszuschließen. Gerade wegen der Seltenheit des Auftretens einer solchen Erkrankung sind jedoch auch hierzulande Handlungsrichtlinien notwendig, um gegebenenfalls einer Verbreitung entgegenzuwirken. Die Entwicklung konkreter Schutzvorkehrungen und Handlungsalgorithmen sowie das Vorhalten geeigneter Diagnostik- und Behandlungseinrichtungen ist in den einzelnen Regionen Deutschlands sehr unterschiedlich ausgeprägt. Ein bundesweiter Rahmenplan fehlt. Der vorliegende Konzeptentwurf zeigt, wie die Vorsorge mit vertretbarem finanziellen Mehraufwand durch eine gemeinsame überregionale Nutzung der z. T. vorhandenen Infrastruktur und durch eine Vereinbarung bundeseinheitlicher Vorgehensweisen wesentlich verbessert werden kann.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1437-1588
    Keywords: Schlüsselwörter Tropenkrankheiten ; Virale hämorrhagische Fieber ; Lassa-Fieber ; Infektionsschutz ; Quarantäne ; BSL4 ; Seuchenhygiene ; Öffentliches Gesundheitswesen ; Rettungswesen ; Krankentransport ; Krankenpflege ; Schutzkleidung ; Kontaktpersonen ; Keywords Tropical Diseases ; Viral Haemorrhagic Fever ; Lassa-Fever ; Epidemic Control ; Preparedness Plans ; Quarantine ; BSL4 ; Patient Isolation ; Barrier Nursing ; Protective Equipment ; Contact Tracing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Patients infected with viral haemorrhagic fevers (VHF), pneumonic plague or zoonotic orthopoxvirus infections usually require intensive care and a special isolation. Contact persons must be traced and monitored. Last year our working group published a concept for the management and control of these life-threatening highly contagious diseases. Now the principles of our plan have been accepted. The development of guidelines for rapid reaction to those communicable diseases is an important task for all EU Member States. In Germany microbiological diagnosis is performed by a diagnostic centre (Biosafety-Level BSL4) and supported by a corresponding confirmation laboratory. At present four high security infectious disease units for patient care (HSIU) are available in Munich, Leipzig, Hamburg and Berlin. Another one located in Frankfurt will be functional by 2001. In addition to the HSIU a corresponding number of centres of competence shall be established in order to support and advise the hospitals initially treating the patients as well as the local public health officer. The risk categorisation for contact persons, which has been developed by our working group, has proved to be very useful in practice. Ambulances should be used for transfer of patients to the HSIU. So-called transport-isolators are not suitable for patients who are seriously ill. Air-based transport without using an isolator is a problem, since no decontamination procedure exists. As soon as the last HSIU in the Rhine Main area is working the centres of competence will be established. This will provide competent health care for VHF-patients and a convincing management for these kinds of threats to public health everywhere in Germany.
    Notes: Zusammenfassung Verschiedene virusbedingte hämorrhagische Fieber (VHF), Pocken (humane Affenpocken) sowie Lungenpest erfordern besondere Maßnahmen zum Schutz des Krankenhauspersonals und anderer Personen vor Ansteckung. Kontaktpersonen müssen ermittelt und überwacht werden, um eine Ausbreitung zu verhindern. Ein im Mai 1999 veröffentlichtes Konzept zum Management und zur Kontrolle dieser lebensbedrohenden hochkontagiösen Infektionskrankheiten wurde inzwischen mit Fachöffentlichkeit und Gesundheitsbehörden diskutiert. Bei den zwischenzeitlich aufgetretenen Fällen bestätigte sich das vorgeschlagene Vorgehen : In Deutschland werden die mikrobiologische Diagnostik und Differentialdiagnostik zentral von einem Zentrum der biologischen Sicherheitsstufe BSL4 und einem entsprechenden Bestätigungslabor vorgenommen. Für Isolierung und klinische Behandlung der Patienten stehen vier Behandlungszentren zur Verfügung, ein fünftes soll im nächsten Jahr betriebsbereit sein. Die zunehmende Inanspruchnahme zeigt, dass sich die vorgesehene Schwerpunktversorgung durchsetzt. Handelsübliche Transportisolatoren sind für schwer kranke Personen nicht geeignet. Ohne deren Verwendung können Luftfahrzeuge jedoch nicht regelrecht dekontaminiert werden. Transporte sollen daher grundsätzlich auf dem Landweg erfolgen. Zur Unterstützung und Beratung der erstversorgenden Krankenhäuser und der örtlich zuständigen Amtsärzte sollen um die Behandlungszentren sog. Kompetenzzentren entstehen. Der Personal- und Platzbedarf bei der Versorgung eines an einem VHF Erkrankten in fortgeschrittenem Stadium ist höher als erwartet. Die adäquate Versorgung von Kranken in sog. Bettisolatoren ist nicht möglich. Routinelaboruntersuchungen müssen in der Behandlungseinheit erfolgen. Maßnahmen zur Verhinderung der Weiterverbreitung müssen stärker koordiniert werden. Die von uns vorgeschlagene Einteilung der Kontaktpersonen wird um eine Auflistung der empfohlenen Maßnahmen ergänzt.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Environmental geochemistry and health 5 (1983), S. 88-90 
    ISSN: 1573-2983
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Medicine
    Type of Medium: Electronic Resource
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