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  • 1
    Electronic Resource
    Electronic Resource
    Diminished pregnancy rates in endometriosis due to impaired uterotubal transport assessed by hysterosalpingoscintigraphy (2005)
    Oxford, UK and Malden, USA : Blackwell Science Ltd
    BJOG 112 (2005), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective  To investigate uterotubal transport by means of hysterosalpingoscintigraphy (HSSG) in women with and without endometriosis.Design  A prospective observational study.Setting  University Hospital, Department of Obstetrics and Gynaecology, Division of Reproductive Medicine and Gynaecologic Endocrinology with 350 in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) cycles and 400 intrauterine insemination (IUI) cycles/year.Population  Cases included 56 infertile women with laparoscopic proven endometriosis and patent fallopian tubes. Twenty-two women with partners suffering from male factor infertility served as controls.Methods  A diagnostic cycle incorporating HSSG was performed. Subsequently, patients underwent either four cycles of timed intercourse (TI) or IUI in order to achieve pregnancy. If pregnancy did not occur, IVF or ICSI was performed.Main outcome measures  Evaluation of uterotubal transport capacity in women with endometriosis and healthy controls.Results  Patients suffering from endometriosis (group I) showed a significant reduction in physiologic uterotubal transport function: While 20 patients (36%) had ipsi- or bilateral uterotubal transport, there was pathological uterotubal transport contralateral to the dominant follicle or a complete failure of transport capacity (negative HSSG) in 36 patients (64%). In the controls (group II), transport function was significantly different: 15 of 22 patients (68%) revealed ipsi- and bilateral tubal demonstration, while 5 patients (22%) showed contralateral transport and 2 patients (10%) showed negative HSSG (P= 0.01). Twenty-three pregnancies were observed (pregnancy rate: 29%). Eleven out of 14 (79%) women with ipsi- or bilateral tubal transport function fell pregnant by means of TI or IUI. In seven of nine patients (78%) with a failure in tubal transport, pregnancy was achieved by IVF/ICSI, despite acceptable semen parameters (P= 0.01).Conclusions  Endometriosis is significantly associated with a reduction in physiologic uterotubal transport capacity compared with controls. This resulted in diminished pregnancy rates even in women with normozoospermic partners. Therefore, IVF/ICSI may be required even when fallopian tubes are patent or semen quality is normal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.2005.00676.x
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  • 2
    Electronic Resource
    Electronic Resource
    Early psychopathological symptoms in senile dementia of the Alzheimer type (1989)
    Springer
    Journal of neural transmission 1 (1989), S. 56-56 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02312233
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  • 3
    Electronic Resource
    Electronic Resource
    Nuklearmedizinische Tumordiagnostik und -therapie: Gegenwärtiger Stand und Zukunft (1996)
    Springer
    Der Onkologe 2 (1996), S. 271-277 
    Details
    ISSN: 1433-0415
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Das hier Gesagte trifft auch auf die onkologische Nuklearmedizin zu. Wenn auch die Immunszintigraphie nicht die Erwartungen erfüllt hat, so lassen neuere Entwicklungen doch erhoffen, daß die Nuklearmedizin für die onkologische Diagnostik und Therapie wichtige Ergebnisse liefern kann. Fortschritte sind neben der weiteren Verbreitung aufwendiger Untersu-chungsgeräte durch neue Radiopharmaka zu erwarten. Hierbei erlauben dedizierte 3-Kopf-Kameras bzw. Ringkristallsysteme eine bessere Ortsauflösung und eine verbesserte Ausnutzung der emittierten Gammaenergie. Auf ,,konventionellem`` Gebiet werden sich Tc-99m markierte, niedermolekulare Peptide durchsetzen. Die Positronenemissionstomographie (PET) wird in Zukunft verstärkt zum Einsatz kommen. Logistische Schwierigkeiten – bedingt durch die kurze Halbwertszeit von F-18 Fluordeoxyglucose (FDG) – lassen sich durch flächendeckende Produktion am Zyklotron reduzieren. Im folgenden werden der gegenwärtige Stand und die zukünftige Entwicklung der einzelnen Verfahren dargelegt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007610050046
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  • 4
    Electronic Resource
    Electronic Resource
    Comparison of fluorine-18 fluorodeoxyglucose positron emission tomography and technetium-99m methoxyisobutylisonitrile scintimammography in the detection of breast tumours (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 1138-1145 
    Details
    ISSN: 1619-7089
    Keywords: Fluorine-18 fluorodeoxyglucose ; Positron emission tomography ; Technetium-99m methoxyisobutylisonitrile ; Scintimammography ; Breast cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to compare, in breast cancer patients, the diagnostic accuracy of positron emission tomography (PET) using fluorine-18 fluorodeoxyglucose (FDG) and scintimammography (SMM) using technetium-99m methoxyisobutylisonitrile (MIBI). A total of 20 patients (40 breasts with 22 lesions) were evaluated serially with MIBI and, on the following day, with FDG. For SMM, planar and single-photon emission tomography imaging in the prone position was performed starting at 10 min following the injection of MIBI (740 MBq). For PET, scans were acquired 45–60 min after the injection of FDG (370 MBq) and attentuation correction was performed following transmission scans. Results from SMM and PET were subsequently compared with the histopathology results. True-positive results were obtained in 12/13 primary breast cancers (mean diameter=29 mm, range 8–53 mm) with both FDG and MIBI. False-negative results were obtained in two local recurrences (diameter 〈9 mm) with both FDG and MIBI. In benign disease, FDG and MIBI did not localize three fibrocystic lesions, two fibroadenomas and one inflammatory lesion (true-negative), but both localized one fibroadenoma (false-positive). Collectively, the results demonstrate a sensitivity of 92%, and a specificity of 86%, for primary breast cancer regardless of whether FDG or MIBI was used. In contrast to MIBI scintigraphy, FDG PET scored the axillae correctly as either positive (metastatic disease) or negative (no axillary disease) in all 12 patients. The tumour/non-tumour ratio for MIBI was 1.97 (range 1.43–3.1). The mean standard uptake value (SUV) for FDG uptake was 2.57 (range 0.3–6.2). The diagnostic accuracy of SMM was equivalent to that of FDG PET for the detection of primary breast cancer. For the detection of in situ lymph node metastases of the axilla, FDG seems to be more sensitive than99mTc-MIBI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01254246
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  • 5
    Electronic Resource
    Electronic Resource
    Nicotine receptor mapping (1996)
    Springer
    European journal of nuclear medicine 23 (1996), S. 1012-1013 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01084381
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  • 6
    Electronic Resource
    Electronic Resource
    Comparison of fluorine-18 fluorodeoxyglucose positron emission tomography and technetium-99m methoxyisobutylisonitrile scintimammography in the detection of breast tumours (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 1138-1145 
    Details
    ISSN: 1619-7089
    Keywords: Key words: Fluorine-18 fluorodeoxyglucose ; Positron emission tomography ; Technetium-99m methoxyisobutylisonitrile ; Scintimammography ; Breast cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The aim of this study was to compare, in breast cancer patients, the diagnostic accuracy of positron emission tomography (PET) using fluorine-18 fluorodeoxyglucose (FDG) and scintimammography (SMM) using technetium-99m methoxyisobutylisonitrile (MIBI). A total of 20 patients (40 breasts with 22 lesions) were evaluated serially with MIBI and, on the following day, with FDG. For SMM, planar and single-photon emission tomography imaging in the prone position was performed starting at 10 min following the injection of MIBI (740 MBq). For PET, scans were acquired 45–60 min after the injection of FDG (370 MBq) and attentuation correction was performed following transmission scans. Results from SMM and PET were subsequently compared with the histopathology results. True-positive results were obtained in 12/13 primary breast cancers (mean diameter=29 mm, range 8–53 mm) with both FDG and MIBI. False-negative results were obtained in two local recurrences (diameter 〈9 mm) with both FDG and MIBI. In benign disease, FDG and MIBI did not localize three fibrocystic lesions, two fibroadenomas and one inflammatory lesion (true-negative), but both localized one fibroadenoma (false-positive). Collectively, the results demonstrate a sensitivity of 92%, and a specificity of 86%, for primary breast cancer regardless of whether FDG or MIBI was used. In contrast to MIBI scintigraphy, FDG PET scored the axillae correctly as either positive (metastatic disease) or negative (no axillary disease) in all 12 patients. The tumour/non-tumour ratio for MIBI was 1.97 (range 1.43–3.1). The mean standard uptake value (SUV) for FDG uptake was 2.57 (range 0.3–6.2). The diagnostic accuracy of SMM was equivalent to that of FDG PET for the detection of primary breast cancer. For the detection of in situ lymph node metastases of the axilla, FDG seems to be more sensitive than 99mTc-MIBI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01254246
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  • 7
    Electronic Resource
    Electronic Resource
    Scintimammography with technetium-99m methoxyisobutylisonitrile: comparison with mammography and magnetic resonance imaging (1996)
    Springer
    European journal of nuclear medicine 23 (1996), S. 940-946 
    Details
    ISSN: 1619-7089
    Keywords: Breast cancer ; Scintimammography ; Technetium-99m methoxyisobutylisonitrile ; Mammography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of the study was to compare the diagnostic accuracy of scintimammography with technetium-99m methoxyisobutylisonitrile (MIBI; SMM) in the detection of primary breast cancer with that of mammography (MM) and magnetic resonance imaging (MRI). Fifty-six patients with suspected lesions detected by palpation or MM were included in the study. Within the 4 weeks preceding excisional biopsy, MM and MRI were performed in all patients. Between 5 and 10 min after the injection of 740 MBq99mTc-MIBI, SMM in the prone position was performed. In the total group of 56 patients, 43 lesions were palpable, while 13 were non-palpable but were detected by MM. Breast cancer was confirmed by histopathology in 27 of the patients (22 palpable and 5 non-palpable carcinomas). The tumour size ranged from 6 to 80 mm in diameter. For non-palpable lesions, the sensitivity of SMM, MM and MRI was 60%, 60% and 100%, respectively, while the specificity was 75%, 25% and 50%, respectively. For palpable breast lesions, all methods showed high sensitivity (SMM 91%, MM 95%, MRI 91%) but SMM demonstrated significantly higher specificity (SMM 62%, MM 10%, MRI 15%). In two mammographically negative tumours (dense tissue), SMM showed a positive result. In comparison to MRI, one additional carcinoma could be diagnosed by SMM. It may be concluded that for palpable breast lesions, the diagnostic accuracy of SMM is superior to that of MM and MRI. Through the complementary use of SMM it is possible to increase the sensitivity for the detection of breast cancer and multicentric disease. In patients in whom the status of a palpable breast mass remains unclear, SMM may help to reduce the amount of unnecessary biopsies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01084368
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  • 8
    Electronic Resource
    Electronic Resource
    SPECT patterns in probable Alzheimer’s disease (1999)
    Springer
    European archives of psychiatry and clinical neuroscience 249 (1999), S. 190-196 
    Details
    ISSN: 1433-8491
    Keywords: Key words HMPAO-SPECT ; Alzheimer’s disease ; Hypoperfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The primary objective of this study was to test hypotheses about the relationship between HMPAO-SPECT findings and probable Alzheimer’s disease (DAT) in a relatively large sample of patients diagnosed according to DSM-III-R. SPECT patterns of 20 controls and 116 DAT patients were investigated. Left and right frontal, temporal, parietal and occipital regions of the brain were rated as showing a hypoperfusion or not. A wide variety of patterns were found and these are described in detail below. In DAT patients, temporal and/or parietal regions were affected significantly more often (88%, p 〉 0.001) than frontal and/or occipital regions (70%). A bilateral temporoparietal pattern, which has been repeatedly reported as typical for DAT, was observed in 48% of DAT patients, but also in 25% of controls, and did not differentiate significantly between these two groups (p 〉 0.05). Conversely, more than three regions with hypoperfusion were observed significantly more often in DAT patients (48%, p 〈 0.01) than in controls (10%). In DAT patients, the number of regions with hypoperfusion correlated significantly with the score of the Mini Mental State Examination (MMSE, r = 0.33, p 〈 0.001). The frequency of at least one hypoperfusion was approximately equal in left and right hemispheres (77% vs. 73%, p = 0.2). The hypothesis that cognitive decline in DAT starts in the temporal regions was tested in 14 SPECT patterns showing only one region with hypoperfusion. In 12 of these patterns, a temporal region was in fact affected (p 〈 0.001). Whereas hypoperfusion in frontal areas was not accompanied by a significantly lower MMSE than when only temporoparietal regions were affected, MMSE scores were significantly lower when occipital regions were affected in addition to temporoparietal regions (p 〈 0.05). The clinical use of SPECT findings was tested in discriminating analyses with the MMSE and a delayed recall test as additional predictors of DAT. Whereas the MMSE and the delayed recall test differentiated significantly between DAT patients and controls, SPECT findings yielded no further differentiation. In conclusion, the theoretical and clinical implications of SPECT findings and their relationships to other physiological and psychological variables deserve further investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004060050086
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  • 9
    Electronic Resource
    Electronic Resource
    Klinische Wertigkeit der Positronen-Emissions-Tomographie in der Neuromedizin Positionspapier zu den Ergebnissen einer interdisziplinären Konsensuskonferenz (1998)
    Springer
    Der Nervenarzt 69 (1998), S. 1045-1060 
    Details
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Positronen-Emissions-Tomographie (PET) ; Neurologie ; Neurochirurgie ; Psychiatrie ; Key words Positron emission tomography ; Neurology ; Neurosurgery ; Psychiatry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary To date, positron emission tomography (PET) is the most powerful method for the in-vivo investigation of human brain metabolism. Besides extensive application of this technology in the neurosciences, PET is also being increasingly used as a clinical tool. However, despite its acceptance in clinical practice, a major obstacle is its high costs. The present article reviews the literature on the clinical use of PET in neurology, neurosurgery, and psychiatry in order to substantiate the clinical indications for PET in these specialties as established by an interdisciplinary conference.
    Notes: Zusammenfassung Die Positronen-Emissions-Tomographie (PET) ist das derzeit leistungsfähigste Verfahren zur In-vivo-Untersuchung des zerebralen Stoffwechsels. Neben einem breitgefächerten Einsatz von PET in der neuromedizinischen Forschung findet die PET zunehmend auch Eingang in die klinische Diagnostik. Dieser Entwicklung entgegen stehen die relativ hohen Kosten, die mit diesem Verfahren verbunden sind. Die vorliegende Arbeit begründet die, in einer interdisziplinären Konferenz erarbeiteten Konsensusindikationen für den klinischen Einsatz der PET in der Neurologie, Neurochirurgie und Psychiatrie durch Aufarbeitung der einschlägigen Literatur.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001150050382
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  • 10
    Electronic Resource
    Electronic Resource
    The creation of a small bowel pouch by tissue expansion —an experimental study in pigs (1990)
    Springer
    Langenbeck's archives of surgery 375 (1990), S. 145-150 
    Details
    ISSN: 1435-2451
    Keywords: Gewebeexpansion ; Dünndarm ; Kurzdarmsyndrom ; Ileumkontinenztasche
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Tissue expanders (inflatable silicone balloons) were implanted into a bypassed ileum segment of seven pigs and consecutively filled over 8 to 12 weeks. The mean increase of the volume of the small bowel loops was 12 fold with a maximum of 22.8 times the original volume. The final volume 9 weeks after expander removal still presented an increase of 500%. Histologically there was an increase of the thickness of all layers of the bowel wall, especially in the tunica muscularis. The mucosa showed a value above normal in mean in vitro 14C-resorption capacity per surface area in the reintegrated bowel. Possible clinical applications of the augmentation of the gut by expansion as a rectum substitute after proctocolectomy, as a urinary bladder or stomach substitute, and for the treatment of short bowel syndrome are discussed.
    Notes: Zusammenfassung Gewebeexpander (auffüllbare Silikonballons) wurden bei sieben Schweinen in ein ausgeschaltetes Ileumsegment implantiert und anschließend über 8 bis 12 Wochen aufgefüllt. Die mittlere Volumenzunahme der Dünndarmschlinge lag beim Zwölffachen des Ausgangswertes (maximal 22,8fach). Neun Wochen nach Expanderentfernung und Wiedereinschaltung in die Kontinuität betrug das mittlere Endvolumen immer noch 500%. Histologisch fand sich eine Zunahme der Dicke aller Darmwandschichten, insbesondere der Tunica muscularis. Die mittlere in-vitro-l4C-Glukoseresorptionsleistung des wiedereingeschalteten Ileums lag über den Kontrollen. Eine mögliche Nutzung der Darmvergrößerung durch Expansion als Mastdarm-, Blasen- oder Magenersatz und zur Behandlung des Kurzdarmsyndroms werden diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00206807
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