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  • 1
    Electronic Resource
    Electronic Resource
    Anti-HBc IgM bei akuter und chronischer Hepatitis-B-Virus-Infektion (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 837-842 
    Details
    ISSN: 1432-1440
    Keywords: Hepatitis B virus ; Hepatitis markers ; Anti-hepatitis B core immunoglobulin M
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hepatitis B core antigen (HBcAg) synthesized in E. coli was used for determination of immunoglobulin M class-specific antibodies against HBcAg. It was found that 98% of cases with acute hepatitis B surface antigen (HBsAg) positive hepatitis type B were anti-HBc immunoglobulin M (IgM) positive. Atypical hepatitis B was detected in 33% of anti-HBc-positive HBsAg-negative cases with acute hepatitis. Anti-HBc IgM was positive for 6 months in acute resolving hepatitis type B, whereas cases resulting in chronic hepatitis B remained anti-HBc IgM-positive for up to 900 days. Chronic HBsAg carriers with severe liver disease had anti-HBc IgM more often than individuals with minor liver damage; 83% of HBsAg-positive liver cirrhoses, 63% of chronic aggressive hepatitis, 50% of HBsAg-positive liver carcinoma, but only 17% of chronic persistent hepatitis or 7% of healthy blood donors were anti-HBc IgM-positive. Determination of anti-HBc IgM is useful in detecting atypical hepatitis B virus infections without HBsAg in serum and, with some restrictions, in discriminating acute and chronic hepatitis type B.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711864
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Use of hepatitis B core antigen produced inEscherichia coli to detect immunoglobulin M specific antibodies in an enzyme-linked immunosorbent assay (1984)
    Springer
    European journal of clinical microbiology & infectious diseases 3 (1984), S. 30-34 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The antigenic activity of HBcAg produced inEschericha coli and HBcAg from human liver was compared in aμ-specific solid-phase antibody-capture assay for detection of anti-HBc-IgM. HBcAg from liver could be detected in dilutions up to 1∶3, HBcAg fromEscherichia coli in dilutions up to 1∶10, 000. Using HBcAg fromEschericha coli, sera from five patients with acute resolving hepatitis B and sera from four patients with actue hepatitis B who had developed chronic liver disease were tested for anti-HBc-IgM in ELISA. IgM fractions separated out of the same sera by immunoaffinity chromatography were tested for anti-HBc-IgM using a commercially available test. The results were in good agreement with those obtained by ELISA. Anti-HBc-IgM could be detected up to 900 days after onset of disease. Different groups of patients were tested for presence of anti-HBc-IgM in ELISA. Fifty-nine of 60 patients with acute hepatitis B were positive for anti-HBc-IgM at onset of illness. Ten of 16 patients with chronic aggressive hepatitis and seven of 23 HBsAg positive dialysis patients were also positive for anti-HBc-IgM, whereas only two of 12 patients with chronic persistent hepatitis and one of 15 HBsAg positive blood donors (“healthy” carriers of HBsAg) had detectable anti-HBc-IgM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02032811
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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