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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 20 (1970), S. 31-36 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The influence of platelet lipids and ADP on the contact product of the clotting system is reported. ADP together with platelet factor 3 cause an activation of the contact factors.
    Notes: Zusammenfassung Es wird über die Beeinflussung des Kontaktproduktes des Gerinnungssystems durch Plättchenlipid und ADP berichtet. ADP bewirkt zusammen mit Plättchenfaktor 3 eine Aktivierung der Kontaktfaktoren.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A report is given about the clotting analysis of 53 dogs, in all of whom an experimental pancreatitis was produced. A part of them was treated by intravenous or intraarterial application of Trasylol, another part received low molecular weight dextran intraarterially. During the first hours after operation a definite hypercoagulability of the blood was found. The clotting analysis reminded at the early phase of a consumptive clotting defect (Verbrauchskoagulopathie), which in some animals developed with the full picture. Those dogs given Trasylol or Rheomacrodex did not show this hypercoagulability. A vicious circle of the following criteria is discussed in the pathogenesis of acute pancreatitis: Trypsin-and Elastase-effect, Thromboplastin and intravascular clotting because of hypocirculation and shock. They may participate with different accentuation in the individual case and determine its outcome. The therapeutical effect of Trasylol is thought to be due to its anticoagulative effect on the one side, to its beneficial influence on the general circulatory situation on the other side. This is evidenced by the good effect low molecular weight dextran exerts on the coagulation by means of improving the microcirculation.
    Notes: Zusammenfassung Es wird über die Gerinnungsanalysen von 53 Hunden mit experimentell erzeugter Pankreatitis berichtet, die zum Teil einer Behandlung mit Trasylol (intravenös und intraarteriell) und niedermolekularem Dextran (intraarteriell) unterworfen wurden. Es zeigte sich in den ersten Stunden nach erfolgter Operation eine deutliche Hypercoagulabilität des Blutes. Das gerinnungsanalytische Bild erinnerte an die Frühphase einer Verbrauchscoagulopathie, die bei einigen Tieren zur vollständigen Entwicklung gelangte. Unter Trasylol- und Rheomacrodexbehandlung wurde die Hypercoagulabilität nicht beobachtet. Zur Pathogenese der Gerinnungsstörung bei der akuten Pankreatitis wird ein Circulus vitiosus unterschiedlicher Akzentuierung von Trypsin- und Elastaseeffekt, Thromboplastin und vasculärer Gerinnung infolge Hypozirkulation und Schock diskutiert. Die therapeutische Wirkung des Trasylols wird einerseits auf seinen anticoagulativen Effekt, andererseits auf die Beeinflussung der allgemeinen Kreislaufsituation zurückgeführt. Zur Bestätigung der letzten Annahme wird der ebenfalls positive Effekt des mikrozikulationsfördernden Rheomacrodex auf die Gerinnungsverhältnisse angeführt.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 46 (1968), S. 650-653 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Addition of plasma, heated to 56°, to platelet rich plasma resulted in a significant increase of platelet aggregation. Further increase of aggregation was achieved, when the euglobulin fraction of a heated plasma was used. Lower values were found by using serum fractions. After precipitation of plasma with 2% inulin the sediment showed a strong platelet aggregating effect while the supernatant was free of activity. Similar results could be produced by using zymosan instead of inulin. This aggregating principle was not destroyed by heating to 56°. It is suggested that inulin or zymosan precipitation resulted in a crude purification of a platelet aggregating factor.
    Notes: Zusammenfassung Nach Zugabe eines auf 56° erhitzten Plasmas zu plättchenreichem Plasma nahm die Plättchenaggregation signifikant stärker zu als nach Zugabe eines Nativplasmas. Eine noch stärkere Plättchenaggregation wurde durch die Zugabe der Euglobulinfraktion eines auf 56° erhitzten Plasmas erreicht. Nicht so deutlich war die Aggregationssteigerung der entsprechenden Serumzusätze. Wurde eine Fällung mit 2%iger Inulinsuspension vorgenommen, so nahm die Plättchenaggregation durch das Sediment der Inulinfällung signifikant zu, während dieser Effekt durch Zugabe des Überstandes vermißt wurde. Praktisch gleichsinnige Ergebnisse wurden durch die Zugabe eines durch Zymosan gefällten Plasmasediments erzielt. Erhitzen auf 56° zerstört diesen Faktor nicht. Es wird diskutiert, ob durch die Inulin- bzw. Zymosanfällung ein Plasmafaktor angereichert wird, der die Plättchenaggregation steigert.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 58 (1980), S. 557-561 
    ISSN: 1432-1440
    Keywords: Hepatic coma ; Electroencephalogram ; Hemoperfusion ; Lebercoma ; Elektroenzephalogramm ; Hämoperfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 6 Patienten, 2 Männer und 4 Frauen, im Alter zwischen 15 und 60 Jahren, wurden im Lebercoma Stadium IV und schwersten EEG-Veränderungen mit Hämoperfusion behandelt. Die Ursachen, die zum Coma führten, waren zweimal akute Virushepatitis A, dreimal Hepatitis B und einmal eine Knollenblätterpilz-Intoxikation. Nur die Patientin mit der Pilzintoxikation überlebte. Bei Klinikaufnahme bestanden bei allen Patienten schwerste EEG-Veränderungen des Stadium IV. Sie gingen bei der Hälfte der Patienten, die zu diesem Zeitpunkt allenfalls im Coma Stadium II waren, der klinischen Manifestation des Coma Stadium IV bis zu einem Tag voraus. Bei Therapiebeginn in niedrigeren Coma-Stadien werden bessere Überlebenschancen berichtet. Man müßte also, ausgehend von den bei einem Teil der Patienten dem klinischen Coma vorausgehenden schwer pathologischen EEG-Befunden, einen früheren Therapiebeginn fordern.
    Notes: Summary Six patients (two men and four women) aged between 15 and 60 years in hepatic coma stage IV and with very severe EEG changes were treated with hemoperfusion. The causes leading to coma were acute virus hepatitis A in two cases, hepatitis B in three cases, and Amanita intoxication in one case. Only the patient with Amanita intoxication survived. On admission to the hospital, there were very severe EEG changes of stage IV in all patients. They preceded the clinical manifestation of coma stage IV up to one day in half of the patients who were at most in coma stage II at this time. At the beginning of therapy better survival chances are reported in the lower coma stages. On the basis of the severely pathological EEG findings preceding the clinical coma in a proportion of the patients, an earlier start of therapy should thus be demanded.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 62 (1984), S. 837-842 
    ISSN: 1432-1440
    Keywords: Hepatitis B virus ; Hepatitis markers ; Anti-hepatitis B core immunoglobulin M
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hepatitis B core antigen (HBcAg) synthesized in E. coli was used for determination of immunoglobulin M class-specific antibodies against HBcAg. It was found that 98% of cases with acute hepatitis B surface antigen (HBsAg) positive hepatitis type B were anti-HBc immunoglobulin M (IgM) positive. Atypical hepatitis B was detected in 33% of anti-HBc-positive HBsAg-negative cases with acute hepatitis. Anti-HBc IgM was positive for 6 months in acute resolving hepatitis type B, whereas cases resulting in chronic hepatitis B remained anti-HBc IgM-positive for up to 900 days. Chronic HBsAg carriers with severe liver disease had anti-HBc IgM more often than individuals with minor liver damage; 83% of HBsAg-positive liver cirrhoses, 63% of chronic aggressive hepatitis, 50% of HBsAg-positive liver carcinoma, but only 17% of chronic persistent hepatitis or 7% of healthy blood donors were anti-HBc IgM-positive. Determination of anti-HBc IgM is useful in detecting atypical hepatitis B virus infections without HBsAg in serum and, with some restrictions, in discriminating acute and chronic hepatitis type B.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 66 (1988), S. 1099-1101 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 63 (1985), S. 164-167 
    ISSN: 1432-1440
    Keywords: Hepatitis ; Epidemiology ; HBsAg ; Delta virus ; Anti-Delta
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The frequency of delta infection was studied in sera of 203 patients with acute hepatitis B, further 461 hepatitis B virus surface antigen-(HBsAg)-positive patients and 117 HBsAg-negative controls by determination of anti-delta by a competitive enzyme immunoassay. Sera have been collected since 1974. None of the sera of acute hepatitis B was anti-delta-positive whereas seven of the HBsAg-positive carriers were anti-delta-positive. Two of the anti-delta-positive patients had chronic hepatitis, four had liver cirrhosis. One of the anti-delta-positive patients with liver cirrhosis died of liver failure. Risk factors included Italian origin and parenteral routes of infection. All sera of 19 relatives of three anti-delta-positive index cases remained anti-delta-negative.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 46 (1968), S. 507-509 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A drecrease of platelet ATP under the influence of a heatstable plasma factor is described. This factor can be precipitated by inulin and belongs to the euglobulin fraction. The factor has no relation to the heatstable contact factors of the coagulation system. The process of heating and precipitation represents a purification rather than an activation.
    Notes: Zusammenfassung Es wird über einen hitzestabilen Plasmafaktor berichtet, der einen ATP-Verlust von Blutplättchen verursacht. Dieser Faktor läßt sich mit Inulin und Erniedrigung des pH auf 5,3 fällen. Er hat keine Beziehung zu den hitzestabilen Kontaktfaktoren des Gerinnungssystems. Erhitzen und Fällung stellen keine Aktivierung, sondern eine Anreicherung dar.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 58 (1980), S. 365-370 
    ISSN: 1432-1440
    Keywords: Hepatitis A ; Hepatitis B ; Hämodialyse ; Hepatitis A ; Hepatitis B ; Hemodialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In 113 hemodialysed patients, 167 hospitalized patients, and 143 outpatients the frequency of HAV and HBV markers were studied by testing HBsAg, anti-HBs, anti-HBc, HBeAg, anti-HBe, and anti-HAV. The hemodialysis patients in a dialysiscenter had significantly more often HBV markers (85.7%) than those maintained on home-dialysis (46.5%). 29.9% of the hospitalized patients and 32.1% of the outpatients had HBV markers. By the anti-HBc test up to 41% of additional HBV infections could be detected. — The prevalence of anti-HAV was very high in all groups. Significant differences between the hemodialysis patients and the control groups existed only in the age groups up to 39 years. — The frequencies of HAV and HBV markers were related to age, duration of dialysis treatment, transfusional frequency, and transaminases. The HBV appeared as the clinically important hepatitis agent in dialysis.
    Notes: Zusammenfassung Die Häufigkeit von HAV- und HBV-Infektionen wurde bei 113 Hämodialysepatienten, 167 hospitalisierten und 146 ambulanten Patienten untersucht, indem anti-HAV, HBsAg, anti-HBs, anti-HBc, HBeAg und anti-HBe bestimmt wurden. Die Hämodialysepatienten in einem Zentrum hatten signifikant häufiger HBV-Marker (85,7%) als Heimdialysepatienten (46,5%). 29,9% der hospitalisierten und 32,1% der ambulanten Patienten hatten HBV-Marker. Der anti-HBc-Test entdeckte bis zu 41% zusätzliche HBV-Infektionen. — Die Prävalenz von anti-HAV war in allen Gruppen sehr hoch. Nur in den Altersgruppen bis 39 J. gab es signifikante Unterschiede zwischen den Hämodialysepatienten und den Kontrollgruppen. — Die Häufigkeit von HAV-und HBV-Marker wurde nach Alter, Dialysedauer, Zahl der Bluttransfusionen und Transaminasen untersucht. Das HBV erwies sich als die klinisch wichtige Hepatitisform in der Dialyse.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 49 (1971), S. 47-48 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Einige Chargen von Antilymphocytenserum (aus Tonsillen und Blutlymphocyten) zeigten sowohl in vitro (PAT-Test, TEG, Thrombocytenagglutinationstest), als auch bei klinischer Anwendung eine ausgeprägte thrombopenische Nebenwirkung. Mittels Cr51 markierter Thrombocyten wurde die Sequestrationskinetik der Thrombocyten nach ALS-Medikation untersucht. Sequestrationsort waren Milz und/oder Leber.
    Notes: Summary Some batches of antilymphocytic globulin prepared from tonsil material and peripheral blood lymphocytes were shown to cause thrombocytopenia. The results of thein vitro tests are described (PAT, TEG, platelet agglutination). The kinetics of platelet sequestration were evaluated by means of Cr51 labelling. Platets were found to be sequestrated in the spleen and/or liver, respectively.
    Type of Medium: Electronic Resource
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