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  • 1
    Electronic Resource
    Electronic Resource
    Analysis of Residual Stress States in Friction-Weldings by Means of Neutron Diffraction (1993)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 133-136 (Jan. 1993), p. 549-554 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/00/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.133-136.549.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    Computer assisted localizer for planning of surgery and intra-operative orientation (1992)
    Springer
    Acta neurochirurgica 119 (1992), S. 166-170 
    Details
    ISSN: 0942-0940
    Keywords: Computer assisted neurosurgery ; planning of surgery ; intra-operative localization ; brain tumour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary There is discrepancy between the exact representation of anatomical structures and tumours in the CT or MRI scan and the more or less accurate intra-operative localisation methods based mostly upon landmarks of the skull and extracerebral space and visible abnormalities of the cerebral surface. To overcome these problems of exact intra-operative localisation a Computer Assisted Localizer (CAL) is presented which allows precise intra-operative orientation without these aids. It consists of a mechanically articulated arm with six degrees of freedom with a high precision digital incremental and an image processor for 3 D data of the head. MRI and/or CT investigation is done pre-operatively with four reference markers fixed on the patient's head. They are visible on the CT or MRI slices and are used as reference points during surgery for adjustment of the device. The co-ordinates of the digitalizer arm tip are projected into the corresponding axial, sagittal and coronal CT slices so that the system simultaneously presents three orthogonal multiplanar CT reconstructions with a reticule indicating the position of the tip of the arm. As the surgeon directs the arm to the region of interest the corresponding CT slices are displayed on the monitor at a rate of 20 slices/sec determined by the motion of the arm. The accuracy of measurement of the device itself lies within 1 mm. The accuracy is somewhat reduced however by the thickness of CT or MRI slices (routinely 2 mm slices were taken) and by deviations of the reference markers on the skin surface which amount up to 3 mm. Intra-operatively the accuracy decreases with CSF and tumour removal. Nevertheless the system has proved to be extremely useful in 50 cases to focus a trepanation and to guide the surgeon to subcortical lesions, invisible from the surface of the brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01541803
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  • 3
    Electronic Resource
    Electronic Resource
    Etching and deposition phenomena in an R.F. CH"4 plasma
    Amsterdam : Elsevier
    Thin Solid Films 147 (1987), S. 83-92 
    Details
    ISSN: 0040-6090
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0040-6090(87)90043-5
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  • 4
    Electronic Resource
    Electronic Resource
    Millet, a potentially life-threatening allergen (2001)
    Copenhagen : Munksgaard International Publishers
    Allergy 56 (2001), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.2001.00061.x
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  • 5
    Electronic Resource
    Electronic Resource
    Comparison of olfactory function in patients with seasonal and perennial allergic rhinitis (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 53 (1998), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Hyposmia is a common symptom in allergic rhinitis. However, little is known about differences in the olfactory function of patients with seasonal or perennial allergy. A prospective controlled study was performed on 28 patients with allergic rhinitis to grass pollen and on 47 patients with allergic rhinitis to mites. Sixty-six healthy volunteers served as a control. Olfactory function was evaluated by a modified Connecticut Chemosensory Clinical Research Center testing procedure for threshold, identification, and discrimination. The grass pollen-allergic patients were tested prcseasonally and after 3 weeks of intraseasonal grass pollen exposure: the mite-allergic patients and the volunteers were tested once. In the mite allergies, olfactory threshold, identification, and discrimination tests were significantly worse than in the volunteers (all P〈0.0001). In the grass pollen allergies, the results in olfactory identification and discrimination tests were not different from the controls if tested out of the season (both F〉0.05). However, in threshold testing (P=0.0139), the results were worse. Intraseasonally, the grass pollen allergies showed a significant decrease in threshold, identification (both P〈0.001), and discrimination testing (P=0.0()29). If the intraseasonal pollen allergies were compared to the mite allergies, they showed better results in identification (F=0.(X)87) and threshold (F〈0.001) tests, but worse results m discrimination testing (P=0.(XM)2). Therefore, the different kind of allergen exposure seems to result in a different pattern of allergic olfactory dysfunction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1998.tb03890.x
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  • 6
    Electronic Resource
    Electronic Resource
    Generic or disease-specific quality of life scales to characterize health status in all_ergic rhinitis? (2001)
    Copenhagen : Munksgaard International Publishers
    Allergy 56 (2001), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  In patients with all_ergic rhinitis (AR), various instruments have been validated for the measurement of quality of life (QOL), which may be greatly reduced. However, it is not clear which QOL instruments should be used for the different types of AR and whether they are sensitive to treatment. Methods:  The QOL of patients suffering from symptomatic seasonal AR (sSAR) (before and during treatment with a topical or systemic antihistamine), symptomatic perennial AR (sPAR), and asymptomatic seasonal AR (aSAR) was determined with the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) as disease specific and with the Munich Life Dimension List (MLDL) and the Visual Analogue Scale for Quality of Life (VAS-QOL) as generic QOL instruments. Results:  The different forms of AR were associated with typical QOL patterns. In sSAR, we found severe limitation of the global QOL, reduced global life satisfaction, high ranking of practical problems, high limitation of activity, and a high degree of disturbance in all_ subscales of the RQLQ. In sPAR, there were moderate limitation of the global QOL, normal global life satisfaction, high ranking of practical problems, moderate limitation of activity, and a high degree of disturbance by common symptoms. Under antihistamine treatment, both systemic and nasal, a significant improvement of QOL parameters was found, reaching the levels of patients with aSAR after 2 weeks. Conclusions:  QOL instruments can distinguish the impairment resulting from sSAR from that of sPAR and are sensitive to treatment with topical and systemic antihistamines. However, as the RQLQ was not designed to measure the short-term variations of disease status that appear in SAR, it may not demonstrate the rapid improvement of QOL under antihistamine treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.2001.00919.x
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  • 7
    Electronic Resource
    Electronic Resource
    Mometasone furoate nasal spray improves olfactory performance in seasonal allergic rhinitis (2003)
    Oxford, UK : Munksgaard International Publishers
    Allergy 58 (2003), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.2003.00162.x
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  • 8
    Electronic Resource
    Electronic Resource
    Tree-pollen allergy is efficiently treated by short-term immunotherapy (STI) with seven preseasonal injections of molecular standardized allergens (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 53 (1998), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The efficacy and tolerance of short-term immunotherapy (STI) by seven preseasonal injections of tree-pollen allergens (ALK7 FrUhbltihermischung®) was investigated in a double-blind, placebo-controlled, multicenter study with 111 rhinoconjunctivitis patients. Nasal and bronchial symptoms simultaneously analyzed, and nasal symptoms as a single end point, but not the overall score of nasal, bronchial, and conjunctival symptoms, showed a significantly lower increase with STI during birch-pollen exposure (both P= 0.033, n= 105, Mann-Whitney U-test). However, a selective analysis with patients from centers with high recruitment figures (nS10 patients, n=29 STI, n=32 placebo) showed a significantly lower increase of nasal, bronchial, and overall symptom score (STI 11.0 vs placebo 18.0, P=0.001, U-test). STI had equidirected effects on conjunctival, nasal, and bronchial symptoms analyzed as multiple end points, although conjunctival symptoms were not significantly different as a single end point. The seasonal increase in drug use was reduced by 62% in the STI group compared with placebo (P=0.032, Mest), Specific IgG4 increased only after STI (P〈0,001); IgE was not significantly different. Eosinophil cationic protein remained unchanged with STI, but significantly increased with placebo in the pollen season (P=Qm3). STI was well tolerated. In conclusion, STI was shown to be efficacious and safe for the treatment of patients with tree-pollen rhinoconjunctivitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1998.tb03969.x
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  • 9
    Electronic Resource
    Electronic Resource
    Increased in vitro cvsteinvl leukotriene release from blood leukocytes in patients with asthma, nasal polyps, and aspirin intolerance (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 51 (1996), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In vitro cysteinyl leukotriene (cLT) release from blood leukocytes was measured in eight normal individuals (NI), nine patients with nasal polyps (NP) without aspirin intolerance, and eight patients with NP, asthma, and aspirin intolerance (AI). Blood leukocytes were prestimulated with interleukin-3 (IL-3) and incubated with acetylsalicylic acid (ASA) (10 and 100 pglml) together with C5a (10--8 mol/l) for 18 h. cLT release (LTC4, LTD4 and LTE4) from blood leukocytes was measured with a competitive enzyme-linked immunoassay. Background cLT release was 259±66 pg/ml (mean±æM) in the NI group, 185±33 pg/ml in the NP group, and 578±136 pg/ml in the A1 group (P = 0.1). After incubation with 10 μg/ml ASA, cLT concentration was lower in normal subjects (346±72 pg/ml) and in patients with NP (209±53) than in patients with A1 (686±75 pg/ml, P = 0.002). After incubation with 100 μg/ml ASA, cLT concentrations were 285±272 pg/ml in the NI group, 313±77 pg/ml in the NP group, and 654±121 pg/ml in the AI group (P = 0.04), respectively. Simultaneous incubation with ASA 10 μg/ml and C5a (10--8mol/l) resulted in a cLT concentration of 751±171 pg/ml in the NI group, 343±102 pg/ml in the NP group, and 2196±480 pg/ml in patients with A1 (P = 0.0006), whereas simultaneous incubation with ASA 100g/ml and C5a (10--8mol/l) resulted in 268±51 pg/ml in the NI group, 412±97 pg/ml in the NP group, and 1701±368 pg/ml in the AI group (P= 0.005). In patients with AI, cLT release from blood leukocytes is altered when compared with normals and patients with NP. The presented cLT-release assay could be of potential use in the in vitro diagnosis of AI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1996.tb04657.x
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  • 10
    Electronic Resource
    Electronic Resource
    Sedation in allergic rhinitis is caused by the condition and not by antihistamine treatment (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 51 (1996), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Sedation is regarded as a common side-effect of most H1-antihistamines. This view must be accepted. yet can hardly be assessed under treatment of allergic disorders. Since central sedative potency is hard to evaluate, different methods of measurement have been introduced in the four phases of clinical investigation. While tests of high complexity in early trials can detect true central effects, they seem to have the disadvantage of not taking into consideration the important interactions of drugs with the disorder. Therefore, we used a visual analog scale (VAS) as an instrument to demonstrate sedative effects in five clinical studies carried out between 1989 and 1994 with a total number of 1070 patients. Thereby, we could assess the result of the different components of the central interaction. In 1989, in a double-blind, placebo-controlled trial, we could show that the vigilance of patients suffering from seasonal allergic rhinitis increased significantly more under treatment with an antihistamine (mizolastine) than under placebo. From 1992 until 1994, we compared azelastine nasal spray either by the double-dummy technique with oral antihistamines (cetirizine, loratadine, and astemizole) or by the double-dummy or placebo-controlled design with monotherapy or combined therapy with azelastine tablets. A marked or statistically significant improvement of vigilance was found for all compounds (loratadine: P 〈 0.0001; cetirizine: P 〈 0.0254; and azelastine nasal spray: P 〈 0.1409 to P 〈 0.0001). Even when taking azelastine as oral application, patients, in spite of the warning, reported a similar increase in vigilance (P 〈 0.2628 to P 〈 0.0001). Finally, we assessed the range of physiologic vigilance using the same VAS in healthy volunteers. In conclusion, we could prove that in all trials the baseline values of vigilance of untreated symptomatic patients were far below physiologic condition and improved under treatment to the upper range of healthy persons. Therefore, any sedative properties of modern H1-antihistamines should not limit their therapeutic use. since the truly threatening sedation results from the disorder itself.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1996.tb04490.x
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