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  • 1
    Electronic Resource
    Electronic Resource
    Transcriptional up-regulation of histamine receptor-1 in epithelial, mucus and inflammatory cells in perennial allergic rhinitis (2005)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 35 (2005), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Histamine receptors play an important role in the pathogenesis of nasal allergy. Activation of histamine receptor 1 (H1R) and 2 (H2R) can cause allergic symptoms which can be blocked effectively by antihistamines. H1R and H2R transcript levels have been found to be up-regulated in perennial – but not in seasonal – allergic rhinitis (AR). The present study aimed to explore H1R and H2R expression in complex tissues of the nasal mucosa of perennial allergic rhinitis (PAR).Methods Ten patients with PAR and 13 non-AR subjects were recruited for the study by medical history, physical examination and laboratory screening tests. In this study, we have analysed single cells dissected from the nasal mucosa biopsies by laser-assisted microdissection. H1R mRNA expression was analysed in different cell types such as epithelial, endothelial, mucus and inflammatory cells isolated from the nasal mucosa of PAR in comparison with non-AR subjects.Results H1R mRNA gene expression level was significantly increased in the nasal mucosa of PAR in comparison with non-AR (P〈0.0001). H1R mRNA was significantly elevated in epithelial (P〈0.001) and mucus cells (P〈0.05) of PAR in comparison with non-AR whereas H1R gene expression levels in endothelial cells between both groups were not changed (P=0.23). Interestingly, inflammatory cells in the nasal mucosa of PAR patients were also strongly expressed H1R mRNA (P〈0.001).Conclusion The present study indicates that PAR alters the expression of H1R mRNA in epithelial, mucus and inflammatory cells of the nasal mucosa and but not in endothelial cells. Therefore, epithelial, mucus and inflammatory cells may play an important role in histamine-mediated allergic airway inflammation in PAR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.2005.02359.x
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  • 2
    Electronic Resource
    Electronic Resource
    Phenotypic alteration of neuropeptide-containing nerve fibres in seasonal intermittent allergic rhinitis (2004)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 34 (2004), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Allergic rhinitis (AR) is the most common allergic disease affecting the respiratory tract. Next to inflammatory changes, the airway innervation plays an important modulatory role in the pathogenesis of the disease.Objective To examine the participation of different neuropeptides in the human nasal mucosa of intermittent (seasonal) AR tissues in the allergic season.Methods Immunohistochemistry for substance P (SP), calcitonin gene-related peptide (CGRP), vasoactive intestinal polypeptide (VIP) and neuropeptide tyrosine (NPY) was related to the characterization of inflammatory cells in tissues of patients with seasonal AR (n=18).Results While there was a significant increase in the number of eosinophils present if compared with a control group, no changes occurred in mast cell numbers. Immunostaining was abundantly found in different nerve fibre populations of both groups. SP expression was significantly increased in mucosal nerve fibres of patients with intermittent (seasonal) AR. Also, significantly increased numbers of VIP- and NPY-immunoreactive nerve fibres were found in biopsies of rhinitis patients in comparison with sections of normal human nasal mucosa. In contrast, CGRP expression did not change significantly.Conclusion The increase of neuropeptide expression in mucosal nerve fibres indicates a major role of the autonomous mucosal innervation in the pathophysiology of intermittent (seasonal) AR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.2004.01990.x
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  • 3
    Electronic Resource
    Electronic Resource
    Tree-pollen allergy is efficiently treated by short-term immunotherapy (STI) with seven preseasonal injections of molecular standardized allergens (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 53 (1998), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The efficacy and tolerance of short-term immunotherapy (STI) by seven preseasonal injections of tree-pollen allergens (ALK7 FrUhbltihermischung®) was investigated in a double-blind, placebo-controlled, multicenter study with 111 rhinoconjunctivitis patients. Nasal and bronchial symptoms simultaneously analyzed, and nasal symptoms as a single end point, but not the overall score of nasal, bronchial, and conjunctival symptoms, showed a significantly lower increase with STI during birch-pollen exposure (both P= 0.033, n= 105, Mann-Whitney U-test). However, a selective analysis with patients from centers with high recruitment figures (nS10 patients, n=29 STI, n=32 placebo) showed a significantly lower increase of nasal, bronchial, and overall symptom score (STI 11.0 vs placebo 18.0, P=0.001, U-test). STI had equidirected effects on conjunctival, nasal, and bronchial symptoms analyzed as multiple end points, although conjunctival symptoms were not significantly different as a single end point. The seasonal increase in drug use was reduced by 62% in the STI group compared with placebo (P=0.032, Mest), Specific IgG4 increased only after STI (P〈0,001); IgE was not significantly different. Eosinophil cationic protein remained unchanged with STI, but significantly increased with placebo in the pollen season (P=Qm3). STI was well tolerated. In conclusion, STI was shown to be efficacious and safe for the treatment of patients with tree-pollen rhinoconjunctivitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1998.tb03969.x
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  • 4
    Electronic Resource
    Electronic Resource
    erbB-2/Her-2 gene amplification and overexpression in parotid gland tumors (1993)
    Springer
    European archives of oto-rhino-laryngology and head & neck 250 (1993), S. 150-153 
    Details
    ISSN: 1434-4726
    Keywords: Proto-oncogenes ; Gene amplification ; Overexpression ; Parotid gland tumors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Proto-oncogenes represent a family of normal cellular genes that were identified on the basis of their similarity to genetic sequences with known tumorigenic + or transforming potential. Accumulating evidence links alterations in either the structure, copy number, or expression of one or another of these genes to neoplasia. One such gene, called erbB-2/Her-2 was found amplified in an adenocarcinoma of the human salivary gland and has also been found associated with primary human breast cancer. Patients with multiple copies of the gene have had a shorter overall survival. In the present study, 21 tumors of the parotid gland were examined by Southern and Northern blot hybridization for amplification and possible overexpression of the erbB-2/Her-2 oncogene. Normal parotid gland tissue was used as negative control. The parotid gland lesions comprised 7 pleomorphic adenomas, 5 squamous cell carcinomas, 4 cases of chronic fibrotic sialadenosis, 3 mucoepidermoid carcinomas as well as 1 lymphoma and 1 cystadenolymphoma. Gene amplification was found in 1 of the pleomorphic adenomas, with 2 tumors showing a significant overexpression of the erbB-2/Her-2 oncogene. Because 3–5% of all pleomorphic adenomas undergo malignant transformation, close follow-up of patients is currently underway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171701
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  • 5
    Electronic Resource
    Electronic Resource
    Otoplastik zur Korrektur abstehender Ohrmuscheln (1999)
    Springer
    HNO 47 (1999), S. 688-694 
    Details
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Otoplastik ; Abstehende Ohrmuscheln ; Key words Otoplasty ; Protruding ears
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Protruding ears are the most common auricular deformities for which patients seek consultation. These deformities belong to the first degree dysplasias and result from an overdeveloped concha, an underdeveloped anthelix or a prominent lobule. Otoplastic techniques to correct these malformations are based on such surgical principles as suturing, incision, excision, scoring and burring of the auricular cartilage. By emphasizing these basic procedures the most useful techniques are described. Special importance is placed on the indications for surgery, basic principles and techniques used.
    Notes: Zusammenfassung Abstehende Ohrmuscheln zählen zu den Ohrmuscheldysplasien ersten Grades und stellen die häufigste Indikation zur Durchführung einer Otoplastik dar. Die Ursachen bestehen meist in einer Conchahyperplasie, einer ungenügenden Anthelixbildung oder einem prominenten Lobulus. Operationsverfahren zur Korrektur dieser Formabweichungen können bestimmten Basistechniken wie der Naht-, Schnitt-, Fräs- oder Ritztechnik zugeordnet werden. Im Hinblick auf diese grundlegenden Prinzipien werden die wichtigsten Otoplastiktechniken beschrieben und deren Indikationen beurteilt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001060050446
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  • 6
    Electronic Resource
    Electronic Resource
    Prick-Test und nasaler Provokationstest mit individuellen Mehlextrakten bei Bäckerrhinitis (1999)
    Springer
    HNO 47 (1999), S. 718-722 
    Details
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Berufskrankheit ; Mehlstauballergie ; Diagnostik ; Sensitivität ; Key words Occupational rhinitis ; Flour allergy ; Bakers’ rhinitis ; Diagnostic testing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The reliability of skin prick tests (SPT) may be insufficient for the screening of occupational inhalant allergies. The influence of different flour extracts on the SPT in flour allergic subjects has not been compared previously. In this study, SPT reactions against two commercially available rye and wheat flour extracts and individually prepared extracts from flour samples were compared in 35 patients with known bakers’ rhinitis. Flour sensitization was confirmed by a positive nasal provocation test (NPT) and/or serum-specific IgE. The sensitivity of NPT with a combination of rye and wheat flour extracts of individual flour samples was 94%. Wheat and/or rye flour specific IgE (RAST≥2) was true positive in 86%. The sensitivity of the SPT was 94% for individual rye flour extracts compared to 38% and 59% for two commercially available rye flour extracts and 88% for individual wheat flour extract compared to 53% and 48% for commercially available wheat flour extracts. SPT and sIgE did not reveal a significant difference in prevalence between rye and wheat flour sensitization. Thirty healthy volunteers served as the control group. Three control subjects with histamine equivalent SPT reactions to grass pollen had a positive SPT reaction against individual flour extracts, whereas NPT with undiluted individual flour extracts was negative in all controls. SPT with individually prepared flour extracts appears to be sensitive for the demonstration of inhalant flour allergy. Our findings show that extracts of individual flour samples rather than commercially available extracts should be used for both SPT and NPT if flour allergy is suspected.
    Notes: Zusammenfassung Mehlstäube sind die häufigsten Auslöser einer beruflich bedingten allergischen Erkrankung der Atemwege. Der Einfluß unterschiedlicher Roggen- und Weizenmehlextrakte auf die Sensitivität und Spezifität des Prick-Tests bei Mehlallergien wurde bisher nicht untersucht. In der vorliegenden Studie wurde die Reaktion im Prick-Test und im nasalen Provokationstest (NPT) bei 35 Patienten mit inhalativer Mehlstauballergie untersucht. Der Prick-Test wurde mit aus eingesandten Mehlproben individuell hergestellten wäßrigen Extrakten sowie Roggen- bzw. Weizenmehlextrakten von 2 Herstellern durchgeführt. Der nasale Provokationstest wurde mit einer Mischung aus individuell hergestellten Extrakten durchgeführt. Eine Kontrollgruppe bestand aus 30 gesunden Personen. Der Nachweis von Serum-IgE gegen Roggen- und/oder Weizenmehl (RAST≥2) hatte eine Sensitivität von 86%. Der beiderseits durchgeführte NPT mit individuellen Roggen- und Weizenmehlextrakten hatte eine Sensitivität von 94%. Die Sensitivität des Prick-Tests mit individuellen Roggen- bzw. Weizenmehlextrakten betrug 97 bzw. 91%. Die entsprechenden Zahlen für die beiden kommerziell erhältlichen Roggen- bzw. Weizenmehlextrakte waren 38 und 59% bzw. 53 und 52%; 3 gegen Gräserpollen sensibilisierte Kontrollpersonen (10%) reagierten im Prick-Test gegen Mehlextrakte. Eine positive Reaktion im NPT trat in der Kontrollgruppe nicht auf. Für den Nachweis einer inhalativen Mehlallergie sollten für den Prick-Test und die nasale Provokationstestung Extrakte aus individuellen Mehlproben verwendet werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001060050451
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  • 7
    Electronic Resource
    Electronic Resource
    Sensibilisierung auf Chlorhexidin (1998)
    Springer
    HNO 46 (1998), S. 178-178 
    Details
    ISSN: 1433-0458
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001060050219
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  • 8
    Electronic Resource
    Electronic Resource
    erb B-3, a third member of the erbB/epidermal growth factor receptor gene family: its expression in head and neck cancer cell lines (1993)
    Springer
    European archives of oto-rhino-laryngology and head & neck 250 (1993), S. 392-395 
    Details
    ISSN: 1434-4726
    Keywords: Proto-oncogenes ; Gene amplification ; Growth factor receptors ; Head and neck cancer cell lines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Proto-oncogenes encoding growth factor receptors constitute several distinct families with close overall structural homology. The highest degree of homology can be observed in their catalytic domains, which are essential for intrinsic tyrosine kinase activity. Growth factor receptors in several of these families play critical roles in the regulation of normal cell growth and development. Some of these molecules have been implicated in the neoplastic process as well. A related DNA fragment distinct from epidermal growth factor receptor and erbB-2 genes was detected by reduced stringency hybridization of v-erbB to normal genomic human DNA. The expression of erbB-3 was studied by southern and northern blot technique in a subset of nine head and neck tumor cell lines, as well as in three immortalized cultures established from normal human salivary glands. No gene amplification of erb-B-3 was noted in any of the head and neck cell lines. The 6.2 kb transcript of erbB-3 was elevated significantly in an epidermoid carcinoma of the larynx (A388) and an esophageal carcinoma (HA 114).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180383
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  • 9
    Electronic Resource
    Electronic Resource
    Das Nasometer Ein Instrument zur Objektivierung der Hyperrhinophonie bei LKG-Patienten (1994)
    Springer
    Journal of orofacial orthopedics 55 (1994), S. 176-180 
    Details
    ISSN: 1615-6714
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The aim of this study was to evaluate the reliability and validity of the nasometer indiagnosing hypernasality in cleft palate patients. For this purpose the results of the nasometric examination of 30 patients with hypernasality were compared with the results obtained by using the currently taught methods. Sensitivity and specificity of nasometry were high with coefficients, respectively, of 0.80 and 1.00. Overall accuracy reached 0.90. Our results, which correspond almost exactly to those obtained in similar Anglo-American studies, demonstrate that also in German speaking countries the nasometer can be a reliable instrument for diagnosing hypernasality. Moreover, the nasometer presents the possibility of calculating the extent of hypernasality during routine examination and diagnosis.
    Notes: Zusammenfassung Aufgabe dieser Studie war es, die Zuverlässigkeit und Gültigkeit des Nasometers in der Diagnose der Hyperrhinophonie bei Patienten mit Lippen-Kiefer-Gaumen-Spalten zu überprüfen. Hierzu wurder die Ergebnisse der Nasometer-Untersuchung von 30 Spaltträgern den logopädischen Einschätzungen gegenübergestellt. Die Sensitivität erreichte einen Wert von 0,80, die Spezifität von 1,00 Die insgesamte Übereinstimmung belief sich auf 0,90. Unsere Ergebnisse-die nahezu denen vergleichbarer Untersuchungen im anglo-amerikanischen Sprachraum entsprechen-weisen das Nasometer als zuverlässiges Instrument in der Diagnose des offenen Näselns auch in der deutschen Sprache aus. Zudem bietet es die Möglichkeit, das Ausmaß der Hyperrhinophonie in der Routinediagnostik zu objektivieren.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02285408
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