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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Der Hautarzt 50 (1999), S. 499-502 
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Erworbene Acrodermatitis enteropathica ; Zinkmangeldermatosen ; Malnutrition ; Key words Acuired acrodermatitis enteropathica ; Zinc deficiency dermatitis ; Malnutrition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A patient on long term parenteral nutrition developed acrodermatitis enteropathica-like skin changes. Just as in the autosomal recessive disorder, acrodermatitis enteropathica, the lesions in our patient were caused by zinc deficiency. Replacement therapy with zinc led to rapid improvement.
    Notes: Zusammenfassung Wir stellen einen Fall von Acrodermatitis-enteropathica-ähnlichen Hautveränderungen bei einer Patientin mit längerfristiger parenteraler Ernährung vor. Ähnlich der autosomal rezessiven Acrodermatitis enteropathica beruhen auch die Hautveränderungen dieser Patientin auf einem Zinkmangel des Organismus. Die Substitution von Zink führt zu einer beeindruckenden Besserung.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Der Hautarzt 49 (1998), S. 730-732 
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Nävuszellnävus ; Nävus corymbiformis ; Zerebriformer intradermaler Nävus ; Key words Lobulated intradermal nevus ; Corymbiform nevus ; Cerebriform nevus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary There is a wide morphological variety in the appearance of melanocytic nevi. We report a case of a 77-year-old woman with a pedun-culated, lobulated intradermal nevus on her trunk. For this grape-like clinical variant, we propose the term „corymbiform nevus”.
    Notes: Zusammenfassung Nävuszellnävi zeigen eine ausgesprochene Variabilität ihrer klinischen Morphe. Wir berichten über eine 77jährige Patientin mit einem gestielten, lobulären, intradermalen Nävuszellnävus am Rumpf. Für dieses traubenförmige Erscheinungsbild schlagen wir den Ausdruck „Nävus corymbiformis” vor.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In a multicentre study of the German Contact Dermatitis Research Group, sodium lauryl sulfate (SLS) 0.25% and 0.5% aq. has been added to routine allergen patch tests to assess its properties as a convenient diagnostic indicator of individual susceptibility to irritation at the time of patch testing. Previous studies indicated that irritant SLS reactivity may be related to individual factors such as age and sex. As these factors are, in turn, among the important predictors of contact allergy to many allergens, e.g. summarized in the ‘MOAHLFA index’, the impact of the MOAHLFA factors on irritant SLS patch test reactivity, and thus a potential for confounding, was assessed in the 5971 participating patients. As a result of 2 logistic regression analyses with an irritant reaction to 0.25% and 0.5% SLS, respectively, as outcome, male sex was identified as a relatively weak but significant risk factor (OR 1.38), while age 40 years or older was an even weaker risk factor (OR 1.22 and 1.15, respectively). Upon detailed analysis, no clear age gradient could, however, be identified. 1-day exposure time almost halved the odds of an irritant SLS reaction. In conclusion, this type of SLS patch test can be regarded as robust, indicating individual irritability relatively independent from the individual factors analysed here.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Copenhagen : Munksgaard International Publishers
    Contact dermatitis 45 (2001), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: For testing with sodium lauryl sulphate (SLS), measurements of transepidermal water loss (TEWL) and cutaneous blood flow with laser Doppler (LD) are considered to be the most reliable methods. The aim of this study was to determine which method of measurement should be preferred when conducting SLS testing under varying conditions. Patch testing with SLS at different concentrations and exposure times was performed. TEWL values were compared with those of LD. TEWL values showed distinct changes at low SLS concentrations and short application periods. By contrast, higher SLS concentrations were necessary to increase LD values. Short application of patches changed TEWL rather than LD values. When evaluating SLS patch testing by bioengineering methods, TEWL measurement appears to be more suitable for a test procedure that provokes mild skin reactions (SLS concentration 〈1%), whereas LD measurement is more appropriate to evaluate pronounced skin reactions (SLS concentration 〈inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:01051873:COD450506:ges" location="ges.gif"/〉1%).
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK; Malden, USA : Blackwell Science Ltd/Inc.
    Contact dermatitis 50 (2004), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background and Objectives:  Tape stripping is a common method for investigating stratum corneum (SC) physiology as well as bioavailability and bioequivalence of topical drugs. However, little is known concerning the influence of procedures (anatomic site, pressure, pressure duration, tape removal rate) inherent in each stripping protocol.Methods:  Tape stripping was performed using tapes on the forearm, forehead and back. On the forearm different pressures (165 and 330 g cm−2), durations of pressure (2s and 10s), and removal rate (slow and rapid removal) was performed. Changes in skin physiology were evaluated by measurement of transepidermal water loss (TEWL) and hydration.Results:  A significant influence of all parameters on the TEWL-increase as a function of tape strip number was observed. The fastest increase was demonstrated on the forehead, followed by the back and, lastly, the forearm. Rapid removal produced a protracted increase in comparison to the slow removal. 10s pressure induced a faster increase of TEWL than 2s pressure. Likewise, the 330 g cm−2 pressure induced an earlier increase than the 165 g cm−2. Skin hydration was not influenced by the variables tested.Conclusion:  Tape stripping results are influenced dramatically by all investigated parameters. A standardized procedure is necessary for a comparable study design. A dynamic SC stress test to more closely investigate SC cohesion is proposed based on the present observations.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 33 (1995), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To examine the skin harrier function of patients with acute and healed irritant contact dermatitis (n= 80) baseline transepidermal water loss (TEWL) was quantitatively measured using an evaporimeter. Healthy subjects served as controls (n= 40). Test areas were the forearm and the thigh. A significant increase in TCVV'L was observed in the patients with acute and with healed irritant contact dermatitis (ICD) as compared LO healthy volunteers (P≤ 0.01). TEWL values in both test areas were com parable and markedly correlated (p≤ 0.01). with each other in every group. Thus, it is possible that basal TEWL depends more on the intrinsic skin barrier function of the subjects rather than the 2 anatomical regions examined. TEWL at the forearm with acme ICD was significantly higher (P≤ 0.01). than that of the group with healed ICD, but not for TCWL at the thigh suggesting that ICD may aggravate the barrier function of the adjacent involved skin. It is assumed, that increased basal TEWL in patients with ICD may relied a constitutional deviation of epidermal barrier function. This event seems to be comparable with the well-known symptom of atopic individuals. Using a detailed atopic scoring system in such a study may clarify the question of whether a proportion of patients with hand ICD may indeed be atopic individuals.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 40 (1999), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The relevance of the irritant skin reaction of individuals with an atopic history (atopic dermatitis, rhinoconjunctivitis or atopic asthma) to sodium lauryl sulfate (SLS), a widely used irritant, is still controversial. The aim of this study was to evaluate transepidermal water loss (TEWL) as an indicator of stratum corneum integrity, before and after SLS patch testing, in various groups of atopic individuals with and without atopic dermatitits. 95 volunteers were divided into 4 groups: (1) individuals with active atopic dermatitis; (2) individuals with a history of atopic dermatitis but without active skin lesions; (3) individuals with rhinoconjunctivitis or atopic asthma without any symptoms at the time of testing; (4) healthy individuals serving as controls. The volunteers were patch-tested at the unaffected volar side of the forearm with aqueous SLS 0.5% for 48 h. TEWL was measured before application and after removal of the patch. Individuals with active atopic dermatitis showed a significantly higher TEWL value after SLS and a tendency to a higher basal TEWL as compared to the 3 other groups. There were no significant differences in TEWL between individuals who were classified as atopic but without active dermatitis, individuals with rhinoconjunctivitis or atopic asthma and healthy controls, either at the basal or at the post-SLS measurement. Enhanced skin susceptibility is only present in individuals with active dermatitis. The skin susceptibility of atopic individuals might therefore be increased as soon as the skin becomes ec-zematous, suggesting a reduced epidermal integrity probably caused by the endogenous atopy and/ or respiratory allergens. When interpreting the atopy score in relation to skin susceptibility, the actual condition of the skin should hence be taken into consideration.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Der Hautarzt 50 (1999), S. 769-778 
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Irritationstest ; Hautphysiologische Meßmethoden ; Hautempfindlichkeit ; Key words Irritant testing ; Bioengineering methods ; Skin susceptibility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Patch testing with sodium lauryl sulfate (SLS) has been frequently used in the last decade. The evaluation of the SLS test can be performed visually, or with bioengineering methods. Among these, the transepidermal water loss is the most appropriate method, but measurements by laser Doppler flowmetry, colorimetry or corneometry may yield additional relevant data. Various factors such as age, area of testing or climatic conditions may also influence the SLS test, so such factors should be considered when different studies are compared. If correctly used, the SLS test can provide valuable information regarding the skin susceptibility to irritation. An overestimation of the test, just based on objective measurements with bioengineering methods, should be avoided, as the bioengineering data are capable of great precision and reproducibility, but can only define phenomena and not the causal event.
    Notes: Zusammenfassung Das Detergens Natriumlaurylsulfat wird zunehmend in der dermatologischen Hauttestung zur Untersuchung irritativer Reaktionen eingesetzt. Die Testung besteht entweder aus einer einmaligen Applikation (akute Irritation) oder wiederholten Applikationen (chronische Irritation). Die Evaluation des Tests kann visuell sowie unter Zuhilfenahme von hautphysiologischen Meßmethoden vorgenommen werden. Bewährt hat sich v.a. die Messung des transepidermalen Wasserverlusts, aber auch die Laser-Doppler-Rheometrie, die Colorimetrie oder die Corneometrie können je nach Fragestellung wertvolle Ergebnisse liefern. Verschiedene Faktoren wie Alter, Teststelle und klimatische Bedingungen haben einen Einfluß auf die Testresultate, was bei dem Vergleich unterschiedlicher Studien berücksichtigt werden muß. Richtig angewandt kann der Natriumlaurylsulfat-Test wertvolle Aufschlüsse über die individuelle Hautirritabilität geben. Vor einer Überbewertung des Tests, gerade durch die scheinbar exakte Auswertung mittels hautphysiologischer Meßmethoden, muß jedoch gewarnt werden.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Der Hautarzt 51 (2000), S. 203-218 
    ISSN: 1432-1173
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Als Lernziel dieses Artikels soll der Leser die wichtigsten epidemiologischen, ätiopathogenetischen, klinischen und therapeutischen Aspekte der irritativen Kontaktdermatitis erfahren. Mit einem Überblick über gebräuchliche Hautirritabilitätstests und hautphysiologische Messmethoden soll der Leser diagnostische Methoden kennenlernen. Die Notwendigkeit einer engen, motivierenden Führung des Patienten wird herausgearbeitet, da neben der suffizienten dermatologischen Lokaltherapie eine längerfristige Besserung nur durch eine Verhaltensänderungen des Patienten erreicht werden kann. Erläuterungen zur Prophylaxe sollen eine frühzeitige Risikoeinschätzung ermöglichen und zur Beratung ermutigen.
    Type of Medium: Electronic Resource
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