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  • 1
    Electronic Resource
    Electronic Resource
    Assignment of the gene for carboxypeptidase A to human chromosome 7q22→qter and to mouse chromosome 6 (1986)
    Springer
    Human genetics 〈Berlin〉 72 (1986), S. 27-31 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A rat cDNA probe for preprocarboxypeptidase A was used to follow the segregation of the human gene for carboxypeptidase A (CPA) in 49 human x mouse somatic cell hybrids using Southern filter hybridization techniques. CPA was assigned to human chromosome 7q22→qter. Similarly, the probe was used to follow the segregation of the mouse gene for carboxypeptidase A (Cpa) in 19 mouse x Chinese hamster somatic cell hybrids. Cpa was assigned to mouse chromosome 6. The gene for carboxypeptidase A forms part of a syntenic group that is conserved in man and mouse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00278813
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  • 2
    Electronic Resource
    Electronic Resource
    Mouse immune interferon (IFN-γ) gene is on chromosome 10 (1984)
    Springer
    Somatic cell and molecular genetics 10 (1984), S. 531-534 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A cDNA clone for mouse immune interferon has been used to map the mouse interferon γ gene (Ifg)to a specific chromosome. This clone, which contains a 638-bp insert, detects an 18-kb HindIII fragment of mouse DNA. The presence of the mouse Ifgtgene in cell hybrids and its chromosomal location were determined by assaying cell hybrid DNA for the presence of the 18-kb HindIII fragment by Southern filter hybridization. Under the hybridization conditions used, Chinese hamster DNA did not hybridize to the cDNA probe. The segregation of mouse chromosomes in cell hybrids indicated that Ifgis located on chromosome 10. Previously, we have mapped immune interferon to the p12.05 → qter region of chromosome 12 in humans (1). This region of chromosome 12 also contains the genes for peptidase B and citrate synthase. The homologous genes in mouse are also located on chromosome 10, suggesting that these genes comprise a conserved linkage group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01534857
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  • 3
    Electronic Resource
    Electronic Resource
    Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse (1984)
    Springer
    Somatic cell and molecular genetics 10 (1984), S. 377-383 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The mouse genes for the serine proteases trypsin (Try-1,chymotrypsin B (Ctrb),and elastase (Ela-1)were chromosomally assigned using Southern blot hybridization of mouse × Chinese hamster cell hybrid DNA. cDNA probes for the three genes were hybridized to cell hybrid DNA cleaved with BamHI or HindIII and the segregation of Try-1, Ctrb,and Ela-1was correlated with the segregation of mouse chromosomes. Try-1is located on chromosome 6, Ctrbis on chromosome 8, and Ela-1is on chromosome 15. The three genes fall into three syntenic groups that are conserved in the mouse and human genomes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01535633
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  • 4
    Electronic Resource
    Electronic Resource
    Mapping thyrotropin β subunit gene in man and mouse (1986)
    Springer
    Somatic cell and molecular genetics 12 (1986), S. 307-311 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Thyrotropin (TSH) is composed of two subunits: α and β. Previously, we have mapped the TSHα gene to human chromosome 6 and mouse chromosome 4. In this study we have located the human TSHβ gene on chromosome 1 and the mouse TSHβ gene to chromosome 3. These data suggest that the TSHβ gene lies in a conserved linkage group with the genes for amylase 1 and 2, nerve growth factor, and the protooncogene Nras.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01570791
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  • 5
    Electronic Resource
    Electronic Resource
    Human β-glucuronidase: Assignment of the structural gene to chromosome 7 using somatic cell hybrids (1977)
    Springer
    Biochemical genetics 15 (1977), S. 367-382 
    Details
    ISSN: 1573-4927
    Keywords: human β-glucuronidase ; chromosome 7 structural gene assignment ; tetrameric structure ; lysosomal enzyme linkages ; cell hybrids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract β-Glucuronidase (GUS) has become an important enzyme model for the genetic study of molecular disease, enzyme realization, and therapy, and for the biogenesis and function of the lysosome and lysosomal enzymes. The genetics of human β-glucuronidase was investigated utilizing 188 primary man-mouse and man-Chinese hamster somatic cell hybrids segregating human chromosomes. Cell hybrids were derived from 16 different fusion experiments involving cells from ten different and unrelated individuals and six different rodent cell lines. The genetic relationship of GUS to 28 enzyme markers representing 19 linkage groups was determined, and chromosome studies on selected cell hybrids were performed. The evidence indicates that the β-glucuronidase gene is assigned to chromosome 7 in man. Comparative linkage data in man and mouse indicate that the structural gene GUS is located in a region on chromosome 7 that has remained conserved during evolution. Involvement of other chromosomes whose genes may be important in the final expression of GUS was not observed. A tetrameric structure of human β-glucuronidase was demonstrated by the formation of three heteropolymers migrating between the human and mouse molecular forms in chromosome 7 positive cell hybrids. Linkage of GUS to other lysosomal enzyme genes was investigated. β-Hexosaminidase HEX B) was assigned to chromosome 5; acid phosphatase2 (ACP 2) and esterase A4 (ES-A 4) were assigned to chromosome 11; HEX A was not linked to GUS; and α-galactosidase (α-GAL) was localized on the X chromosome. These assignments are consistent with previous reports. Evidence was not obtained for a cluster of lysosomal enzyme structural genes. In demonstrating that GUS was not assigned to chromosome 9 utilizing an X/9 translocation segregating in cell hybrids, the gene coding for human adenylate kinase1 was confirmed to be located on chromosome 9.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00484467
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  • 6
    Electronic Resource
    Electronic Resource
    Homologs of genes and anonymous loci on human Chromosome 13 map to mouse Chromosomes 8 and 14 (1995)
    Springer
    Mammalian genome 6 (1995), S. 263-268 
    Details
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract To enhance the comparative map for human Chromosome (Chr) 13, we identified clones for human genes and anonymous loci that cross-hybridized with their mouse homologs and then used linkage crosses for mapping. Of the clones for four genes and twelve anonymous loci tested, cross-hybridization was found for six, COL4A1, COL4A2, D13S26, D13S35, F10, and PCCA. Strong evidence for homology was found for COL4A1, COL4A2, D13S26, D13S35, and F10, but only circumstantial homology evidence was obtained for PCCA. To genetically map these mouse homologs (Cf10, Col4a1, Col4a2, D14H13S26, D8H13S35, and Pcca-rs), we used interspecific and intersubspecific mapping panels. D14H13S26 and Pcca-rs were located on the distal portion of mouse Chr 14 extending by ∼30 cM the conserved linkage between human Chr 13 and mouse Chr 14, assuming that Pcca-rs is the mouse homolog of PCCA. By contrast, Cf10, Col4a1, Col4a2, and D8H13S35 mapped near the centromere of mouse Chr 8, defining a new conserved linkage. Finally, we identified either a closely linked sequence related to Col4a2, or a recombination hot-spot between Col4a1 and Col4a2 that has been conserved in humans and mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00352413
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