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  • 1
    Electronic Resource
    Electronic Resource
    Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer (1987)
    [s.l.] : Nature Publishing Group
    Nature 329 (1987), S. 451-454 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] DNA samples prepared from tumour and normal tissues of the same individual were obtained from cultured cell lines HI28 and H209 with matching B-cell lines (H128BL and H209BL) and seven autopsy samples of normal and tumour tissue. All cases were histologically confirmed as small-cell lung ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/329451a0
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  • 2
    Electronic Resource
    Electronic Resource
    Assignment of the gene for carboxypeptidase A to human chromosome 7q22→qter and to mouse chromosome 6 (1986)
    Springer
    Human genetics 〈Berlin〉 72 (1986), S. 27-31 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A rat cDNA probe for preprocarboxypeptidase A was used to follow the segregation of the human gene for carboxypeptidase A (CPA) in 49 human x mouse somatic cell hybrids using Southern filter hybridization techniques. CPA was assigned to human chromosome 7q22→qter. Similarly, the probe was used to follow the segregation of the mouse gene for carboxypeptidase A (Cpa) in 19 mouse x Chinese hamster somatic cell hybrids. Cpa was assigned to mouse chromosome 6. The gene for carboxypeptidase A forms part of a syntenic group that is conserved in man and mouse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00278813
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  • 3
    Electronic Resource
    Electronic Resource
    Human parathyroid hormone gene (PTH) is on short arm of chromosome 11 (1983)
    Springer
    Somatic cell and molecular genetics 9 (1983), S. 609-616 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The human gene for parathyroid hormone (PTH) was chromosomally mapped using human-rodent hybrids and Southern filter hybridization of cell hybrid DNA. A recombinant DNA probe containing human PTHcDNA insert (pPTHm122) hybridized to a 3.7-kb fragment in human DNA cleaved with the restriction enzyme EcoRI. By correlating the presence of this fragment in somatic cell hybrid DNA with the human chromosomal content of the hybrid cells, the PTHgene was mapped to the short arm of the chromosome 11.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01574261
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  • 4
    Electronic Resource
    Electronic Resource
    Chromosomal assignments of human genes for serine proteases trypsin, chymotrypsin B, and elastase (1984)
    Springer
    Somatic cell and molecular genetics 10 (1984), S. 369-376 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The genes for the serine proteases trypsin, chymotrypsin B, and elastase were chromosomally assigned in man using cDNA probes that have been isolated from a rat pancreatic cDNA library. DNA from human × rodent somatic cell hybrids was cleaved with BamHI or EcoRI and analyzed by Southern filter hybridization methods for the segregation of the genes for trypsin-1 (TRY1), chymotrypsin B (CTRB), and elastase-1 (ELA1). TRY1 was assigned to human chromosome 7q22→qter, CTRB to chromosome 16, and ELA1 to chromosome 12. Although the three genes are members of the same gene family, they are dispersed over different chromosomes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01535632
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  • 5
    Electronic Resource
    Electronic Resource
    Mouse immune interferon (IFN-γ) gene is on chromosome 10 (1984)
    Springer
    Somatic cell and molecular genetics 10 (1984), S. 531-534 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A cDNA clone for mouse immune interferon has been used to map the mouse interferon γ gene (Ifg)to a specific chromosome. This clone, which contains a 638-bp insert, detects an 18-kb HindIII fragment of mouse DNA. The presence of the mouse Ifgtgene in cell hybrids and its chromosomal location were determined by assaying cell hybrid DNA for the presence of the 18-kb HindIII fragment by Southern filter hybridization. Under the hybridization conditions used, Chinese hamster DNA did not hybridize to the cDNA probe. The segregation of mouse chromosomes in cell hybrids indicated that Ifgis located on chromosome 10. Previously, we have mapped immune interferon to the p12.05 → qter region of chromosome 12 in humans (1). This region of chromosome 12 also contains the genes for peptidase B and citrate synthase. The homologous genes in mouse are also located on chromosome 10, suggesting that these genes comprise a conserved linkage group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01534857
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  • 6
    Electronic Resource
    Electronic Resource
    Localization of human U1 small nuclear RNA genes to band p36.3 of chromosome 1 by in situ hybridization (1984)
    Springer
    Somatic cell and molecular genetics 10 (1984), S. 307-313 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Ul small nuclear RNA (Ul snRNA) is encoded by a large family of genes (30–125 copies/haploid genome) which are transcribed by RNA polymerase II. Ul snRNA is thought to function in gene splicing. Since the Ul genes were found to be 〉20 kb apart by analyzing genomic phage clones, the chromosomal location of Ul genes in the human genome was determined using Southern filter analysis of DNA isolated from human-rodent somatic cell hybrids and by in situ hybridization. Human DNA digested with PvuII and probed with a Ul-specific probe, pD2, show several major hybridizing fragments. Of these, two human PvuII fragments of 1.4 kb and 2.4 kb had unique mobilities compared to mouse fragments. In a study of 19 cell hybrids, the human-specific Ul fragments segregated with the chromosome 1 markers peptidase C and adenylate kinase 2. All other chromosomes showed〉-19% discordancy. An additional 13 karyotyped cell hybrids, analyzed by Southern filter analysis, confirmed the assignment of this class of Ul genes to chromosome 1. Additional digests with MspI and PstI indicated that most Ul genes are located on chromosome 1. To determine if the Ul RNAs are located predominantly at one site or dispersed over chromosome 1, a tritium-labeled Ul probe was hybridized in situ to metaphase chromosomes. The majority of the grains were at band 1p36.3, suggesting that most of the Ul genes are located in this region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01535252
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  • 7
    Electronic Resource
    Electronic Resource
    Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse (1984)
    Springer
    Somatic cell and molecular genetics 10 (1984), S. 377-383 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The mouse genes for the serine proteases trypsin (Try-1,chymotrypsin B (Ctrb),and elastase (Ela-1)were chromosomally assigned using Southern blot hybridization of mouse × Chinese hamster cell hybrid DNA. cDNA probes for the three genes were hybridized to cell hybrid DNA cleaved with BamHI or HindIII and the segregation of Try-1, Ctrb,and Ela-1was correlated with the segregation of mouse chromosomes. Try-1is located on chromosome 6, Ctrbis on chromosome 8, and Ela-1is on chromosome 15. The three genes fall into three syntenic groups that are conserved in the mouse and human genomes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01535633
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  • 8
    Electronic Resource
    Electronic Resource
    Mapping thyrotropin β subunit gene in man and mouse (1986)
    Springer
    Somatic cell and molecular genetics 12 (1986), S. 307-311 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Thyrotropin (TSH) is composed of two subunits: α and β. Previously, we have mapped the TSHα gene to human chromosome 6 and mouse chromosome 4. In this study we have located the human TSHβ gene on chromosome 1 and the mouse TSHβ gene to chromosome 3. These data suggest that the TSHβ gene lies in a conserved linkage group with the genes for amylase 1 and 2, nerve growth factor, and the protooncogene Nras.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01570791
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  • 9
    Electronic Resource
    Electronic Resource
    Human gastrin-releasing peptide gene is located on chromosome 18 (1987)
    Springer
    Somatic cell and molecular genetics 13 (1987), S. 87-91 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Gastrin-releasing peptide (GRP), a bombesin-like peptide, increases plasma levels of gastrin, pancreatic polypeptide, glucagon, gastric inhibitory peptide, and insulin. GRP is produced in large quantities by small-cell lung cancer and acts as a growth factor for these cells. To determine if chromosomal changes in small-cell lung cancer are related to the expression of GRP, we chromosomally mapped the gene using human-mouse somatic cell hybrids. Twenty hybrids, characterized for human chromosomes, were analyzed by Southern filter hybridization of DNA digested with EcoRI. Human DNA cut with EcoRI yields a major band of 6.8 kb and a minor band of 11.3 kb. The 6.8 kb band segregated concordantly with chromosome 18 and the marker peptidase A. The chromosome 3 abnormalities seen in small-cell lung cancer do not correlate with the chromosomal location of GRP, suggesting that the elevated expression of this gene may be due to mechanisms other than chromosomal rearrangement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02422303
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  • 10
    Electronic Resource
    Electronic Resource
    Characterization of naturally occurring auxotrophic mammalian cells (1979)
    Springer
    Somatic cell and molecular genetics 5 (1979), S. 271-277 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In a previous study, several cultured cell lines were detected which are naturally occurring auxotrophs. In this investigation, the enzyme deficiencies involved are described. It is demonstrated that the Chinese hamster cell lines CHO(Kl), YH21, RJK-36, and CHW-1102 are deficient in cystathionase and argininosuccinate synthetase. In addition, CHO (Kl) and CHW-1102 were found to lack argininosuccinate lyase. CHW-1102 cells were also found to be unable to proliferate in medium containing branchedchain α-keto acids in place of the corresponding L-amino acids since CHW-1102 cells lack branched-chain aminotransferase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01539166
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