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  • 1
    Electronic Resource
    Electronic Resource
    Clinical trial of natural human lymphocyte-derived interleukin 2 in cancer patients: Effects on cytokine production and suppressor cell status (1991)
    Springer
    Biotherapy 3 (1991), S. 309-318 
    Details
    ISSN: 1573-8280
    Keywords: cancer immunotherapy ; natural interleukin 2 ; suppressor cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Lymphocyte-derived, natural, glycosylated interleukin 2 (IL 2) may have different effectsin vivo than the non-glycosylated recombinant IL 2 hitherto employed in clinical trials. To test this, 9 tumor patients were given 3–6 × 106 U/day natural IL 2 by continuous infusion for 5 days. Compared with previously published results obtained using recombinant IL 2, as far as similar tests were performed, no unexpected results were obtained with natural IL 2 in the present study. Plasma TNF-α levels increased considerably during therapy, IFN-γ very slightly, whereas IL 2-stimulated secretion of either cytokinein vitro fluctuated greatly. CD 16+ and CD25+ cells increased and CD45R+ cells decreased after treatment, consistent with significant lymphocyte activationin vivo. MHC-unrestricted cytotoxicity increased after treatment. The level of CD8+ cells was and remained within the normal range, although suppressive activity generated in mixed lymphocyte culture was deficient prior to therapy. Interestingly, this normalised after therapy. These results extend studies of immunological monitoring of patients receiving IL 2, based on the first trial using natural rather than recombinant IL 2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02221323
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  • 2
    Electronic Resource
    Electronic Resource
    Geochronology of high-pressure rocks on Sifnos (Cyclades, Greece) (1979)
    Springer
    Contributions to mineralogy and petrology 70 (1979), S. 245-255 
    Details
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Polymetamorphic rocks of Sifnos (Greece) have been investigated by Rb-Sr, K-Ar, and fission track methods. Critical mineral assemblages from the northern and southernmost parts of Sifnos include jadeite+quartz+3T phengite, and omphacite+garnet +3T phengite, whereas the central part is characterized by the assemblage albite+chlorite+epidote+2M 1 phengite. K-Ar and Rb-Sr dates on phengites (predominantly 3T) of the best preserved high P/itTmetamorphic rocks from northern Sifnos gave concordant ages around 42 m.y., indicating a Late Lutetian age for the high P/T metamorphism. Phengites (2M 1+3T) of less preserved high P/T assemblages yielded K-Ar dates between 48 and 41 m.y. but generally lower Rb-Sr dates. The higher K-Ar dates are interpreted as being elevated by excess argon. K-Ar and Rb-Sr ages on 2M 1 phengites from central Sifnos vary between 24 and 21 m.y. These ages date a second, greenschist-facies metamorphism which overprinted the earlier high-pressure metamorphic rocks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00375354
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  • 3
    Electronic Resource
    Electronic Resource
    Produktionsintegrierter Umweltschutz - Verwertung von ReststoffenVortrag von H. Lenz auf dem Jahrestreffen der Verfahrens-Ingenieure, 27. bis 29. Sept. 1989 in Berlin. (1989)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 61 (1989), S. 860-866 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Production-integrated environmental protection - Utilization of residues. Chemical plants as well as coal-fired powerstations utilize chemical reactions in order to produce materials or energy. Most of these reactions additionally produce gaseous, liquid, or solid residues. It is the main objective of production-integrated environmental protection to use these residues as suitable feedstocks in order to reduce environmental pollution and lower the consumption of raw materials. Several examples from the BASF Group will show how, by crossing the borders of the respective plant, reasonable solutions for material, or at least energetic, utilization of residues can be achieved. As a result of permanent efforts in production-integrated environmental protection over many years and despite increasing outputs the emissions of the chemical industry have been continuously reduced.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330611104
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    Paper (German National Licenses)
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