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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 58 (1986), S. 200-202 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food processing and preservation 28 (2004), S. 0 
    ISSN: 1745-4549
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Peak histamine concentrations of 0.023, 0.031 and 0.027 g histamine/100 g muscle and maximal bacteria concentrations of 1.75, 1.59 and 0.423 g dry cells/100 g muscle were observed in muscles of jack mackerel stored at 25, 15 and 5C, respectively. Incubated fish homogenates suggest rate and transport limitations in histamine formation in muscle. The Mulchandani model predicted bacterial growth in muscle. The Luedeking and Piret expression fitted histamine formation in muscle; α values were 3.0 × 10−3, 1.23 × 10−2 and 4.17 × 10−2 g histamine/g dry cells, while β-values were 4.5 × 104, 8.0 × 10−5 and 0 g histamine/g dry cells × h at 25, 15, and 5C, respectively. The model predicts that jack mackerel could be stored from 4.5 to 5.5 days in ice, from 1 to 2 days at 15C and from 17 h to 2 days at 25C before fishmeal quality might be affected.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Pharmakokinetik von Cefoperazon wurde bei sechs Patienten mit T-Drainage nach zweistündiger Infusion von 2 g der Substanz untersucht. Acht gesunde freiwillige Probanden bildeten die Kontrollgruppe. Wie die Ergebnisse an fünf Patienten mit normalen Leberfunktionstests bestätigten, wurden ungewöhnlich hohe Konzentrationen in Serum und Galle erzielt. Die Galle-Cefoperazon-Konzentrationen betrugen mehr als 2000 mg/l und waren 10- bis 20mal so hoch wie die Serumkonzentrationen, obwohl sich im Vergleich zu den Kontrollen eine verminderte biliäre Exkretion der Substanz heraussteilte. Bei dem sechsten Patienten mit cholestatischem Ikterus war die extrarenale Clearance von Cefoperazon deutlich vermindert, jedoch wurden immer noch therapeutisch wirksame Konzentrationen in der Galle erreicht.
    Notes: Summary The pharmacokinetics of cefoperazone were studied in six patients with T-tube drainage after a two-hour intravenous infusion of 2 g. Eight healthy volunteers constituted the control group. The results of five patients with normal liver function tests confirmed that unusually high concentrations were obtained in serum and bile. Cefoperazone concentrations in the bile reached more than 2,000 mg/l and were 10 to 20 times higher than those in serum, although the findings showed reduced biliary excretion when compared with the control group. In the sixth patient with cholestatic jaundice, extrarenal clearance of cefoperazone was markedly reduced, but therapeutic biliary concentrations were still obtained.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 353 (1981), S. 241-250 
    ISSN: 1435-2451
    Keywords: Peritonitis ; Prognostic factors ; Chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 78 Kranke mit waschungsbedürftiger Bauchfellentzündung aus drei chirurgischen Kliniken werden nach Ursprungsort, Art und Ausmaß der Peritonitis analysiert. Die operative Therapie wird dargestellt. Bei diesen 78 Kranken wird als zusätzliche Behandlung das neue Chemotherapeuticum und Antiendotoxin Taurolin anstelle eines Antibioticum angewandt. Über den postoperativen Verlauf wird detailliert berichtet (Temperaturen über 38 °C, Sekundärheilung, Entlassungszeitpunkt und ernstere Komplikationen). Eigenschaften des postoperativen Verlaufs lassen sich mit prä- und intraoperativen Befunden korrelieren: 1. postoperatives Fieber über 38 °C tritt bei der Hälfte der Patienten auf, überdurchschnittlich häufig nach Perforation von Magen und Zwölffingerdarm; 2. jeder zweite Patient heilt sekundär, vermehrt häufig nach gallenwegsbedingter und appendicitischer Peritonitis; 3. ernstere Komplikationen ereignen sich bei 29,5 % der Patienten, besonders nach Peritonitis ausgehend von Magen, Dünn- oder Dickdarm; 4. die Gesamtletalität von 11,5 % wird bei Dünn- oder Dickdarmbedingter Peritonitis deutlich überschritten. Der Peritonitisindex gebildet aus prä- und intraoperativen Faktoren kann signifikant zwischen den später Verstorbenen und Überlebenden unterscheiden. Bei 80 % dieser 78 Kranken mit schwerer Peritonitis war Taurolin ohne zusätzliche Gabe eines Antibiotikum erfolgreich.
    Notes: Summary From three different surgical departments 78 patients with purulent peritonitis are analyzed according to cause, origin, and extent of peritonitis. Operative therapy is presented. As additional antibacterial therapy the new chemotherapeutic agent, Taurolin, with antiendotoxin-effect is used. The postoperative course (temperature exceeding 38 °C, secondary wound healing, day of discharge, and serious complications) is correlated with pre- and intraoperative parameters; for instance, 1. postoperative fever occurs in one half of the patients, more frequently following perforation of stomach and duodenum; 2. every second patient shows secondary wound healing, this happens even more often in peritonitis arising from biliary disease or appendicitis; 3. in 29.5 % of the patients serious complications arise, especially in patients with peritonitis originating in stomach, small intestine or large bowel; 4. overall mortality of 11.5 % is surpassed in patients with peritonitis originating from small intestine or large bowel. The so-called peritonitis-index (calculated on the basis of pre- and intraoperative factors) shows a significant difference between survivors and patients dying during the postoperative course. In 80 % of the 78 patients with purulent peritonitis taurolin was effective as a substitute for the usual antibiotics.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The Intersection Point Method (IPM) is a new method for the determination of an analyte in the presence of several unknown interferences. The method is based on the Apparent Content Curves (ACC) from derivative signals. To test the proposed procedure an analysis of mixtures of indicators with strong spectral overlapping was carried out. Results obtained agree with the theoretical values. Besides, the determination of caffeine in several pharmaceuticals by IPM provides good results.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    International journal of colorectal disease 1 (1986), S. 152-154 
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twenty-two patients treated for rectal trauma between 1975 and 1985 were reviewed. There were 13 males and nine females, of mean age 38 years (18–72 years). Causes included gunshot (2), sexual trauma (8), road accident (5), impalement (5), polypectomy (2). Two patients died, giving a treatment mortality of 9%. Cases with peritonitis or sphincter injury were treated by defunctioning colostomy and immediate repair of rectum and sphincter. Of 14 such patients the colostomy had been closed in all but one, who accounted for the only failed sphincter repair out of eight performed. The results show the success of a policy of faecal diversion for intraperitoneal rectal injury and sphincter damage and of local repair without diversion for most cases with extraperitoneal rectal injury.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    International journal of colorectal disease 9 (1994), S. 163-164 
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    International journal of colorectal disease 13 (1998), S. 108-111 
    ISSN: 1432-1262
    Keywords: Key words Human papilloma virus ; HPV ; Anal carcinoma ; Cervical dysplasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les virus HPV (16 et 18) sont connus pour jouer un rôle important dans l'étiologie de la dysplasie cervicale, mais les relations avec le cancer du canal anal demeurent peu claires. Des prélèvements chirurgicaux chez 80 femmes traitées pour un cancer épidermoïde du canal anal à la Policlinique de Chirurgie de Genève entre 1976 et 1989 ont été analysés rétrospectivement. La recherche du virus HPV a été réalisée chez 41 d'entre elles dont le DNA a été suffisamment préservé pour permettre une telle analyse. 17 prélèvements (42%) contiennent du HPV avec un pourcentage élevé de HPV de haut grade (15/41, 36%). 38 des 80 patientes ont également subi des frottis du col utérin dont 18% ont révélé la présence d'un carcinome cervical. Les résultats de cette étude ont été comparés avec les données épidémiologiques et suggèrent qu'une infection génitale HPV prédispose non seulement au cancer du col, mais également au cancer du canal anal par contamination de contiguïté.
    Notes: Abstract Human papilloma virus (HPV; 16 and 18) is known to play an important etiologic role in cervical dysplasia, but its relationship with anal carcinoma is still unclear. Surgical samples from 80 female patients treated for anal epidermoid carcinoma in the Policlinic of Surgery in Geneva between 1976 and 1989 were retrospectively studied. Of these, HPV detection was performed in 41 whose DNA was preserved well enough to allow such an analysis. Seventeen (42%) samples contained HPV, with a high percentage of high risk HPV (15/41, 36%). Thirty-eight of the 80 patients had a cervical smear, of which 18% revealed cervical carcinoma. When compared with epidemiological data, the results of this study suggest that genital HPV infection predisposes not only to cervical cancer, but also to anal carcinoma, possibly by means of contiguous contamination.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    International journal of colorectal disease 3 (1988), S. 132-134 
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rectal varices represent a rare condition even in cases of portal hypertension. A case of bleeding ano-rectal varices presenting as the first manifestation of portal hypertension is reported. Treatment by sclerotherapy was successful.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    International journal of colorectal disease 13 (1998), S. 154-156 
    ISSN: 1432-1262
    Keywords: Key words Hemorrhoids ; Rubber band ligation ; Success rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé La ligature élastique représente une technique de choix pour traiter les hémorroïdes de stade II. Les résultats à long terme (〉5 ans) ne sont cependant pas établis. Nous avons, sur une période de 18 ans et un suivi moyen de 5,6 ans, determiné les récidives après traitement par ligatures élastiques de premières poussées symptomatiques d'hémorroïdes de stade II chez 92 patients. Une analyse selon la méthode de Kaplan-Meier permet de définir la probabilité cumulative de succès de ce traitement de 0,77 (intervalle: 0,67–0,88) à 4.9 ans et de 0,68 (intervalle: 0,50–0,86) à 10,6 ans. Les résultats à long terme du traitement des hémorroïdes de stade II sont bons et justifient l'utilisation de cette technique comme traitement de premier recours.
    Notes: Abstract Rubber band ligation is a well established treatment of internal second-degree hemorrhoids. Up to now, the long-term results (〉5 years) of this method have not been assessed. The aim of this study was to determine the long-term success rate of rubber band ligation in patients with a first episode of second-degree hemorrhoids not responding to medical treatment (local cream with laxative). A total of 92 patients who were treated between 1979 and 1997 for second-degree hemorrhoids responded to a questionnaire. The need for complementary conservative (sclerotherapy, cryotherapy or rubber band ligation) or surgical treatment was considered indicative of relapse. The collected data were analyzed according to the Kaplan-Meier method. The average follow-up time was 5.6 years. There were 21 patients who suffered a relapse. The probability of successful treatment was 0.77 (range: 0.67–0.88) after 5 years and 0.68 (range: 0.5–0.86) after 10.6 years. We conclude that rubber band ligation represent an efficient long-term treatment for second-degree hemorrhoids. Approximately two thirds of the patients are cured after 5 years and more than a half after 10 years.
    Type of Medium: Electronic Resource
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