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  • 1
    Electronic Resource
    Electronic Resource
    Phosphorylcholine antibodies in pulmonary infection (1990)
    Springer
    Medical microbiology and immunology 179 (1990), S. 205-214 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Phosphorylcholine (PC) antibodies in serum from patients with pulmonary infection, and from normal individuals, were studied. Anti-PC antibodies were detectable in the serum from normal individuals at mean concentrations of 320 μg/ ml for the IgG class and 110 μg/ml for the IgM class. Concentrations of anti-PC antibodies which were higher than normal for both the IgG and IgM classes were observed in the serum in pulmonary infection (1,440 μg/ml and 210 μg/ml, respectively). Despite the significant difference in the concentration of anti-PC antibodies, the PC-specific B cell precursor frequency in the peripheral blood lymphocytes showed no difference between normal individuals and the patients with pulmonary infection, or between the acute phase and the chronic phase in a single patient with chronic pulmonary infection. Serologically, the purified IgG anti-PC antibody did not share the cross-reactive idiotype of TEPC 15, which is the most common idiotype of the murine anti-PC antibodies. However, the purified IgM anti-PC antibody expressed a very weak cross-reactive idiotype of TEPC 15. It appears from these studies that human anti-PC antibodies may play an important biological role in pulmonary infection by microorganisms which possess a PC determinant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00195251
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  • 2
    Electronic Resource
    Electronic Resource
    Increased plasma fibronectin in patients with systemic lupus erythematosus (1990)
    Springer
    Clinical rheumatology 9 (1990), S. 214-219 
    Details
    ISSN: 1434-9949
    Keywords: Fibronectin ; Systemic Lupus Erythematosus ; Mononuclear Phagocytic System
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To add to our knowledge of collagen diseases, plasma fibronectin (FN) in patients with systemic lupus erythematosus (SLE) has been measured, and it was determined that the plasma FN value in those with SLE was 454±36 μg/ml, is significantly higher than the FN value in normal subjects (234±21 μg/ml. Further, the plasma FN value of patients with active SLE was significantly higher (591±46 μg/ml than that of patients with non-active SLE (287±31 μg/ml. The plasma FN value of SLE patients was also seen to be associated with the peripheral blood platelet count and with the dose level of the corticosteroid hormone administered to patients. In active SLE patients, it was similarly found that the plasma FN value had a significant correlation with the peripheral blood lymphocyte count and with the dose level of the corticosteroid hormone given to patients. Since the plasma FN value is known to be high in untreated SLE patients, it was felt that the increase of the FN value in SLE patients is not due to the effect of the corticosteroid but to the disease itself.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02031971
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Therapeutic effect of tiopronin followingd-penicillamine toxicity in a patient with rheumatoid arthritis (1998)
    Springer
    Clinical rheumatology 17 (1998), S. 73-74 
    Details
    ISSN: 1434-9949
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01450965
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Patient with both lupus anticoagulant and acute disseminated encephalomyelitis (1996)
    Springer
    Clinical rheumatology 15 (1996), S. 501-503 
    Details
    ISSN: 1434-9949
    Keywords: Acute Disseminated Encephalomyelitis ; Convulsion ; Diphenylhydantoin ; Lupus Anticoagulant ; Pulse Methylprednisolone Therapy ; Type IV-Hypersensitivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We present the unusual case of 16-year-old girl who developed intractable convulsions five days after the onset of a cold. Meningeal signs, lymphopenia, proteinuria, and lupus anticoagulant were also present. Treatment with anticonvulsants, antituberculous agents, and adenine arabinoside were ineffective. The initiation of methylprednisolone pulse therapy immediately resolved convulsions and fever. The diagnosis, suggested by the clinical course and the marked improvement of the meningoencephalitis by pulse therapy, was an encephalitic form of acute disseminated encephalomyelitis. Clinical and laboratory findings indicated that an immune disorder may have triggered an abnormal response to a viral infection leading to this patient's neurologic disorder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02229651
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Successful methotrexate therapy for adult Still's disease with Marked thrombocytopenia (1998)
    Springer
    Clinical rheumatology 17 (1998), S. 256-257 
    Details
    ISSN: 1434-9949
    Keywords: Adult Still's disease ; Methotrexate ; Prednisolone ; Thrombocytopenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 34-year-old Japanese woman developed spiking fever, splenomegaly, arthritis, neutrophilia, hyperferritinaemia (22517 ng/ml), elevated C-reactive protein (9.1 mg/ml) and severe thrombocytopenia (1.7×104/μl). The patient had depressed antithrombin III activity and abnormally high concentrations of both fibrin degradation products and thrombin-antithrombin complexes. This condition was resistant to high-dose prednisolone therapy (120 mg/day) and non-steroidal anti-inflammatory drugs. We initiated oral methotrexate therapy (7.5 mg/week, orally) with a favourable outcome. The patient's spiking fever subsided on the first day of methotrexate administration. Elevated levels of ferritin and C-reactive protein in the sera rapidly normalised. Methotrexate rapidly improved the disease state which suggested that methotrexate act via modulation of cytokine production or secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01451061
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  • 6
    Electronic Resource
    Electronic Resource
    Elevation of Serum Soluble Tumour Necrosis Factor Receptors in Patients with Polymyositis and Dermatomyositis (2000)
    Springer
    Clinical rheumatology 19 (2000), S. 352-359 
    Details
    ISSN: 1434-9949
    Keywords: Key words: Dermatomyositis – Polymyositis – Soluble TNF receptor 1 – Soluble TNF receptor 2 – TNF-receptor 1 – TNF-receptor 2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: The aim of the study was, to examine the relationship between serum levels of soluble tumour necrosis factor receptors (sTNF-R) and the gene expression of two types of receptor for TNF (TNF-R), a 55 kDa receptor (TNF-R1) and a 75 kDa receptor (TNF-R2), in peripheral blood mononuclear cells (PBMC) from patients with polymyositis and dermatomyositis (PM/DM). Soluble tumour necrosis factor receptor 1 (sTNF-R1) and soluble tumour necrosis factor receptor 2 (sTNF-R2) levels in sera from patients were measured by enzyme-linked immunosorbent assay. Expression of TNF-R1 and TNF-R2 mRNAs in PBMC was analysed by Northern blotting. Serum sTNF-R1 and sTNF-R2 levels were elevated significantly in 25 patients with active-stage PM/DM, compared to those in 18 patients with inactive-stage PM/DM and 32 normal controls. Serum concentrations of sTNF-R1 and sTNF-R2 were correlated with PM/DM disease activity. TNF-R1 gene expression was enhanced in freshly isolated PBMC from patients with active-stage PM/DM. In contrast, TNF-R2 mRNA was expressed constitutively in patients with active-stage PM/DM and in normal controls. The expression of TNF-R1 and TNF-R2 mRNAs in PBMC and elevation of their soluble forms in the sera of patients with active-stage PM/DM suggest increased proteolytic cleavage of cell surface TNF-R from PBMC in patients with active-stage PM/DM, and that sTNF-R may regulate TNF-α-mediated muscle fibre damage in PM/DM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100670070027
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  • 7
    Electronic Resource
    Electronic Resource
    Multiple high intensity lesions considered as “état criblé” (1996)
    Springer
    Clinical rheumatology 15 (1996), S. 219-221 
    Details
    ISSN: 1434-9949
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02230350
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Analysis of exploratory eye movement in a patient with lupus psychosis (1998)
    Springer
    Clinical rheumatology 17 (1998), S. 383-386 
    Details
    ISSN: 1434-9949
    Keywords: Electroencephalograph ; Exploratory eye movement analysis ; Interferon α ; Lupus psychosis ; Systemic lupus erythematosus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The psychiatric and cognitive condition of a patient with lupus psychosis was evaluated. Using a device that detects the corneal reflection of infrared light, the patterns of eye tracking movements were recorded before the onset of lupus psychosis, after remission, and again 1 year later. Electroencephalographic findings and cerebrospinal fluid levels of both interferon α and interleukin-6 were also obtained longitudinally. Electroencephalographic findings and clinical signs were correlated to the levels of interferon α in cerebrospinal fluid. Analysis of exploratory eye movements revealed marked decreases in the number of eye fixations, mean eye-scanning length and total eye-scanning length. Even though the lupus psychosis resolved and the electroencephalographic findings became normal, the eye movement patterns showed remaining deterioration. It was concluded that analysis of exploratory eye movements in patients with systemic lupus erythematosus may be useful in diagnosing lupus psychosis, and may also present a diagnostic clue to subclinical lupus psychosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01450896
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