Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 9 (1930), S. 2217-2227 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Development genes and evolution 161 (1968), S. 147-161 
    ISSN: 1432-041X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung An Hühnerembryonen der Stadien 5–21 wurde das Auftreten von Cholinesterase-Aktivität in Zellverbänden verfolgt, die bei der Abfaltung des Embryos von Bedeutung sind. Im Neuroektoderm treten während der Neuralrohrbildung Cholinesterase-positive Zellen auf. Diese Aktivität verschwindet, wenn das Neuralrohr ausgebildet ist. Anschließend lassen sich Cholinesterase-positive Neuroblasten darstellen. Im Oberflächenektoderm tritt Cholinesterase-Aktivität während der Ausbildung der Kopffalte und der Grenzrinnen auf. Die Aktivität verschwindet, wenn sich die Kopfanlage vom extraembryonalen Teil der Keimblätter getrennt hat. Bei der Ausbildung der Entodermwülste und während des Einwanderns derselben zum Darmrohrschluß bilden sich palisadenartige Epithelverdickungen aus, die Cholinesterase aufweisen. Wenn das Darmrohr geschlossen ist, verschwindet die Aktivität wieder. Während der Darmrohrbildung wird das nach ventral und medial einwachsende Entoderm von palisadenartig strukturiertem Mesoderm begleitet, das Cholinesterase-Aktivität aufweist. Nach Schluß des Darmrohres löst sich die palisadenartige Anordnung auf und die Cholinesterase-Aktivität verschwindet.
    Notes: Summary The localization of cholinesterase activity in chick embryo of stage 5 up to stage 21 has been studied in cell layers that are involved in the formation of the primitive body tube. During the formation of the neural tube, cholinesterase activity can be demonstrated in cells of the neural plate. This pattern of enzyme activity disappears after formation of the neural tube. Thereafter, the enzyme is localized in neuroblasts. In the ectodermal layer, cholinesterase activity is found during the formation of the head fold and the lateral body folds. Again, the enzyme disappears after the development of the cephalic outgrowth. Formation of the entodermal folds and their fusion in the midline — thus establishing the gut tube — is associated with cholinesterase activity in palisade cell layers. There is no enzyme activity in the completed gut. During the formation of the gut tube, the mediad invading entodermal folds are covered by mesodermal cell palisades, which are positive for cholinesterase. After the formation of the gut tube, the palisades disappear as does the enzyme activity.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Postoperative Übelkeit und postoperatives Erbrechen ; Inhalationsanästhesie ; Prädiktion ; Risikoscore ; Key words Postoperative nausea and vomiting ; PONV ; Prediction ; Risk score
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Despite numerous factors are thought to affect postoperative vomiting (PV) recent studies demonstrated that the risk of PV can be predicted by considering just the most important ones. Therefore, the aim of this study was to present the clinically most relevant factors, a risk score based upon those factors and its clinical applicability for other types of surgery. Methods: In a prospective study 2220 adult inpatients scheduled for elective surgery were monitored for PV after inhalational anaesthesia over 24 hours. None of the patients received prophylactic antiemetic treatment. Multivariate analyses were perfomed with data of patients who underwent otolaryngological procedures to identify the major risk factors and to derive a risk score. The applicability of the score in surgical and ophthalmological procedures was tested by linear regression analysis of expected and observed incidences. Results: In the multivariate model, clinically most important risk factors for PV were female gender, young age, a positive history of postoperative nausea and vomiting or motion sickness, non-smoking and a long duration of anaesthesia, whereas the relative impact of the ”type of operation itself” was small. Expected and observed incidences in patients undergoing other types of surgery were strongly correlated (R2=0.99, P〈0.001). Conclusion: The risk for PV after inhalational anaesthesia in adults can be predicted using a score which is based on individual risk factors and the duration of anaesthesia only.
    Notes: Zusammenfassung Trotz der multifaktoriellen Genese postoperativen Erbrechens (PE) konnte jüngst gezeigt werden, daß das PE-Risiko anhand weniger Faktoren abgeschätzt werden kann. Ziel dieser Arbeit war daher, die klinisch relevanten Faktoren darzustellen, einen daraus abgeleiteten Score vorzustellen und dessen praktische Anwendbarkeit zu demonstrieren. Methodik: Im Rahmen einer prospektiven Studie erhielten 2220 Patienten eine Inhalationsanästhesie ohne antiemetische Prophylaxe. Mittels einer multivariaten Analyse der Patientendaten der HNO-Klinik wurden klinisch relevante Faktoren herausgearbeitet und ein Risikoscore errechnet. Die Anwendbarkeit dieses Scores auf Patienten der Chirurgie und Augenklinik wurde mittels linearer Regression zwischen erwarteter und tatsächlicher Inzidenz überprüft. Ergebnisse: Die wichtigsten Risikofaktoren für PE waren weibliches Geschlecht, junges Alter, Übelkeit und Erbrechen nach Operationen oder eine Reisekrankheit in der Anamnese, Nichtraucherstatus und eine lange Narkosedauer. Obgleich primär einige Operationen mit hohen und andere mit niedrigen Erbrechensinzidenzen einhergingen, war in einem multivariaten Modell der Einfluß der ”Operation an sich” gegenüber den zuvor erwähnten Risikofaktoren gering. Bei der Anwendung des Risikoscores auf andere Operationen zeigte sich eine signifikante Korrelation zwischen erwarteter und tatsächlicher Inzidenz (r2=0,99, p〈0,001). Schlußfolgerungen: Die Wahrscheinlichkeit, mit der bei einem Erwachsenen nach Inhalationsanästhesien PE auftritt, läßt sich anhand individueller Risikofaktoren sowie der Narkosedauer voraussagen. Die bekannten Unterschiede zwischen verschiedenen Operationen sind vor allem durch die zuvor beschriebenen Faktoren bedingt.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 38 (1982), S. 254-256 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In rats, the hemorrhagic gastric erosions produced by ethanol, and the fatal hemorrhagic hepatic recrosis induced by phalloidin, were significanlty reduced by regular somatostatin, but not by derivatives devoid of-SH containing cysteines. These effects of the hormone were abolished in animals which received, in a dditiion, the sulfhydryl blocker nethylmaleimide before the toxic chemicals. Thus, somatostain exhibits organoprotection dependent on endogenous sulfhydryls.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1432-1440
    Keywords: TRH ; Brain ; Pancreas ; Human ; Plasma ; Selective blood sampling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Endogenous TRH levels were determined in plasma obtained selectively via percutaneous transhepatic and femoral catheterization. TRH was measured using a very sensitive RIA method. In the pancreatic veins, internal jugular vein, left testicular vein, and other described veins, normal peripheral levels were found. An involvement of the TRH degrading enzyme (TDE) or a rapid intravasal dilution leading to normal peripheral TRH levels in the veins leaving the brain or pancreas, respectively, is discussed.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1432-1440
    Keywords: Hyperthyroidism, latent ; TSH ; Circadian rhythm ; Pulsatile secretion ; Diagnostic methods
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In euthyroidism the circadian rhythm and pulsatility of TSH is well known. With regard to hyperthyroidism only very preliminary data were described. In this tudy we investigated the secretion pattern of the pituitary-thyroid axis hormones during 24 h in latent and overt hyperthyroidism and in euthyroidism with regard to common and different properties. Blood was obtained for 24 h at 10-min intervals. In euthyroidism we found intraindividually three overlapping patterns of TSH, which are different in amplitude and frequency and can be found interindividually, too. These patterns are equal to the circadian rhythm, pulsatile secretion and lastly to the methodic rustle. The circadian rhythm in latent hyperthyroidism is distinctly suppressed and in overt hyperthyroidism totally. Whereas in latent hyperthyroidism pulsatile secretion is extant, in overt hyperthyroidism the TSH pulses are absent. To record the patients' TSH circadian rhythm with only three blood samples, we defined the TSH-Triplex. In young as well as in elderly healthy volunteers it demonstrated significantly higher TSH levels at midnight (at 24:00 h) than it did at 4 p.m. and 8 a.m. The present study shows a significantly different TSH pattern in latent hyperthyroidism compared to euthyroidism. It should be discussed whether latent hyperthyroidism could be defined as hyperthyroidism stage I. On the other hand, latent hyperthyroidism could be an illness with its own cause, different from hyperthyroidism. Our data suggest that the laboratory findings of latent hyperthyroidism in each age are non-physiological. However, the cause for this disorder is unclear until now; hence further investigations are necessary.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Isologous transplants of cellular suspensions of embryonic organs (stomach, intestine, pancreas, suprarenal body, liver, lungs, kidney, cartilage, and nerve tissue) were made on the adult rat. It was demonstrated that histiotypical organs develop from the suspensions.
    Notes: Zusammenfassung Aus isolog transplantierten Zellsuspensionen embryonaler Organanlagen der Ratte entwickeln sich beim erwachsenen Empfängertier histiotypische Organe. Dies gelang uns bisher für folgende Organe: Magen, Darm, Pankreas, Nebenniere, Leber, Lunge, Niere, Knorpel und Nervengewebe.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1432-1440
    Keywords: Primary hypogonadism ; testicular tubules ; nerve fibers ; cholinesterase ; Primärer Hodenschaden ; Hodentubuli ; Nervenfasern ; Cholinesterase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Enzymhistochemische und elektronenoptisch-enzymhistochemische Untersuchungen an Hodenbiopsien von 12 Klinefelter-Patienten, 4 Patienten mit Kryptorchismus sowie 5 Kontrollhoden ergaben: 1. Bei Klinefelter-Patienten konnten ausschließlich in der Zeit nach Beginn der Pubertät in den Wänden von Hodentubuli Cholinesterase-positive, marklose Nervenfasern nachgewiesen werden. 2. Diese Nervenfasern durchziehen die gesamte Tunica propria bis zur Basalmembran. Die Basalmembran wurde nie durchbrochen. 3. Der gleiche Befund konnte bei 2 Patienten mit Kryptorchismus erhoben werden. 4. In der Wand der Hodentubuli von präpuberalen Klinefelter-Patienten sowie in total sklerohyalinisierten Tubuli erwachsener Klinefelter-Patienten konnten, wie bei allen Kontrollhoden, keine Nervenfasern gefunden werden. 5. Das Vorkommen von Nervenfasern in den Tubuluswänden während einer bestimmten Phase der Degeneration zeigt möglicherweise einen bisher unbekannten pathogenetischen Mechanismus auf, der für die Entstehung primärer Hodenschäden von Bedeutung sein könnte.
    Notes: Summary Enzyme-histochemical and electron microscopic studies of testicular biopsies of 12 patients with Klinefelter's syndrome including 4 patients with cryptorchism and 5 controls yielded the following results: 1. In postpuberal Klinefelter patients, cholinesterase-positive non-myelinated nerve fibers were shown to exist in the walls of testicular tubules. 2. These nerve fibers were found in the whole tunica propria except in the basement membrane. The basement membrane was never perforated. 3. The same findings were observed in 2 patients with cryptorchism. 4. However, these nerve fibers could never be demonstrated in the testicular tubules of controls, prepuberal Klinefelter patients or of Klinefelter patients with total sclerohyalinated tubules. 5. The appearance of nerve fibers in the tubules during a certain period of degeneration is not entirely understood at the moment. It is possibly part of a hitherto unknown pathogenetic mechanism in the development of primary hypogonadism.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 64 (1986), S. 1261-1266 
    ISSN: 1432-1440
    Keywords: Autoimmune diseases ; Autoreactive T- and B-lymphocytes ; Insulin dependent diabetes mellitus ; Rheumatoid arthritis ; Immunosuppressants ; Ciamexone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Both organ-specific diseases such as insulin dependent diabetes mellitus as well as non organ-specific disorders such as rheumatoid arthritis are thought to be autoimmune in origin. Both T-cell and B-cell mediated immune responses are involved in these deseases. More or less specific immunosuppressants are therefore widely used drugs in the treatment of autoimmune diseases which, however, suppress the immune reactions not only against autoantigens but also against foreign antigens. Cyclosporine (Cyclosporin A) has been a tremendous step forward in a more specific direction but it creates problems in the long term treatment of autoimmune diseases due to the impairment of immune reactions against foreign antigens as well as to compound specific side effects. Ciamexone, a new highly selective immunomodulator, might be an interesting new approach in the treatment of autoimmune diseases. The compound has had effect in different experimental autoimmune situations such as the diabetic BB-rat and experimentally-induced arthritis in mice or rats. The compound does not show antiproliferative activity on T-lymphocytes or B-lymphocytes. The immune response against foreign antigens, e.g. foreign major histocompatibility complex, viral or fungal antigens is not impaired. On the other hand, however, Ciamexone suppresses the antibody production in different animal systems. It is likely that Ciamexone exhibits its immunosuppressive property via the induction of regulating mechanisms. Due to its remarkably good tolerance, Ciamexone has been used in first pilot trials in different human autoimmune situations such as rheumatoid arthritis and insulin dependent diabetes mellitus. The first results of these open trials showed some encouraging effects so that double blind controlled trials are in progress.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...