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  • 1
    Electronic Resource
    Electronic Resource
    THE RELATION BETWEEN PREGNANCY SPECIFIC β1 GLYCOPROTEIN (SP1) LEVELS AND ABNORMAL GLUCOSE TOLERANCE IN PREGNANCY (1979)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 86 (1979), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Pregnancy specific β1 glycoprotein (SP1) levels were measured in 54 potentially diabetic patients in the third trimester of pregnancy using a laser nephelometric method. All patients were tested by the 50 g oral glucose tolerance test. The results show that a significantly greater number of patients with abnormal glucose tolerance had SP1 levels above the mean compared with patients with normal glucose responses. All patients with a diabetic type response had SP1 levels above the mean. There was no significant difference in SP1 levels in the fasting and two-hour plasma samples. The study suggests that patients with asymptomatic glucose intolerance in pregnancy have higher SP1 levels than patients with normal glucose tolerance. It is possible that one of the factors controlling the placental output of SP1 is the maternal blood glucose level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1979.tb10789.x
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  • 2
    Electronic Resource
    Electronic Resource
    THE RADIOIMMUNOASSAY OF A PREGNANCY SPECIFIC-β1-GLYCOPROTEIN IN PLASMA AS A PREGNANCY TEST FOR SUBFERTILE WOMEN (1980)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 87 (1980), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We used a pregnancy specific-β-glycoprotein (SP1) radioimmunoassay to monitor 72 menstrual cycles of 38 apparently subfertile women who were trying to become pregnant. Blood samples were taken up to day 42 from the start of the previous menstrual cycle. Using serum SP1 levels greater than 6μg/1 as indicative of pregnancy, we obtained 16 positive results of which 11 were later confirmed by a human chorionic gonadotrophin haemagglutination pregnancy test. Three of the five women whose pregnancies were not confirmed had a subsequent history of spontaneous abortion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1980.tb04585.x
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  • 3
    Electronic Resource
    Electronic Resource
    Peri-operative endocrine effects of etomidate (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 40 (1985), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study investigated the effects of etomidate on endocrine responses to anaesthesia and surgery. Patients undergoing abdominal hysterectomy received standard anaesthetics of either etomidate for induction with etomidate infusion, or thiopentone and halo thane. Etomidate suppressed the secretion of cortisol and aldosterone for between 8 and 22 hours after the end of the etomidate infusion; 11-deoxycortisol secretion was not suppressed during the etomidate infusion, but rose postoperatively; 17α-hydroxyprogesterone suppression also lasted only as long as the etomidate infiion. There were no effects on plasma oestradiol, A CTH, or prolactin, but growth hormone concentrations were elevated in the etomidate group. Etomidate was concluded to have influenced adrenocortical function only, where it probably inhibits 11 β-hydroxylation, 17 α-hydroxylation and other intramitochondrial hydroxylation reactions. There were no clinical sequelae attributable to adrenocortical suppression. The relationship of chemical structure of etomidate and other phenylated imidazoles to inhibition of steroidogenesis is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1985.tb10702.x
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  • 4
    Electronic Resource
    Electronic Resource
    Exposure of the fetus and infant to hens' egg ovalbumin via the placenta and breast milk in relation to maternal intake of dietary egg (2005)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 35 (2005), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Maternally derived allergens may be transferred to the developing infant during pregnancy and lactation. However, it is not known how manipulation of environmental allergen levels might impact on this early-life exposure.Objective To measure dietary egg allergen (ovalbumin (OVA)) in gestation-associated environments, in relation to maternal dietary egg intake.Method OVA was measured by allergen-specific ELISA in maternal blood collected throughout pregnancy, infant blood at birth (umbilical cord) and in breast milk at 3 months post-partum. Samples derived from pregnant women undergoing diagnostic amniocentesis at 16–18 weeks gestation who were not subject to any dietary intervention, and from pregnant women, with personal or partner atopy, randomized to complete dietary egg exclusion or an unmodified healthy diet before 20 weeks gestation as a primary allergy prevention strategy. Maternal dietary egg intake was monitored closely throughout the study period by diary record and serial measurement of OVA-specific immunoglobulin G concentration.Results Circulating OVA was detected throughout pregnancy in 20% of women and correlated with both presence (P〈0.001) and concentration (r=0.754, P〈0.001) of infant OVA at birth (umbilical cord). At 3 months post-partum OVA was detected in breast milk samples of 35% women, in higher concentrations than measured in blood. Blood and breast milk OVA were not related to maternal dietary intake or atopic pre-disposition.Conclusions Rigorous dietary egg exclusion does not eliminate trans-placental and breast milk egg allergen passage. This early-life exposure could modulate developing immune responses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.2005.02346.x
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  • 5
    Electronic Resource
    Electronic Resource
    Determinants of Bone Loss in Elderly Men and Women: A Prospective Population-Based Study (1999)
    Springer
    Osteoporosis international 10 (1999), S. 384-391 
    Details
    ISSN: 1433-2965
    Keywords: Key words:Anthropometry – Bone loss – Epidemiology – Lifestyle – Osteoporosis – Prospective
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: While several studies have described the rate and pattern of involutional bone loss in women, far less information is available for men. Furthermore, the roles of lifestyle and body build in determining bone loss rate in both sexes have been largely extrapolated from cross-sectional studies. We addressed this issue in a population-based longitudinal study which sought to ascertain rates of bone loss at the femoral neck and lumbar spine in a cohort of men and women aged 60–75 years at baseline, and to relate this loss to anthropometric and lifestyle variables. We additionally investigated the capacity of biochemical markers of bone turnover to predict bone loss rates in these subjects. Women lost bone at all sites; this ranged from 0.20%/year at the lumbar spine to 1.43%/year at the femoral trochanteric region. By contrast, men lost only 0.20%/year at the trochanteric region, and gained at the lumbar spine (0.33%/year) and at Ward’s triangle (0.27%/year) over the 4-year period. Anthropometric measurements were associated with bone loss in both sexes; lower baseline body mass index (BMI) and a greater rate of loss of adiposity over the follow-up period were both associated with greater bone loss at all proximal femoral sites. These attained statistical significance after Bonferroni correction at the total proximal femur among both men (r= 0.29), p〈0.01) and women (r= 0.31, p〈0.05). Lifestyle factors associated with lower rates of bone loss (after adjustment for BMI) included alcohol consumption at the femoral neck among women (p= 0.007) and physical activity at the lumbar spine among men (p = 0.05). Serum parathyroid hormone, 25-hydroxyvitamin D and biochemical markers of bone turnover did not predict bone loss after adjustment for adiposity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001980050244
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  • 6
    Electronic Resource
    Electronic Resource
    The effect of induced hyperglucagonaemia on the zucker fatty rat (1978)
    Springer
    Diabetologia 14 (1978), S. 405-412 
    Details
    ISSN: 1432-0428
    Keywords: Long-acting glucagon ; Zucker fatty and lean rats ; adenylate cyclase ; radioreceptor assay ; Scatchard analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of chronic treatment with a long-acting glucagon preparation on liver glucagon and insulin receptors, adenylate cyclase and plasma lipids has been examined in Zucker fatty rats (fa/fa) and their lean littermates (Fa/−). Liver insulin and glucagon receptors were examined using radioreceptor assay techniques. Neither fatty nor lean rats showed any change in insulin receptors after glucagon treatment. Glucagon receptors of the fatty rats showed a 33% drop in the number of the glucagon receptors after glucagon treatment, whilst there was no such change in the lean group. Plasma membranes of the treated fatty rats and their controls bound only 50% as much insulin per mg of liver membrane protein as those of the treated lean rats and their controls. Glucagon treatment raised plasma NEFA in lean rats and reduced them in fatty ones. Plasma cholesterol levels were reduced in both groups of animals as were plasma triglycerides, though to a lesser degree in fatty than in lean animals. Glucagon treatment increased basal and stimulated adenylate cyclase activity in the lean rats and even more so in the fatty ones. The data lend no support to the concept that hypertriglyceridaemia in fatty Zucker rats is a consequence of abnormal glucagon responsiveness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01228135
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  • 7
    Electronic Resource
    Electronic Resource
    Differences in pituitary and testicular function between diabetic patients on insulin and oral anti-diabetic agents (1978)
    Springer
    Diabetologia 15 (1978), S. 13-17 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes ; pituitary function ; testicular function ; testosterone ; oral anti-diabetic agents ; growth hormone ; impotence ; gonadotrophins ; prolactin ; insulin ; thyrotrophin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pituitary responsiveness to thyrotrophin releasing hormone (TRH) and luteinizing hormone releasing hormone (LHRH) was studied in thirty one male diabetics, of whom sixteen were insulin-dependent and fifteen on oral antidiabetic agents. Ten age-matched controls were also studied. TRH and LHRH were simultaneously administered intravenously, each in a small dose of 10 μg followed two hours later by 190 μg and 90 μg respectively. Basal hormone levels were measured in a further group of thirty six patients (twelve on insulin, twelve on oral agents and twelve on dietary restrictions alone). Higher thyrotrophin (TSH) response was observed following the small dose of TRH in the patients treated with oral agents than in the control subjects. The response of prolactin was lower in patients treated with oral agents compared with those treated with insulin. There was no difference in plasma T3 and T4 levels in the patients treated with insulin or oral agents. Significantly higher basal growth hormone (GH) levels were observed in the diabetics. The insulin-dependent group showed a more marked response of GH to TRH/LHRH. No response was observed in the controls. Plasma testosterone levels were significantly lower in the oral agent group (13.8 nmol/l) than in the insulin group (19.4 nmol/l), patients on dietary restrictions (18.4 nmol/l) and the control subjects (19.0 nmol/l). The LH response to the smaller dose of LHRH was impaired in patients on insulin and oral agents. There was a significant difference in FSH response between impotent and sexually normal patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01219321
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  • 8
    Electronic Resource
    Electronic Resource
    Book review (1987)
    Springer
    New forests 1 (1987), S. 351-352 
    Details
    ISSN: 1573-5095
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00031744
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  • 9
    Electronic Resource
    Electronic Resource
    Book Review (1989)
    Springer
    New forests 3 (1989), S. 201-201 
    Details
    ISSN: 1573-5095
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00021583
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