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  • 1
    ISSN: 1432-1920
    Keywords: Key words Multiple sclerosis ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We evaluated the effect of consensus formation and training on the agreement between observers in scoring the number of new and enlarging multiple sclerosis (MS) lesions on serial T2-weighted MRI studies. The baseline and month 9 MRI studies of 16 patients with a range of MRI activity were used (dual-echo conventional spin-echo sequence, TR 2000, TE 34 and 90 ms, 5 mm contiguous slices, in-plane resolution 1 mm). First, the serial studies were visually analysed for the presence of new and enlarging lesions, on two occasions, by five experienced observers, without adopting any consensus strategy and in isolation. Next, the observers met to identify the common sources of inconsistencies in reporting between observers and formulate consensus rules. Finally, a further independent reading session was performed on the same MRI dataset, this time applying the consensus rules. Agreement between observers was assessed using kappa scores. Without the consensus rules, interobserver kappa scores for the first and second reading sessions for new lesions were only 0.51 and 0.39 respectively; agreement for enlarging lesions was even worse. The mean intraobserver kappa score for new lesions was higher at 0.72, reflecting the fact that the observers were consistently applying their individual assessment strategies. Application of the consensus rules did not lead to a significant improvement in inter observer kappas; the kappa scores adopting the guidelines were 0.46 and 0.21 for new and enlarging lesions respectively. Consensus guidelines thus did not improve the reproducibility of visual analysis of serial T2-weighted MRI, and the level of agreement between observers remained only moderate. Suboptimal repositioning is likely to be a major source of residual variability and this suggests a future role for image registration strategies; until then, a single observer, or pair of observers working in consensus, should be used in MS studies.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Dissektion ; Intramurales Hämatom ; Atherom ; Therapie ; Key words Dissection ; Intramural hematoma ; Atheroma ; Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Improved methods of imaging the cerebral vascular system have increased the detection of traumatic or spontaneous dissection of the vertebral and carotid arteries. Especially MRI allows direct demonstration of intramural hematomas that are a sign of dissection of the vessel wall. We report on a patient who had an acute onset of dysarthria and monocular blurred vision, which recurred several times. Doppler ultrasound showed stenosis in both internal carotid arteries with reduced velocity of the flow; angiography confirmed the stenosis, showing a long stretch of stenosis (70%) of the right and a short stretch of stenosis (60%) of the left internal carotid arteries. MRI demonstrated a narrowing of the lumen by an intramural mass, whose signal characteristics were typical for blood. The MRI findings were thus consistent with the diagnosis of a spontaneous dissection of the carotid arteries. Since the Doppler ultrasound follow-up showed no change during the following 3 days, we interpreted the MRI findings as an indication of bleeding in an atheroma. The carotid disobliteration, performed first on the left side and later on the right side, confirmed this interpretation. Since stenosis due to a fissuring atheroma or bleeding in an atheroma requires different therapy than a dissection, it is thus important to consider the possible differential diagnosis in interpreting the MRI.
    Notes: Zusammenfassung Durch die Fortschritte in den bildgebenden Verfahren werden traumatische, bzw. spontane Dissektionen der A. carotis und der A. vertebralis zunehmend häufiger diagnostiziert. Insbesondere die Magnetresonanztomographie ermöglicht dabei einen direkten Nachweis von intramuralen Hämatomen als Zeichen der Dissektion. Wir berichten nun über einen Patienten, der akut beginnend und im Verlauf rezidivierend eine Dysarthrie sowie monokuläre Sehstörungen des linken Auges bemerkte. Dopplersonographisch fand sich beidseits, rechts betont, eine im Bulbus der A. carotis communis beginnende, bis in die A. carotis interna reichende Stenose, in der arteriellen digitalen Subtraktionsangiographie eine langstreckige etwa 70%ige A.-carotis-interna-Stenose rechts und eine kurzstreckige etwa 60%ige Stenose links. Diese Befunde ließen sowohl an eine ausgeprägte arteriosklerotische Makroangiopathie als auch an eine Dissektion denken. In der Kernspintomographie fand sich dann eine verdickte Gefäßwand der A. carotis interna beidseits mit einem schmalen Restlumen. Dieses wurde beidseits von in der T1w-Gewichtung mit selektiver Fettunterdrückung hyperintensivem Gewebe, am ehesten einem intramuralen Hämatom entsprechend, eingeengt. Dieser Befund ließ dann an eine beidseitige Dissektion der A. carotis interna denken. Auf Grund der in der Duplexsonographie über Tage unveränderten Befunde wurde das Bild dann als eine Einblutung in Wandatherome beidseits bei arteriosklerotischer Makroangiopathie gewertet und der Patient wegen der rezidivierenden, hämodynamisch bedingten Symptomatik operiert. Bei der zweizeitig durchgeführten Karotisdesobliteration beidseits bestätigte sich der Verdacht auf intramurale Atherome. Intramurale Atherome mit oder ohne Einblutung sind eine kernspintomographische Differentialdiagnose zu intramuralen Hämatomen bei Karotisdissektion.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1084
    Keywords: Key words: Cranial nerves – MR imaging – Pulse sequences – 3D MRI
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The aim of this study was to evaluate the sensitivity of the three-dimensional constructive interference of steady state (3D CISS) sequence (slice thickness 0.7 mm) and that of the T2-weighted fast spin echo (T2-weighted FSE) sequence (slice thickness 3 mm) for the visualization of all cranial nerves in their cisternal course. Twenty healthy volunteers were examined using the T2-weighted FSE and the 3D CISS sequences. Three observers evaluated independently the cranial nerves NI–NXII in their cisternal course. The rates for successful visualization of each nerve for 3D CISS (and for T2-weighted FSE in parentheses) were as follows: NI, NII, NV, NVII, NVIII 40 of 40 (40 of 40), NIII 40 of 40 (18 of 40), NIV 19 of 40 (3 of 40), NVI 39 of 40 (5 of 40), NIX, X, XI 40 of 40 (29 of 40), and NXII 40 of 40 (4 of 40). Most of the cranial nerves can be reliably assessed when using the 3D CISS and the T2-weighted FSE sequences. Increasing the spatial resolution when using the 3D CISS sequence increases the reliability of the identification of the cranial nerves NIII–NXII.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European radiology 10 (2000), S. 1606-1609 
    ISSN: 1432-1084
    Keywords: Key words: Dural arteriovenous fistula – MR imaging – Endovascular therapy – Myelopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. We report on a 46-year-old patient in whom an intracranial dural arteriovenous (AV) fistula, supplied by a branch of the ascending pharyngeal artery, drained into spinal veins and produced rapidly progressive symptoms of myelopathy and brainstem dysfunction including respiratory insufficiency. Magnetic resonance imaging studies demonstrated brainstem oedema and dilated veins of the brainstem and spinal cord. Endovascular embolization of the fistula led to good neurological recovery, although the patient had been paraplegic for 24 h prior to embolization. This case demonstrates the MRI characteristics of an intracranial dural AV fistula with spinal drainage and illustrates the importance of early diagnosis and treatment. Even paraplegia may be reversible, if angiography is performed and the fistula treated before ischaemic and gliotic changes become irreversible.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1459
    Keywords: Key words Multiple sclerosis ; Magnetic resonance imaging ; Disease activity ; Fast spin echo ; Fast fluid-attenuated inversion ; recovery ; Reproducibility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Previous studies have addressed the question of the precision in assessing multiple sclerosis (MS) activity by counting enhancing lesions on gadolinium enhanced brain magnetic resonance imaging (MRI). However, counting the active lesions on serial unenhanced MRI obtained by various pulse sequences has not been yet considered. We compared the interobserver levels of agreement in reporting active MS lesions on serial enhanced and unenhanced MRI to assess whether the use of various unenhanced techniques may change the degree of interobserver measurement reproducibility. Dual-echo conventional spin echo (CSE), dual-echo fast spin echo (FSE), fast fluid-attenuated inversion recovery (FLAIR) and Gd-enhanced T1-weighted brain MRI were obtained from five MS patients at baseline and monthly for 2 months. Six experienced observers independently identified and counted active MS lesions on the two follow-up MRI scans. Active lesions were considered to be all the enhancing lesions and any new or enlarging lesion on enhanced and unenhanced scans. Interobserver levels of agreement were calculated by weighted κ values. Very good agreement was reached only for counting total and new Gd-enhancing lesions. Good agreement was achieved for counting new lesions on the three unenhanced techniques, whereas the agreement for counting enlarging lesions was poor with all the MRI techniques. The level of agreement was significantly heterogeneous for various MRI techniques but not for various lesion sites. These results confirm that counting enhancing lesions is the most reliable method for assessing MS activity, but the use of any of the available unenhanced MRI techniques did not result in different levels of interobserver agreement when reporting new and enlarging MS lesions on serial scans.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Karotis-Sinus-cavernosus-Fistel ; Antikoagulation ; Venenthrombose ; Venöser Infarkt ; A-V-Malformation ; Key words Carotid cavernous fistula ; Anticoagulation ; Venous thrombosis ; Venous infarct ; A-V malformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Dural carotid cavernous fistulas (DCCF) can be associated with venous thrombosis. We report on a rare case of a patient who developed a venous infarct, which was diagnosed on CT and MRI. The DCCF predominantly drained through a frontobasal cortical vein into the superior sagittal sinus. The shunt volume was small and was therefore thought not to be sufficient to explain the massive ocular signs, such as severe exophthalmus and reduction of visual acuity. We therefore postulated a venous congestion owing to a secondary spontaneous venous thrombosis of the draining venous pathways to be responsible for the ocular signs. Under anticoagulative medication, the patient's signs and symptoms improved gradually. Control angiography after 3 months showed that the DCCF had disappeared. In the presence of DCCF, anticoagulation should always be considered when a venous thrombosis is suspected.
    Notes: Zusammenfassung Durale Karotis-Sinus-cavernosus-Fisteln (DCCF) können mit einer Venenthrombose vergesellschaftet sein. Wir berichten über 1 Patientin mit einer DCCF, die einen ausgedehnten venösen Infarkt entwickelte. Die Drainage der DCCF erfolgte überwiegend über eine frontobasale Vene in den Sinus sagittalis superior. Das geringe Shuntvolumen der DCCF konnte die ausgeprägte okulare Symptomatik mit deutlichem Exophthalmus und erheblicher sekundärer Visusverschlechterung nicht erklären. Daher gingen wir von einer spontanen Thrombose im Bereich der Drainagewege der DCCF aus und haben die Patientin antikoaguliert. Unter dieser Therapie bildeten sich Exophthalmus und Visusstörung rasch zurück. In der Kontrollangiographie nach 3 Monaten war die DCCF nicht mehr nachweisbar. Eine Antikoagulation sollte bei vorliegender DCCF immer dann erwogen werden, wenn eine ausgeprägte venöse Thrombose vermutet wird.
    Type of Medium: Electronic Resource
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