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  • Electronic Resource  (8)
  • 1975-1979  (8)
  • 1
    Electronic Resource
    Electronic Resource
    Differenzierung der Proteinurie durch die Mikroelektrophorese in kontinuierlichen Polyacrylamid-Gradientengelen (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 19-24 
    Details
    ISSN: 1432-1440
    Keywords: Polyacrylamide-gradient gels ; microelectrophoresis ; proteinuria ; glomerulonephritis ; Polyacrylamid-Gradientengele ; Mikroelektrophorese ; Proteinurie ; Glomerulonephritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über die Anwendung der Mikroelektrophorese in Polyacrylamid-Gradientengelen zur Differenzierung der Proteinurie bei Glomerulonephritis berichtet. Die zeitlichen und methodischen Vorteile dieser Elektrophorese erlauben eine routinemäßige Durchführung in der Klinik. Durch die Auftrennung der Urinproteine nach ihrer Molekulargröße und Form lassen sich vier Proteinuriemuster unterscheiden: kleinmolekular, mittelmolekular, intermediär und hochmolekular. Glomerulonephritisformen, die konstante morphologische und klinische Veränderungen zeigen (z.B. minimal proliferierende Glomerulonephritis, mesangioproliferative Glomerulonephritis mit diffuser Halbmondbildung), lassen eine Zuordnung ihrer Proteinurie zu einem der vier Proteinuriemuster zu, während bei den anderen Glomerulonephritisformen (z.B. perimembranöse Glomerulone-phritis, mesangioproliferative Glomerulonephritis) eine Abhängigkeit des Proteinuriemusters von der Glomerulonephritisphase vermutet wird.
    Notes: Summary It is possible to differentiate the proteinuria of glomerulonephritis by means of microelectrophoresis in polyacrylamide-gradient gels. The advantages of this method (quick, cheap, concentration of the urine not required) led to its introduction into clinical use. Upon separating the urinary proteins according to their molecular weight and form, four patterns of proteinuria may be differentiated: low molecular, middle molecular, intermediate and high molecular. Those forms of glomerulonephritis which show constant morphological and clinical findings (e.g. minimal proliferative glomerulonephritis, mesangioproliferative glomerulonephritis with crescents) can be related to one of the four patterns of proteinuria, whereas the pattern of proteinuria in other forms of glomerulone-phritis (e.g. (peri-)membranous glomerulonephritis, mesangioproliferative glomerulonephritis) are dependent on the phase of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01466982
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  • 2
    Electronic Resource
    Electronic Resource
    PRELIMINARY ESTIMATES OF THE DOPAMINE β-HYDROXYLASE CONTENT AND ACTIVITY IN PURIFIED NORADRENERGIC VESICLES (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 28 (1977), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The dopamine β-hydroxylase (DβH) content and activity of large dense-core noradrenergic vesicles purified from bovine splenic nerve were determined using two assay procedures : enzymic activity expressed in Units per mg protein and homospecific activity based on radioimmunoassay expressed in Units per mg DβH antigen. Approximately two-thirds of the total enzyme activity is latent in these vesicles, even after various treatments designed to compromise vesicle integrity. DβH can be completely unmasked by brief treatment with 0.01-0.05% Triton X-100 and activity increases from 0.20 to 0.64 Units per mg vesicle protein. Calculations based on both assay methods suggested that an average of 7% (range 3-15%) of the total vesicle protein was DβH and that the average vesicle contained about 4 molecules of enzyme (range 2-9 molecules). The estimated homospecific activities indicated an average of 25 and 50% (range 18-72%) of the vesicle enzyme was inactive in the various samples using the two antibodies. The vesicle can synthesize up to 30 molecules of noradrenaline/s per molecule of DβH at near optimal substrate concentration, and 60-270 molecules of norepinephrine/s per vesicle. The assumptions used in the various calculations were critically analyzed and, based on the methods employed, it is tentatively considered to be unlikely that there could be more than 5-12 molecules of DβH per vesicle. The possibility that circulating DβH originates primarily, if not exclusively, from the large dense-core vesicle type is considered and the functional implications of the data support the concept of vesicle reuse during several cycles of exocytosis involving a quantal size equal to a fraction of the vesicle transmitter content.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1977.tb07711.x
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  • 3
    Electronic Resource
    Electronic Resource
    Pathogenetic mechanisms of recurrent herpes simplex virus infections (1976)
    Springer
    Archives of virology 51 (1976), S. 1-13 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01317829
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  • 4
    Electronic Resource
    Electronic Resource
    Isolation of herpes simplex virus clones and drug resistant mutants in microcultures (1975)
    Springer
    Archives of virology 49 (1975), S. 73-80 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Suitable dilutions of herpes simplex virus (HSV) preparations inoculated into microcultures of confluent monolayers of human foreskin or Vero cells, in individual wells of plastic “microplates”, induced viral cytopathic effects that resulted from the infection of the cultures by single virus particles. The clonal nature of the viral progeny in isolated wells was supported by visual control over the development of viral foci and by statistical analysis. The method has the advantage of speed and economy, while it also yields a large primary clonal virus stock. HSV clones resistant to phosphonoacetic acid (PAA) and 5-iodo-2′-deoxyuridine (IUdR) could be readily isolated by the described technique.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02175598
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  • 5
    Electronic Resource
    Electronic Resource
    Latent herpes simplex virus in ganglia of mice after primary infection and reinoculation at a distant site (1978)
    Springer
    Archives of virology 57 (1978), S. 161-166 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Herpes simplex virus (HSV)-infected hairless mice with evidence of latent infection in spinal ganglia did not develop latent HSV infections in trigeminal ganglia upon reinfection in the oro-facial area. HSV-infected and PAA-treated mice without evidence of latent HSV infection in spinal ganglia were resistant to reinfection in the lumbar region, but not to that performed in the oro-facial area.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01315677
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  • 6
    Electronic Resource
    Electronic Resource
    Depolarized light scattering from interacting brownian spheres (1979)
    Springer
    The European physical journal 32 (1979), S. 237-243 
    Details
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The initial decay time of the spectrum and the integrated intensity of depolarized light scattered from a system of interacting spherical and optically isotropic colloidal particles as a function of scattering angle is calculated in the double scattering approximation. These quantities can be reduced in the short-time regime to the static structure factor of single scattering, as observed in polarized scattering for systems of intermediate concentrations of colloidal particles. The results are applied to charged polysterene spheres in solutions and it is shown by numerical calculations that the presence of interactions can modify the angular dependence of initial decay time and integrated intensity considerably.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01320119
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  • 7
    Electronic Resource
    Electronic Resource
    $$\bar \Lambda $$ Production inK − p interactions at 32 GeV/c (1979)
    Springer
    The European physical journal 2 (1979), S. 7-10 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Antilambda production is studied inK − p interactions at 32 GeV/c. Both total and differential cross sections are presented. The inclusive $$\bar \Lambda $$ production cross section amounts to 109±7 μb. A remarkable energy dependence is observed, σ( $$\bar \Lambda $$ ) increasing by a factor of four between 14.3 and 32 GeV/c. Thep ⊥ 2 distribution exhibits an exponential fall-off with a slope of 3.3±0.2 (GeV/c)−2. Most of the $$\bar \Lambda $$ 's are emitted in the forward hemisphere. The invariantx distribution increases between 14.3 and 32 GeV/c. Data are presented for $$\bar \Lambda $$ production inK - p→Λ $$\bar \Lambda $$ +X K - p→ $$\bar \Lambda $$ K n +X, andK - p→ $$\bar \Lambda $$ p+X.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01546229
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  • 8
    Electronic Resource
    Electronic Resource
    A numerical method to obtain optimal quadrature formulas (1978)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 12 (1978), S. 487-504 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper present a numerical method to obtain optimal quadrature formulas of Gauss type and Radau type in the sense of Sard. Using the relation between optimal quadrature formulas and nonospline functions, the optimal quadrature formula can be obtained by solving a set of no-linear simultaneous algebraic equations induced from the interpolatory conditions of the monospline. In attempting to solve this set of non-linear algebraic equations for numbers of knots and degrees of interpolution required in estimation problem applications insurmountable numerical errors were encountered. This paper solves the numerical problem by first reducing the number of unknowns and equations to approximately one half the original number. This is accomplished by showing and then using a symmetry property of the monospline. Second an iteration scheme which partitions the reduced order set of non-linear algebraic equations into a linear subsystem and a non-linear subsystem is developed to numerically solve the equations. This iteration algorithm provides the advantages of reducing the computational complexity, dynamically checking the convergence and explicitly evluating the resulting accuracy.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620120310
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